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| 1 | Tectonic types and evolution of Ordovician proto-type basins in the Tarim region显示文摘The Ordovician system is an important target for exploration in the Tarim Basin. Restoration of the Ordovician tectono-depositional environment is a key basis for the study of the structural development history in Tarim block and the prediction of the favorable Ordovician reservoir belts (zones). Based on the surrounding tectonic settings, the litho-facies and sedimentary fill, the palaeo-geography, palaeoclimate and palaeo-ecology, and the structural deformation and magmatic eruptions, in this paper we combine the sedimentary fill in the basin with the development of the surrounding orogenic belts and re-build the proto-type basins of the different Ordovician periods. During the Ordovician period, the Tarim region was characterized by the composite of the interior cratonic depression with the peripheral cratonic depression. The interior cratonic depression in the central and western parts is mainly the depositional area of the platform facies while the peripheral cratonic depression in the eastern part is mainly the zone of deepwater basin facies, with the slope acting as the transition belt between them. During the Late Ordovician period, the closure of the Northern Kunlun Ocean and destruction of the trencharc-basin system in the Altyn Tagh region put the southern part of the Tarim block under compression and uplifting and turned the central and western parts of the carbonate platform into the mixed depositional continental shelf. The eastern region of the basin had the over-compensated flysch sedimentation with huge thickness, marking the drastic turn of the basin nature. The basin tectonic framework turned to the south-north differentiation of the Silurian period from the east-west differentiation of the Ordovician period. | HE DengFa ZHOU XinYuan ZHANG ChaoJun YANG XiaoFa | 2007 | Chinese Science Bulletin2007，52，A01： | 15 |
| 2 | Microstructural evolution and stress state related to mechanical properties of electron beam melted Ti-6Al-4V alloy modified by laser shock peening显示文摘This work characterizes microstructural evolutions of electron beam melted(EBM) Ti-6 Al-4 V alloy modified via laser shock peening(LSP).The depth stress distribution and tensile properties of EBM Ti-6 Al-4 V alloy were measured before and after LSP.The results indicate that microstructure consists of β phase with 7.2%±0.4% vol.% and balance α lamellar in EBM sample,and the α lamella was refined into nano-equiaxed grains and submicro-equiaxed grains after LSP.The dominant refinement mechanism is revealed during LSP.Stacking faults were found in the LSP-treated sample,and their corresponding planes were determined as(0001) basal plane,(1010) prismatic plane,and(1011) pyramidal plane obtained by high resolution transmission electron microscopy.The subgrains and high-angle grains formed during dynamic recrystallization were identified by selected area electron diffraction pattern.The LSP treatment produces a significantly residual compressive stress approximately-380 MPa with the depth of compressive stress layer reaching 450 μm.Strength and elongation of the EBM sample were significantly increased after LSP.The strength and ductility enhancements are attributed to compre s sive stress,grain refinement and grain gradient distribution of α phase. | Liang Lan Xinyuan Jin Shuang Gao Bo He Yonghua Rong | 2020 | Journal of Materials Science & Technology2020，47，15： | 11 |
| 3 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 4 | Extraction of palaeochannel information from remote sensing imagery in the east of Chaohu Lake, China显示文摘Palaeochannels 是 unconsolidated 沉积或在古老的、当前不活跃的河和流隧道系统里扔的巩固半的沉积岩石的存款。它从当前活跃的河隧道的 overbank 存款是不同的,包括定期不流动的短暂的水功课。我们介绍了一光谱从有特殊时间阶段的 SPOT-5 形象的基于特征的 palaeochannel 信息抽取模型,它被遥感机制的分析的优点造了并且光谱 palaeochannel 的特征,从空间分发与它的区别结合了并且光谱当前活跃的河隧道的特征,另外,随遥感判定的建立,在遥感的 palaeochannel 的特征想象。这个模型跟随监督分类的进程[箭头权利] 掩盖的农田和主要部件分析[箭头权利] 地下的 palaeochannel 信息抽取[箭头权利] 信息联合[箭头权利] palaeochannel 系统图象。在乔胡·莱克的东方的 Zhegao 河山谷作为一个学习区域被选择,并且 SPOT-5 形象被用作数据的来源。当这个方法成功地被使用了提取 palaeochannel 信息时,结果是令人满意的,它能为地区性的遥感考古学和 neotectonic 研究提供好参考。然而,这个方法的适用性需要作为空间特征在另外的区域进一步被测试并且光谱 palaeochannel 的反应可能是不同的[出版摘要] | Xinyuan WANG Zhenya GUO Li WU Cheng ZHU Hui HE | 2012 | Frontiers of Earth Science2012，6，1： | 4 |
