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| 1 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 2 | Treatment of chronic prostatitis in Chinese men显示文摘The aim of this study is to assess the status of treatment of chronic prostatitis(CP)in Chinese men.A population-based cross-sectional survey was performed,in which 15000 men aged between 15 and 60 years were randomly selected to receive a questionnaire designed to assess National Institutes of Health Chronic Prostatitis Symptoms Index(NIH-CPSI)status,therapeutic efficacy and 28 other items.A total of 12743 men(84.95%)completed the questionnaire,of whom 1071(8.4%)were identified as having prostatitis-like symptoms and 517(4.5%)were diagnosed with CP according to NIH-CPSI criteria and prostatitis-like symptomatology.Of the CP patients,372(65%)underwent long-term routine treatment 12 times per year.Additionally,217(72.8%)patients received antibiotic therapy and 215(79.3%)men showed therapeutic effects.The treatment cost USD 1151(8059 yuan)per person per year on average.Most CP patients received routine treatment,in most cases with antibiotics.Treatment was costly and most CP patients were not satisfied with its effectiveness.Antibacterial treatment might have been effective primarily in patients with bacterial disease. | Chao-Zhao Liang Hong-Jun Li Zhi-Ping Wang Jun-Ping Xing Wei-Lie Hu Tao-Fu Zhang Wei-Wei Ge Zong-Yao Hao Xian-Sheng Zhang Jun Zhou Yu Li Zheng-Xing Zhou Zhi-Guo Tang | 2009 | Asian Journal of Andrology2009，11，2： | 27 |
| 3 | 电针和经皮穴位电刺激技术在生殖医学中的应用:专家共识(英文)显示文摘本文从传统针刺治疗不孕症的选穴依据与现代电针/经皮穴位电刺激技术的相关原理着手,从最优刺激参数选择、穴位辨证、疗程与治疗次数的确定及基本原理等方面阐述了电针/经皮穴位电刺激技术在多囊卵巢综合症、取卵镇痛、卵巢储备功能降低、胚胎移植以及男性少/弱精症等生殖领域中的具体应用。首次对电针/经皮穴位电刺激技术在生殖领域优势病种中的应用进行了系统的分析和总结,在最优刺激参数选择、穴位辨证、疗程与治疗次数的确定等方面提出了一系列专家共识,并为临床实践提供了指导意见和理论依据。 | Fan QU Rong LI Wei SUN Ge LIN Rong ZHANG Jing YANG Li TIAN Guo-gang XING Hui JIANG Fei GONG Xiao-yan LIANG Yan MENG Jia-yin LIU Li-ying ZHOU Shu-yu WANG Yan WU Yi-jing HE Jia-yu YE Song-ping HAN Ji-sheng HAN | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，3： | 24 |
| 4 | Over-expression of Metastasis-associated in Colon Cancer-1 (MACC1) Associates with Better Prognosis of Gastric Cancer Patients显示文摘Objective: The aim of this study was to detect metastasis-associated in colon cancer-1 (MACC1) expression in Chinese gastric cancer and analyze the relationship between MACC1 expression and postoperative survival. Methods: The expression of MACC1 and c-MET protein in a sample of 128 gastric cancer tissues was detected by immunohistochemistry. A retrospective cohort study on the prognosis was carried out and data were collected from medical records. Results: The positive rate of MACC1 protein expression in gastric cancer was 47.66%, higher than that in adjacent noncancerous mucosa (P<0.001). MACC1 protein expression was not related to the clinicopathological variables involved. Kaplan-Meier analysis revealed that the survival of MACC1 positive group tended to be better than that of MACC1 negative group, particularly in patients with stage III carcinoma (P=0.032). Cox regression analysis revealed that MACC1 protein over-expression in gastric cancer tended to be a protective factor with hazard ratio of 0.621 (P=0.057). Immunohistochemical analysis showed that the positive rate of c-MET protein expression was much higher in cases with positive MACC1 expression in gastric cancer (P=0.002), but P53 expression was not associated with MACC1 expression. Conclusion: MACC1 over-expression implies better survival and may be an independent prognostic factor for gastric cancer in Chinese patients. | Shao-hua Ge Xiao-jiang Wu Xiao-hong Wang Xiao-fang Xing Lian-hai Zhang Yu-bing Zhu Hong Du Bin Dong Ying Hu Jia-fu Ji | 2011 | Chinese Journal of Cancer Research2011，23，2： | 19 |
