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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Numerical algorithm of distributed TOPKAPI model and its application显示文摘The TOPKAPI (TOPographic Kinematic APproximation and Integration) model is a physically based rainfall-runoff model derived from the integration in space of the kinematic wave model. In the TOPKAPI model, rainfall-runoff and runoff routing processes are described by three nonlinear reservoir differential equations that are structurally similar and describe different hydrological and hydraulic processes. Equations are integrated over grid cells that describe the geometry of the catchment, leading to a cascade of nonlinear reservoir equations. For the sake of improving the model's computation precision, this paper provides the general form of these equations and describes the solution by means of a numerical algorithm, the variable-step fourth-order Runge-Kutta algorithm. For the purpose of assessing the quality of the comprehensive numerical algorithm, this paper presents a case study application to the Buliu River Basin, which has an area of 3 310 km2, using a DEM (digital elevation model) grid with a resolution of 1 km. The results show that the variable-step fourth-order Runge-Kutta algorithm for nonlinear reservoir equations is a good approximation of subsurface flow in the soil matrix, overland flow over the slopes, and surface flow in the channel network, allowing us to retain the physical properties of the original equations at scales ranging from a few meters to 1 km. | Deng Peng Li Zhijia Liu Zhiyu | 2008 | Water Science and Engineering2008，1，4： | 5 |
| 3 | Phylogenetic Analyses Reveal a Unique Species of Elaphe(Serpentes,Colubridae)New to Science显示文摘The snakes comprising the monophyletic group referred to as ratsnakes are found throughout Asia,Europe and the New World.Recently,three snake samples likely belonging to the ratsnakes were collected in Zoige County,Sichuan Province,China.Species identity was difficult to delimit morphologically because the specimens were juveniles and partially damaged.Subsequently,a molecular phylogenetic approach was used.Portions of three mitochondrial genes(cyt b,ND4 and 12S rRNA) were sequenced and analyzed.The results showed that they were sister to the genus Elaphe.Very little genetic variation was found among the three samples.The minimum genetic distances between these samples and those within Elaphe were greater than any currently recognized species within the genus.We conclude that this likely represents a new species within the genus Elaphe.Adult specimens and a morphologic description are needed for further study. | LING Chen LIU Shaoying HUANG Song Frank T.Burbrink GUO Peng SUN Zhiyu ZHAO Jie | 2010 | Asian Herpetological Research2010，1，2： | 4 |
| 4 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 5 | A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration显示文摘The osteogenic microenvironment of bone-repairing materials plays a key role in accelerating bone regeneration but remains incompletely defined,which significantly limits the application of such bioactive materials.Here,the transcriptional landscapes of different osteogenic microenvironments,including three-dimensional(3D)hydroxyapatite(HA)scaffolds and osteogenic medium(OM),for mesenchymal stromal cells(MSCs)in vitro were mapped at single-cell resolution.Our findings suggested that an osteogenic process reminiscent of endochondral ossification occurred in HA scaffolds through sequential activation of osteogenic-related signaling pathways,along with inflammation and angiogenesis,but inhibition of adipogenesis and fibrosis.Moreover,we revealed the mechanism during OM-mediated osteogenesis involves the ZBTB16 and WNT signaling pathways.Heterogeneity of MSCs was also demonstrated.In vitro ossification of LRRC75A+MSCs was shown to have better utilization of WNT-related ossification process,and PCDH10+MSCs with superiority in hydroxyapatite-related osteogenic process.These findings provided further understanding of the cellular activity modulated by OM conditions and HA scaffolds,providing new insights for the improvement of osteogenic biomaterials.This atlas provides a blueprint for research on MSC heterogeneity and the osteogenic microenvironment of HA scaffolds and a database reference for the application of bioactive materials for bone regeneration. | Peng Guo Xizhe Liu Penghui Zhang Zhongyuan He Zhen Li Mauro Alini RGeoff Richards Sibylle Grad Martin J.Stoddart Guangqian Zhou Xuenong Zou Danny Chan Wei Tian Dafu Chen Manman Gao Zhiyu Zhou Shaoyu Liu | 2022 | Bioactive Materials2022，7，3： | 3 |