| 5 | An oncolytic adenovirus delivering TSLC1 inhibits Wnt signaling pathway and tumor growth in SMMC-7721 xenograft mice model显示文摘Tumor suppressor in lung cancer-1(TSLC1)was first identified as a tumor suppressor for lung cancer,and frequently downregulated in various types of cancers including hepatocellular carcinoma(HCC).The Wnt pathway plays a critical role in tumorigenesis,migration,and invasion in HCC.However,the function of TSLC1 in modulating Wnt signaling in HCC is unclear.In this study,we evaluated the effect of TSLC1-armed oncolytic adenovirus(S24-TSLC1)on the Wnt/β-catenin pathway,cell viability,invasion and migration abilities of HCC in vitro and the growth of SMMC-7721-xenografted tumor in mice model.We detected the expression of TSLC1 in tumor samples and HCC cell lines.The results showed that TSLC1 expression was low in HCC,but high in pericarcinomatous tissue and normal cells,which implied that TSLC1 is a tumor suppressor of liver cancer.S24-TSLC1 exhibited an antitumor effect on HCC cell growth in vitro,but did little damage to normal liver cells.Overexpression of TSLC1 downregulated the transcriptional activity of TCF4/β-catenin and inhibited the mRNA or protein expression of Wnt target genes cyclinD1 and c-myc.S24-TSLC1 also inhibited the invasion and migration of HCC cells.Animal experiments further confirmed that S24-TSLC1 significantly inhibited tumor growth of the SMMC-7721-xenografted tumor.In conclusion,TSLC1 could downregulate the Wnt signal pathway and suppress HCC cell growth,migration and invasion,suggesting that S24-TSLC1 may be a potent antitumor agent for future clinical trials in liver cancer treatment. | Yigang Wang Panpan Huang Yanping Hu Keni Guo Xiaoyuan Jia Biao Huang Xinyuan Liu Xianglei He Fang Huang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 2 |
| 6 | Singularity detection of the rabbit electrocardiogram:An evolutionary spectral method显示文摘The time-frequency characteristics of the spectral density of non-stationary signals(NSS) in the neighborhood of an instant time point can be determined using the evolutionary spectral analysis.An experimental rabbit model involving ligation of the left anterior descending coronary artery to simulate the physiology of early phase myocardial ischemia(EPMI) has been previously described.Clinically,EPMI derived from left coronary artery stenosis is the main symptom of coronary heart diseases including acute myocardial infarction.Here,we propose a new algorithm for estimating the evolutionary spectral density functions,which is an effective approach to determine the instantaneous frequency spectra(IFS) of NSS under the uncertainty principle in the time-frequency domain.The localization singularity information in the data recorded from a living system could be detected by means of the IFS.Electrocardiogram(ECG) data recorded from experimental rabbits were analyzed with the new algorithm.Results showed that the Q's value of the evolutionary spectral quality number of the QRS-complex data was the characteristic parameter of ECG,and there was a matched connection between the time-frequency characteristics of QRS-complex data and the myocardial ischemia symptoms of the rabbits.These results provide valuable information regarding features of the EPMI for use in clinical diagnoses. | Xinyuan Liu Dingwu He Liuqing Pei Suming Zhang | 2009 | Progress in Natural Science:Materials International2009，19，10： | 2 |
| 7 | Loss/Down-Regulation of Tumor Suppressor in Lung Cancer 1 Expression Is Associated With Tumor Progression and Is a Biomarker of Poor Prognosis in Ovarian Carcinoma显示文摘 | Guofen Yang Weipeng He Muyan Cai Fei Luo Hsiangfu Kung Xinyuan Guan Yixin Zeng Dan Xie | 2011 | International Journal of Gynecological Cancer2011，，3： | 1 |
| 8 | Loss/Down-Regulation of Tumor Suppressor in Lung Cancer 1 Expression Is Associated With Tumor Progression and Is a Biomarker of Poor Prognosis in Ovarian Carcinoma显示文摘 | Guofen Yang Weipeng He Muyan Cai Fei Luo Hsiangfu Kung Xinyuan Guan Yixin Zeng Dan Xie | 2011 | International Journal of Gynecological Cancer2011，，3： | 1 |
