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| 1 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 2 | Overexpression of micro RNA_(40)8 enhances photosynthesis, growth, and seed yield in diverse plants显示文摘The ability of a plant to produce grain, fruit, or forage depends ultimately on photosynthesis. There have been few attempts, however, to study micro RNAs, which are a class of endogenous small RNAs post-transcriptionally programming gene expression, in relation to photosynthetic traits. We focused on miR_(40)8, one of the most conserved plant miRNAs, and overexpressed it in parallel in Arabidopsis, tobacco, and rice. The transgenic plants all exhibited increased copper content in the chloroplast, elevated abundance of plastocyanin,and an induction of photosynthetic genes. By means of gas exchange and optical spectroscopy analyses, we showed that higher expression of miR_(40)8 leads to enhanced photosynthesis through improving efficiency of irradiation utilization and the capacity for carbon dioxide fixation. Consequently, miR_(40)8 hyper-accumulating plants exhibited higher rate of vegetative growth. An enlargement of seed size was also observed in all three species overproducing miR_(40)8. Moreover, we conducted a 2-year-two-location field trial and observed miR_(40)8 overexpression in rice significantly increased yield, which was primarily attributed to an elevation in grain weight. Taken together, these results demonstrate that miR_(40)8 is a positive regulator of photosynthesis and that its genetic engineering is a promising route for enhancing photosynthetic performance and yield in diverse plants. | Jiawei Pan Dahui Huang Zhonglong Guo Zheng Kuang He Zhang Xinyu Xie Zengfeng Ma Shaopei Gao Manuel T.Lerdau Chengcai Chu Lei Li | 2018 | Journal of Integrative Plant Biology2018，60，4： | 8 |
| 3 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 4 | Genetic-algorithm-based deep neural networks for highly efficient photonic device design显示文摘While deep learning has demonstrated tremendous potential for photonic device design,it often demands a large amount of labeled data to train these deep neural network models.Preparing these data requires high-resolution numerical simulations or experimental measurements and cost significant,if not prohibitive,time and resources.In this work,we present a highly efficient inverse design method that combines deep neural networks with a genetic algorithm to optimize the geometry of photonic devices in the polar coordinate system.The method requires significantly less training data compared with previous inverse design methods.We implement this method to design several ultra-compact silicon photonics devices with challenging properties including power splitters with uncommon splitting ratios,a TE mode converter,and a broadband power splitter.These devices are free of the features beyond the capability of photolithography and generally in compliance with silicon photonics fabrication design rules. | YANGMING REN LINGXUAN ZHANG WEIQIANG WANG XINYU WANG YUFANG LEI YULONG XUE XIAOCHEN SUN WENFU ZHANG | 2021 | Photonics Research2021，9，6： | 6 |
| 5 | Preparation and Characterization of Waterborne Polyurethane/Cellulose Nanocrystal Composite Membrane from Recycling Waste Paper显示文摘Cellulose plays a key role in abundant organic natural materials meeting the increasing demand for green and biocompatible products.The highly crystalline nanoscale component of cellulose nanocrystals has recently attracted great attention due to the versatile performance as filler or matrix in producing functional materials.In this work,we prepared the waterborne polyurethane via a prepolymer process,and obtained cellulose and cellulose nanocrystals from waste paper via a facile acid hydrolysis process.After that,the cellulose nanocrystals were assembled into film and mixed with polyurethane to prepare flexible polyurethane/cellulose nanocrystals composite membrane with different soaking time.The correlation between the bulk structure and applied properties including thermal resistance and mechanical property was investigated by using Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),scanning electron microscopy(SEM),thermogravimetric analysis(TGA),differential