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| 1 | Comparative analysis of modern and ancient buried Phoebe zhennan wood:surface color,chemical components,infrared spectroscopy,and essential oil composition显示文摘We compared the chemical components and essential oils of ancient buried Zhennan(Phoebe zhennan)wood with those in samples from living trees.After removal of the carbon layer the recovered Zhennan exhibited a dark green color,which differed from the yellow color of the living samples.Low molecular weight components(including hot-water and toluene-alcohol extractives),hemicellulose,and 1 % Na OH solubility in the recovered wood were greatly degraded.Degradation of cellulose was minor.Moreover,the ancient wood had somewhat more klason lignin than the modern wood.Fourier transform infrared(FTIR) analysis gave further evidence on the differences in chemical components.According to the GC–MS results,naphthalene derivatives were detected in the essential oils from both the modern and recovered wood.The delicate fragrance of the modern and recovered wood may be attributed to the aromatic constituents as identified by GC–MS. | Jiulong Xie Jinqiu Qi Xingyan Huang Ni Zhou Yao Hu | 2015 | Journal of Forestry Research2015，26，2： | 8 |
| 2 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 3 | TiO_2/Schwertmannite nanocomposites as superior co-catalysts in heterogeneous photo-Fenton process显示文摘The heterogeneous photo-Fenton reaction is an effective technique in combating organic contaminants for both soil and water remediation,and extensive studies have focused on enhancing its efficiency and reducing its costs.In this work,we developed novel photoFenton catalysts by simply milling commercially available TiO_2(P25)with Schwertmannite(Sh),a natural iron-oxyhydroxysulfate nanomineral.We expect that the photo-generated electrons from TiO_2could continuously migrate to Sh,which then could enhance the separation of electron-hole pairs on TiO_2and accelerate the reduction of Fe(III)to Fe(II)on Sh,leading to high degradation efficiency of the target organic contaminants.SEM and TEM results showed the distribution of TiO_2on Sh surface for the nanocomposites(TiO_2/Sh).Under simulated sunlight irradiation,the much higher content of Fe(II)was determined on TiO_2/Sh than on Sh via a common method in the iron ore,and the consumption of H_2O_2and the production of·OH were more significant in the TiO_2/Sh system than those in the TiO_2and Sh systems.These results well support our hypothesis that the photo-generated electrons could migrate from TiO_2to Sh on the composites,and can also explain the much higher degradation efficiency of Rhodamine B(RhB)in the TiO_2/Sh system.Besides,TiO_2/Sh had lower Fe dissolution as compared with Sh,and retained high catalytic stability after four repeated cycles.Above merits of the TiO_2/Sh composites,in combining with their simple synthesis method and low-cost property,indicated that they should have promising applications as heterogeneous photo-Fenton catalysts. | Yanping Zhu Chun Zeng Runliang Zhu Yin Xu Xingyan Wang Huijun Zhou Jianxi Zhu Hongping He | 2019 | Journal of Environmental Sciences2019，31，6： | 5 |
| 4 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 5 | Mitigation of methane/air explosion in a closed vessel by ultrafine water fog显示文摘 | ZHANG Pengpeng ZHOU Yihui CAO Xingyan | 2014 | Safety Science2014，62，2014： | 1 |
| 6 | Suppression of methane/air explosion by ultrafine water mist containing sodium chloride additive显示文摘 | CAO Xingyan REN Jingjie ZHOU Yihui | 2015 | Journal of Hazardous Materials2015，285，： | 1 |
| 7 | Impact of Interannual Variation of Synoptic Disturbances on the Tracks and Landfalls of Tropical Cyclones over theWestern North Pacific显示文摘This study investigates the tropical cyclone(TC)activity associated with the two leading modes of interannual variability in synoptic disturbances.Both leading modes are found to be related to a dipole pattern of TC occurrence between the subtropical western North Pacific and the South China Sea.Therefore,in this study we performed composite analyses on TC tracks and landfalls,based on the cases of combined modes,to highlight the differences.The composite results indicate that these cases are characterized by distinct features of TC tracks and landfalls:more TCs tend to take recurving tracks and attack eastern China,Korea and Japan,or more TCs exhibit straight-moving tracks and hit the Philippines,Vietnam and southern China.Further analyses suggest that these distinctions in the TC prevailing tracks and landfalls can be attributed to the differences in large-scale steering flow and TC genesis location. | Xingyan ZHOU Riyu LU Guanghua CHEN | 2018 | Advances in Atmospheric Sciences2018，35，12： | 1 |