| 5 | Preliminary study on LGM climate simulation and the diagnosis for East Asia显示文摘LGM climate study is a hot topic in international fields on global changes. Climate simulation in this study applies both common designs of 21 kaBP boundary conditions from the Paleoclimate Modeling Intercomparison Project (PMIP), including insolation, glaciation, sea surface temperature and atmospheric CO2 concentration, and land surface conditions from Eurasia continent by compilation of geological evidence. The simulation outputs are in agreement with climate spatial patterns reconstructed by observation records. Sensitive experiment on land surface conditions shows that changes in vegetation would make significant impacts on temperature and precipitation. Particularly in the Tibetan Plateau, this change would increase in differences of winter and summer temperature, precipitation and P-E. | YU Ge CHEN Xing LIU Jian WANG Sumin | 2001 | Chinese Science Bulletin2001，46，5： | 16 |
| 6 | Paleoclimate Modeling in China: A Review显示文摘This paper provides a review of paleoclimate modeling activities in China. Rather than attempt to cover all topics, we have chosen a few climatic intervals and events judged to be particularly informative to the international community. In historical climate simulations, changes in solar radiation and volcanic activity explain most parts of reconstructions over the last millennium prior to the industrial era, while atmospheric greenhouse gas concentrations play the most important role in the20 th century warming over China. There is a considerable model–data mismatch in the annual and boreal winter temperature change over China during the mid-Holocene [6000 years before present(ka BP)], while coupled models with an interactive ocean generally perform better than atmospheric models. For the Last Glacial Maximum(21 ka BP), climate models successfully reproduce the surface cooling trend over China but fail to reproduce its magnitude, with a better performance for coupled models. At that time, reconstructed vegetation and western Pacific sea surface temperatures could have significantly affected the East Asian climate, and environmental conditions on the Qinghai–Tibetan Plateau were most likely very different to the present day. During the late Marine Isotope Stage 3(30–40 ka BP), orbital forcing and Northern Hemisphere glaciation, as well as vegetation change in China, were likely responsible for East Asian climate change. On the tectonic scale,the Qinghai–Tibetan Plateau uplift, the Tethys Sea retreat, and the South China Sea expansion played important roles in the formation of the East Asian monsoon-dominant environment pattern during the late Cenozoic. | JIANG Dabang YU Ge ZHAO Ping CHEN Xing LIU Jian LIU Xiaodong WANG Shaowu ZHANG Zhongshi YU Yongqiang LI Yuefeng JIN Liya XU Ying JU Lixia ZHOU Tianjun YAN Xiaodong | 2015 | Advances in Atmospheric Sciences2015，32，2： | 12 |
| 7 | Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 2019显示文摘As a representative drug for the treatment of severe community-acquired pneumonia and sepsis,Xuebijing(XBJ)injection is also one of the recommended drugs for the prevention and treatment of coronavirus disease 2019(COVID-19),but its treatment mechanism for COVID-19 is still unclear.Therefore,this study aims to explore the potential mechanism of XBJ injection in the treatment of COVID-19 employing network pharmacology and molecular docking methods.The corresponding target genes of 45 main active ingredients in XBJ injection and COVID-19 were obtained by using multiple database retrieval and literature mining.102 overlapping targets of them were screened as the core targets for analysis.Then built the PPI network,TCM-compound-target-disease,and disease-target-pathway networks with the help of Cytoscape 3.6.1 software.After that,utilized DAVID to perform gene ontology(GO)function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis to predict the action mechanism of overlapping targets.Finally,by applying molecular docking technology,all compounds were docked with COVID-193 CL protease(3 CLpro),spike protein(S protein),and angiotensin-converting enzyme II(ACE2).The results indicated that quercetin,luteolin,apigenin and other compounds in XBJ injection could affect TNF,MAPK1,IL6 and other overlapping targets.Meanwhile,anhydrosafflor yellow B(AHSYB),salvianolic acid B(SAB),and rutin could combine with COVID-19 crucial proteins,and then played the role of anti-inflammatory,antiviral and immune response to treat COVID-19.This study revealed the multiple active components,multiple targets,and multiple pathways of XBJ injection in the treatment of COVID-19,which provided a new perspective for the study of the mechanism of traditional Chinese medicine(TCM)in the treatment of COVID-19. | XING Yan HUA Ying-Rong SHANG Jing GE Wei-Hong LIAO Jun | 2020 | Chinese Journal of Natural Medicines2020，18，12： | 11 |
