|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparative investigation on high-speed grinding of TiCp/Ti–6Al–4V particulate reinforced titanium matrix composites with single-layer electroplated and brazed CBN wheels显示文摘In order to develop the high-efficiency and precision machining technique of Ti Cp/Ti–6Al–4V particulate reinforced titanium matrix composites(PTMCs), high-speed grinding experiments were conducted using the single-layer electroplated cubic boron nitride(CBN) wheel and brazed CBN wheel, respectively. The comparative grinding performance was studied in terms of grinding force, grinding temperature, grinding-induced surface features and defects. The results display that the grinding forces and grinding temperature obtained with the brazed CBN wheel are always lower than those with the electroplated CBN wheel. Though the voids and microcracks are the dominant grinding-induced surface defects, the brazed CBN wheel produces less surface defects compared to the electroplated wheel according to the statistical analysis results. The maximum materials removal rate with the brazed CBN wheel is much higher than that with the electroplated one. All above indicate that the single-layer brazed CBN super-abrasive wheel is more suitable for high-speed grinding of PTMCs than the electroplated counterpart. | Li Zheng Ding Wenfeng Shen Long Xi Xinxin Fu Yucan | 2016 | Chinese Journal of Aeronautics2016，29，5： | 11 |
| 2 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 3 | EABDS: Attribute-Based Secure Data Sharing with Efficient Revocation in Cloud Computing显示文摘Ciphertext-policy attribute-based encryption(CP-ABE) is becoming a promising solution to guarantee data security in cloud computing. In this paper,we present an attribute-based secure data sharing scheme with Efficient revocation(EABDS) in cloud computing.Our scheme first encrypts data with Data encryption key(DEK) using symmetric encryption and then encrypts DEK based on CP-ABE, which guarantees the data confidentiality and achieves fine-grained access control. In order to solve the key escrow problem in current attribute based data sharing schemes, our scheme adopts additively homomorphic encryption to generate attribute secret keys of users by attribute authority in cooperation with key server, which prevents attribute authority from accessing the data by generating attribute secret keys alone.Our scheme presents an immediate attribute revocation method that achieves both forward and backward security.The computation overhead of user is also reduced by delegating most of the decryption operations to the key server.The security and performance analysis results show that our scheme is more secure and efficient. | HUANG Qinlong MA Zhaofeng YANG Yixian FU Jingyi NIU Xinxin | 2015 | Chinese Journal of Electronics2015，24，4： | 8 |
| 4 | Whole-genome resequencing of Osmanthus fragrans provides insights into flower color evolution显示文摘Osmanthus fragrans is a well-known ornamental plant that has been domesticated in China for 2500 years.More than 160 cultivars have been found during this long period of domestication,and they have subsequently been divided into four cultivar groups,including the Yingui,Jingui,Dangui,and Sijigui groups.These groups provide a set of materials to study genetic evolution and variability.Here,we constructed a reference genome of O.fragrans‘Liuyejingui’in the Jingui group and investigated its floral color traits and domestication history by resequencing a total of 122 samples,including 119 O.fragrans accessions and three other Osmanthus species,at an average sequencing depth of 15×.The population structure analysis showed that these 119 accessions formed an apparent regional cluster.The results of linkage disequilibrium(LD)decay analysis suggested that varieties with orange/red flower color in the Dangui group had undergone more artificial directional selection;these varieties had the highest LD values among the four groups,followed by the Sijigui,Jingui,and Yingui groups.Through a genome-wide association study,we further identified significant quantitative trait loci and genomic regions containing several genes,such as ethylene-responsive transcription factor 2 and Arabidopsis pseudoresponse regulator 2,that are positively associated with petal color.Moreover,we found a frameshift mutation with a 34-bp deletion in the first coding region of the carotenoid cleavage dioxygenase 4 gene.This frameshift mutation existed in at least one site on both alleles in all varieties of the Dangui group.The results from this study shed light on the genetic basis of domestication in woody plants,such as O.fragrans. | Hongguo Chen Xiangling Zeng Jie Yang Xuan Cai Yumin Shi Riru Zheng Zhenqi Wang Junyi Liu Xinxin Yi Siwei Xiao Qiang Fu Jingjing Zou Caiyun Wang | 2021 | Horticulture Research2021，8，1： | 5 |