| 8 | The Unprecedented Extreme Anticyclonic Anomaly over Northeast Asia in July 2021 and Its Climatic Impacts显示文摘This study investigates the evolution of an extreme anomalous anticyclone(AA)event over Northeast Asia,which was one of the dominant circulation systems responsible for the catastrophic extreme precipitation event in July 2021 in Henan,and further explores the significant impact of this AA on surface temperatures beneath it.The results indicate that this AA event over Northeast Asia was unprecedented in terms of intensity and duration.The AA was very persistent and extremely strong for 10 consecutive days from 13 to 22 July 2021.This long-lived and unprecedented AA led to the persistence of warmer surface temperatures beyond the temporal span of the pronounced 500-hPa anticyclonic signature as the surface air temperatures over land in Northeast Asia remained extremely warm through 29 July 2021.Moreover,the sea surface temperatures in the Sea of Japan/East Sea were extremely high for 30 consecutive days from 13 July to 11 August 2021,persisting well after the weakening or departure of this AA.These results emphasize the extreme nature of this AA over Northeast Asia in July 2021 and its role in multiple extreme climate events,even over remote regions.Furthermore,possible reasons for this long-lasting AA are explored,and it is suggested to be a byproduct of a teleconnection pattern over extratropical Eurasia during the first half of its life cycle,and of the Pacific-Japan teleconnection pattern during the latter half. | Xingyan ZHOU Riyu LU | 2024 | Advances in Atmospheric Sciences2024，41，4： | 0 |
| 9 | A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication显示文摘The process of domestication has led to dramatic differences in behavioral traits between domestic dogs and gray wolves.Whole-genome research found that a class of putative positively selected genes were related to various aspects of learning and memory,such as long-term potentiation and long-term depression.In this study,we constructed a single-nucleus transcriptomic atlas of the dog hippocampus to illustrate its cell types,cell lineage and molecular features.Using the transcriptomes of 105057 nuclei from the hippocampus of a Beagle dog,we identified 26 cell clusters and a putative trajectory of oligodendrocyte development.Comparative analysis revealed a significant convergence between dog differentially expressed genes(DEGs)and putative positively selected genes(PSGs).Forty putative PSGs were DEGs in glutamatergic neurons,especially in Cluster 14,which is related to the regulation of nervous system development.In summary,this study provides a blueprint to understand the cellular mechanism of dog domestication. | Qi-Jun Zhou Xingyan Liu Longlong Zhang Rong Wang Tingting Yin Xiaolu Li Guimei Li Yuqi He Zhaoli Ding Pengcheng Ma Shi-Zhi Wang Bingyu Mao Shihua Zhang Guo-Dong Wang | 2022 | National Science Review2022，9，11： | 0 |
| 10 | Interannual Variations in Synoptic-Scale Disturbances over the Western North Pacific显示文摘The present study investigates the interannual variation of June–November synoptic disturbance activity over the western North Pacific(WNP) and its relationship with large-scale circulation for the period 1958–2014. Two leading modes of eddy kinetic energy for the disturbance variability over the WNP are obtained by EOF analysis, characterized by anomalous eddy kinetic energy over the subtropical WNP and around the Philippines, respectively. These modes explain a large portion of the interannual variance of synoptic disturbance activity over the WNP. Both are associated with lower-level cyclonic anomalies, but with different locations: over the subtropical WNP for the first mode and over the South China Sea for the second mode. Considering the impact of ENSO on synoptic disturbance activity over the WNP, we repeat the analyses after removing the effect of ENSO, which is simply defined as the components linearly regressed onto the Ni o3.4 index, and find similar results, suggesting that the leading modes and their relationships with large-scale circulation exist without SST effects.Further analyses suggest that the meridional shear of zonal winds caused by cyclonic anomalies is crucial for maintaining the leading modes through barotropic conversion. | Xingyan ZHOU Riyu LU Guanghua CHEN Liang WU | 2018 | Advances in Atmospheric Sciences2018，35，5： | 0 |
| 11 | Identification of novel loci influencing refractive error in East Asian populations using an extreme phenotype design显示文摘The global 'myopia boom' has raised significant international concerns. Despite a higher myopia prevalence in Asia, previous large-scale genome-wide association studies(GWASs) were mostly based on European descendants. Here, we report a GWAS of spherical equivalent(SE) in 1852 Chinese Han individuals with extreme SE from Guangzhou(631 <-6.00 D and 574 > 0.00 D) and Wenzhou(593 <-6.00 D and54 >-1.75 D), followed by a replication study in two independent cohorts with totaling 3538 East Asian individuals. The discovery GWAS and meta-analysis identify three novel loci, which show genome-wide significant associations with SE, including 1 q25.2 FAM163 A, 10 p11.22 NRP1/PRAD3, and 10 p11.21 ANKRD30 A/MTRNR2 L7, together explaining 3.34% of SE variance. 