scanning calorimetry(DSC)and folding test.The structure analysis indicates that cellulose nanocrystals prepared from used paper have a quality similar to that of commercial cellulose.Meanwhile,the cellulose nanocrystals have been mixed with polyurethane uniformly.Polyurethane can significantly benefit to the thermal resistance and mechanical property of the cellulose nanocrystals film.The polyurethane/cellulose nanocrystals composite membrane present good flexibility and may hold a significantly potential application as visual and flexible material. | Xing Zhou Xin Zhang Dong Wang Changqing Fang Wanqing Lei Zhigang Huang Yonghua Song Xinyu He Yingwei Huang | 2020 | Journal of Renewable Materials2020，8，6： | 5 |
| 6 | Modulating the threshold voltage of oxide nanowire field-effect transistors by a Ga^+ ion beam显示文摘在这份报纸,我们报导一个方法改变 SnO 的阀值电压<潜水艇class=“ a-plus-plus ”> 2 并且在里面<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”>由 Ga 的 3 只 nanowire 晶体管<啜class=“ a-plus-plus ”>+离子照耀。不同于在更早的报告的结果, SnO 的阀值电压<潜水艇class=“ a-plus-plus ”> 2 并且在里面<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”>在在 Ga 以后的否定的门电压方向的 3 nanowire 地效果晶体管(联邦货物税)移动<啜class=“ a-plus-plus “>+离子照耀。更小的阀值电压,由 Ga 完成了 < 啜 class= “ a-plus-plus ” >+ 离子照耀,为高效、低电压的操作被要求。阀值电压移动能被归因于 Ga 引起的表面缺点的降级 < 啜 class= “ a-plus-plus ” >+ 离子照耀。在照耀以后,当前的开/关比率稍微衰退,但是离 10 仍然靠近 < 啜 class= “ a-plus-plus ” > 6 。结果显示那 Ga < 啜 class= “ a-plus-plus ” >+ 离子横梁照耀在改进氧化物 nanowire 联邦货物税的表演起一个重要作用。 | Wenqing Li Lei Liao Xiangheng Xiao Xinyue Zhao Zhigao Dai Shishang Guo Wei Wu Ying Shi Jinxia Xu Feng Ren Changzhong Jiang | 2014 | Nano Research2014，7，11： | 5 |
| 7 | Doped, conductive SiO_(2) nanoparticles for large microwave absorption显示文摘Although many materials have been studied for the purpose of microwave absorption,SiO_(2) has never been reported as a good candidate.In this study,we present for the first time that doped,microwave conductive SiO_(2) nanoparticles can possess an excellent microwave absorbing performance.A large microwave reflection loss(RL)of−55.09 dB can be obtained.The large microwave absorption originates mainly from electrical relaxation rather than the magnetic relaxation of the incoming microwave field.The electrical relaxation is attributed to a large electrical conductivity that is enabled by the incorporation of heterogeneous(N,C and Cl)atoms.The removal of the magnetic susceptibility only results in a negligible influence of the microwave absorption.In contrast,the removal of the heterogeneous atoms leads to a large decrease in the electrical conductivity and microwave absorption performance.Meanwhile,the microwave absorption characteristics can be largely adjusted with a change of the thickness,which provides large flexibility for various microwave absorption applications. | Michael Green Zhanqiang Liu Peng Xiang Yan Liu Minjie Zhou Xinyu Tan Fuqiang Huang Lei Liu Xiaobo Chen | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 8 | mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration显示文摘Hair follicles(HFs)undergo cycles of degeneration(catagen),rest(telogen),and regeneration(anagen)phases.Anagen begins when the hair follicle stem cells(HFSCs)obtain sufficient activation cues to overcome suppressive signals,mainly the BMP pathway,from their niche cells.Here,we unveil that mTOR complex 1(mTORC1)signaling is activated in HFSCs,which coincides with the HFSC activation at the telogen-to-anagen transition.By using both an inducible conditional gene targeting strategy and a pharmacological inhibition method to ablate or inhibit mTOR signaling in adult skin epithelium before anagen initiation,we demonstrate that HFs that cannot respond to mTOR signaling display significantly delayed HFSC activation and extended telogen.Unexpectedly,BMP signaling activity is dramatically prolonged in mTOR signaling-deficient HFs.Through both gain-and loss-of-function studies in vitro,we show that mTORC1 signaling negatively affects BMP signaling,which serves as a main mechanism whereby mTORC1 signaling facilitates HFSC activation.Indeed,in vivo suppression of BMP by its antagonist Noggin rescues the HFSC activation defect in mTORC1-null skin.Our findings reveal a critical role for mTOR signaling in regulating stem cell activation through counterbalancing BMP-mediated repression during hair regeneration. | Zhili Deng Xiaohua Lei Xudong Zhang Huishan Zhang Shuang Liu Qi Chen Huimin Hu Xinyue Wang Lina Ning Yujing Cao Tongbiao Zhao Jiaxi Zhou Ting Chen Enkui Duan | 2015 | Journal of Molecular Cell Biology2015，7，1： | 3 |