| 9 | Trends of Cirrhosis-related Mortality in the USA during the COVID-19 Pandemic显示文摘Immunocompromised status and interrupted routine care may render patients with cirrhosis vulnerable to the coronavi-rus disease 2019(COVID-19)pandemic.A nationwide data-set that includes more than 99%of the decedents in the U.S.between April 2012 and September 2021 was used.Projected age-standardized mortality during the pandemic were esti-mated according to prepandemic mortality rates,stratified by season.Excess deaths were determined by estimating the difference between observed and projected mortality rates.A temporal trend analysis of observed mortality rates was also performed in 0.83 million decedents with cirrhosis between April 2012 and September 2021 was included.Following an increasing trend of cirrhosis-related mortality before the pandemic,with a semiannual percentage change(SAPC)of 0.54%[95%confidence interval(CI):(0.0-1.0%),p=0.036],a precipitous increase with seasonal variation occurred dur-ing the pandemic(SAPC 5.35,95%CI:1.9-8.9,p=0.005).Significantly increased mortality rates were observed in those with alcohol-associated liver disease(ALD),with a SAPC of 8.44(95%CI:4.3-12.8,p=0.001)during the pandemic.All-cause mortality of nonalcoholic fatty liver disease rose stead-ily across the entire study period with a SAPC of 6.79(95%CI:6.3-7.3,p<0.001).The decreasing trend of HCV-related mortality was reversed during the pandemic,while there was no significant change in HBV-related deaths.While there was significant increase in COVID-19-related deaths,more than 55%of the excess deaths were the indirect impact of the pandemic.We observed an alarming increase in cirrhosis-related deaths during the pandemic especially for ALD,with evidence in both direct and indirect impact.Our findings have implications on formulating policies for patients with cirrhosis. | Yee Hui Yeo Xinyuan He Fan Lv Yunyu Zhao Yi Liu Ju Dong Yang Jian Zu Fanpu Ji Mindie H.Nguyen | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 10 | thermal degradation of syndiotactic polypropylene and the influence of stereoregularity on the thermal degradation hehaviour by in situ FTIR spectroscopy 显示文摘 | Peng He Yan Xiao Puming Zhang Chunhua Xing Na Zhu Xinyuan Zhu Deyue Yan | 2005 | Polymer Degradation and Stability2005，，88： | 1 |
| 11 | Modal analysis of rubbing acoustic emission for rotor-bearing system based on reassigned wavelet scalogram显示文摘 | He Yongyong Yin Xinyuan Chu Fulei | 2008 | Journal of Vibration and Acoustics2008，130，6： | 1 |
| 12 | Spatiotemporal Changes in NDVI and Its Driving Factors in the Kherlen River Basin显示文摘Vegetation is an important factor linking the atmosphere,water,soil,and biological functions,and it plays a specific role in the climate change response and sustainable development of regional economies.However,little information is available on vegetation vulnerability and its driving mechanism.Therefore,studying temporal and spatial change characteristics of vegetation and their corresponding mechanisms is important for assessing ecosystem stability and formulating ecological policies in the Kherlen River Basin.We used Moderate-resolution Imaging Spectroradiometer(MODIS)normalized difference vegetation index(NDVI)remote sensing images from 2000 to 2020 to analyse temporal changes in NDVI with the autoregressive moving average model(ARMA)and the breaks for additive season trend(BFAST)in the basin and to assess natural,anthropogenic and topographic factors with the Geodetector model.The results show that:1)the long NDVI time series remained stable in the Kherlen River Basin from 2000 to 2020,with a certain significant mutation period from 2013 to 2017;2)the coefficient of variation(CV)in the analysis of the spatial NDVI was generally constant,mainly at the level of 0.01–0.07,and the spatial NDVI change was minimally impacted by external interference;and 3)temperature and precipitation are the key factors affecting the NDVI in the basin,and changes in local hydrothermal conditions directly affect the local NDVI.The results of this study could provide a scientific basis for the effective protection of the ecological environment and will aid in understanding the influence of vegetation change mechanisms and the corresponding factors. | MUHAMMAD Naveed HE Hongshi ZONG Shengwei DU Haibo SATTI Zulqarnain TAN Xinyuan QAZI Muhammad Yasir | 2023 | Chinese Geographical Science2023，33，2： | 1 |