| 8 | Dissolved Organic Nitrogen Leaching from Rice-Wheat Rotated Agroecosystem in Southern China显示文摘The rice-wheat rotation in southern China is characterized by frequent flooding-draining water regime and heavy nitrogen(N)fertilization. There is a substantial lack of studies into the behavior of dissolved organic nitrogen(DON) in the intensively managed agroecosystem. A 3-year in situ field experiment was conducted to determine DON leaching and its seasonal and yearly variations as affected by fertilization, irrigation and precipitation over 6 consecutive rice/wheat seasons. Under the conventional N practice(300kg N ha-1for rice and 200 kg N ha-1for wheat), the seasonal average DON concentrations in leachate(100 cm soil depth) for the three rice and wheat seasons were 0.6–1.1 and 0.1–2.3 mg N L-1, respectively. The cumulative DON leaching was estimated to be1.1–2.3 kg N ha-1for the rice seasons and 0.01–1.3 kg N ha-1for the wheat seasons, with an annual total of 1.1–3.6 kg N ha-1. In the rice seasons, N fertilizer had little effect(P > 0.05) on DON leaching; precipitation and irrigation imported 3.6–9.1 kg N ha-1of DON, which may thus conceal the fertilization effect on DON. In the wheat seasons, N fertilization had a positive effect(P < 0.01)on DON. Nevertheless, this promotive effect was strongly influenced by variable precipitation, which also carried 1.8–2.9 kg N ha-1of DON into fields. Despite a very small proportion to chemical N applied and large variations driven by water regime, DON leaching is necessarily involved in the integrated field N budget in the rice-wheat rotation due to its relatively greater amount compared to other natural ecosystems. | SONG Ge ZHAO Xu WANG Shen-Qiang XING Guang-Xi ZHU Zhao-Liang | 2015 | Pedosphere2015，25，1： | 11 |
| 9 | Compromised cerebrovascular modulation in chronic anxiety:evidence from cerebral blood flow velocity measured by transcranial Doppler sonography显示文摘客观服的自动调整(CA ) 是尽管有变化,经常的服的血流动被在服的灌注压力维持的机制。CA 能被与 transcranial Doppler sonography (TCD ) 的服的血流动速度(CBFV ) 的动态监视评估。现在的学习试图长期的焦虑地探索 CA。有哈密尔顿焦虑的方法题目放大分数 14 被注册,响应 orthostatic 挑战的 CBFV 的动态变化用 TCD 被调查。在两个的结果焦急并且健康题目,吝啬的 CBFV 在正直的位置是显著地更低的比什么时候仰卧。然而, CBFV 变化从对仰卧笔直地不同在之间焦急并且健康的组。焦急题目与突然的站在 CBFV 显示出更显著的减少。我们的结果显示那脑血管的调整的结论长期的焦虑地被损害;焦急题目在在姿势的变化以后维持服的灌注有某不足。给焦虑和损害 CA 与心血管的疾病被联系,用 TCD 的损害脑血管的调整的早探查可能在焦急人口建议 interventional 治疗,并且改进心血管的疾病的主要预防的事实。 | Hong-Liang Zhang Zhen-Ni Guo Ge Yang Le Yang Ke Han Jiang Wu Yingqi Xing Yi Yang | 2012 | Neuroscience Bulletin2012，28，6： | 11 |
| 10 | Recent development of methanol electrooxidation catalysts for directmethanol fuel cell显示文摘Direct methanol fuel cells(DMFCs) are very promising power source for stationary and portable miniature electric appliances due to its high efficiency and low emissions of pollutants. As the key material, catalysts for both cathode and anode face several problems which hinder the commercialization of DMFCs.In this review, we mainly focus on anode catalysts of DMFCs. The process and mechanism of methanol electrooxidation on Pt and Pt-based catalysts in acidic medium have been introduced. The influences of size effect and morphology on electrocatalytic activity are discussed though whether there is a size effect in MOR catalyst is under debate. Besides, the non Pt catalysts are also listed to emphasize though Pt is still deemed as the indispensable element in anode catalyst of DMFCs in acidic medium. Different catalyst systems are compared to illustrate the level of research at present. Some debates need to be verified with experimental evidences. | Liyuan Gong Zhiyuan Yang Kui Li Wei Xing Changpeng Liu Junjie Ge | 2018 | Journal of Energy Chemistry2018，27，6： | 9 |