| 9 | Iron metabolism,ferroptosis,and lncRNA in cancer: knowns and unknowns显示文摘Cancer cells undergo substantial metabolic alterations to sustain increased energy supply and uncontrolled proliferation.As an essential trace element,iron is vital for many biological processes.Evidence has revealed that cancer cells deploy various mechanisms to elevate the cellular iron concentration to accelerate proliferation.Ferroptosis,a form of cell death caused by iron-catalyzed excessive peroxidation of polyunsaturated fatty acids(PUFAs),is a promising therapeutic target for therapyresistant cancers.Previous studies have reported that long noncoding RNA(lncRNA)is a group of critical regulators involved in modulating cell metabolism,proliferation,apoptosis,and ferroptosis.In this review,we summarize the associations among iron metabolism,ferroptosis,and ferroptosis-related lncRNA in tumorigenesis.This information will help deepen understanding of the role of lncRNA in iron metabolism and raise the possibility of targeting lncRNA and ferroptosis in cancer combination therapy. | Lei QU Xinyu HE Qian TANG Xiao FAN Jian LIU Aifu LIN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，10： | 3 |
| 10 | Association of serum lipids and severity of epithelial ovarian cancer:an observational cohort study of 349 Chinese patients显示文摘While obesity and fat intake have been associated with the risk and prognosis of epithelial ovarian cancer, the association between the lipid levels and epithelial ovarian cancer phenotype remains controversial. We conducted a retrospective study of 349 epithelial ovarian cancer patients who received treatment at Jiangsu Cancer Hospital, China between 2011 and 2017. We analyzed age at diagnosis, blood pressure, plasma glucose content, body mass index(BMI), lipid levels and clinical parameters. Severity of epithelial ovarian cancer was classified according to the International Federation of Gynecology and Obstetrics(FIGO) grading system. Univariate analysis of the clinical factors according to the severity of epithelial ovarian cancer was followed by logistic regression analysis to identify clinical factors significantly associated with epithelial ovarian cancer severity. Univariate analysis indicated that age,BMI, triglyceride(TG), and high density lipoproteins(HDL) differed significantly among different stages of epithelial ovarian cancer(P<0.05). In the logistic regression model, elevated TG(OR: 1.883; 95% CI= 1.207-2.937), and low HDL(OR: 0.497; 95% CI = 0.298-0.829) levels were significantly associated with the high severity epithelial ovarian cancer. Our data indicate that high TG and low HDL levels correlate with a high severity of epithelial ovarian cancer. These data provide important insight into the potential relationship between the lipid pathway and epithelial ovarian cancer phenotype and development. | Yi Zhang Jing Wu Junya Liang Xing Huang Lei Xia Dawei Ma Xinyu Xu Pingping Wu | 2018 | The Journal of Biomedical Research2018，32，5： | 3 |
| 11 | Relationship between increase rate of human plague in China and global climate index as revealed by cross-spectral and cross-wavelet analyses显示文摘Plague has caused the death of hundreds of millions of people throughout the human history.Today this disease is again re-emerging and hence is again becoming an increasing threat to human health in several parts of the world.However,impacts of global climate variation(e.g.El Nino and Southern Oscillation[ENSO])and global warming on plagues are largely unknown.Using cross-spectral analysis and cross-wavelet analysis,we have analyzed the relationship between increase rate of human plague in China during 1871–2003 and the following climate factors(as measured by the Southern Oscillation Index[SOI],Sea Surface Temperature of east Pacific equator[SST]and air Temperature of the Northern Hemisphere[NHT]).We found in the frequency domain that increase rate of human plague was closely associated with SOI and SST.Cross-spectral