| 13 | Fabrication of porous scaffolds with protein nanogels显示文摘A novel type of porous scaffold was fabricated from single protein nanogels. The nanogels with single protein as core and crosslinked polymer network as shell were prepared through a two-step procedure including surface acryloylation and in situ radical polymerization. The formation of single protein nanogels was verified by matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometer, transmission electron microscopy (TEM) and dynamic light scattering (DLS) analyses. Subsequently, the porous scaffolds were fabricated through a solvent evaporating process of aqueous nanogel solutions. The porous scaffolds were characterized by Fourier transform infrared (FTIR), scanning electronic microscopy (SEM), atomic force microscopy (AFM), and fluorescence microscopy. Interestingly, the obtained porous nanogel scaffolds presented multi-level porous morphologies with macro and nano scale pores, providing better spaces and microenvironments than normal macro porous scaffolds. Cell proliferation assay of nanogels showed low cytotoxicity. Considering that both the protein species and polymer constitutes can be pre-designed and adjusted, these multi-level porous nanogel scaffolds are promising candidates for tissue culture applications. | ZHU Qi YAN Ming HE Lin ZHU XinYuan LU YunFeng YAN DeYue | 2011 | Science China Chemistry2011，54，6： | 1 |
| 14 | Influence of multiple laser shock peening treatments on the microstructure and mechanical properties of Ti-6Al-4V alloy fabricated by electron beam melting显示文摘Laser shock peening(LSP)is an attractive post-processing method to tailor surface microstructure and enhance mechanical performances of additive manufactured(AM)components.The effects of multiple LSP treatments on the microstructure and mechanical properties of Ti-6Al-4V part produced by electron beam melting(EBM),as a mature AM process,were studied in this work.Microstructure,surface topography,residual stress,and tensile performance of EBM-manufactured Ti-6Al-4V specimens were systematically analyzed subjected to different LSP treatments.The distribution of porosities in EBM sample was assessed via X-ray computed tomography.The results showed that EBM samples with two LSP treatments possessed a lower porosity value of 0.05%compared to the value of 0.08%for the untreated samples.The strength of EBM samples with two LSP treatments was remarkably raised by 12%as compared with the as-built samples.The grains ofαphase were refined in near-surface layer,and a dramatic increase in the depth and magnitude of compressive residual stress(CRS)was achieved in EBM sample with multiple LSP treatments.The grain refinement ofαphase and CRS with larger depth were responsible for the strength enhancement of EBM samples with two LSP treatments. | Liang Lan Ruyi Xin Xinyuan Jin Shuang Gao Bo He | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，9： | 1 |
| 15 | Effect of Kushen(Radix Sophorae flavescentis) extract on laryngeal neoplasm Hep2 cells显示文摘OBJECTIVE:To evaluate the effect of fermented extract of Kushen(Radix Sophorae Flavescentis) or non-fermented ESF on laryngeal neoplasms Hep2 cells.METHODS:Use 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay to explore the effect of fermented ESF and non-fermented ESF on Hep2 cells,and detect the mRNA and protein expression level of Bcl-2,Bax and Caspase-3 with reverse transcription polymerase chain reaction(RT-PCR) andWestern blot.RESULTS:Both fermented ESF and non-fermented ESF could inhibit laryngeal neoplasm's Hep2 cells,but and the cells did not response to the dilution 1:320 of fermented ESF,nor to the 1:1280 dilution of non-fermented ESF.As time progressed,the dilution 1:80 of fermented ESF and 1:320 dilution of non-fermented ESF could significantly reduce Bcl-2 mRNA and protein expression and down-regulate Caspase-3 mRNA and protein expression.Bax mRNA and protein were not expressed in Hep2 cells.CONCLUSIONS:Both fermented ESF and non-fermented ESF could inhibit the proliferation of Hep2 cells,and the effect of non-fermented ESF was significantly better than that of the fermented. | Yingzi Wang Chunchao Han Xinsheng Fang Xinyuan Shi Ailing Feng Kuibang He Shenghai Zhang Xiuyu Sun | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 1 |