| 5 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 6 | Control for a Class of Stochastic Mechanical Systems Based on the Discrete-Time Approximate Observer显示文摘This paper investigates the observer-based control problem of a class of stochastic mechanical systems. The system is modelled as a continuous-time It o stochastic differential equation with a discrete-time output. Euler-Maruyama approximation is used to design the discrete-time approximate observer, and an observer-based feedback controller is derived such that the closed-loop nonlinear system is exponentially stable in the mean-square sense. Also, the authors analyze the convergence of observer error when the discrete-time approximate observer servers as a state observer for the exact system. Finally, a simulation example is used to demonstrate the effectiveness of the proposed method. | FU Xinxin KANG Yu LI Pengfei YU Peilong | 2019 | Journal of Systems Science & Complexity2019，32，2： | 4 |
| 7 | Attribute Based DRM Scheme with Dynamic Usage Control in Cloud Computing显示文摘In order to achieve fine-grained access control in cloud computing,existing digital rights management(DRM) schemes adopt attribute-based encryption as the main encryption primitive.However,these schemes suffer from inefficiency and cannot support dynamic updating of usage rights stored in the cloud.In this paper,we propose a novel DRM scheme with secure key management and dynamic usage control in cloud computing.We present a secure key management mechanism based on attribute-based encryption and proxy re-encryption.Only the users whose attributes satisfy the access policy of the encrypted content and who have effective usage rights can be able to recover the content encryption key and further decrypt the content.The attribute based mechanism allows the content provider to selectively provide fine-grained access control of contents among a set of users,and also enables the license server to implement immediate attribute and user revocation.Moreover,our scheme supports privacy-preserving dynamic usage control based on additive homomorphic encryption,which allows the license server in the cloud to update the users' usage rights dynamically without disclosing the plaintext.Extensive analytical results indicate that our proposed scheme is secure and efficient. | HUANG Qinlong | 2014 | China Communications2014，11，4： | 3 |
| 8 | Secure Data Sharing and Retrieval Using Attribute-Based Encryption in Cloud-Based OSNs显示文摘The Online social networks(OSNs) offer attractive means for social interactions and data sharing,but also raise a number of security and privacy issues. Since the OSNs service provider is always semi-trusted, current solutions propose to encrypt data before sharing. However,data encryption causes a lot of inconveniences and large overheads for data dissemination and data retrieval. In this paper, we propose a secure data sharing and retrieval scheme in cloud-based OSNs. Based on ciphertext-policy attribute-based encryption, our scheme achieves multiparty access control, which allows data owners to outsource encrypted data to the OSNs service provider for sharing,and enables data disseminators to disseminate the data owners' data by customizing new access policy. Our scheme also provides searchable encryption scheme to support fast searches in massive amount of encrypted data from both data owners and data disseminators. Further, our scheme preserves the privacy of data owners and data retrievers during the data sharing and retrieval processes. In addition, the computation overhead of data retrievers is reduced by delegating most of the decryption operations to the OSNs service provider. The security and performance analysis results indicate that our scheme is secure and privacy-preserving. | HUANG Qinlong MA Zhaofeng YANG Yixian FU Jingyi NIU Xinxin | 2014 | Chinese Journal of Electronics2014，23，3： | 3 |
| 9 | Metabolic manifestations of insulin deficiency do not occur without glucagon action显示文摘 | Young Lee Eric D. Berglund May-yun Wang Xiaorong Fu Xinxin Yu Maureen J. Charron Shawn C. Burgess Roger H. Unger | 2012 | Proceedings of the National Academy of Sciences2012，，37： | 2 |