analysis reveals that significant coherencies between increase rate of human plague and ENSO were found over short periods(2–3 years),medium periods(6–7 years)and long periods(11–12 years,30–40 years).Cross-wavelet analysis reveals that increase rate of human plague oscillates in phase with SOI,but in anti-phase with SST over periods of 2–4 years and approximately 8 years(6–10 years).These results indicate that ENSO-driven climate variation may be important for occurrences of human plague in China.However,there is a need for a further analysis of the underlying mechanism between human plague in China and ENSO. | Zhibin ZHANG Zhenqing LI Yi TAO Min CHEN Xinyu WEN Lei XU Huidong TIAN Nils Chr.STENSETH | 2007 | Integrative Zoology2007，2，3： | 3 |
| 12 | Highly stretchable and reliable graphene oxide- reinforced liquid gating membranes for tunable gas/liquid transport显示文摘The ability of membrane technologies to dynamically tune the transport behavior for gases and liquids is critical for their applications.Although various methods have been developed to improve membrane success,tradeoffs still exist among their properties,such as permeability,selectivity,fouling resistance,and stability,which can greatly affect the performance of membranes.Existing elastomeric membrane designs can provide antifracture properties and flexibility;however,these designs still face certain challenges,such as low tensile strength and reliability.Additionally,researchers have not yet thoroughly developed membranes that can avoid fouling issues while realizing precise dynamic control over the transport substances.In this study,we show a versatile strategy for preparing graphene oxide-reinforced elastomeric liquid gating membranes that can finely modulate and dynamically tune the sorting of a wide range of gases and liquids under constant applied pressures.Moreover,the produced membranes exhibit antifouling properties and are adaptable to different length scales,pressures,and environments.The filling of graphene oxide in the thermoplastic polyurethane matrix enhances the composites through hydrogen bonds.Experiments and theoretical calculations are carried out to demonstrate the stability of our system.Our membrane exhibits good stretchability,recovery,and durability due to the elastic nature of the solid matrix and dynamic nature of the gating liquid.Dynamic control over the transport of gases and liquids is achieved through our optimized interfacial design and controllable pore deformation,which is induced by mechanical stimuli.Our strategy will create new opportunities for many applications,such as gas-involved chemical reactions,multiphase separation,microfluidics,multiphase microreactors,and particulate material synthesis. | Wei Lv Zhizhi Sheng Yinglin Zhu Jing Liu Yi Lei Rongrong Zhang Xinyu Chen Xu Hou | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 13 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 14 | Design,preparation and measurement of protein/CNTs hybrids:A concise review显示文摘With the development of nanobiotechnology,the carbon nanotubes(CNTs)and protein hybrids system has attracted an increasing attention for great potential application in nanotechnology,medicine,smart materials,light industry,and biology.In this review,the main preparation processes,impact factors,measurement of interactions and potential applications of CNTs/protein are presented from the aspect of experiments.Meanwhile,the proper forces detection methods are illustrated comprehensively to complete the quantitative measurement.Atomic force microscope(AFM)and surface force apparatus(SFA)experiments are described in detail to confirm the powerful function in measuring the interaction forces.In addition,the impact of different protein structures(amino acid residues,αHelix,polypeptide chain,and assembled subunits)on interactions between CNTs and protein is presented and different amino acid residues may intervene largely on interactions.Owing to the relatively little knowledge about the structure,function,and spatial orientation of proteins interaction with CNTs surface,we assume that the key problem is how to prepare CNTs and protein specimen with unique structure(such as the variation of secondary and tridimensional structure of protein or the single CNTs)to investigate the interaction forces instead of the designed,preparation,and detection methods. | Xing Zhou Jian Su Chenxi Wang Changqing Fang Xinyu He Wanqing Lei Chaoqun Zhang Zhigang Huang | 2020 | Journal of Materials Science & Technology2020，42，11： | 3 |
