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| 1 | Topology optimization of compliant adaptive wing leading edge with composite materials显示文摘An approach for designing the compliant adaptive wing leading edge with composite material is proposed based on the topology optimization. Firstly, an equivalent constitutive relationship of laminated glass fiber reinforced epoxy composite plates has been built based on the symmetric laminated plate theory. Then, an optimization objective function of compliant adaptive wing leading edge was used to minimize the least square error(LSE) between deformed curve and desired aerodynamics shape. After that, the topology structures of wing leading edge of different glass fiber ply-orientations were obtained by using the solid isotropic material with penalization(SIMP) model and sensitivity filtering technique. The desired aerodynamics shape of compliant adaptive wing leading edge was obtained based on the proposed approach. The topology structures of wing leading edge depend on the glass fiber ply-orientation. Finally, the corresponding morphing experiment of compliant wing leading edge with composite materials was implemented, which verified the morphing capability of topology structure and illustrated the feasibility for designing compliant wing leading edge. The present paper lays the basis of ply-orientation optimization for compliant adaptive wing leading edge in unmanned aerial vehicle(UAV) field. | Tong Xinxing Ge Wenjie Sun Chao Liu Xiaoyong | 2014 | Chinese Journal of Aeronautics2014，27，6： | 12 |
| 2 | Higher alcohol synthesis over Cu-Fe composite oxides with high selectivity to C_(2+)OH显示文摘Cu-Fe composite oxides were prepared by co-precipitation method and tested for higher alcohol synthesis from syngas. The selectivity to C2+OH and C6+OH in alcohol distribution was very high while the methane product fraction in hydrocarbon distribution was rather low, demonstrating a promising potential in higher alcohols synthesis from syngas. The distribution of alcohols and hydrocarbons approximately obeyed Anderson-Schulz-Flory distribution with similar chain growth probability, indicating alcohols and hydrocarbons derived from the same intermediates. The effects of Cu/Fe molar ratio, reaction temperature and gas hourly space velocity (GHSV) on catalytic performance were studied in detail. The sample with a Cu/Fe molar ratio of 10/1 exhibited the best catalytic performance. Higher reaction temperature accelerated water-gas-shift reaction and led to lower total alcohols selectivity. GHSV showed great effect on catalytic performance and higher GHSV increased the total alcohol selectivity, indicating there existed visible dehydration reaction of alcohol into hydrocarbon. | Zhenghong Bao Kang Xiao Xingzhen Qi Xinxing Wang Liangshu Zhong Kegong Fang Minggui Lin Yuhan Sun | 2013 | Journal of Energy Chemistry2013，22，1： | 10 |
| 3 | Metabolic regulation of T cell development by Sinl-mTORC2 is mediated by pyruvate kinase M2显示文摘Glucose metabolism plays a key role in thymocyte development. The mammalian target of rapamycin complex 2 (mT0RC2) is a critical regulator of cell growth and metabolism, but its role in early thymocyte development and metabolism has not been fully studied. We show here that genetic ablation of Sinl, an essential component of mTORC2, in T lineage cells results in severely impaired thymocyte development at the CD4^- CD8^- double negative (DN) stages but not at the CD4^+ CD8^+ double positive (DP) or later stages. Notably, Sinl-deficient DN thymocytes show markedly reduced proliferation and glycolysis.Importantly, we discover that the M2 isoform of pyruvate kinase (PKM2) is a novel and crucial Sinl effector in promoting DN thymocyte development and metabolism. At the molecular level, we show that Sinl-mTORC2 controls PKM2 expression through an AKT-dependent PPAR-y nuclear translocation. Together, our study unravels a novel mTORC2-PPAR-γ-PKM2 pathway in immune-metabolic regulation of early thymocyte development. | Xinxing Ouyang Yuheng Han Guojun Qu Man Li Ningbo Wu Hongzhi Liu Omotooke Arojo Hongxiang Sun Xiaobo Liu Dou Liu Lei Chen Qiang Zou Bing Su | 2019 | Journal of Molecular Cell Biology2019，11，2： | 3 |
