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| 1 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 2 | Extrahepatic manifestations of chronic hepatitis C virus infection:297 cases from a tertiary medical center in Beijing, China显示文摘 | Cheng Zhaojing Zhou Baotong Shi Xiaochun Zhang Yao Zhang Lifan Chen Limeng Liu Xiaoqing | 2014 | Chinese Medical Journal2014，，7： | 6 |
| 3 | Impact of global change on transmission of human infectious diseases显示文摘Global change,which refers to large-scale changes in the earth system and human society,has been changing the outbreak and transmission mode of many infectious diseases.Climate change affects infectious diseases directly and indirectly.Meteorological factors including temperature,precipitation,humidity and radiation influence infectious disease by modulating pathogen,host and transmission pathways.Meteorological disasters such as droughts and floods directly impact the outbreak and transmission of infectious diseases.Climate change indirectly impacts infectious diseases by altering the ecological system,including its underlying surface and vegetation distribution.In addition,anthropogenic activities are a driving force for climate change and an indirect forcing of infectious disease transmission.International travel and rural-urban migration are a root cause of infectious disease transmission.Rapid urbanization along with poor infrastructure and high disease risk in the rural-urban fringe has been changing the pattern of disease outbreaks and mortality.Land use changes,such as agricultural expansion and deforestation,have already changed the transmission of infectious disease.Accelerated air,road and rail transportation development may not only increase the transmission speed of outbreaks,but also enlarge the scope of transmission area.In addition,more frequent trade and other economic activities will also increase the potential risks of disease outbreaks and facilitate the spread of infectious diseases. | WU XiaoXu TIAN HuaiYu ZHOU Sen CHEN LiFan XU Bing | 2014 | Science China Earth Sciences2014，57，2： | 6 |
| 4 | Activation of β-catenin signaling in aggrecan-expressing cells in temporomandibular joint causes osteoarthritis-like defects显示文摘β-Catenin plays a critical role in cartilage formation and development. To further understand the role of β-catenin in osteoarthritis(OA) development in temporomandibular joint(TMJ), we have generated β-catenin conditional activation mice(β-cat(ex3)^(Agc1CreER))by breeding Agc1-CreER mice with β-catenin^(flox(ex3)/+)mice. Results of histologic analysis showed the progressive TMJ defects in 3-and 6-month-old β-cat(ex3)^(Agc1CreER)mice(tamoxifen induction was performed at 2 weeks of age), including decreased chondrocyte numbers in the superficial layer associated with less Alcian blue staining, increased numbers of hypertrophic chondrocytes in deep layers, and rough articular surface. Compared to the TMJ phenotype of β-cat(ex3)^(Col2CreER)mice, β-cat(ex3)^(Agc1CreER)mice showed much severe morphological defects in the superficial layer of TMJ. This may reflect that Agc1-CreER mice could efficiently target cells in the superficial layer of TMJ. Results of immunostaining showed significantly increased expression of MMP13, Col-X, Adamts4,and Adamts5 in TMJ of β-cat(ex3)^(Agc1CreER)mice. Results of proliferating cell nuclear antigen(PCNA), Ki67, and terminal deoxinucleotidyl transferase-mediated d UTP-fluorescein nick end labeling(TUNEL) staining further demonstrated that cell proliferation was decreased and cell apoptosis was increased in condylar cartilage of β-cat(ex3)^(Agc1CreER)mice. Our findings indicate that abnormal upregulation of β-catenin in TMJ leads to defects assembling to OA-like phenotype, further demonstrating that β-catenin plays a critical role in TMJ pathogenesis. | Tianqian Hui Yachuan Zhou Tingyu Wang Jun Li Shanxing Zhang Lifan Liao Jianhong Gu Ling Ye Lan Zhao Di Chen | 2018 | International Journal of Oral Science2018，10，2： | 6 |