| 15 | Arenobufagin is a novel isoform-specific probe for sensing human sulfotransferase 2A1显示文摘Human cytosolic sulfotransferase 2 A1(SULT2A1) is an important phase II metabolic enzyme. The detection of SULT2A1 is helpful for the functional characterization of SULT2A1 and diagnosis of its related diseases. However, due to the overlapping substrate specificity among members of the sulfotransferase family, it is difficult to develop a probe substrate for selective detection of SULT2A1. In the present study, through characterization of the sulfation of series of bufadienolides, arenobufagin(AB) was proved as a potential probe substrate for SULT2A1 with high sensitivity and specificity. Subsequently, the sulfation of AB was characterized by experimental and molecular docking studies. The sulfate-conjugated metabolite was identified as AB-3-sulfate.The sulfation of AB displayed a high selectivity for SULT2A1 which was confirmed by in vitro reaction phenotyping assays. The sulfation of AB by human liver cytosols and recombinant SULT2A1 both obeyed Michaelis-Menten kinetics, with similar kinetic parameters. Molecular docking was performed to understand the interaction between AB and SULT2A1, in which the lack of interaction with Met-137 and Tyr-238 of SULT2A1 made it possible to eliminate substrate inhibition of AB sulfation. Finally, the probe was successfully used to determine the activity of SULT2A1 and its isoenzymes in tissue preparations of human and laboratory animals. | Xiangge Tian Chao Wang Peipei Dong Yue An Xinyu Zhao Weiru Jiang Gang Wang Jie Hou Lei Feng Yan Wang Guangbo Ge Xiaokui Huo Jing Ning Xiaochi Ma | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 2 |
| 16 | MOF-Like 3D Graphene-Based Catalytic Membrane Fabricated by One-Step Laser Scribing for Robust Water Purification and Green Energy Production显示文摘Increasing both clean water and green energy demands for survival and development are the grand challenges of our age.Here,we successfully fabricate a novel multifunctional 3D graphene-based catalytic membrane(3D-GCM)with active metal nanoparticles(AMNs)loading for simultaneously obtaining the water purification and clean energy generation,via a“green”one-step laser scribing technology.The as-prepared 3D-GCM shows high porosity and uniform distribution with AMNs,which exhibits high permeated fluxes(over 100 L m^(−2) h^(−1))and versatile super-adsorption capacities for the removal of tricky organic pollutants from wastewater under ultra-low pressure-driving(0.1 bar).After adsorption saturating,the AMNs in 3D-GCM actuates the advanced oxidization process to self-clean the fouled membrane via the catalysis,and restores the adsorption capacity well for the next time membrane separation.Most importantly,the 3D-GCM with the welding of laser scribing overcomes the lateral shear force damaging during the long-term separation.Moreover,the 3D-GCM could emit plentiful of hot electrons from AMNs under light irradiation,realizing the membrane catalytic hydrolysis reactions for hydrogen energy generation.This“green”precision manufacturing with laser scribing technology provides a feasible technology to fabricate high-efficient and robust 3D-GCM microreactor in the tricky wastewater purification and sustainable clean energy production as well. | Xinyu Huang Liheng Li Shuaifei Zhao Lei Tong Zheng Li Zhuiri Peng Runfeng Lin Li Zhou Chang Peng Kan-Hao Xue Lijuan Chen Gary J.Cheng Zhu Xiong Lei Ye | 2022 | Nano-Micro Letters2022，14，11： | 2 |
| 17 | Microstructuring of carbon/tin quantum dots via a novel photolithography and pyrolysis-reduction process显示文摘 | Xufeng Hong Liang He Xinyu Ma Wei Yang Yiming Chen Lei Zhang Haowu Yan Zhaohuai Li Liqiang Mai | 2017 | Nano Research2017，10，11： | 2 |