| 10 | Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis显示文摘 | Wei Li Baoyang Hu XuepengWang Tianda Li Tongtong Cui Dawei Yu Chao Liu Liyuan Jiang Guihai Feng Lei wang Rui Fu Xinxin Zhang Jie Hao Yukai Wang Liu Wang Qi Zhou | 2018 | Cell Research2018，28，1： | 2 |
| 11 | Coarsening kinetics of γ' precipitates in a Re-containing Ni-based single crystal superalloy during long-term aging显示文摘The morphological evolution and coarsening kinetics ofγ'precipitates in a Re-containing Ni-based single crystal superalloy were investigated during isothermal aging at 900,950 and 1000℃.After heat treatment,well-defined cuboidalγ'precipitates with low misfit was obtained within the experimental alloy.Then coarsening rate constants and particle size distribution(PSD)ofγ'phases were calculated and specified based on the measured precipitate sizes for va rying periods of aging times from 100 to 2000 h.After aging for 2000 h,γ'precipitates maintained cubical shape at 900℃,while exhibited sphere at 950 and 1000℃.Coarsening models based on diffusion-controlled process with a functional relationship of r^(3) vs.t(classic Lifshitz-Slyozov-Wagner coarsening model)and interface-controlled model with a function of r^(2) vs.t(trans-interface diffusion-controlled coarsening model)were investigated to fit between the experimental results and theoretical analysis.It was found that Re as the slowest diffusing solute in the alloy constituted the rate-limited step for coarsening based on LSW model,while the process limiting coarsening as governed by an interface diffusion process could possibly be related to the Al diffusion through theγ/γ'interface.The PSDs and coarsening exponent were discussed by comparing the experimental data with predictions of LSW and TIDC models.Finally,coarsening mechanism could be divided into four regimes:(i)coarsening by diffusion-controlled;(ii)coarsening by diffusion and interface cocontrolled;(iii)coarsening by interface-controlled;(iv)coarsening by interface-controlled accompanied withγ'coalescence. | Jiachen Zhang Lin Liu Taiwen Huang Jia Chen Kaili Cao Xinxin Liu Jun Zhang Hengzhi Fu | 2021 | Journal of Materials Science & Technology2021，，3： | 2 |
| 12 | Effect of photoionisation on initial discharge in air under nanosecond pulse voltage显示文摘Effects of photoionisation on the development and electron runaway of the initial discharge in atmospheric air under nanosecond pulse voltage were studied via twodimensional particle-in-cell/Monte Carlo collision simulations.It was found that photoionisation has little effect at the beginning of the initial discharge.However,as the discharge channel gradually develops towards the anode,photoionisation shows greater impacts on the morphology of discharge but has little influence on the velocity of discharge development.Photoionisation does not appear to have a decisive effect on the growth trend of the highest energy of runaway electrons,but it does affect the change rate of the highest energy and overall distribution of electron energy,resulting in a higher proportion of energetic electrons.The difference in the distributions of the electron energy between the two cases,with and without considering photoionisation,can be attributed to the impact of photoionisation on the discharge morphology,which in turn distorted the electric field.The spatial density distributions of the electrons produced by photoionisation further explained the differences.The authors’results explicitly demonstrate the influence of photoionisation on the development and the electron runaway of the initial discharge under nanosecond pulse voltage,which provides more comprehensive knowledge for the atmospheric air gap nanosecond pulse discharge physics. | Yutai Li Yangyang Fu Zhigang Liu Handong Li Peng Wang Haiyun Luo Xiaobing Zou Xinxin Wang | 2023 | High Voltage2023，8，2： | 2 |