| 6 | Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration显示文摘It has been proven that the mechanical microenvironment can impact the differentiation of mesenchymal stem cells(MSCs).However,the effect of mechanical stimuli in biofabricating hydroxyapatite scaffolds on the inflammatory response of MSCs remains unclear.This study aimed to investigate the effect of mechanical loading on the inflammatory response of MSCs seeded on scaffolds.Cyclic mechanical loading was applied to biofabricate the cell-scaffold composite for 15 min/day over 7,14,or 21 days.At the predetermined time points,culture supernatant was collected for inflammatory mediator detection,and gene expression was analyzed by qRT-PCR.The results showed that the expression of inflammatory mediators(IL1B and IL8)was downregulated(p<0.05)and the expression of ALP(p<0.01)and COL1A1(p<0.05)was upregulated under mechanical loading.The cell-scaffold composites biofabricated with or without mechanical loading were freeze-dried to prepare extracellular matrix-based scaffolds(ECM-based scaffolds).Murine macrophages were seeded on the ECM-based scaffolds to evaluate their polarization.The ECM-based scaffolds that were biofabricated with mechanical loading before freeze-drying enhanced the expression of M2 polarization-related biomarkers(Arginase 1 and Mrc1,p<0.05)of macrophages in vitro and increased bone volume/total volume ratio in vivo.Overall,these findings demonstrated that mechanical loading could dually modulate the inflammatory responses and osteogenic differentiation of MSCs.Besides,the ECM-based scaffolds that were biofabricated with mechanical loading before freeze-drying facilitated the M2 polarization of macrophages in vitro and bone regeneration in vivo.Mechanical loading may be a promising biofabrication strategy for bone biomaterials. | Penghui Zhang Xizhe Liu Peng Guo Xianlong Li Zhongyuan He Zhen Li Martin J.Stoddart Sibylle Grad Wei Tian Dafu Chen Xuenong Zou Zhiyu Zhou Shaoyu Liu | 2021 | Bioactive Materials2021，6，10： | 2 |
| 7 | Phosphoproteomics reveals therapeutic targets of esophageal squamous cell carcinoma显示文摘Dear Editor,Esophageal squamous cell carcinoma(ESCC)is one of the most aggressive squamous cell carcinomas and highly prevalent in Asia.The incidence of ESCC is affected by environmental factors(alcohol consumption,tobacco use,etc.)and genetic factors,both result in tumorigenesis by altering proteomic,posttranslational modification(PTM)and metabolic characterization of esophageal epithelial cells.Recently,large-scale investigations of ESCC have been performed,focusing on the discovery of new driver mutations.However,the mechanisms underlying ESCC development remain unclear,and comprehensive protein profiling of ESCC is necessary to understand its underlying mechanisms.So far,the approaches to the treatment of ESCC patients mainly include endoscopic therapy,surgery and chemoradiotherapy.However,most patients especially with poor prognosis ESCC still lack effective targeted treatment. | Yi Li Bin Yang Yanchun Ma Xiaojun Peng Zhiyu Wang Bin Sheng Zichao Wei Yongping Cui Zhihua Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 2 |
| 8 | Milliampere He^2+ beam generator using a compact GHz ECRIS显示文摘Multi-charged helium ion beam He2+ is useful for helium accelerator to obtain a higher energy with lower cost and for deuterium accelerator to avoid neutron activation during machine commissioning.An attempt to generate milliampere multi-charged helium He2+ion beam with a 2.45 GHz electron cyclotron resonance ion source(ECRIS) was tested recently.A design using a specfic permanent magnet 2.45 GHz ECRIS(PMECRIS) source(ERCIS) is reported and the He2+beam production ability is described.With this source,we produced a total helium beam of 40 mA at 40 kV with 180 W of net microwave power and a gas flow of less than 0.5 sccm.At steady state the He2+beam intensity is 4.4 mA,that being the fraction of multi-charged helium ion beam is at approximately 11%. | REN HaiTao PENG ShiXiang XU Yuan ZHAO Jie CHEN Jia ZHANG Tao ZHANG AiLin GUO ZhiYu CHEN JiaEr | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，10： | 2 |
