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| 1 | Biostratigraphy of Triassic Marine Reptiles in Southwest Guizhou and Its Adjacent Area显示文摘This paper briefly reviews the Triassic marine reptile fossils inGuizhou Province, especially the fossils that have been recently found in the Guanling area. Based on three sections at Guanling and Xingyi, Guizhou Province and Luoping, Yunnan Province, four horizons with vertebrate fossils are recognized in the Middle and Upper Triassic of this area; They are from bottom to top: Member I and Member Ⅱ of the Guanling Formation, and the Zhuganpo Member and the Wayao Member of the Falang Formation. | WANG Liting, LI Jinling, WANG Xinjin, LI Chun,WU Tianzhuang and LIU Jun Bureau of Geology and Mineral Exploration and Development of Guizhou ProvinceGuiyang 550004 Institute of Vertebrate Palaeontology and Palaeoanthropology,Chinese Academy of Sciences, Beijing 100044 Guizhou Museum, Guiyang 550004 | 2001 | Acta Geologica Sinica(English Edition)2001，75，4： | 17 |
| 2 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 3 | Shale pore characteristics of Shahejie Formation: Implication for pore evolution of shale oil reservoirs in Dongying sag, north China显示文摘The pore characteristics of shale reservoirs in the lower submember of Member 3 to upper submember of Member 4 of Shahejie Formation in Dongying sag are analyzed,influences of mineral content and organic matter content on porosity and pore size are also investigated,and through the diagenetic thermal simulation experiment,the main pore evolution is further discussed.The results show that the pore structure of shale reservoirs is complex,the micron-nanometer pores can storage liquid hydrocarbons,and the free-phase crude oil is mainly distributed in intergranular dissolution pores of calcite,recrystallized intergranular pores,intergranular shrinkage fractures of clay mineral which have large pore size.Framework minerals and organic matter content directly influence porosity and pore size of shale reservoirs,relationship between porosity and content of felsic mineral as well as content of organic matter content is linear and positive,while relationship between content of carbonated mineral is negative.At the buried depth from 2500 to 3500 m,concentration of organic acid from hydrocarbon generation and expulsion of organic matter,increasing range of pressure coefficient,are well corresponding to highporosity intervals;pore formation in shale oil reservoirs are almost controlled by diagenetic evolution of clay minerals;framework storage spaces formed by carbonate grain crystals as well as intergranular and intergranular dissolution pores of carbonate increases porosity of shale oil reservoirs;local increase of porosity at the depth of 3500e3800 m is mainly caused by coupling of hydrocarbon-generating overpressure and dissolution,and size,distribution and connectivity of pores are enhanced obviously. | Shun Zhang Huimin Liu Min Wang Xinjin Liu Huilai Liu Youshu Bao Weiqing Wang Runze Li Xin Luo Zhengwei Fang | 2019 | Petroleum Research2019，4，2： | 2 |
| 4 | 高强度聚焦超声对中晚期胰腺癌的止痛作用(英文)显示文摘Objective: The aim of this study was to evaluate the analgesic effect of high intensity focused ultrasound (HIFU) in patients with advanced pancreatic cancer. Methods: A total of 106 patients with advanced pancreatic cancer accompanied by abdominal pain were treated by HIFU. Pain intensities and quantities of morphine consumption before and after treatment were observed and compared. Results: The average pain intensities before treatment, and at d3, d7 after treatment were 5.80 ± 2.14, 2.73 ± 2.68, 2.45 ± 2.43 respectively (P < 0.01). Fifty-nine cases (55.7%) got to extremely effective, and 29 cases (27.4%) effective. Total efficient rate was 83.0 %. The average quantities of morphine consumption before and after treatment in the patients with grade III pain were 114.9 ± 132.5 mg, 16.8 ± 39.7 mg each person everyday respectively (P < 0.01). Conclusion: HIFU can relieve pain suffered by patients with pancreatic cancer effectively. It is a new adjuvant treatment for pancreatic cancer pain. | Xinjin Tan Jian Chen Li Ren Ruilu Lin Zailian Chen | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，8： | 0 |