| 5 | A genome-wide landscape of mRNAs,lncRNAs,and circRNAs during subcutaneous adipogenesis in pigs显示文摘Background: Preadipocyte differentiation plays a critical role in subcutaneous fat deposition in pigs.However,the roles of different RNAs,such as messenger RNAs(mRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs) in the differentiation process of subcutaneous preadipocytes,are still largely unclear.In the present study,a transcriptome analysis,including the analysis of mRNAs,lncRNAs,and circRNAs,during different differentiation stages,namely,day 0(D0),day 2(D2),day 4(D4),and day 8(D8),of subcutaneous preadipocytes from Chinese Erhualian pigs was performed.Results: A total of 1554,470,1344,1777,and 676 differentially expressed(DE) mRNAs,112,58,95,136,and 93 DE lncRNAs,and 902,787,710,932,and 850 DE circRNAs were identified between D2 and D0,between D4 and D2,between D8 and D4,between D4 and D0,and between D8 and D0,respectively.Furthermore,functional enrichment analysis showed that the common DE mRNAs during the entire differentiation process were mainly involved in lipid metabolic and cell differentiation processes.Additionally,co-expression network analysis identified the potential lncRNAs related to adipogenesis,e.g.,MSTRG.131380 and MSTRG.62128.Conclusions: Our study provides new insights of the expression changes of RNAs during adipogenic differentiation,which might contribute to the phenotype of subcutaneous adipogenesis.These results greatly improve our understanding of the molecular mechanisms regulating subcutaneous fat deposition in pigs. | Xin Liu Kaiqing Liu Baosen Shan Shengjuan Wei Dongfeng Li Haiyin Han Wei Wei Jie Chen Honglin Liu Lifan Zhang | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 5 |
| 6 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 7 | Design and fabrication of 1-D semiconductor nanomaterials for high-performance photovoltaics显示文摘To date, the cost-effective utilization of solar energy by photovoltaics for large-scale deployment remains challenging. Further cost minimization and efficiency maximization, through reduction of material consumption, simplification of device fabrication as well as optimization of device structure and geometry, are required. The usage of 1D nanomaterials is attractive due to the outstanding light coupling effect, the ease of fabrication, and integration with one-dimensional(1-D) semiconductor materials. The light absorption efficiency can be enhanced significantly, and the corresponding light-toelectricity conversion efficiency can be as high as their bulk counterparts. Also, the amount of active materials used can be reduced. This review summarizes the recent development of 1-D nanomaterials for photovoltaic applications, including the anti-reflection, the light absorption,the minority diffusion, and the semiconductor junction properties. With solid progress and prospect shown in the past 10 years, 1-D semiconductor nanomaterials are attractive and promising for the realization of high-efficiency and low-cost solar cells. | Ning Han Zaixing Yang Lifan Shen Hao Lin Ying Wang Edwin Y.B.Pun Yunfa Chen Johnny C.Ho | 2016 | Science Bulletin2016，61，5： | 3 |
| 8 | Enterprise WeChat Groups: Their Effect on Work-Life Conflict and Life-Work Enhancement显示文摘社会媒介技术为要连接工作的雇员使它逐渐地可行。WeChat,一个最新新兴的社会媒介平台,广泛地在日常生活被使用,还几乎仍然没有在企业的 WeChat 组的使用的后果的小理解。基于边界理论,我们建议在企业的 WeChat 组的使用为雇员有两利弊。我们从 202 个雇员的联机调查收集了数据。在企业 WeChat 张贴工作相关的内容组织的结果表演为雇员在工作上有有益的影响而且引起了工作生活冲突(WLC ) 。然而,在企业 WeChat 组张贴生活相关的内容贡献雇员一生的工作改进(LWE ) 。贡献和这些调查结果的未来学习方向被讨论。 | Shengming Liu Ye Zhang Lifan Chen Li Guo Dongling Yu | 2015 | Frontiers of Business Research in China2015，9，4： | 2 |
| 9 | Development and Cross-Cultural Application of a Specific Instrument to Measure Entrepreneurial Intention显示文摘 | Lifan F Chen Y W | 2009 | Entrepreneurship: Theory and Practice2009，33，3： | 1 |