| 11 | Impact of climate change on maize yield in China from 1979 to 2016显示文摘Climate change severely impacts agricultural production, which jeopardizes food security. China is the second largest maize producer in the world and also the largest consumer of maize. Analyzing the impact of climate change on maize yields can provide effective guidance to national and international economics and politics. Panel models are unable to determine the group-wise heteroscedasticity, cross-sectional correlation and autocorrelation of datasets, therefore we adopted the feasible generalized least square(FGLS) model to evaluate the impact of climate change on maize yields in China from 1979–2016 and got the following results:(1) During the 1979–2016 period, increases in temperature negatively impacted the maize yield of China. For every 1℃ increase in temperature, the maize yield was reduced by 5.19 kg 667 m^–2(1.7%). Precipitation increased only marginally during this time, and therefore its impact on the maize yield was negligible. For every 1 mm increase in precipitation, the maize yield increased by an insignificant amount of 0.043 kg 667 m^–2(0.014%).(2) The impacts of climate change on maize yield differ spatially, with more significant impacts experienced in southern China. In this region, a 1℃ increase in temperature resulted in a 7.49 kg 667 m^–2 decrease in the maize yield, while the impact of temperature on the maize yield in northern China was insignificant. For every 1 mm increase in precipitation, the maize yield increased by 0.013 kg 667 m^–2 in southern China and 0.066 kg 667 m^–2 in northern China.(3) The resilience of the maize crop to climate change is strong. The marginal effect of temperature in both southern and northern China during the 1990–2016 period was smaller than that for the 1979–2016 period. | WU Jian-zhai ZHANG Jing GE Zhang-ming XING Li-wei HAN Shu-qing SHEN Chen KONG Fan-tao | 2021 | Journal of Integrative Agriculture2021，20，1： | 9 |
| 12 | The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)显示文摘The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST's special design allows both a large aperture (effective aperture of 3.6 m-4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror's surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects. | Xiang-Qun Cui Yong-Heng Zhao Yao-Quan Chu Guo-Ping Li Qi Li Li-Ping Zhang Hong-Jun Su Zheng-Qiu Yao Ya-Nan Wang Xiao-Zheng Xing Xin-Nan Li Yong-Tian Zhu Gang Wang Bo-Zhong Gu A-Li Luo Xin-Qi Xu Zhen-Chao Zhang Gen-Rong Liu Hao-Tong Zhang De-Hua Yang Shu-Yun Cao Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Ying Chen Jia-Ru Chu Lei Feng Xue-Fei Gong Yong-Hui Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua Li Yan Li Ye-Ping Li Guan-QunLiu Zhi-Gang Liu Huo-Ming Shi Zheng-Hong Tang Qing-Sheng Tao Xiang-Yan Yuan Chao Zhai Jing Zhang Yan-Xia Zhang Yong Zhang Ming Zhao Fang Zhou Guo-Hua Zhou Jie Zhu Si-Cheng Zou | 2012 | Research in Astronomy and Astrophysics2012，12，9： | 8 |
| 13 | Synthesis of a Novel Core-shell Type Acrylic-polyurethane Hybrid Emulsion Containing Siloxane and Fluorine as well as Water and the Oil Resistances of Cured Film显示文摘Siliconated polyurethane (Si-PU) was synthesized using isophorone diisocyanate (IPDI), hydroxybutyl-terminated polydimethylsiloxane (PDMS), polytetramethylene ether glycol (PTMG), polypropylene glycol (PPG), 1,6-hexanediol (HDO), dimethylol propionic acid (DMPA) and triethylamine (TEA). Based on butyl acrylate (BA), 2, 2, 2-trifluoroethylmethacrylate (TFEMA) and Si-PU as a seed emulsion, a novel core-shell type acrylic-polyurethane hybrid emulsion, containing siloxane and fluorine (F-Si-PU), was prepared by seeded emulsion polymerization. The contents of siloxane and fluorine were determined according to the feed ratio. Fourier transform infrared spectroscopy (FTIR) was used to identify the chain structures of Si-PU and F-Si-PU. Investigation of transmission electron microscopy (TEM) confirmed the core-shell structure of F-Si-PU emulsion. Measurement results of water contact angle and the swelling ratio in water and n-octane for cured film showed that the water and the oil resistances for F-Si-PU had been significantly improved at a suitable content of fluorine and siloxane. | Jing CHAO Xing Yuan ZHANG Jia Bing DAI Zhen GE Lin Lin FENG | 2006 | Chinese Chemical Letters2006，17，8： | 7 |