| 16 | Improving anammox activity and reactor start-up speed by using CO_(2)/NaHCO_(3) buffer显示文摘Anammox bacteria grow slowly and can be affected by large pH fluctuations.Using suitable buffers could make the start-up of anammox reactors easy and rapid.In this study,the effects of three kinds of buffers on the nitrogen removal and growth characteristics of anammox sludge were investigated.Reactors with CO_(2)/NaHCO_(3)buffer solution(CCBS)performed the best in nitrogen removal,while 4-(2-hydroxyerhyl)piperazine-1-ethanesulfonic acid(HEPES)and phosphate buffer solution(PBS)inhibited the anammox activity.Reactors with 50 mmol/L CCBS could start up in 20 days,showing the specific anammox activity and anammox activity of 1.01±0.10 gN/(gVSS·day)and 0.83±0.06 kgN/(m^(3)·day),respectively.Candidatus Kuenenia was the dominant anammox bacteria,with a relative abundance of 71.8%.Notably,anammox reactors could also start quickly by using 50 mmol/L CCBS under nonstrict anaerobic conditions.These findings are meaningful for the quick start-up of engineered anammox reactors and prompt enrichment of anammox bacteria. | Shaoan Cheng Huahua Li Xinyuan He Hua Chen Longxin Li | 2024 | Journal of Environmental Sciences2024，，5： | 0 |
| 17 | Carbon Emission Cycle and Literature Measurement of Carbon Fiber Vehicles显示文摘Carbon fiber is a kind of high-temperature fiber with high modulus and strength characteristics.Carbon fiber material is made of carbon fiber braid with carbon content>90%.Among them,resin-based carbon fiber reinforced composite material is often used as automotive structural material.Compared with the A36 steel commonly used in automobiles,the T300/5208 carbon fiber reinforced epoxy resin composite commonly used in automobiles has a higher tensile strength of 2500-3300 MPa and a lower density of 6.25 g/cm 3,showing great performance advantages.In this paper,by analyzing the trend of automobile lightweight,and exploring the development prospects of carbon fiber in the field of automobile lightweight,the literature in the Elsevier database is analyzed by scientific measurement analysis method,and the research hotspot in the field is listed.The relationship between the development of fiber materials and the promotion of policies is analyzed by comparing the number of carbon fiber automobile literature publications and key event nodes.This paper proposes a keyword-based influence calculation method.Through drawing analysis tools of information visualization scientific knowledge map and scientific measurement methods of keyword,it proposes the scientific measurement analysis literature of on-board carbon fiber,explores and discusses some frontier directions of automotive carbon fiber materials.The research provides reference for studying automobile lightweight carbon fiber material. | Junpeng CHEN Dongri LIAO Tao YUAN Jize WANG Jing TANG Xinyuan HE Jingjun JIANG | 2020 | Meteorological and Environmental Research2020，11，6： | 0 |
| 18 | A versatile AIE fluorogen with selective reactivity to primary amines for monitoring amination,protein labeling,and mitochondrial staining显示文摘Specific bioconjugation for native primary amines is highly valuable for both chemistry and biomedical research.Despite all the efforts,scientists lack a proper strategy to achieve high selectivity for primary amines,not to mention the requirement of fast response in real applications.Herein,we report a chromone-based aggregation-induced emission(AIE)fluorogen called CMVMN as a self-reporting bioconjugation reagent for selective primary amine identification,and its applications for monitoring bioprocesses of amination and protein labeling.CMVMN is AIE-active and capable of solid-state sensing.Thus,its electrospun films are manufactured for visualization of amine diffusion and leakage process.CMVMN also shows good biocompatibility and potential mitochondria-staining ability,which provides new insight for organelle-staining probe design.Combined with its facile synthesis and good reversibility,CMVMN would not only show wide potential applications in biology,but also offer new possibilities for molecular engineering. | Xinyuan He Huilin Xie Lianrui Hu Pengchao Liu Changhuo Xu Wei He Wutong Du Siwei Zhang Hao Xing Xinyue Liu Hojeong Park Tsz Shing Cheung Min-Hui Li Ryan T.K.Kwok Jacky W.Y.Lam Jian Lu Ben Zhong Tang | 2023 | Aggregate2023，4，1： | 0 |