| 5 | Bacterial coinfections contribute to severe COVID-19 in winter显示文摘Dear Editor,Although most cases of COVID-19 caused by SARS-CoV-2 Omicron variants are mild or asymptomatic worldwide,coinfection with SARS-CoV-2 and other respiratory pathogens may still aggravate the severity of the illness.1,2 The current literature indicates that coinfection with COVID-19 could occur in 3.70%–9.7%of patients.1,3,4 The proportion of bacterial,and other respiratory viral coinfections may range from 3.02%to 9.7%and 5.41%to 6.61%,respectively.However,these studies demonstrated that coinfections with respiratory pathogens are not common. | Hui Fan Li Zhou Jingjun Lv Shimin Yang Guozhong Chen Xinjin Liu Chunyan Han Xue Tan Shengnan Qian Zegang Wu Shan Yu Ming Guo Chengliang Zhu Yu Chen Ke Lan | 2023 | Cell Research2023，33，7： | 0 |
| 6 | Copper-Mediated Deuterotrifluoromethylation of α-Diazo Esters显示文摘α
的调停铜的 deuterotrifluoromethylation ? 在重氢氧化物的提升下面的重氮基的酉旨(D 2 O ) 为标记重氢的 trifluoromethyl 混合物的合成被开发了。这 deuterotrifluoromethylation 反应具有宽广范围并且能负担得起 deuterated 产品与比 99% 同位素的纯净高。而且,这调查的结果也提供一些试验性的证据支持我们的以前建议的 trifluoromethylation 机制。 | Mingyou Hu Qiqiang Xie Xinjin Li Chuanfa Ni Jinbo Hu | 2016 | Chinese Journal of Chemistry2016，34，5： | 0 |
| 7 | ANXA2 Facilitates Enterovirus 71 Infection by Interacting with 3D Polymerase and PI4KB to Assist the Assembly of Replication Organelles显示文摘Similar to that of other enteroviruses, the replication of enterovirus 71(EV71) occurs on rearranged membranous structures called replication organelles(ROs). Phosphatidylinositol 4-kinase Ⅲ(PI4KB), which is required by enteroviruses for RO formation, yields phosphatidylinositol-4-phosphate(PI4P) on ROs. PI4P then binds and induces conformational changes in the RNA-dependent RNA polymerase(Rd Rp) to modulate Rd Rp activity. Here, we targeted 3D polymerase, the core enzyme of EV71 ROs, and found that the host factor Annexin A2(ANXA2) can interact with 3 D polymerase and promote the replication of EV71. Then, an experiment showed that the annexin domain of ANXA2, which possesses membranebinding capacity, mediates the interaction of ANXA2 with EV71 3 D polymerase. Further research showed that ANXA2 is localized on ROs and interacts with PI4KB. Overexpression of ANXA2 stimulated the formation of PI4P, and the level of PI4P was decreased in ANXA2-knockout cells. Furthermore, ANXA2, PI4KB, and 3D were shown to be localized to the viral RNA replication site, where they form a higher-order protein complex, and the presence of ANXA2 promoted the PI4 KB-3D interaction. Altogether, our data provide new insight into the role of ANXA2 in facilitating formation of the EV71 RNA replication complex. | Qiuhan Zhang Siliang Li Ping Lei Zixian Li Feifei Chen Qi Chen Yulu Wang Jiami Gong Qi Tang Xinjin Liu Ke Lan Shuwen Wu | 2021 | Virologica Sinica2021，36，6： | 0 |
| 8 | Gas-assisted microfluidic step-emulsification forgenerating micron- and submicron-sized droplets显示文摘Micron- and submicron-sized droplets have extensive applications in biomedical diagnosis and drug delivery.Moreover, accurate high-throughput analysis requires a uniform droplet size distribution and high production rates.Although the previously reported microfluidic coflow step-emulsification method can be used to generate highlymonodispersed droplets, the droplet diameter (d) is constrained by the microchannel height (b), d\3b, while theproduction rate is limited by the maximum capillary number of the step-emulsification regime, impedingemulsification of highly viscous liquids. In this paper, we report a novel, gas-assisted coflow step-emulsificationmethod, where air serves as the innermost phase of a precursor hollow-core air/oil/water emulsion. Air graduallydiffuses out, producing oil droplets. The size of the hollow-core droplets and the ultrathin oil layer thickness bothfollow the scaling laws of triphasic step-emulsification. The minimal droplet size attains d 1:7b, inaccessible instandard all-liquid biphasic step-emulsification. The production rate per single channel is an order-of-magnitudehigher than that in the standard all-liquid biphasic step-emulsification and is also superior to alternative emulsificationmethods. Due to low gas viscosity, the method can also be used to generate micron- and submicron-sized droplets ofhigh-viscosity fluids, while the inert nature of the auxiliary gas offers high versatility. | Biao Huang Xinjin Ge Boris Y.Rubinstein Xianchun Chen Lu Wang Huiying Xie Alexander M.Leshansky Zhenzhen Li | 2023 | Microsystems & Nanoengineering2023，9，4： | 0 |
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