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| 1 | Newly discovered hydrothermal fields along the ultraslow-spreading Southwest Indian Ridge around 63°E显示文摘The ultraslow-spreading Southwest Indian Ridge(SWIR) to the east of the Melville fracture zone is characterized by very low melt supply and intensive tectonic activity. Due to its weak thermal budget and extremely slow spreading rate, the easternmost SWIR was considered to be devoid of hydrothermal activity until the discovery of the inactive Mt. Jourdanne hydrothermal field(27°51′S, 63°56′E) in 1998. During the COMRA DY115-20 cruise in2009, two additional hydrothermal fields(i.e., the Tiancheng(27°51′S, 63°55′E) and Tianzuo(27°57′S, 63°32′E)fields) were discovered. Further detailed investigations of these two hydrothermal sites were conducted by Chinese manned submersible Jiaolong in 2014–2015. The Tiancheng filed can be characterized as a lowtemperature(up to 13.2°C) diffuse flow hydrothermal field, and is hosted by fractured basalts with hydrothermal fauna widespread on the seafloor. The Tianzuo hydrothermal field is an inactive sulfide field, which is hosted by ultramafic rocks and controlled by detachment fault. The discovery of the three hydrothermal fields around Segment #11 which receives more melt than the regional average, provided evidence for local enhanced magmatism providing heat source to drive hydrothermal circulation. We further imply that hydrothermal activity and sulfide deposits may be rather promising along the easternmost SWIR. | CHEN Jie TAO Chunhui LIANG Jin LIAO Shili DONG Chuanwan LI Huaiming LI Wei WANG Yuan YUE Xihe HE Yonghua | 2018 | Acta Oceanologica Sinica2018，37，11： | 5 |
| 2 | Derivation of hypermethylated pluripotent embryonic stem cells with high potency显示文摘天真的 hypomethylated 胚胎的 pluripotent 干细胞(转换字符) 离胚囊的 preimplantation epiblast 发展地最靠近,与潜力到贡献所有胚胎的纸巾和 germline,除了在妄想的胚胎的胚胎外的纸巾。由对比,类似于 postimplantation epiblast 的 epiblast 干细胞(EpiSCs ) 是相对更多的 methylated 和表演为 chimerism 的一个有限潜力。第一次,这里,我们在 pluripotent 房间以外发展地揭示先进 pluripotent 干细胞(ASC ) ,它是在内部房间团中,但是与更高的力量比 EpiSCs。因此,单个 ASC 在怪物很高效地作出贡献到胎儿, germline,蛋黄囊和胎盘的迷宫。因为他们是,发展地,更多进展了, ASC 不贡献 trophoblast。ASC 在与 Activin A 和基本成纤维细胞生长因素补充的化学上定义的媒介在二个步骤从胚囊被导出,在包含 ActA, BMP4, CHIR99021 和白血病的 ABCL 媒介由 culturing 列在后面禁止的因素。尤其是, ASC 与天真的 pluripotency 基因,以及 mesodermal 的表示展出不同 transcriptome 体的基因;Eomes,时代, Tdgf1, Evx1, hand1, Wnt5a 和不同重复元素。到 ASC 的确定的转换字符的变换也是可完成的。重要地, ASC 作为与 hypomethylated 相比展出稳定的 hypermethylated epigenome 和主要未经触动的印记胚囊和天真的转换字符的内部房间质量。ASC 的性质建议他们以在 pluripotency 的天真、告知的状态之间的一个中间的细胞的状态代表房间。 | Siqin Bao Walfred WC Tang Baojiang Wu Shinseog Kim Jingyun Li Lin Li Toshihiro Kobayashi Caroline Lee Yanglin Chen Mengyi Wei Shudong Li Sabine Dietmann Fuchou Tang Xihe Li | 2018 | Cell Research2018，28，1： | 4 |
| 3 | Accelerated generation of oligodendrocyte progenitor cells from human induced pluripotent stem cells by forced expression of Sox10 and Olig2显示文摘Oligodendrocyte progenitor cells(OPCs) hold great promise for treatment of dysmyelinating disorders, such as multiple sclerosis and cerebral palsy. Recent studies on generation of human OPCs mainly use human embryonic stem cells(hESCs) or neural stem cells(NSCs) as starter cell sources for the differentiation process. However, NSCs are restricted in availability and the present method for generation of oligodendrocytes(OLs) from ESCs often requires a lengthy period of time. Here, we demonstrated a protocol to efficiently derive OPCs from human induced pluripotent stem cells(hiPSCs) by forced expression of two transcription factors(2TFs), Sox10 and Olig2. With this method, PDGFRα+ OPCs can be obtained in 14 days and O4^+ OPCs in 56 days.Furthermore, OPCs may be able to differentiate to mature OLs that could ensheath axons when co-cultured with rat cortical neurons. The results have implications in the development of autologous cell therapies. | Pengyan Li Mo Li Xihe Tang Shuyan Wang Y.Alex Zhang Zhiguo Chen | 2016 | Science China(Life Sciences)2016，59，11： | 4 |