| 19 | Tracing drug release process with dual-modal hyperbranched polymer-gold nanoparticle complexes显示文摘Dual-modal surface enhanced Raman spectrum(SERS)-fluorescence polymer/metal hybrid complexes have been prepared for tracing drug release process in tumor cells. Firstly, the hyperbranched poly((S-(4-vinyl) benzyl S′-propyltrithiocarbonate)-co-(poly(ethylene glycol) methacrylate))(HPVBEG) was synthesized via the combination of reversible addition-fragmentation chain-transfer(RAFT) polymerization and self-condensing vinyl polymerization(SCVP). Subsequently, the anticancer drug doxorubicin(DOX) was linked to HPVBEG via pH sensitive Schiff base bonds to form HPVBEG-g-DOX conjugates.Through aminolysis reaction, HPVBEG-g-DOX was coordinated with gold nanoparticles(GNP), resulting in the formation of HPVBEG-g-DOX/GNP complexes. In neutral condition, the HPVBEG-g-DOX/GNP complexes were stable, and DOX was bound to the surface of GNPs. Therefore, the SERS of DOX could be observed, while the fluorescence of DOX was quenched by GNPs. Under an acidic environment, DOX was released from the surface of GNPs with breakage of Schiff base bonds.Thus, the SERS signal of DOX was gradually reduced. Correspondingly, the fluorescence signal of DOX was enhanced.Through dual-modal SERS-fluorescence technique, the DOX delivery and release process was traced in tumor cells. Moreover,the viability of MCF-7 cells incubated with HPVBEG-g-DOX/GNP complexes was investigated by Cell Counting Kit-8(CCK-8) assay. The experimental results showed that HPVBEG-g-DOX/GNP complexes had similar proliferation inhibition effect compared with free DOX. Definitely, the dual-modal SERS-fluorescence complexes for tracing drug delivery and release will have promising prospects on tumor diagnosis and therapy. | Yuanyuan Zhuang Dali Wang Chunhui Yin Hongping Deng Mo Sun Lin He Yue Su Xinyuan Zhu | 2016 | Science China Chemistry2016，59，12： | 0 |
| 20 | Nanostructure enabled extracellular vesicles separation and detection显示文摘Extracellular vesicles(EVs)have recently attracted significant research attention owing to their important biological functions,including cell-to-cell communication.EVs are a type of membrane vesicles that are secreted into the extracellular space by most types of cells.Several biological biomolecules found in EVs,such as proteins,microRNA,and DNA,are closely related to the pathogenesis of human malignancies,making EVs valuable biomarkers for disease diagnosis,treatment,and prognosis.Therefore,EV separation and detection are prerequisites for providing important information for clinical research.Conventional separation methods suffer from low levels of purity,as well as the need for cumbersome and prolonged operations.Moreover,detection methods require trained operators and present challenges such as high operational expenses and low sensitivity and specificity.In the past decade,platforms for EV separation and detection based on nanostructures have emerged.This article reviews recent advances in nanostructure-based EV separation and detection techniques.First,nanostructures based on membranes,nanowires,nanoscale deterministic lateral displacement,and surface modification are presented.Second,high-throughput separation of EVs based on nanostructures combined with acoustic and electric fields is described.Third,techniques combining nanostructures with immunofluorescence,surface plasmon resonance,surface-enhanced Raman scattering,electrochemical detection,or piezoelectric sensors for high-precision EV analysis are summarized.Finally,the potential of nanostructures to detect individual EVs is explored,with the aim of providing insights into the further development of nanostructure-based EV separation and detection techniques. | Xinyuan He Wei Wei Xuexin Duan | 2023 | Nanotechnology and Precision Engineering2023，6，4： | 0 |
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