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| 1 | Field investigations of high stress soft surrounding rocks and deformation control显示文摘Field investigations of high stress soft rock deformations show that the high stress soft rock roadway can slide with large deformation. Severe extrusion and floor heave can also be subsequently observed. The supported roadway can be locally damaged or completely fail, where the floor has a large deformation and/or is seriously damaged. The factors inducing large deformation of surrounding rocks in deep roadway are rock strengths, structure face cutting types, stress states, stress release, support patterns,and construction methods. Based on the deformation characteristics of high stress soft rock roadway, a comprehensive support scheme is proposed. The overall support technology of 'step-by-step and joint,hierarchical reinforcement' for roadway is presented, and the anchor cable and bolt parameters to check the design methods are also given. Finally, the proposed comprehensive support method 'bolt t metal mesh t U-steel arch t shortcrete t grouting and cable' is used in the extension section of east main haulage roadway at 850 m level of Qujiang coal mine. The 173-day monitoring results show that the average convergence of sidewalls reaches 208 mm, and the average relative convergence of roof and floor reaches 448 mm, suggesting that this kind of support technology for controlling large deformation of high stress soft surrounding rock roadway is effective. | Weijian Yu Weijun Wang Xinyuan Chen Shaohua Du | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，4： | 12 |
| 2 | Effects of cerium substitution on phase components, microstructures and magnetic properties of Nd-Fe-Ti-B alloy显示文摘(Nd(1-x)Cex)(12)Fe(77)Ti5B6(x=0,0.2,0.3,0.4,0.6,0.8)alloys were prepared by melt-spinning and annealing techniques.The phase constitutions,microstructures and magnetic properties were investigated by powder X-ray diffraction(XRD),a differential scanning calorimeter(DSC),a vibrating sample magnetometer(VSM)and a transmission electron microscope(TEM).It is found that with the increase of Ce content,the coercivity of the(Nd(1-x)Cex)(12)Fe(77)Ti5B6 alloys reaches maximum first and then decreases.The maximum coercivity reaches 18.5 kOe obtained in the sample of 20%Ce substituted which is 34%higher than the Ce-free sample.TEM results reveal that the micro structure refinement effect is responsible for the coercivity improvement.This phenomenon implies that in some cases,Ce and Ti co-doping is more beneficial to improving of the coercivity than Ti single doping in Nd-Fe-B alloys.With further Ce addition,magnetic properties deteriorate due to the formation of CeFe2 and TbCu7-type phases. | Haijun Peng Yang Luo Yakun Dou Xinyuan Bai Wenlong Yan Dunbo Yu Yuanfei Yang Shulin Diao | 2019 | Journal of Rare Earths2019，37，8： | 4 |
| 3 | Magnetic properties enhancement of hot-deformed NdFeB magnets by two different methods of CeNdCu diffusion显示文摘Two different ways were used to control the distribution of cerium for the enhancement of coercivity.One was by coating CeNdCu in the prepared magnet and annealing to make CeNdCu diffuse into the grain boundary to increase the coercivity,the other was by mixing CeNdCu with initial magnetic powders and then preparing the hot-deformed magnet.The SEM-EDS result indicates that cerium diffuses more easily into the main phase by the mixing way,while cerium is mainly distributed in the grain boundary via the coating way.The heat-treatment process may be one of the dominant influencing factors for the distribution of Ce,Multi-steps heat treatment in the mixing way,consisting of hot-pressing,hot-deforming and post heat process,easily introduces Ce into the main phase Nd2 Fe14B,which forms the Ce2 Fe14B shell resulting in the decrease of HA.But the coating way can ensure uniform dispersion of Ce in the grain boundary,which leads to the high coercivity. | Guibing Shi Zilong Wang Xinyuan Bai Wenlong Yan Yang Luo Dunbo Yu | 2020 | Journal of Rare Earths2020，38，12： | 3 |