| 9 | Progress in the beam commissioning of separated function RFQ accelerator显示文摘Separated Function RFQ (SFRFQ) was proposed as a post accelerator of RFQ to accelerate heavy ions at low frequency. It introduces gap accelerating in the quadrupole electrodes, and therefore it has higher accelerating efficiency than the conventional RFQ accelerator. The first SFRFQ prototype cavity has been specially designed and constructed as a post accelerator to accelerate O+ beam from 1.03 MeV to 1.64 MeV. Based on accomplishment of low power measurement and high power test, the beam commissioning was carried out to verify its feasibility. The measured energy gain per cell of SFRFQ is 45 keV, which is about 60% higher than that of Peking University Integral Split Ring (ISR) RFQ. | MingLei Kang (1) YuanRong Lu (1) Zhi Wang (1) Kun Zhu (1) XueQing Yan (1) ZhiYu Guo (1) ShuLi Gao (1) ShiXiang Peng (1) Ao Liu (2) JiaXun Fang (1) JiaEr Chen (1) | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 2 |
| 10 | Effect of surface species on Cu-TiO 2 photocatalytic activity显示文摘 | Baifu Xin Peng Wang Dandan Ding Jia Liu Zhiyu Ren Honggang Fu | 2008 | Applied Surface Science2008，，9： | 1 |
| 11 | Milliampere He2+ beam generator using a compact GHz ECRIS显示文摘 | Haitao Ren Shixiang Peng Yuan Xu Jie Zhao Jia Chen Tao Zhang Ailin Zhang Zhiyu Guo and Jiaer Chen | | SCIENCE CHINA Physics Mechanics & Astronomy 00，，： | 1 |
| 12 | Study on the mechanisms of photoinduced carriers separation and recombination for Fe^3+-TiO2 photocatalysts显示文摘 | Xin Baifu Ren Zhiyu Wang Peng | 2007 | Applied Surface Science2007，253，： | 1 |
| 13 | Study on the mechanisms of photoinduced carriers separation and re- combination for Fe^3+-TiO2 photocatalysts显示文摘 | Xin Baifu Ren Zhiyu Wang Peng | 2007 | Applied Surface Science2007，253，： | 1 |
| 14 | An Improved Behavioral Model for High-voltage and High-power IGBT Chips显示文摘High-voltage and high-power IGBT chips have a noticeable carrier storage effect,which is related to the load current.However,the research on the carrier storage effect of existing IGBT behavior models is insufficient.In this paper,An improved behavioral model for high-voltage and high-power insulated gate bipolar transistor(IGBT)chips is proposed,which could be used under different load conditions.The problems for applying the traditional behavioral model to more load conditions are discussed.Carrier behavior,in the wide base region,is analyzed,and the analytical expression of the carrierstorage-effect equivalent capacitance and the initial value of the tail current are provided to establish an improved IGBT behavioral model.A corresponding parameter extraction method is proposed.In order to verify the improved behavioral model,an experimental platform is built for resistive load and inductive load,and the results show that the accuracy of the improved behavioral model is much better than that of the traditional model.In addition,the errors of the improved model are within 12.5%under different current and load types.Considering that the maximum error of other models,which could be applied in a variety of load conditions,is more than 25%,the accuracy of the model proposed in this paper is excellent. | Yixuan Yang Zhibin Zhao Cheng Peng Xuebao Li Zhiyu Sun Xiang Cui | 2023 | CSEE Journal of Power and Energy Systems2023，9，1： | 1 |
| 15 | Thermodynamic criterion for judging the symmetry of ternary systems and criterion applications 显示文摘 | Qiao Zhiyu Xing Xiaolin Peng Ming | 1996 | Journal of Phase Equilibria and Diffusion1996，17，6： | 1 |
| 16 | High harmonic exploring on different materials in dynamic atomic force microscopy显示文摘In atomic force microscopy(AFM), high-frequency components consisted in dynamic tip-sample interaction have been recently demonstrated as a promising technique for exploring more extensive material properties. Here we present an exploratory study of high harmonic atomic force microscopy by force-spectroscopy and high harmonic imaging. Since these components are very weak compared to the fundamental response, we firstly designed a high harmonic cantilever by tuning the second order flexural resonance frequency to an integer 6 times of its fundamental mode(i.e. ω_2=6ω_1). Moreover, it is verified that high harmonic can discern extra features than topographies on different samples with amplitude/frequency modulation(AM/FM) dynamic AFM mode. In AM mode, the first resonance amplitude and 6 th harmonic amplitude were discussed. The 6 th harmonic is more sensitive than the first order response. In FM mode, it is noted that the decaying rate of the 6 th harmonic frequency is approximately 6 multiples to the slope of the fundamental frequency shift when the tip approaches to the surface of sample. This non-destructive method was also adopted to investigate the local interlayer coupling and intercalation in the two-dimensional graphene films tentatively. | ZHENG ZhiYue XU Rui YE ShiLi HUSSAIN Sabir JI Wei CHENG Peng LI YanJun SUGAWARA Yasuhiro CHENG ZhiHai | 2018 | Science China(Technological Sciences)2018，61，3： | 1 |