| 18 | Cu/ACF adsorbent modified by non-thermal plasma for simultaneous adsorption–oxidation of H_(2)S and PH_(3)显示文摘Non-thermal plasma(NTP)surface modification technology is a new method to control the surface properties of materials,which has been widely used in the field of environmental protection because of its short action time,simple process and no pollution.In this study,Cu/ACF(activated carbon fiber loaded with copper)adsorbent was modified with NTP to remove H_(2)S and PH_(3) simultaneously under low temperature and micro-oxygen condition.Meanwhile,the effects of different modified atmosphere(air,N_(2) and NH_(3)),specific energy input(0–13 J/mL)and modification time(0–30 min)on the removal of H_(2)S and PH_(3) were investigated.Performance test results indicated that under the same reaction conditions,the adsorbent modified by NH_(3) plasma with 5 J/mL for 10 min had the best removal effect on H_(2)S and PH_(3).CO_(2) temperature-programmed desorption and X-ray photoelectron spectroscopy(XPS)analyzes showed that NH_(3) plasma modification could introduce amino functional groups on the surface of the adsorbent,and increase the types and number of alkaline sites on the surface.Brunauer-Emmett-Teller and scanning electron microscopy showed that NH_(3) plasma modification did not significantly change the pore size structure of the adsorbent,but more active components were evenly exposed to the surface,thus improving the adsorption performance.In addition,X-ray diffraction and XPS analysis indicated that the consumption of active components(Cu and Cu_(2)O)and the accumulation of sulfate and phosphate on the surface and inner pores of the adsorbent are the main reasons for the deactivation of the adsorbent. | Xinyu Yang Kai Li Chi Wang Fei Wang Xin Sun Yixing Ma Yuan Li Lei Shi Ping Ning | 2023 | Journal of Environmental Sciences2023，，5： | 2 |
| 19 | The mechanism of dentine hypersensitivity:Stimuli-induced directional cation transport through dentinal tubules显示文摘Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains unclear.The long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain processes.However,no experimental evidence supports the statements.Here,we demonstrate that stimuli-induced directional cation transport,rather than fluid-flow,through dentinal tubules actually leads to dentine hypersensitivity.The in vitro/in vivo electro-chemical and electro-neurophysiological approaches reveal the cation current through the nanoconfined negatively charged dentinal tubules coming from external stimuli(pressure,pH,and temperature)on dentin surface and further triggering the nerve impulses causing the dentine hypersensitivity.Furthermore,the cationic-hydrogels blocked dentinal tubules could significantly reduce the stimuli-triggered nerve action potentials and the anionhydrogels counterpart enhances those,supporting the cation-flow transducing dentine hypersensitivity.Therefore,the inspired ion-blocking desensitizing therapies have achieved remarkable pain relief in clinical applications.The proposed mechanism would enrich the basic knowledge of dentistry and further foster breakthrough initiatives in hypersensitivity mitigation and cure. | Nuo Chen Jingjing Deng Shengjie Jiang Xiang-Yu Kong Teng Zhou Kai Zhao Zuohui Xiao Huimin Zheng Weipeng Chen Congcong Zhu Xinyu Liu Liping Wen Yan Wei Xuliang Deng Lei Jiang | 2023 | Nano Research2023，16，1： | 2 |
| 20 | Robust fault diagnosis with disturbance rejection and attenuation for systems with multiple disturbances显示文摘The fault diagnosis problem is investigated for a class of nonlinear neutral systems with multiple disturbances.Time-varying faults are considered and multiple disturbances are supposed to include the unknown disturbance modeled by an exo-system and norm bounded uncertain disturbance.A nonlinear disturbance observer is designed to estimate the modeled disturbance.Then,the fault diagnosis observer is constructed by integrating disturbance observer with disturbance attenuation and rejection performances.The augmented Lyapunov functional approach,which involves the tuning parameter and slack variable,is applied to make the solution of inequality more flexible.Finally,applications for a two-link robotic manipulator system are given to show the efficiency of the proposed approach. | Songyin Cao Lei Guo Xinyu Wen | 2011 | Journal of Systems Engineering and Electronics2011，22，1： | 2 |
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