| 4 | Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells显示文摘Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells(MSCs).However,the biological function of chaperone-mediated autophagy(CMA)in MSCs remains elusive.Here,we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α).In addition,suppression of CMA by knocking down the CMA-related lysosomal receptor lysosomal-associated membrane protein 2(LAMP-2A)in MSCs significantly enhanced the immunosuppressive effect of MSCs on T cell proliferation,and as expected,LAMP-2A overexpression in MSCs exerted the opposite effect on T cell proliferation.This effect of CMA on the immunosuppressive function of MSCs was attributed to its negative regulation of the expression of chemokine C-X-C motif ligand 10(CXCL10),which recruits inflammatory cells,especially T cells,to MSCs,and inducible nitric oxide synthase(iNOS),which leads to the subsequent inhibition of T cell proliferation via nitric oxide(NO).Mechanistically,CMA inhibition dramatically promoted IFN-γplus TNF-α-induced activation of NF-κB and STAT1,leading to the enhanced expression of CXCL10 and iNOS in MSCs.Furthermore,we found that IFN-γplus TNF-α-induced AKT activation contributed to CMA inhibition in MSCs.More interestingly,CMA-deficient MSCs exhibited improved therapeutic efficacy in inflammatory liver injury.Taken together,our findings established CMA inhibition as a critical contributor to the immunosuppressive function of MSCs induced by inflammatory cytokines nd highlighted a previously unknown function of CMA. | Jie Zhang Jiefang Huang Yuting Gu Mingxing Xue Fengtao Qian Bei Wang Wanlin Yang Hongshuang Yu Qiwei Wang Xin Guo Xinyuan Ding Jina Wang Min Jin Yanyun Zhang | 2021 | Cellular & Molecular Immunology2021，18，6： | 3 |
| 5 | Magnetic properties and microstructures of terbium coated and grain boundary diffusion treated sintered Nd-Fe-B magnets by magnetron sputtering显示文摘Tb coating on the surface of commercial sintered Nd-Fe-B magnet was prepared by DC magnetron sputtering.The secondary heat treatment was used to regulate the microstructure for the enhancement of coercivity,namely diffusion treatment and annealing treatment.The coercivity increases significantly from 18.3 to 28.0 kOe,the remanence decreases slightly from 14.1 to 14.0 kGs,and the comprehensive magnetic properties are higher than 75(Hcj+(BH)_(max)=76.7).SEM results indicate that,on the one hand,950℃is the optimal diffusion temperature.Lower diffusion temperature results in insufficient diffusion of Tb element.Higher diffusion temperature can lead to the main phase grain growth,the decrease of Nd-rich phase,and forming holes in the magnet.On the other hand,500℃is the optimal annealing temperature.Lower annealing temperature can result in the reduction of Nd-rich phase.Higher annealing temperature can generate the non-defined Nd-rich thin layer between grains. | Wei Zhu Yang Luo Zilong Wang Xinyuan Bai Haijun Peng Dunbo Yu | 2021 | Journal of Rare Earths2021，39，2： | 2 |
| 6 | Cancer cell reprogramming:a promising therapy converting malignancy to benignity显示文摘In the past decade, remarkable progress has been made in reprogramming terminally differentiated somatic cells and cancer cells into induced pluripotent cells and cancer cells with benign phenotypes. Recent studies have explored various approaches to induce reprogramming from one cell type to another, including lineage-specific transcription factors-, combinatorial small molecules-, microRNAs- and embryonic microenvironment-derived exosome-mediated reprogramming. These reprogramming approaches have been proven to be technically feasible and versatile to enable re-activation of sequestered epigenetic regions, thus driving fate decisions of differentiated cells. One of the significant utilities of cancer cell reprogramming is the therapeutic potential of retrieving normal cell functions from various malignancies. However, there are several major obstacles to overcome in cancer cell reprogramming before clinical translation, including characterization of reprogramming mechanisms, improvement of reprogramming efficiency and safety, and development of delivery methods. Recently, several insights in reprogramming mecha-nism have been proposed, and determining progress has been achieved to promote reprogramming efficiency and feasibility, allowing it to emerge as a promising therapy against cancer in the near future. This review aims to discuss recent applications in cancer cell reprogramming, with a focus on the clinical significance and limitations of different reprogramming approaches, while summarizing vital roles played by transcription factors, small molecules, microR-NAs and exosomes during the reprogramming process. | Lanqi Gong Qian Yan Yu Zhang Xiaona Fang Beilei Liu Xinyuan Guan | 2019 | Cancer Communications2019，39，1： | 2 |