| 14 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 15 | Mitochondrial aldehyde dehydrogenase(ALDH2)rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer’s disease via inhibition of ACSL4-dependent ferroptosis显示文摘Alzheimer’s disease(AD)is associated with high incidence of cardiovascular events but the mechanism remains elusive.Our previous study reveals a tight correlation between cardiac dysfunction and low mitochondrial aldehyde dehydrogenase(ALDH2)activity in elderly AD patients.In the present study we investigated the effect of ALDH2 overexpression on cardiac function in APP/PS1 mouse model of AD.Global ALDH2 transgenic mice were crossed with APP/PS1 mutant mice to generate the ALDH2-APP/PS1 mutant mice.Cognitive function,cardiac contractile,and morphological properties were assessed.We showed that APP/PS1 mice displayed significant cognitive deficit in Morris water maze test,myocardial ultrastructural,geometric(cardiac atrophy,interstitial fibrosis)and functional(reduced fractional shortening and cardiomyocyte contraction)anomalies along with oxidative stress,apoptosis,and inflammation in myocardium.ALDH2 transgene significantly attenuated or mitigated these anomalies.We also noted the markedly elevated levels of lipid peroxidation,the essential lipid peroxidation enzyme acyl-CoA synthetase long-chain family member 4(ACSL4),the transcriptional regulator for ACLS4 special protein 1(SP1)and ferroptosis,evidenced by elevated NCOA4,decreased GPx4,and SLC7A11 in myocardium of APP/PS1 mutant mice;these effects were nullified by ALDH2 transgene.In cardiomyocytes isolated from WT mice and in H9C2 myoblasts in vitro,application of Aβ(20μM)decreased cell survival,compromised cardiomyocyte contractile function,and induced lipid peroxidation;ALDH2 transgene or activator Alda-1 rescued Aβ-induced deteriorating effects.ALDH2-induced protection against Aβ-induced lipid peroxidation was mimicked by the SP1 inhibitor tolfenamic acid(TA)or the ACSL4 inhibitor triacsin C(TC),and mitigated by the lipid peroxidation inducer 5-hydroxyeicosatetraenoic acid(5-HETE)or the ferroptosis inducer erastin.These results demonstrate an essential role for ALDH2 in AD-induced cardiac anomalies through regulation of lipid peroxidation and ferroptosis. | Zhi-yun Zhu Yan-dong Liu Yan Gong Wei Jin Elena Topchiy Subat Turdi Yue-feng Gao Bruce Culver Shu-yi Wang Wei Ge Wen-liang Zha Jun Ren Zhao-hui Pei Xing Qin | 2022 | Acta Pharmacologica Sinica2022，43，1： | 6 |
| 16 | Recent advances in active sites identification and regulation of M-N/C electro-catalysts towards ORR显示文摘Transition metal and nitrogen co-doped carbon(M–N/C) catalysts are recognized as the most prospective alternatives for platinum-based electro-catalysts towards oxygen reduction reaction(ORR) in polymer electrolyte fuel cells. Recently, significant progress has been achieved in the identification and regulation of active sites of this kind of catalysts. In this mini review,we summarize the techniques and strategies to identify active sites in M–N/C catalysts, the main debates on active sites types, the measurement method for active site density, the reactivity descriptors for M–N/C catalysts, and directions to the design of ORR M–N/C catalysts. | Jie Liu Zhao Jin Xian Wang Junjie Ge Changpeng Liu Wei Xing | 2019 | Science China Chemistry2019，62，6： | 6 |
| 17 | Effects of lifestyle interventions on rural patients with type 2 diabetes mellitus显示文摘BACKGROUND The prevalence of type 2 diabetes mellitus(T2DM)is rising rapidly in rural areas,and lifestyle interventions can effectively reduce the blood glucose levels of patients with T2DM.However,current dietary and exercise guidelines are still at experimental stages and are difficult for subjects to understand and implement.The Human Metabolism Analyzer provides real life interventions for the prevention and treatment of T2DM,and our pilot research has demonstrated its effectiveness and good compliance.AIM To investigate the effect of and compliance with lifestyle interventions in rural patients with T2DM.METHODS A total of ten rural villages were randomly selected in Chaoshui Township,Penglai City,Shandong Province,China,to conduct health screening among residents aged 50 years or older.Each rural village represented a group,and 12 patients with T2DM were randomly selected from each group(total:120)to