10 p11.21 is successfully replicated.The allele frequencies of all three loci show significant differences between major continental groups(P < 0.001). The SE reducing(more myopic) allele of rs10913877(1 q25.2 FAM163 A) demonstrates the highest frequency in East Asians and much lower frequencies in Europeans and Africans(EAS = 0.60,EUR = 0.20, and AFR = 0.18). The gene-based analysis additionally identifies three novel genes associated with SE, including EI24, LHX5, and ARPP19. These results provide new insights into myopia pathogenesis and indicate the role of genetic heterogeneity in myopia epidemiology among different ethnicities. | Xiaotong Han Tianzi Liu Xiaohu Ding Jialin Liu Xingyan Lin Decai Wang Moeen Riaz Paul N.Baird Zhi Xie Yuan Cheng Yi Li Yuki Mori Masahiro Miyake Hengtong Li Ching-Yu Cheng Changqing Zeng Kyoko Ohno-Matsui Xiangtian Zhou Fan Liu Mingguang He | 2022 | Journal of Genetics and Genomics2022，49，1： | 0 |
| 12 | Taxifolin attenuates inflammation via suppressing MAPK signal pathway in vitro and in silico analysis显示文摘Objective:Taxifolin is a natural flavonoid compound that can be isolated from onions,grapes,oranges and grapefruit.It also acts as a medicine food homology with extraordinary antioxidant and antiinflammatory activity.This study aims to explain the protective effects and potential mechanisms of taxifolin against inflammatory reaction.Methods:Levels of interleukin(IL)-6,IL-1βand intracellular reactive oxygen species(ROS)were assessed in different time after the treatment of taxifolin in RAW264.7 cells induced by lipopolysaccharide(LPS).Subsequently,the m RNA and protein levels of inducible nitric oxide synthase(i NOS),vascular endothelial growth factor(VEGF),cyclooxygenase(COX)-2,tumor necrosis factor(TNF)-a and the phosphorylation expression levels of the MAPK signal pathway were also evaluated.A silico analysis was used to explain the binding situation for the investigation of taxifolin and MAPK signal pathway.And then MAPK inhibitors were used to reveal the expression level of i NOS,VEGF,COX-2 and TNF-a in RAW264.7 cells.Results:It was demonstrated that cell inflammatory damage induced by LPS was significantly alleviated after the treatment of taxifolin.Then,the m RNA and protein levels of i NOS,VEGF,COX-2 and TNF-a were reduced and the phosphorylation expression levels of the MAPK signal pathway were down-regulated remarkably as well.In silico analysis,taxifolin could form a relatively stable combination with MAPK signal pathway.MAPK inhibitors showed increasing or decreasing effect in the m RNA levels of i NOS,VEGF,COX-2 and TNF-a,which suggesting that taxifolin down-regulated i NOS,VEGF,COX-2 and TNF-a expressions were not entirely through the MAPK pathway.Conclusion:This finding demonstrated that taxifolin improved the inflammatory responses that partly involved in the phosphorylation expression level of MAPK signal pathway in RAW264.7 cells exposed to acute stress. | Xingyan Zhang Xiaoyan Lian Huling Li Wenjing Zhao Xin Li Fujun Zhou Yutong Zhou Tao Cui Yuli Wang Changxiao Liu | 2022 | Chinese Herbal Medicines2022，14，4： | 0 |
| 13 | Recombineering enables genome mining of novel siderophores in a non-model Burkholderiales strain显示文摘Iron is essential for bacterial survival,and most bacteria capture iron by producing siderophores.Burkholde-riales bacteria produce various types of bioactive secondary metabolites,such as ornibactin and malleobactin siderophores.In this study,the genome analysis of Burkholderiales genomes showed a putative novel siderophore gene cluster crb,which is highly similar to the ornibactin and malleobactin gene clusters but does not have pvdF,a gene encoding a formyltransferase for N-δ-hydroxy-ornithine formylation.Establishing the bacteriophage recom-binase Redγ-Redδβ7029 mediated genome editing system in a non-model Burkholderiales strain Paraburkholderia caribensis CICC 10960 allowed the rapid identification of the products of crb gene cluster,caribactins A-F(1-6).Caribactins contain a special amino acid residue N-δ-hydroxy-N-δ-acetylornithine(haOrn),which differs from the counterpart N-δ-hydroxy-N-δ-formylornithine(hOrn)in ornibactin and malleobactin,owing to the absence of pvdF.Gene inactivation showed that the acetylation of hOrn is catalyzed by CrbK,whose homologs proba-bly not be involved in the biosynthesis of ornibactin and malleobactin,showing possible evolutionary clues of these siderophore biosynthetic pathways from different genera.Caribactins promote biofilm production and en-hance swarming and swimming abilities,suggesting that they may play crucial roles in biofilm formation.This study also revealed that recombineering has the capability to mine novel secondary metabolites from non-model Burkholderiales species. | Xingyan Wang Haibo Zhou Xiangmei Ren Hanna Chen Lin Zhong Xianping Bai Xiaoying Bian | 2023 | Engineering Microbiology2023，3，3： | 0 |
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