| 7 | A Novel Unsupervised Change Detection Method with Structure Consistency and GFLICM Based on UAV Images显示文摘With the rapid development of Unmanned Aerial Vehicle(UAV)technology,change detection methods based on UAV images have been extensively studied.However,the imaging of UAV sensors is susceptible to environmental interference,which leads to great differences of same object between UAV images.Overcoming the discrepancy difference between UAV images is crucial to improving the accuracy of change detection.To address this issue,a novel unsupervised change detection method based on structural consistency and the Generalized Fuzzy Local Information C-means Clustering Model(GFLICM)was proposed in this study.Within this method,the establishment of a graph-based structural consistency measure allowed for the detection of change information by comparing structure similarity between UAV images.The local variation coefficient was introduced and a new fuzzy factor was reconstructed,after which the GFLICM algorithm was used to analyze difference images.Finally,change detection results were analyzed qualitatively and quantitatively.To measure the feasibility and robustness of the proposed method,experiments were conducted using two data sets from the cities of Yangzhou and Nanjing.The experimental results show that the proposed method can improve the overall accuracy of change detection and reduce the false alarm rate when compared with other state-of-the-art change detection methods. | Wensong LIU Xinyuan JI Jie LIU Fengcheng GUO Zongqiao YU | 2022 | Journal of Geodesy and Geoinformation Science2022，5，1： | 2 |
| 8 | Effects of grain boundary diffusion of PrCu alloy on microstructure and coercivity of hot deformed(Nd,Ce)-Fe-B magnets显示文摘The technology of using high abundance rare earth element Ce in permanent magnets has attracted many concerns.In this work,the magnetic properties and microstructures of hot deformed(Nd_(1-x)Ce_(x))_(13.8)Fe_(76.1)Co_(4)Ga_(0.5)B_(5.6) magnets and a selective magnet treated with PrCu grain boundary diffusion process(GBDP) were investigated systematically.It is found that Ce is beneficial to improving the plastic deformation ability of NdFeB magnets.The strongest c-axis orientation is achieved in the HD magnets with Ce concentration of x=0.3,resulting in good comprehensive magnetic properties of B_(r)=13.00 kGs,H_(cj)=10.12 kOe,(BH)_(max)=38.42 MGOe.Based on that,the GBDP was implemented on the magnets with the best orientation using Pr_(68)Cu_(32) ribbons and the magnetic properties of B_(r)=12.87 kGs,H_(cj)=15.65 kOe,(BH)_(max)=37.48 MGOe were obtained.The results of composition distribution and Curie temperature test of the GBDPed magnets illustrate that Pr diffuses into the(Nd,Ce)_(2)(Fe,Co)_(14)B grains to substitute Ce,which not only improves the Curie temperature of the grains,but also enhances the magnetic performance of the magnets.Through GBDP,the thermal stability of magnets has also been improved. | Haijun Peng Dunbo Yu Xinyuan Bai Xiao Lin Yongjun Mao Zilong Wang Yang Luo | 2021 | Journal of Rare Earths2021，39，8： | 1 |
| 9 | Component reconstitution-driven photoelectrochemical sensor for sensitive detection of Cu2+ based on advanced CuS/CdS p-n junction显示文摘The rational design of robust photoactive material and artful sensing strategy are vital for the construction of an ultrasensitive photoelectrochemical(PEC)sensor.Although great progress has been made in PEC sensing,the resultant detection performances and adoptable sensing strategies are still limited.Herein,through the design of a subtle component reconstitution strategy,an ultrasensitive PEC sensor is developed for the detection of Cu2+based on advanced CuS/CdS nanohybrids(NHs).This proposed sensor shows superior sensing performances with a low detection limit of 0.1 nM and a wide detection range from 0.2 nM to 60 pM due to the formation of p-n junction between CuS and CdS and the component transformation of CdS to CuxS(x=1,2).Moreover,such PEC sensor also displays goodish results for monitoring the Cu^2+released from apoptotic HeLa cells in vitro.This idea of component reconstitution provides a new paradigm for the design of advanced PEC sensors. | Jing Liu Ying Liu Wei Wang Jing Li Xinyuan Yu Qinshu Zhu Zhihui Dai | 2019 | Science China Chemistry2019，62，12： | 1 |