participate in this study and receive real life lifestyle interventions and medication guidance.Lifestyle interventions included changing the meal order(A),postprandial activities(B),resistance exercise(C),and reverse abdominal breathing(D).Diabetes education was conducted at least once a month with a weekly phone follow-up to monitor exercise and diet.Waist circumference,blood pressure,body mass index(BMI),motor function,body composition,fasting blood glucose,and glycated hemoglobin(HbA1c)were analyzed before and 3 mo after the intervention.Moreover,patient compliance and adjustments of hypoglycemic drugs were evaluated.RESULTS A total of 109 subjects completed the study.The compliance rates for lifestyle interventions A,B,C,and D were 57.79%,60.55%,64.22%,and 75.23%,respectively.Among the subjects who received hypoglycemic drugs,the dose was reduced 2 to 3 times based on blood glucose in 54(67.50%)subjects and was tapered and discontinued in 5(6.25%)subjects within 3 mo,with no significant fluctuations in blood glucose after dose reduction and withdrawal.After lifestyle interventions,waist circumference,BMI,fasting blood glucose,and HbA1c significantly decreased(P<0.001);motor function and body composition also significantly improved(P<0.001).CONCLUSION For patients with T2DM,compliance to real-life lifestyle interventions is good,and the interventions significantly improve metabolic indicators such as waist circumference,BMI,blood pressure,HbA1c,body composition,and motor function.Some patients are able to taper or discontinue hypoglycemic drugs. | Bo Wang Xiao-Li Mu Juan Zhao Hai-Ping Jiang Shan-Shan Li Ge Yan Ying-Ying Hua Xue-Yi Ren Li-Xia Xing Yan Liang Shu-Dong Zhang Yu-Chi Zhao | 2020 | World Journal of Diabetes2020，11，6： | 5 |
| 18 | Correlating Fe source with Fe-N-C active site construction: Guidancefor rational design of high-performance ORR catalyst显示文摘Pyrolyzed Fe-N_X/C materials derived from Fe-doped ZIF-8 are recently emerged as promising alternatives to noble metal platinum-based catalysts towards oxygen reduction reaction(ORR) and elucidating the dependacne of Fe source on the active site structure and final ORR performance is highly desirbale for further development of these materials. Here, we designed and synthesized a series of Fe-N-C catalysts using ZIF-8 and various iron salts(Fe(acac)_3, FeCl_3, Fe(NO_3)_3) as precusors. We found that the iron precursors,mainly the molecular size, hydrolysis extent, do play a major role in determining the final morphology of Fe, namely forming the Fe-Nx coordination or Fe_3C nanoparticles, as well as the site density, therefore,significantly affecting the ORR activity. Among the three iron sources, Fe(acac)_3 is most advantageous to the preferential formation of single-atom Fe-Nx active sites and the derived catalyst demonstrated best ORR performance. | Liqin Gao Meiling Xiao Zhao Jin Changpeng Liu Jianbing Zhu Junjie Ge Wei Xing | 2018 | Journal of Energy Chemistry2018，27，6： | 4 |
| 19 | Nanocluster PtNiP supported on graphene as an efficient electrocatalyst for methanol oxidation reaction显示文摘In this study,phosphorus doped graphene supported PtNiP nanocluster electrocatalyst(PtNiP/P-graphene)was successfully prepared via a simple hypophosphite-assisted co-reduction method.The improved anchoring force and increased anchoring sites of graphene support result from phosphorus doping as well as size-confined growth effect of NaH_(2)PO_(2) leads to uniform dispersion of ultrafine PtNiP nanoclusters.Doped P also promotes the removal of CO-like intermediate by adjusting Pt electronic structure combining with alloyed Ni via electronic effects.As a result,the as-prepared PtNiP/P-graphene catalyst with more exposed active sites and optimized electronic structure of Pt alloy shows excellent electrocatalytic performances for methanol oxidation reaction(MOR)both in activity and durability in an acidic medium. | Long Yang Guoqiang Li Rongpeng Ma Shuai Hou Jinfa Chang Mingbo Ruan Wenbin Cai Zhao Jin Weilin Xu Guiling Wang Junjie Ge Changpeng Liu Wei Xing | 2021 | Nano Research2021，14，8： | 4 |
| 20 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
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