| 10 | Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19显示文摘COVID-19 patients exhibit differential disease severity after SARS-CoV-2 infection.It is currently unknown as to the correlation between the magnitude of neutralizing antibody(NAb)responses and the disease severity in COVID-19 patients.In a cohort of 59 recovered patients with disease severity including severe,moderate,mild,and asymptomatic,we observed the positive correlation between serum neutralizing capacity and disease severity,in particular,the highest NAb capacity in sera from the patients with severe disease,while a lack of ability of asymptomatic patients to mount competent NAbs.Furthermore,the compositions of NAb subtypes were also different between recovered patients with severe symptoms and with mild-tomoderate symptoms.These results reveal the tremendous heterogeneity of SARS-CoV-2-specific NAb responses and their correlations to disease severity,highlighting the needs of future vaccination in COVID-19 patients recovered from asymptomatic or mild illness. | Xiangyu Chen Zhiwei Pan Shuai Yue Fei Yu Junsong Zhang Yang Yang Ren Li Bingfeng Liu Xiaofan Yang Leiqiong Gao Zhirong Li Yao Lin Qizhao Huang Lifan Xu Jianfang Tang Li Hu Jing Zhao Pinghuang Liu Guozhong Zhang Yaokai Chen Kai Deng Lilin Ye | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 11 | A New Globally Reconstructed Sea Surface Temperature Analysis Dataset since 1900显示文摘A new globally reconstructed sea surface temperature(SST)analysis dataset developed by the China Meteorological Administration(CMA-SST),available on 2°×2°and monthly resolutions since 1900,is described and assessed in this study.The dataset has been constructed from a newly developed integrated dataset with denser and wider sampling of in situ SST observations and follows similar analysis techniques to the Extended Reconstructed SST,version 5(ERSST.v5).Assessments show that the larger observation quantity of the input data source is beneficial to making the reconstructed SSTs more realistic than those reconstructed with ICOADS 3.0+GTS(International Comprehensive Ocean-Atmosphere Dataset 3.0 and Global Telecommunication System),especially in China’s offshore sea area.Besides,a specific parameter for bias correction has been upgraded to be self-adaptive to the input data source,and serves as a mediator to improve the accuracy of the reconstructed SSTs.Generally,the reconstructed CMA-SST dataset is comparable to currently congeneric products.Its biases are similar to those of ERSST.v5,the Centennial Observation-Based Estimates of SST version 2(COBE-SST2),the Hadley Centre Sea Ice and SST dataset version 2(Had ISST2),and the Hadley Centre SST dataset version 3(Had SST3);and more specifically,they are closest to ERSST.v5 and lower than Had ISST2 and Had SST3 at high latitudes of the Southern Hemisphere where in situ observations are limited.Moreover,its temporal characteristics,such as the year-to-year variations of globally averaged SST anomalies and time series of the Nino-3.4,Atlantic multidecadal oscillation,and Pacific decadal oscillation indices are also a good match to those of congeneric products.Although the warming rates of CMA-SST are a little higher in many regions over the periods 1900-2019 and 1950-2019,they are found to be acceptable and within the quantified uncertainties of ERSST.v5.However,there are noticeable differences in the strength and stability of spatial standard deviations among the various datasets,as well as low correlations between CMA-SST and the other products around 60°S where in situ sampling is very limited.These aspects necessitate further investigation and improvement of CMA-SST. | Lifan CHEN Lijuan CAO Zijiang ZHOU Dongbin ZHANG Jie LIAO | 2021 | Journal of Meteorological Research2021，35，6： | 1 |
| 12 | A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global pandemic of novel coronavirus disease(COVID-19).The neutralizing monoclonal antibodies(mAbs)targeting the receptor-binding domain(RBD)of SARS-CoV-2 are among the most promising strategies to prevent and treat COVID-19.However,SARS-CoV-2 variants of concern(VOCs)profoundly reduced the efficacies of most of mAbs and vaccines approved for clinical use.Herein,we demonstrated mAb 35B5 efficiently neutralizes both wild-type(WT)SARS-CoV-2 and VOCs. | Xiaofei Wang Ao Hu Xiangyu Chen Yixin Zhang Fei Yu Shuai Yue Arong Li Junsong Zhang Zhiwei Pan Yang Yang Yao Lin Leiqiong Gao Jing Zhou Jing Zhao Fang Li Yaling Shi Feng Huang Xiaofan Yang Yi Peng Luoyang Tu Huan Zhang Huanying Zheng Jun He Hui Zhang Lifan Xu Qizhao Huang Yongqun Zhu Kai Deng Lilin Ye | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 1 |