| 10 | Controllable synthesis of a hollow Cr2O3 electrocatalyst for enhanced nitrogen reduction toward ammonia synthesis显示文摘As a fascinating alternative to the energy-intensive Haber-Bosch process,the electrochemically-driven N_(2) reduction reaction(NRR)utilizing the N_(2) and H_(2)O for the production of NH3 has received enormous attention.The development and preparation of promising electrocatalysts are requisite to realize an efficient N_(2) conversion for NH3 production.In this research,we propose a template-assisted strategy to construct the hollow electrocatalyst with controllable morphology.As a paradigm,the hollow Cr_(2)O_(3) nanocatalyst with a uniform size(~170 nm),small cavity and ultrathin shell(~15 nm)is successfully fabricated with this strategy.This promising hollow structure is favourable to trap N_(2) into the cavity,provides abundant active sites to accelerate the three-phase interactions,and facilitates the reactant transfer across the shell.Attributed to these synergetic effects,the designed catalyst displays an outstanding behaviour in N_(2) fixation for NH3 production in ambient condition.In the neutral electrolyte of 0.1 mol·L^(-1) Na_(2)SO_(4),an impressive electrocatalytic performance with the NH3 generation rate of 2.72μg·h^(-1)·cm^(-2) and a high FE of 5.31%is acquired respectively at-0.85 V with the hollow Cr_(2)O_(3) catalyst.Inspired by this work,it is highly expected that this approach could be applied as a universal strategy and extended to fabricating other promising electrocatalysts for realizing highly efficient nitrogen reduction reaction(NRR). | Lei Shi Yu Yin Hong Wu Rajan Arjan Kalyan Hirani Xinyuan Xu Jinqiang Zhang Nasir Rafique Abdul Hannan Asif Shu Zhang Hongqi Sun | 2022 | Chinese Journal of Chemical Engineering2022，35，1： | 1 |
| 11 | Cluster Randomization Trial of Sequence Mass Screening for Colorectal Cancer显示文摘 | Shu Zheng M.D. Kun Chen M.D. Xiyong Liu M.D. Xinyuan Ma M.D. Hai Yu Ph.D. Kang Chen Kaiyan Yao Lun Zhou M.D. Linbo Wang M.D. Peiling Qiu M.D. Yongchuan Deng M.D. Suzhan Zhang M.D | 2003 | Diseases of the Colon & Rectum2003，，1： | 1 |
| 12 | β-cell dynamics in type 2 diabetes and in dietary and exercise interventions显示文摘Pancreaticβ-cell dysfunction and insulin resistance are two of the major causes of type 2 diabetes(T2D).Recent clinical and experimental studies have suggested that the functional capacity ofβ-cells,particularly in the first phase of insulin secretion,is a primary contributor to the progression of T2D and its associated complications.Pancreaticβ-cells undergo dynamic compensation and decompensation processes during the development of T2D,in which metabolic stresses such as endoplasmic reticulum stress,oxidative stress,and inflammatory signals are key regulators ofβ-cell dynamics.Dietary and exercise interventions have been shown to be effective approaches for the treatment of obesity and T2D,especially in the early stages.Whilst the targeted tissues and underlying mechanisms of dietary and exercise interventions remain somewhat vague,accumulating evidence has implicated the improvement ofβ-cell functional capacity.In this review,we summarize recent advances in the understanding of the dynamic adaptations ofβ-cell function in T2D progression and clarify the effects and mechanisms of dietary and exercise interventions onβ-cell dysfunction in T2D.This review provides molecular insights into the therapeutic effects of dietary and exercise interventions on T2D,and more importantly,it paves the way for future research on the related underlying mechanisms for developing precision prevention and treatment of T2D. | Chengan Lv Yuchen Sun Zhe Yu Zhang Zeyad Aboelela Xinyuan Qiu Zhuo-Xian Meng | 2022 | Journal of Molecular Cell Biology2022，14，7： | 1 |