| 4 | An Outbreak of the SARS-CoV-2 Omicron Variant BA.1—Zhuhai City,Guangdong Province,China,January 13,2022显示文摘On January 13,2022,Zhuhai CDC received a notification that a coronavirus disease 2019(COVID-19)case was found in the fever clinic in nearby Zhongshan City.Zhuhai CDC promptly carried out large-scale population screening in three nearby counties.A total of 4 COVID-19 cases were found in Nanping County.34 cases were screened from close contacts,and 2 cases were reported from close contacts in other cities of Guangdong Province.The 20 cases were sequenced by Guangdong CDC and identified as the variant of concern(VOC)/Omicron variant BA.1.Since January 14,Zhuhai has carried out 8 rounds of nucleic acid screening for COVID-19 in the county where the cases occurred.Four large-scale nucleic acid screening tests for COVID-19 were conducted across the city,and no new community cases were reported after January 15. | Feng Ruan Xuebao Zhang Songjian Xiao Xihe Ni Xiling Yin Zhongwen Ye Guorong Chen Tingting Zhu Zeling Chen Gang Yao Long Chen Sichen Huang Huitao Huang Yi Zhou Heyan Wu Hui Huang Kejing Zhu Shanzi Huang Xiaoou Tang Min Kang Bosheng Li Wenhua Mei | 2022 | China CDC weekly2022，4，30： | 2 |
| 5 | Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: Influences of fatty acids显示文摘 | Shuyu Xie Luyan Zhu Zhao Dong Xiaofang Wang Yan Wang Xihe Li WenZhong Zhou | 2010 | Colloids and Surfaces B: Biointerfaces2010，，2： | 1 |
| 6 | A new inorganic–organic hybrid compound constructed from polyoxoanions and rare earth coordination complexes显示文摘 | Juan Li Xihe Yu Hongfang Wang Kun Xu Xinyu Wu Lei Hou Jing Li | 2006 | Transition Metal Chemistry2006，，6： | 1 |
| 7 | Photorefractive properties of MnO-doped near stoichiometric LiNbO3 crystals显示文摘 | SUN Zhijie LI Hongtao ZHEN Xihe | 2004 | J Phys Chem Solids2004，65，： | 1 |
| 8 | Mercury drop trend in urban soils in Beijing, China, since 1987显示文摘 | Hangxin Cheng Chuandong Zhao Fei Liu Ke Yang Yinghan Liu Min Li Min Peng Kuo Li Haifeng Nie Qin Zhang Xiaomeng Cheng Qihe Ruan Li Guo Yue Li Xihe Huo | 2013 | Journal of Geochemical Exploration2013，，： | 1 |
| 9 | 显示文摘 | sun Zhije Li Hongtao Zhen Xihe | 2004 | Journal of Physics and Chemistry of Solids2004，65，： | 1 |
| 10 | Growth and optical properties of In: Er: LiNbO3 crystals 显示文摘 | Zhen Xihe Xu Wusheng Li Qiang | 2004 | Journal of Crystal Growth2004，271，34： | 1 |
| 11 | Photorefractive properties of MnO-doped near stoichiometric LiNbO3 crystals显示文摘 | SUN Zhijie LI Hongtao ZHEN Xihe | 2004 | J Phys Chem Solids2004，65，： | 1 |
| 12 | Effects of different activation treatments on fertilization of horse oocytes by intracytoplasmic sperm injection显示文摘 | Xihe Li L H A Morris W R Allen | 2000 | Journal of Reproduction and Fertility2000，119，： | 1 |
| 13 | Effeet of different activation treatments on fertilization of horse oocytes by intracytoplasinic sperm injection 显示文摘 | LI XIHE MORRIS L H A AI LEN W R M | 2000 | Journal of Reproduction and Fertility2000，119，4： | 1 |
| 14 | All-solid-state CW sodium I)2 resonance radiation based on intracavity frequency-doubled self-Raman laser operation in double-end diffusion-bonded Nd3*:LuVO4 crystal 显示文摘 | Lii Yanfei Zhang Xihe Li Shutao | 2010 | Opt Lett2010，35，17： | 1 |