| 13 | New Anti-HSV-1 Guaiane Lactone from Hainan Gorgonian Echinomuricea indomalaccensis显示文摘A new highly oxygenated guaiane lactone 5-epi-menverin C(1),along with four known compounds including one ses-quiterpene(2)and three steroids(3-5),were isolated from gorgonian Echinomuricea indomalaccensis which were collected from the South China Sea.Through anlyzing the NMR data and comparing with other reported compounds,their structures were determined.The absolute configuration of compound 1 was determined by comparing its experimental ECD with that obtained by calculation.In a bioassay in vitro,5-epi-menverin C(1)displayed antiviral activity against the HSV-1 virus with an inhibition rate of 69.2%(c=25μmol L−1). | ZHOU Lifan CHEN Bao ZHANG Yahui ZHANG Xiuli LI Xin WANG Changyun | 2022 | Journal of Ocean University of China2022，21，4： | 0 |
| 14 | Single-base resolution mapping of 2′-O-methylation sites by an exoribonuclease-enriched chemical method显示文摘2′-O-methylation(Nm)is one of the most abundant RNA epigenetic modifications and plays a vital role in the post-transcriptional regulation of gene expression.Current Nm mapping approaches are normally limited to highly abundant RNAs and have significant technical hurdles in m RNAs or relatively rare non-coding RNAs(nc RNAs).Here,we developed a new method for enriching Nm sites by using RNA exoribonuclease and periodate oxidation reactivity to eliminate 2′-hydroxylated(2′-OH)nucleosides,coupled with sequencing(Nm-REP-seq).We revealed several novel classes of Nm-containing nc RNAs as well as m RNAs in humans,mice,and drosophila.We found that some novel Nm sites are present at fixed positions in different t RNAs and are potential substrates of fibrillarin(FBL)methyltransferase mediated by sno RNAs.Importantly,we discovered,for the first time,that Nm located at the 3′-end of various types of nc RNAs and fragments derived from them.Our approach precisely redefines the genome-wide distribution of Nm and provides new technologies for functional studies of Nm-mediated gene regulation. | Ping Zhang Junhong Huang Wujian Zheng Lifan Chen Shurong Liu Anrui Liu Jiayi Ye Jie Zhou Zhirong Chen Qiaojuan Huang Shun Liu Keren Zhou Lianghu Qu Bin Li Jianhua Yang | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 15 | HVAC Optimal Control Based on the Sensitivity Analysis:An Improved SA Combination Method Based on a Neural Network显示文摘Aiming at optimizing the energy consumption of HVAC,an energy conservation optimization method was proposed for HVAC systems based on the sensitivity analysis(SA),named the sensitivity analysis combination method(SAC).Based on the SA,neural network and the related settings about energy conservation of HVAC systems,such as cooling water temperature,chilled water temperature and supply air temperature,were optimized.Moreover,based on the data of the existing HVAC system,various optimal control methods ofHVAC systems were tested and evaluated by a simulated HVAC system in TRNSYS.The results show that the proposed SA combination method can reduce significant computational load while maintaining an equivalent energy performance compared with traditional optimal control methods. | Lifan Zhao Zetian Huang Qiming Fu Nengwei Fang Bin Xing Jianping Chen | 2023 | Computer Modeling in Engineering & Sciences2023，，9： | 0 |
| 16 | The bright star survey telescope for the planetary transit survey in Antarctica显示文摘Transiting extrasolar planets(exoplanets),especially those orbiting bright stars, are desired for study of the diversity of planetary compositions, internal structures and atmospheres beyond our solar system. Dome A at Antarctica is a promising site for planetary transit surveys,where the continuous darkness and the large clear-sky fraction in the winter months greatly enhance the detection efficiency. The Chinese Small Telescope ARray and the Antarctic Survey Telescopes are the first facilities that have been operated at Dome A for use in exoplanet surveys. To increase the sky coverage, a low-temperature-resistant wide-field robotic telescope, named the bright star survey telescope(BSST), has been developed to join the ongoing planetary transit survey in Antarctica. The BSST has an aperture size of 300 mm and is equipped with a largeframe 4K×4K CCD camera to receive starlight from a 3.