| 4 | MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis显示文摘T cell-mediated immunity in the intestine is stringently controlled to ensure proper immunity against pathogenic microbes and to prevent autoimmunity,a known cause of inflammatory bowel disease.However,precisely how T cells regulate intestine immunity remains to be fully understood.In this study,we found that mitogen-activated protein kinase kinase kinase 2(MAP3K2)is required for the CD4^(+)T cell-mediated inflammation in the intestine.Using a T cell transfer colitis model,we found that MAP3K2-deficient naïve CD4^(+)T cells had a dramatically reduced ability to induce colitis compared to wild type T cells.In addition,significantly fewer IFN-γ-but more IL-17A-producing CD4^(+)T cells in the intestines of mice receiving MAP3K2-deficient T cells than in those from mice receiving wild type T cells was observed.Interestingly,under well-defined in vitro differentiation conditions,MAP3K2-deficient naïve T cells were not impaired in their ability to differentiate into Th1,Th17 and Treg.Furthermore,the MAP3K2-regulated colitis severity was mediated by Th1 but not Th17 cells in the intestine.At the molecular level,we showed that MAP3K2-mediated Th1 cell differentiation in the intestine was regulated by IL-18 and required specific JNK activation.Together,our study reveals a novel regulatory role of MAP3K2 in intestinal T cell immunity via the IL-18-MAP3K2-JNK axis and may provide a novel target for intervention in T cell-mediated colitis. | Ningbo Wu Dongping Chen Hongxiang Sun Jianmei Tan Yao Zhang Tianyu Zhang Yuheng Han Hongzhi Liu Xinxing Ouyang Xiao-Dong Yang Xiaoyin Niu Jie Zhong Zhengting Wang Bing Su | 2021 | Science China(Life Sciences)2021，64，3： | 3 |
| 5 | Enhanced stretch formability and mechanical properties of a magnesium alloy processed by cold forging and subsequent annealing显示文摘 | Xinxing Wu Xuyue Yang Jijun Ma Qinghuan Huo Jun Wang Huan Sun | 2013 | Materials and Design2013，，： | 2 |
| 6 | Low-dimensional catalysts for oxygen reduction reaction显示文摘Developing highly efficient electrocatalysts to facilitate the sluggish cathodic oxygen reduction reaction(ORR)is a key challenge for high-performance fuel cells.Low-dimensional materials have attracted great attention recently because of their unique structure and properties.In this review,the application of zero-dimensional(0D),one-dimensional(1D),and two-dimensional(2D)materials in ORR are discussed and particular attention is given to the relationship between their structure and the ORR activity.Graphene-based materials,transition metal dichalcogenides,transition metal oxide,nanotubes,nanoribbons,nanowires,and single-atom ORR catalysts are introduced and classified by their geometric dimension. | Xin Tong Xinxing Zhan Diane Rawach Zhangsen Chen Gaixia Zhang Shuhui Sun | 2020 | Progress in Natural Science:Materials International2020，30，6： | 2 |
| 7 | Generation of human hepatocytes from extended pluripotent stem cells显示文摘Dear Editor,Human pluripotent stem cells have great potential for application in regenerative medicine,as they permit the generation of different lineages of functional cell types via directed differentiation.1 However,application of conventional human pluripotent stem cells is limited due to several factors,including heterogeneity in pluripotency,differentiation bias,relatively slow proliferation,and poor single-cell survival.2 Toovercome these problems. | Qiming Wang Da Sun Zhen Liang Junyi Wang Xinxing Zhong Yulin Lyu Junning Cao Zhongqing Lin Yuanyuan Du Zhenchuan Miao Shichun Lu Cheng Li Jun Xu Yan Shi Hongkui Deng | 2020 | Cell Research2020，30，9： | 1 |
| 8 | Measurement of One Proton Transfer Reaction 208Pb(7Li,6He)209Bi in Deep Sub-barrier Region显示文摘Due to the limit of the intensity and quality of the radioactive ion beam(RIB),it is a difficult task to extract the optical model potentials(OMPs)of halo nuclear systems directly from the elastic scattering measurement.In view of this fact,the transfer reaction was tried to be used as an alternative method to extract and stud- | LIN Chengjian YANG Lei JIA Huiming MA Nanru SUN Lijie WANG Dongxi XU Xinxing YANG Feng ZHANG Huanqiao LIU Zuhua | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 9 | β-decay Study of Tz=-3/2Proton-rich Nucleus 29S显示文摘The exotic decay of nuclei far from the stability has recently become a hot topic of nuclear structure research.The nuclide 29S is not well investigated in the A=4n+1,Tz=-3/2series of strong+β-delayed proton precursors.The decay schemes of these nuclei are characterized | ZHONG Fupeng XU Xinxing LIN Chengjian WANG Jiansong LI Zhihuan YANG Lei MA Nanru WANG Dongxi WEN Peiwei SUN Lijie WU Hongyi LUO Diwen WU Chenguang JIANG Ying LIU Yang ZANG Hongliang LIANG Pengfei LI Pengjie LI Xiaojing ZHAO Qingqing SHI Guozhu MA