| 15 | Blastoids generated purely from embryonic stem cells both in mice and humans显示文摘Dear Editor,Embryonic stem cells(ESCs)and trophoblast stem cells(TSCs)are derived from blastocysts(Lu et al.,2001).Blastocyst-like structures(blastoids)are self-assembled structures formed by a combination of ESCs and TSCs(Rivron et al.,2018).To increase the success rate of blastoid formation and its similarity with the features of blastocysts,some reports showed that blastoid could also be derived from a combination of three cell lines,ESCs,TSCs,and extraembryonic endoderm cells(XENs),or novel type of stem cells(Sozen et al.,2018;Weatherbee et al.,2023:Wu et al.,2023;Zhang et al.,2023;Zhang et al.,2019). | Baojiang Wu Yanqiu Wang Jia Yan Mengya Liu Xihe Li Fuchou Tang Siqin Bao | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
| 16 | Neighbouring carbonyl group-assisted sequential 1,2-azide and1,4-oxygen migrations of vinyl azides leading to α-azido ketones显示文摘The development of azide migration reactions is a formidable challenge due to potential competition from side processes driven by the release of molecular nitrogen. Here, we show a novel neighbouring carbonyl group-assisted sequential 1,2-azide and 1,4-oxygen migration reaction of α-vinyl azides for the efficient preparation of a range of α-azido ketones. This represents the first transformation of α-vinyl azides into α-azido ketones. Notable features of this method are its high efficiency, broad substrate scope, excellent functional group compatibility, and high yields. The computational studies gave a key insights into the regioselective 1,2-azide and 1,4-oxygen migrations assisted by the neighbouring carbonyl group. Further conversions into a variety of nitrogen-containing compounds demonstrated the synthetic utility of the α-azido ketone products. Preliminary mechanistic studies disclosed a novel reaction mechanism involving neighbouring carbonyl group-assisted sequential 1,2-azide and1,4-oxygen migrations. | Yi Gai Yongquan Ning Paramasivam Sivaguru Xiaomeng Li Yue Zhao Jiayi Wu Xihe Bi | 2020 | Science China Chemistry2020，63，4： | 0 |
| 17 | Silver-catalyzed unstrained C(CO)–alkyl bond scission via[3+2]/retro-[3+2]cycloaddition of ketones with N-isocyanoiminotriphenylphosphorane显示文摘C(CO)–alkyl bonds are ubiquitous in a variety of organic molecules,and their selective activation and functionalization are important for the reconstruction of simple ketones into valuable building blocks.However,due to the thermodynamic and kinetic stability,the cleavage and transformation of the unstrained C(CO)–alkyl bonds remain a significant challenge.Herein,we report a novel silver-catalyzed scission of the unstrained C(CO)–alkyl bond of ketones by reacting with N-isocyanoiminotriphenylphosphorane(NIITP)under mild conditions.This method could transform a variety of unstrained ketones into iminophosphoranes and nitriles in high yields.Experimental and computational studies disclosed the reaction proceeded through an unprecedented[3+2]/retro-[3+2]cycloaddition mechanism. | Zikun Wang Linxuan Li Xueying Zhang Xihe Bi | 2021 | Science China Chemistry2021，64，7： | 0 |
| 18 | Cloning,Sequencing and Analysis of DDX3Y Gene in Five Male Equus Animals显示文摘[Objective] This study analyzed the differences in DDX3 Y gene sequences among male horse,male donkey,male mule,male hinny and male foal to investigate the relationship between DDX3 Y gene structure and the mechanism of infertility in male Equus ferus × asinus. [Method] Partial sequences of DDX3 Y gene in male horse,male donkey,male mule,male hinny and male foal were obtained by genome comparison,sequencing and cloning,and compared by bioinformatics methods. [Result] The CDS regions varied in 5 base pairs and two amino acids. DDX3 Y protein was predicted to be an unstable protein. In addition,the results also showed that DDX3 Y gene in male horse displayed a closer phylogenetic relationship to male mule and male foal; DDX3 Y gene in male donkey displayed a closer phylogenetic relationship to male hinny. [Conclusion]This study provided scientific basis for further exploring the function of DDX3 Y gene and the mechanism of reproductive regulation in male Equus ferus × asinus. | Huamin GUO Yanglin CHEN Shuyu LI Hongmei HAN Jindun ZHANG Lihong FAN Lixia ZHAO Xihe LI | 2015 | Agricultural Biotechnology2015，4，4： | 0 |