°4×3.°4 field of view. The BSST was operated at Lijiang observatory in April and May 2015 for a test run.Photometric precision of 3.5 mmag was achieved for stars with V~11 mag using 75 s exposures. The transiting events of two Jupiter-size exoplanets, HAT-P-3b and HATP-12 b, were observed on May 10 and May 20, 2015,respectively. | Qiguo Tian Peng Jiang Fujia Du Jian Wang Zhengyang Li Xiaoyan Li Zhiyong Zhang Haiping Lu Xiangyan Yuan Huigen Liu Hui Zhang Luming Sun Liang Chang Jianguo Wang Shaohua Zhang Tuo Ji Xiheng Shi Jie Chen Guangyu Zhang Minghao Jia Jiajing Liu Junyan Zhou Xiang Pan Shucheng Dong Fengxin Jiang Hongfei Zhang Jilin Zhou Lifan Wang Hongyan Zhou | 2016 | Science Bulletin2016，61，5： | 0 |
| 17 | Discovery of ARF1-targeting inhibitor demethylzeylasteral as a potential agent against breast cancer显示文摘To the Editor:ADP-ribosylation factor 1 (ARF1) plays a critical role in regulating vesicle formation and transport1. The dysregulation of ARF1 expression and/or activity is involved in many human cancers, such as breast cancer2,3. Therefore, ARF1 is one of the promising therapeutic targets for cancer treatment. | Jie Chang Ruirui Yang Lifan Chen Zisheng Fan Jingyi Zhou Hao Guo Yinghui Zhang Yadan Liu Guizhen Zhou Keke Zhang Kaixian Chen Hualiang Jiang Mingyue Zheng Sulin Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 0 |
| 18 | Spatiotemporal reflectance blending in a wetland environment显示文摘To understand the mechanism of wetland cover change with both moderate spatial resolution and high temporal frequency,this research evaluates the applicability of a spatiotemporal reflectance blending model in the Poyang Lake area,China,using 9 time-series Landsat-5 Thematic Mapper images and 18 time-series Terra Moderate Resolution Imaging Spectroradiometer images acquired between July 2004 and November 2005.The customized blending model was developed based on the enhanced spatial and temporal adaptive reflectance fusion model(ESTARFM).Reflectance of the moderate-resolution image pixels on the target dates can be predicted more accurately by the proposed customized model than the original ESTARFM.Water level on the input image acquisition dates strongly affected the accuracy of the blended reflectance.It was found that either of the image sets used as prior or posterior inputs are required when the difference of water level between the prior or posterior date and target date at Poyang Hydrological Station is<2.68 m to achieve blending accuracy with a mean average absolute difference of 4%between the observed and blended reflectance in all spectral bands. | Ryo Michishita Lifan Chen Jin Chen Xiaolin Zhu Bing Xu | 2015 | International Journal of Digital Earth2015，8，5： | 0 |
| 19 | EFFECTS OF B^+ IMPLANTATION ON MECHANICAL PROPERTIES AND MICROSTRUCTURE OF POLYCRYSTALLINE Ni显示文摘50 keV B+ ions was implanted to polycrvstalline with 50 keV B+ to a dose o/ 3x1017 ions/cm2 at room temperature.The specimens with and without B+implantation weretested in micro-hardness and load or unload tensile fatigue under stress-controlled eondition.The surface layer structure was observed with IMA,SEM and TEM before and afterimplantation and/or fatigue.The B+ implanted surface region consists of amorphousNi-B phase,Ni3B and Ni4B3 second phases,and damage structure.The correspondingmeasurements indicate that both surface micro-hardness and endurance limit of the specimenshave increased after implantation.Compared with unimplanted specimens under the same fa-tigue condition,all implanted specimens show the smallest overall fatigue danage.The cyclicloading at room temperature can lead to migration of implanted B+ out surface layer andreerystallization of amorphous Ni-B phase,Possible strengthening mechanisms.for these ex-perimental results were discussed. | CHEN Lifan BA Tu SHI Changxu State Key Laboratory for Fatigue and Fracture of Materials,Institute of Metal Research,Academia Sinica,Shenyang,China Doctorate Student.Institute of Physics.Academia Sinica,Beijing 100080,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，2： | 0 |
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