| 13 | Improving Security and Sharing in Online Social Efficiency for Encrypted Data Networks显示文摘Despite that existing data sharing systems in online social networks(OSNs)propose to encrypt data before sharing,the multiparty access control of encrypted data has become a challenging issue.In this paper,we propose a secure data sharing scheme in OSNs based on ciphertext-policy attributebased proxy re-encryption and secret sharing.In order to protect users' sensitive data,our scheme allows users to customize access policies of their data and then outsource encrypted data to the OSNs service provider.Our scheme presents a multiparty access control model,which enables the disseminator to update the access policy of ciphertext if their attributes satisfy the existing access policy.Further,we present a partial decryption construction in which the computation overhead of user is largely reduced by delegating most of the decryption operations to the OSNs service provider.We also provide checkability on the results returned from the OSNs service provider to guarantee the correctness of partial decrypted ciphertext.Moreover,our scheme presents an efficient attribute revocation method that achieves both forward and backward secrecy.The security and performance analysis results indicate that the proposed scheme is secure and efficient in OSNs. | HUANG Qinlong | 2014 | China Communications2014，11，3： | 2 |
| 14 | Preparation and characterization of nickel zinc sulphide Bifunctional magnet-ic-optical nanocomposites显示文摘 | Hari Bala Yanhui Yu Xinxin Cao Wuyou Fu | 2008 | Materials Chemistry and Phys-ics2008，111，： | 1 |
| 15 | Multiple Center Research on Relationship Between Screening Quality and Detection of Cervical Cancer—Six Provinces,China,June–December 2021显示文摘The coverage and quality of screening are essential for reducing the incidence of cervical precancers and cervical cancer.This multicenter study aimed to investigate the relationship between screening quality and the detection of cervical precancers and cervical cancer.The study was conducted from June to December 2021 in six hospitals across six provinces.The 2,945 participants were non-pregnant women who underwent colposcopy examinations.The average age of participants was 40.9±11.5 years old.Only 6.9%of participants had received human papillomavirus(HPV)vaccination.A total of 92.6%of participants had abnormal cervical screening results.Of the participants,577 had high-grade squamous intraepithelial lesions(HSIL)or worse(≥HSIL),with a detection rate of 19.6%.Univariate analysis indicated that a lack of cervical cancer screening history in the past five years,as well as positive cervical screening and abnormal colposcopic impression,were independent associated factors of the≥HSIL detection rate.A multivariable logistic regression showed that positive cervical screening[odds ratio(OR)=1.75,95%confidence interval(CI):1.07–2.86]was a risk factor for detecting≥HSIL.Low-grade,high-grade,and cancer of colposcopic impression were associated with a higher risk for detecting≥HSIL(OR=2.94,95%CI:2.13–4.08;OR=36.64,95%CI:26.07–51.48).It is important to disseminate health knowledge to improve public awareness of cervical cancer prevention and to enhance the capacity building of professional staff to improve the quality of cervical cancer screening. | Xiaosong Zhang Weihong Chen Xinxin Zhu Hui Bi Qingping Zhao Yunfeng Fu Lina Zhang Chunmei Zhang Ning Huang | 2023 | China CDC weekly2023，5，14： | 1 |
| 16 | Integrated photonic RF self-interference cancellation on a silicon platform for full-duplex communication显示文摘In-band full-duplex(IBFD) technology can double the spectrum utilization efficiency for wireless communications,and increase the data transmission rate of B5G and 6G networks and satellite communications. RF self-interference is the major challenge for the application of IBFD technology, which must be resolved. Compared with the conventional electronic method, the photonic self-interference cancellation(PSIC) technique has the advantages of wide bandwidth, high amplitude and time delay tuning precision, and immunity to electromagnetic interference.Integrating the PSIC system on chip can effectively reduce the size, weight, and power consumption and meet the application requirement, especially for mobile terminals and small satellite payloads. In this paper, the silicon integrated PSIC chip is presented first and demonstrated for IBFD communication. The integrated PSIC chip comprises function units including phase modulation, time delay and amplitude tuning, sideband filtering, and photodetection, which complete the matching conditions for RF self-interference cancellation. Over the wide frequency range of C, X, Ku, and K bands, from 5 GHz to 25 GHz, a cancellation depth of more than 20 dB is achieved with the narrowest bandwidth of 140 MHz. A maximum bandwidth of 630 MHz is obtained at a center frequency of10 GHz. The full-duplex communication experiment at Ku-band by using the PSIC chip is carried out. Cancellation depths of 24.9 dB and 26.6 dB are measured for a bandwidth of 100 MHz at central frequencies of 12.4 GHz and14.2 GHz, respectively, and the signal of interest(SOI) with 16-quadrature amplitude modulation is recovered successfully. The factors affecting the cancellation depth and maximum interference to the SOI ratio are investigated in detail. The performances of the integrated PSIC system including link gain, noise figure, receiving sensitivity, and spurious free dynamic range are characterized. | XIUYOU HAN XINXIN SU MENG CHAO XINDI YANG WEIHENG WANG SHUANGLING FU YICHENG DU ZHENLIN WU MINGSHAN ZHAO | 2023 | Photonics Research2023，11，10： | 1 |