Junbing MA Peng YU Gongming Dipikap Patel BAI Zhen YANG Feng JIA Huiming ZHANG Huanqiao WANG Jianguo YANG Yanyun MA Weihu HU Qiang JIN Shuya ZHOU Xiaohong LI Ren HOU Dongsheng LIU Minliang HU Zhengguo MA Xinwen YANG Weiqing GAO Zhihao DUAN Fangfang YU Yuechao WANG Yufeng WANG Peng ZHOU Qingwu CUI Danteng WANG Xiang HU Liyuan PAN Min ZHANG Gaolong WANG Xiaoyu | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 10 | Systematic Study of Experimental Fusion Barrier Based on Wong Formula显示文摘Coulomb barrier is the critical point between repulsive Coulomb potential and attractive nuclear potential in central collisions.Nuclear force plays the decisive role in inner barrier region,and the external barrier region is dominated by the Coulomb force.This barrier is usually named as fusion barrier(for light and medium mass heavyion systems)or capture barrier(heavy systems)when taking into account other effects,such as the quasi-fission or fission. | WEN Peiwei LIN Chengjian JIA Huiming CUI Danteng YANG Feng MA Nanru SUN Lijie WANG Dongxi ZHONG Fupeng SUN Haohan YANG Lei XU Xinxing | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 11 | Energy Dependence of Optical Potentials of Halo System 6He+64Zn显示文摘The angular distributions of the transfer reactions of 63Cu(7Li,6 He)64Zn were measured at energies around the Coulomb barrier,to extract and study the optical model potential(OMP)of halo system 6 He+64Zn in the exit channel.Due to the limit of the intensity and quality of the radioactive ion beam(RIB),it is a difficult task to extract the OMPs of halo | YANG Lei LIN Chengjian JIA Huiming MA Nanru SUN Lijie WANG Dongxi XU Xinxing YANG Feng ZHANG Huanqiao LIU Zuhua | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 12 | MUSTA:MUltilayer Silicon Telescope Array for Study of Elastic Scattering and Breakup Reaction of Weakly Bound Nuclei at Energy near Coulomb Barrier显示文摘Nowadays the reaction mechanism study of weakly bound nuclei has been one of the frontier problems of nuclear physics.For weakly bound nucleus,the nuclear force and Coulomb force is so weak that in the process of interaction with target nucleus,weakly bound nucleus may breakup into small pieces easily,and such breakup effect can bring some unconventional physical phenomena to weakly bound nucleus near the drip line:such as halo/skin structure,the disappearance of old magic number and the appearance of new magic number,etc. | MA Nanru LIN Chengjian JIA Huiming CUI Danteng YANG Feng WEN Peiwei WANG Dongxi SUN Lijie ZHONG Fupeng SUN Haohan YANG Lei XU Xinxing | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 13 | Near-barrier Fusion Evaporation and Fission of 28Si+174Yb and 32S+170Er显示文摘Heavy-ion induced fusion-fission reactions at energies around the Coulomb barrier have attracted much attention[1-2],due to many degrees of freedom involved in the interaction processes.It has been experimentally proved that the coupled interactions of some intrinsic motions and relative motion play a significant role in the process | WANG Dongxi JIA Huiming LIN Chengjian YANG Feng XU Xinxing YANG Lei MA Nanru SUN Lijie BAO Pengfei LIU Zuhua ZHANG Huanqiao | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 14 | Author Correction:Regulation of CD8^(+)T memory and exhaustion by the mTOR signals显示文摘Correction to:Cellular&Molecular Immunology http://gffzzd3cc09b8251d45dfs9uvobnuqnp9k65ou.ffgz.tsg.suse.edu.cn/10.1038/s41423-023-01064-3,published online 15 August 2023 In this article the author name Yuheng Han was incorrectly written as Yuhen Han.The original article has been corrected. | Yao Chen Ziyang Xu Hongxiang Sun Xinxing Ouyang Yuheng Han Haihui Yu Ningbo Wu Yiting Xie Bing Su | 2023 | Cellular & Molecular Immunology2023，20，11： | 0 |
| 15 | High-lying excited states in ^10Be from the ^9Be(^9Be,^10Be)^8Be reaction显示文摘A transfer-reaction experiment of ~9Be(~9Be,^(10)Be)~8Be was performed at a beam energy of 45 Me V.Excited states in ^(10)Be up to 18.80 Me V are produced using missing mass and invariant mass methods.Most of the observed high-lying resonant states,reconstructed from theα+~6He and t+~7Li decay channels,agree with the previously reported results.In addition,two new resonances at 15.6 and 18.8 Me V are identified from the present measurement.The 18.55 Me V state is found to decay into both the t + ~7Lig:s: and t + ~7Li?(0.478 MeV) channels, with a relative branching ratio of 0:93 ± 0:33. Further theoretical investigations are encouraged to interpret this new information on cluster structure in neutron-rich light nuclei. | Wei Jiang YanLin Ye ZhiHuan Li ChengJian Lin QiTe Li YuCheng Ge JianLing Lou DongXing Jiang Jing Li ZhengYang Tian Jun Feng Biao Yang ZaiHong Yang Jie Chen HongLiang Zang Qiang Liu PengJie Li ZhiQiang Chen Yun Zhang Yang Liu XiaoHui Sun Jing Ma HuiMing Jia XinXing Xu Lei Yang NanRu Ma LiJie Sun | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 0 |