| 19 | Oocyte Transfer as an Analytical Tool:Vintage Experiments in Domestic Farm Animals显示文摘Four transplant studies are described that focus on fertilisation and early development or the progression of unfertilised oocytes(eggs) in the oviduct.(1) Pig eggs transplanted from ovulations induced during the luteal phase of the estrous cycle were fertilised in the oviducts of inseminated recipient animals in estrus.By contrast,pig eggs from donors in estrus became highly polyspermic when transplanted to the oviducts of animals force-mated during the luteal phase.(2) Pig embryos at the stage of hatched blastocysts(days 7 and 8) could be transplanted successfully to synchronous recipients and full embryonic development demonstrated to between days 19 and 23 of pregnancy.Thus,the exposed trophectoderm of developing embryos could withstand the physical manipulation of recovery and transplantation,and the lifespan of corpora lutea in the unmated recipients could be prolonged by transfer of day 7 and 8 blastocysts.(3) Bovine oocytes aspirated from 2 to 6 mm diameter Graafian follicles and matured in vitro were fertilized normally in the oviducts of inseminated recipient heifers,demonstrating the potential of slaughterhouse ovaries for the generation of embryos.(4) Transplanting equine eggs to a pig oviduct,in which egg descent to the uterus requires only 46 to 48 h,did not reveal a retarded progress of degenerating unfertilised horse eggs,suggesting the involvement of non-physical factors in equine embryo progression to the uterus.Prostaglandins of embryonic origin are now known to be a key.A final section examines the post-ovulatory role of ovarian follicular cells on the secretory activity of the oviductal epithelium. | R. H. F. Hunter Xihe Li | 2011 | Journal of Animal Science and Biotechnology2011，2，4： | 0 |
| 20 | A Comparison of the Effects of Pentoxifylline on Quality of Fresh and Frozen-thawed Bull Spermatozoa显示文摘[Object]This study aimed to examine the effects of 3,7-dimethyl-1-(5-oxo-hexyl)-xanthine(pentoxifylline,PF)on the motility,mitochondrial activity,acrosome integrity and fertilization rate of spermatozoa in both fresh and frozen-thawed bull semen.[Method]Fresh and frozen-thawed bull spermatozoa were exposed to 5 mmol/L PF with untreated samples as controls.[Result]Fresh spermatozoa showed reduced(P<0.05)motility after 2 h incubation with PF whereas,surprisingly,frozen-thawed samples exhibited increased sperm motility(P<0.05)after 2 h incubation with PF and they also showed enhanced longevity compared to controls.Mitochondrial activity in both fresh and frozen-thawed bull spermatozoa increased(P<0.05)during 4 h incubation with PF whereas acrosome integrity remained unchanged in both types of semen.However,treatment with 5 mmol/L PF did not influence the in vitro fertilization efficiency of fresh spermatozoa but improved significantly(P<0.05)that of frozen-thawed spermatozoa.[Conclusion]These results indicate that PF can improve sperm quality of frozenthawed bull semen,and may improve pregnancy rates in bovine artificial insemination programmes employing frozen semen. | Jian ZHANG Huamin GUO Jie SU Lixia ZHAO Yunxia LI Wei SUN Hongmei HAN Shuxiang HU Gaoping ZHAO Yao LI Yanfeng DAI Xihe LI | 2014 | Agricultural Biotechnology2014，3，3： | 0 |
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