| 17 | Research on the Evaluation System of Epoxy Asphalt Steel Deck Pavement Distress Condition显示文摘Epoxy asphalt concrete has been one of the mainstream technology of steel deck pavement in China. But little specification about evaluation system for its distress condition has been researched and maintenance was still unsystematic. The section weight coefficient of different distress is proposed by analyzing the applicability of the “Highway Performance Assessment Standards”. Indexes mainly including SDPCI PDR and PCR are presented to evaluate its distress condition. The evaluation system and maintenance plan decision tree were recommended which can assist scientific maintenance of epoxy asphalt steel deck pavement. | Hui Zhang Yingtao Li Xinxin Fu Youqiang Pan | 2019 | Journal of Harbin Institute of Technology(New Series)2019，26，5： | 1 |
| 18 | Sampled-data Observer Design for a Class of Stochastic Nonlinear Systems Based on the Approximate Discrete-time Models显示文摘In this paper,we studied the approximate sampleddata observer design for a class of stochastic nonlinear systems.Euler-Maruyama approximation was investigated in this paper because it is the basis of other higher precision numerical methods,and it preserves important structures of the nonlinear systems.Also,the form of Euler-Maruyama model is simple and easy to be calculated.The results provide a reference for sampled-data observer design method for such stochastic nonlinear systems,and may be useful to many practical control applications,such as tracking control in mechanical systems.And the effectiveness of the approach is demonstrated by a simulation example. | Xinxin Fu Yu Kang Pengfei Li | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，3： | 1 |
| 19 | Identification and expression analysis of Tubulin gene family in upland cotton显示文摘Background:Cott on fibers are single-celled exte nsions of the seed epidermis,a model tissue for studying cytoskeleton.Tubulin genes play a critical role in synthesizing the microtubules(MT)as a core element of the cytoskeleton.However,there is a lack of studies concerning the systematic characterization of the tubulin gene family in cotton.Therefore,the identification and portrayal of G.hirsutum tubulin genes can provide key targets for molecular manipulation in cotton breeding.Result:In this study,we investigated all tubulin genes from different plant species and identified 98 tubulin genes in G.hirsutum.Phylogenetic an a lysis showed that tubulin family genes were classified into three subfamilies.The protein motifs and gene structure ofβ-tubulin genes are more conserved compared withγ-tubulin genes.Most tubulin genes are located at the proximate ends of the chromosomes.Spatiotemporal expression pattern by transcriptome and qRT-PCR analysis revealed that 12α-tubulin andβ-tubulin genes are specifically expressed during different fiber development stages.However,Gh.A03G027200,Gh.D03G 169300,and Gh.A1lG258900 had differential expression patterns at distinct stages of fiber development in varieties JO2508 and ZRI015.Conclusion:In this study,the evol ut io nary an alysis showed that the tubulin genes were divided into three clades.The genetic structures and molecular functions were highly con served in different plants.Three candidate genes,Gh.A03G027200f Gh.D03G169300,and Gh.A11G258900 may play a key role during fiber development complementing fiber length and strength. | CHEN Baojun ZHAO Junjie FU Guoyong PEI Xinxin PAN Zhao'e LI Hongge AHMED Haris HE Shoupu DU Xiongming | 2021 | Journal of Cotton Research2021，4，3： | 1 |
| 20 | Bioanalytical and instrumental analysis of estrogenic activities in drinking water sources from Yangtze River Delta显示文摘 | HU Xinxin SHI Wei CAO Fu | 2013 | Chemosphere2013，90，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员