| 16 | The effect of evaporator operating parameters on the flow patterns inside horizontal pipes显示文摘A general and simple model for simulating the steady state behaviors of air-to-refrigerant fin-and-tube evaporator is introduced with the focus on the detailed flow patterns inside the tubes.In order to simulate the heat transfer between air and the working fluid,the evaporator is divided into a number of control volumes.Empirical correlations from literature were also adopted to estimate the void fraction,the internal and external heat transfer coefficients,and the pressure drops.Simulations were performed to study the effects of varying inlet air temperature,refrigerant mass flow rate and evaporation pressure on the flow patterns inside the horizontal pipe of the evaporator.The simulation results indicate that the proposed model can be used to predict flow patterns well.The predicted results of the model agree well with experimental results,the difference is within ±3% for the cooling capacity,and is within ±0.2% for refrigerant evaporation temperature. | Lige Tong Haiyan Li Li Wang Xinxing Sun Yunfei Xie | 2011 | Journal of Thermal Science2011，20，4： | 0 |
| 17 | Emerging multifunctional iron-based nanomaterials as polysulfides adsorbent and sulfur species catalyst for lithium-sulfur batteries——A mini-review显示文摘Lithium-sulfur(Li-S)battery has been considered as one of the most promising next generation energy storage technologies for its overwhelming merits of high theoretical specific capacity(1673 m Ah/g),high energy density(2500 Wh/kg),low cost,and environmentally friendliness of sulfur.However,critical drawbacks,including inherent low conductivity of sulfur and Li2S,large volume changes of sulfur cathodes,undesirable shuttling and sluggish redox kinetics of polysulfides,seriously deteriorate the energy density,cycle life and rate capability of Li-S battery,and thus limit its practical applications.Herein,we reviewed the recent developments addressing these problems through iron-based nanomaterials for effective synergistic immobilization as well as conversion reaction kinetics acceleration for polysulfides.The mechanist configurations between different iron-based nanomaterials and polysulfides for entrapment and conversion acceleration were summarized at first.Then we concluded the recent progresses on utilizing various iron-based nanomaterials in Li-S battery as sulfur hosts,separators and cathode interlayers.Finally,we discussed the challenges and perspectives for designing high sulfur loading cathode architectures along with outstanding chemisorption capability and catalytic activity. | Xinxing Sun Shuangke Liu Weiwei Sun Chunman Zheng | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
| 18 | scRNA-seq profiling of neonatal and adult thymus-derived CD4+ T cells by a T cell origin-time tracing model显示文摘It is well documented that the neonatal thymus-derived (neonatal-TD) regulatory T cells (Treg) are essential to prevent lethal autoimmune diseases and allergies, and neonatal and adult thymus possesses distinct output potentials for naïve T cells, including Treg. However, the molecular features and detailed functional differences between neonatal-TD and adult thymus-derived (adult-TD) T cells in terms of their ability to maintain immune homeostasis during long-term environmental influences are still largely unknown, partially due to the lack of appropriate animal models to precisely trace these cells at specific time points. In this study, neonatal-TD and adult-TD CD4+ T cells from the spleen and Peyer's patches were traced for 9 weeks by a T cell origin-time tracing mouse model and analysed by single-cell RNA sequencing. More Treg but fewer naïve T cells were found in neonatal-TD CD4+ T cells from both tissues than those from adult-TD counterparts. Interestingly, the neonatal-TD Treg in both the spleen and Peyer's patches exhibited augmented expression of Foxp3, Gata3, Ctla4, Icos, Il2ra, Tgfb1, and Nrp1, as well as enriched Gene Ontology terms like T cell activation and tolerance induction, indicating an enhanced immunosuppressive function. These results were further