| 13 | FAM64A promotes HNSCC tumorigenesis by mediating transcriptional autoregulation of FOXM1显示文摘Head and neck squamous cell carcinoma(HNSCC)still lacks effective targeted treatment.Therefore,exploring novel and robust molecular targets is critical for improving the clinical outcome of HNSCC.Here,we reported that the expression levels of family with sequence similarity 64,member A(FAM64A)were significantly higher in HNSCC tissues and cell lines.In addition,FAM64A overexpression was found to be strongly associated with an unfavorable prognosis of HNSCC.Both in vitro and in vivo evidence showed that FAM64A depletion suppressed the malignant activities of HNSCC cells,and vice versa.Moreover,we found that the FAM64A level was progressively increased from normal to dysplastic to cancerous tissues in a carcinogenic 4-nitroquinoline-1-oxide mouse model.Mechanistically,a physical interaction was found between FAM64A and forkhead box protein M1(FOXM1)in HNSCC cells.FAM64A promoted HNSCC tumorigenesis not only by enhancing the transcriptional activity of FOXM1,but also,more importantly,by modulating FOXM1 expression via the autoregulation loop.Furthermore,a positive correlation between FAM64A and FOXM1 was found in multiple independent cohorts.Taken together,our findings reveal a previously unknown mechanism behind the activation of FOXM1 in HNSCC,and FAM64A might be a promising molecular therapeutic target for treating HNSCC. | Xinyuan Zhao Huan Chen Yu Qiu Li Cui | 2022 | International Journal of Oral Science2022，14，3： | 1 |
| 14 | Study on dyeable polypropylene fiber and it sproperties显示文摘 | YU Chengbing ZHU Meifang SONG Xinyuan | 2001 | Journal of Applied Polymer Science2001，82，13： | 1 |
| 15 | Structure and formation of the South Yellow Sea water mass in the spring of 2007显示文摘Data obtained from over 250 CTD stations in December 2006 and April 2007 were used to analyze the temperature and salinity structure of the water masses of the South Yellow Sea in spring.Six basic water masses were identifi ed:the Southwest Yellow Sea Coastal Water Mass(SWYSCWM),Southwest Yellow Sea Local Water Mass(SWYSLWM),Qingdao Cold Water Mass(QDCWM),Yellow Sea Warm Current Water Mass(YSWCWM),Inchon Cold Water Mass(ICWM),and Subei Coastal Water Mass(SBCWM).The mechanisms of formation of these water masses are very diff erent.The SWYSCWM is aff ected by continental water,whereas the SWYSLWM and SBCWM are local water masses that are less aff ected by other waters.The QDCWM derives from cold northern water.The YSWCWM exists from winter to spring.Because of the limited data coverage,the mechanism of formation of the ICWM remains unclear. | Xinyuan DIAO Guangcheng SI Chuanjie WEI Fei YU | 2022 | Journal of Oceanology and Limnology2022，40，1： | 0 |
| 16 | Planet-satellite cage hybrids:covalent organic cages encircling metal organic cage显示文摘As a rising type of precisely molecular nanoobjects,porous molecular cages,including covalent organic cages(COCs) and metal organic cages(MOCs),have attracted much more attention.It is fascinating to construct well-defined cage hybrids combining COCs and MOCs to further rich their types,properties,and applications.However,it is a big challenge due to the isotropy of the porous molecular cages.In this article,an anisotropic COC ligand based on aryl ether bonds and bearing one isophthalate moiety has been designed and synthesized.Then planet-satellite cage hybrids(PSCHs),MOC@COCs,have been constructed through the coordination of the anisotropic COC ligand and copper ions with or without the help of extra dicarboxylic ligands in an almost quantitative manner for the first time.Three PSCHs with one different topological MOC(heteroleptic bipolar,distorted cuboctahedral or homoleptic cuboctahedral) as the planet and different numbers of COCs(6,12 or 24) as satellites are obtained.The structural and thermal properties of these PSCHs have also been studied.The obtained PSCHs exhibit discrete,uniform and stable structures,good solubility and strong film-forming property. | Chenjuan Yu Pan Yang Xinyuan Zhu Youfu Wang | 2022 | Science China Chemistry2022，65，5： | 0 |