| 17 | Development of High Intensity Beam Emittance Measurement Unit显示文摘Three sets of High Intensity Beam Emittance Measurement Units (HIBEMUs) are being developed at Peking University. They are HIBEMU-2 (slit-wire type, one direction), HIBEMU-3 (Allison scanner type, one direction) and HIBEMU-4 (slit-wire type, two directions). For HIBEMU-2 and HIBEMU-3, more recent work has been done on software redesign in order to measure beam emittance and to draw phase diagram more efficiently and precisely. Software for control and data processing of them were developed in Labveiw environment, trying to improve calculation rationality and to offer user-friendly interface. Mechanical modification was also done for HIBEMU-3, mainly concentrating on the protection of Faraday cups from being overheated by the high intensity beam and also from interference of secondary electrons. This paper will also cover the mechanical structure as well as the software development of HIBEMU-4, which is a two-direction emittance scanner newly designed and manufactured for the high energy beam transport (HEBT) of Peking University Neutron Imaging FaciliTY (PKUNIFTY). At the end of this paper, comparison and analysis of the three HIBEMUs are given to draw forth better design of the future emittance measurement facility. | LV PengNan PENG ShiXiang GUO ZhiYu YUAN ZhongXi REN HaiTao ZHAO Jie ZHANG Meng CHEN JiaEr LU YuanRong | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 1 |
| 18 | 3D printing of personalized polylactic acid scaffold laden with GelMA/autologous auricle cartilage to promote ear reconstruction显示文摘At present,the clinical reconstruction of the auricle usually adopts the strategy of taking autologous costal cartilage.This method has great trauma to patients,poor plasticity and inaccurate shaping.Three-dimensional(3D)printing technology has made a great breakthrough in the clinical application of orthopedic implants.This study explored the combination of 3D printing and tissue engineering to precisely reconstruct the auricle.First,a polylactic acid(PLA)polymer scaffold with a precisely customized patient appearance was fabricated,and then auricle cartilage fragments were loaded into the 3D-printed porous PLA scaffold to promote auricle reconstruction.In vitro,gelatin methacrylamide(GelMA)hydrogels loaded with different sizes of rabbit ear cartilage fragments were studied to assess the regenerative activity of various autologous cartilage fragments.In vivo,rat ear cartilage fragments were placed in an accurately designed porous PLA polymer ear scaffold to promote auricle reconstruction.The results indicated that the chondrocytes in the cartilage fragments could maintain the morphological phenotype in vitro.After three months of implantation observation,it was conducive to promoting the subsequent regeneration of cartilage in vivo.The autologous cartilage fragments combined with 3D printing technology show promising potential in auricle reconstruction. | Xingyu Gui Zhiyu Peng Ping Song Li Chen Xiujuan Xu Hairui Li Pei Tang Yixi Wang Zixuan Su Qingquan Kong Zhenyu Zhang Zhengyong Li Ying Cen Changchun Zhou Yujiang Fan Xingdong Zhang | 2023 | Bio-Design and Manufacturing2023，6，4： | 0 |
| 19 | 2 - 30 Progress in Analyzing RIBLL1 17F+p Experimental Data显示文摘 | He Jianjun Hu Jun Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Zhang Xueheng Su Jun Li Ertao Hu Zhengguo Guo Zhongyan Xu Xing Yuan Xiaohua Lu Wan Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu Hushan | 2010 | IMP & HIRFL Annual Report2010，，1： | 0 |
| 20 | 2-7 Charge and Frequency Resolved Isochronous Mass Spectrometry in Storage Rings: First Direct Mass Measurement of the Short-lived Neutron-de cient 51Co Nuclide显示文摘Isochronous mass spectrometry in storage rings is a successful technique for the precision mass measurements ofthe nuclides with half-lives down to tens of microseconds[1]. Since the isochronous condition =t greatly reducesthe influence of the velocity difference on the ion revolution periods, the revolution period difference ΔT =T ??TRof a stored ion with respect to a reference time TR is directly related to its mass-to-charge ratio difference Δ(m=q),written in the first order as: | Shuai Peng Xu Hushan Tu Xiaolin Zhang Yuhu Sun Baohua Yu.A.Litvinov Yan Xinliang K.Blaum Wang Meng Zhou Xiaohong He Jianjun Sun Yang K.Kaneko Yuan Youjin Xia Jiawen Yang Jiancheng G.Audi Chen Xiangcheng Jia Guobin Hu Zhengguo Ma Xinwen Mao Ruishi Mei Bo Sun Zhiyu Wang Shitao Xiao Guoqing Xu Xing T.Yamaguchi Y.Yamaguchi Zang Yongdong Zhao Hongwei Zhao Tiecheng Zhang Wei Zhan Wenlong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
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