confirmed by flow cytometry analysis and in vitro immune suppression assays. Flow cytometry also revealed a significantly higher proportion of neonatal-TD Treg in total Treg than that of adult-TD counterparts, suggesting the longer lifespan of neonatal-TD Treg. To investigate the intrinsic features of neonatal-TD and adult-TD CD4+ T cells, a shortened tracing time was performed. Surprisingly, the neonatal-TD and adult-TD CD4+ T cells had similar proportions of Treg and did not exhibit significant differences in Foxp3, Gata3, Ctla4, Icos, Il2ra, and Tgfb1 expression levels after tracing for 12 days. On the other hand, neonatal-TD Treg present an increased Nrp1 expression level compared with adult-TD counterparts, indicating the enhanced stability. Together, our work reveals that the neonatal-TD Treg are more immunosuppressive, which is likely shaped primarily by environmental factors. | Yuheng Han Xinxing Ouyang Yao Chen Shujing Lai Hongxiang Sun Ningbo Wu Chun Ruan Limin Lu Bing Su | 2022 | Journal of Molecular Cell Biology2022，14，12： | 0 |
| 19 | Oleophobic interaction mediated slippery organogels with ameliorated mechanical performance and satisfactory fouling-resistance显示文摘Owing to their inherent semi-solid property and lubricant ability,organogels manifest various unique characteristics and serve as promising candidates for antifouling.However,the poor mechanical properties of organogels often limit their practical applications.Herein,we report a simple and effective method to prepare organogels with reinforced mechanical performance and surface lubricant ability with the synergistic roles played by oleophobic and oleophilic chains.The rigid oleophobic chains have a poor affinity to lubricating solvent,which gives rise to high oleophobic interactions between polymer networks;the soft oleophilic chains possess a high affinity to the low surface energy solvent,which lead to high solvent content to maintain the satisfactory lubricant capacity.The organogel of oleophobic methyl methacrylate(MMA)and oleophilic lauryl methacrylate(LMA)is chosen as a representative example to illustrate this concept.With the optimal composition,the as-prepared organogels offer satisfactory tensile fracture stress,fracture strain,Young’s modulus,toughness,and tearing fracture energy of 480 k Pa,550%,202 k Pa,1.14 MJ m,and 5.14 k J m,respectively,which are far beyond the classical PLMA organogels.Furthermore,the biofouling resistance tests demonstrate 4 to 9-fold reduction of protein and bacteria adhesion on the reinforced organogels surface in comparison to the glass substrate and solvent-free dry organogels.This simple and effective approach to toughen organogels,we hope,can be applied in various fields with different practical functional requirements in the future. | Liangpeng Zeng Hongyuan Cui Huilan Peng Xiaohang Sun Yi Liu Jingliang Huang Xinxing Lin Hui Guo Wei-Hua Li | 2022 | Journal of Materials Science & Technology2022，，26： | 0 |
| 20 | Regulation of CD8^(+)T memory and exhaustion by the mTOR signals显示文摘CD8^(+)T cells are the key executioners of the adaptive immune arm,which mediates antitumor and antiviral immunity.Naïve CD8^(+)T cells develop in the thymus and are quickly activated in the periphery after encountering a cognate antigen,which induces these cells to proliferate and differentiate into effector cells that fight the initial infection.Simultaneously,a fraction of these cells become long-lived memory CD8^(+)T cells that combat future infections.Notably,the generation and maintenance of memory cells is profoundly affected by various in vivo conditions,such as the mode of primary activation(e.g.,acute vs.chronic immunization)or fluctuations in host metabolic,inflammatory,or aging factors.Therefore,many T cells may be lost or become exhausted and no longer functional.Complicated intracellular signaling pathways,transcription factors,epigenetic modifications,and metabolic processes are involved in this process.Therefore,understanding the cellular and molecular basis for the generation and fate of memory and exhausted CD8^(+)cells is central for harnessing cellular immunity.In this review,we focus on mammalian target of rapamycin(mTOR),particularly signaling mediated by mTOR complex(mTORC)2 in memory and exhausted CD8^(+)T cells at the molecular level. | Yao Chen Ziyang Xu Hongxiang Sun Xinxing Ouyang Yuheng Han Haihui Yu Ningbo Wu Yiting Xie Bing Su | 2023 | Cellular & Molecular Immunology2023，20，9： | 0 |
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