| 17 | A Sponge-Driven Elastic Interface for Lithium Metal Anodes显示文摘The lithium(Li)metal is one promising anode for next generation high-energy-density batteries,but the large stress fluctuation and the nonuniform Li deposition upon cycling result in a highly unstable interface of the Li anode.Herein,a simple yet facile engineering of the elastic interface on the Li metal anodes is designed by inserting a melamine sponge between Li and the separator.Driven by the good elasticity of the sponge,the modified Li anode maintains a Coulombic efficiency of 98.8%for 60 cycles and is cyclable at 10 mA cm^(-2) for 250 cycles,both with a high capacity of 10 mA h cm^(-2).We demonstrate that the sponge can be used to replace the conventional polypropylene as a porous yet elastic separator,showing superior cycling and rate performance as well.In addition to the efficiency of the elastic interface on the cycling stability,which is further confirmed by an in situ compression-electrochemistry measurement,the porous structure and polar groups of the sponge demonstrate an ability of regulating the transport of Li ions,leading to a uniform deposition of Li and the suppression of Li dendrites in cycling. | Han Yu Jian Xie Na Shu Fei Pan Jianglin Ye Xinyuan Wang Hong Yuan Yanwu Zhu | 2019 | Research2019，，1： | 0 |
| 18 | Characteristics and processing of Pol Ⅳ-dependent transcripts in Arabidopsis显示文摘In plants,RNA-directed DNA methylation(RdDM)plays an essential role in silencing transposable elements that would otherwise have a deleterious effect on genome integrity.RdDM is an important pathway that establishes and maintains de novo DNA methylation in all three sequence contexts:CG,CHG,and CHH(where H is A,C,or T),and the methylation is targeted by | Hsuan Yu Kuo Elise L.Jacobsen Yanping Long Xinyuan Chen Jixian Zhai | 2017 | Journal of Genetics and Genomics2017，44，1： | 0 |
| 19 | Sulfanion-initiated open-vessel anionic ring-opening polymerization of N-sulfonyl aziridines显示文摘Anionic ring-opening polymerization(AROP)of N-sulfonyl aziridines is an important synthetic route to linear polyethyleneimine(PEI)and its derivatives.In most cases,inert atmosphere and dry solvent were needed because of the oxygen-and water-sensitive initiators/catalysts used.Therefore,the AROP of N-sulfonyl aziridines that can be entirely operated in air atmosphere is still a challenging task.Herein,we report a series of sulfanions,including xanthates,dithiocarbamates,dithiobenzoates,thioacetates,and thiolates,as the initiators for the AROP of N-sulfonyl aziridines.Due to their good stability,openvessel polymerization was achieved with high livingness,affording a range of well-definedα-,ω-telechelic poly(N-sulfonyl aziridine)homopolymers and block copolymers with narrow dispersities and tunable molecular weights.Theα-end group of these polyaziridines was readily converted to thiol group,which enabled further post-polymerization functionalization with benzyl acrylate and poly(ethylene glycol)via thiol-ene click chemistry.The establishment of open-vessel sulfanion-initiated AROP of N-sulfonyl aziridines thus lays a solid foundation for the bulk preparation and application of poly(N-sulfonyl aziridine)s and PEI derivatives. | Meng Huo Yawen Bian Chunyang Yu Gansheng Tong Chongyin Zhang Xinyuan Zhu | 2021 | Science China Chemistry2021，64，10： | 0 |
| 20 | Study of Basic Farmland Protection in Huainan City显示文摘Farmland is the primary resource for food production,related to food security and people's livelihood.The basic farmland is the essence of farmland,and it is necessary to improve the quality of farmland and strengthen the basic farmland protection in order to enhance comprehensive agricultural production capacity.Currently,the contradiction between urban development and farmland protection has been inevitable,and Huainan City is now in the period of rapid development of urbanization.How to better solve the contradiction between urbanization and farmland protection to promote sound and rapid economic development,is an important issue currently facing Huainan City. | Xinyuan LU Zhongxiang YU | 2015 | Asian Agricultural Research2015，7，3： | 0 |
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