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| 1 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 2 | Exosome-guided bone targeted delivery of Antagomir-188 as an anabolic therapy for bone loss显示文摘The differentiation shift from osteogenesis to adipogenesis of bone marrow mesenchymal stem cells(BMSCs)characterizes many pathological bone loss conditions.Stromal cell-derived factor-1(SDF1)is highly enriched in the bone marrow for C-X-C motif chemokine receptor 4(CXCR4)-positive hematopoietic stem cell(HSC)homing and tumor bone metastasis.In this study,we displayed CXCR4 on the surface of exosomes derived from genetically engineered NIH-3T3 cells.CXCR4+exosomes selectively accumulated in the bone marrow.Then,we fused CXCR4+exosomes with liposomes carrying antagomir-188 to produce hybrid nanoparticles(NPs).The hybrid NPs specifically gathered in the bone marrow and released antagomir-188,which promoted osteogenesis and inhibited adipogenesis of BMSCs and thereby reversed age-related trabecular bone loss and decreased cortical bone porosity in mice.Taken together,this study presents a novel way to obtain bone-targeted exosomes via surface display of CXCR4 and a promising anabolic therapeutic approach for age-related bone loss. | Yan Hu Xiaoqun Li Qin Zhang Zhengrong Gu Ying Luo Jiawei Guo Xiuhui Wang Yingying Jing Xiao Chen Jiacan Su | 2021 | Bioactive Materials2021，6，9： | 12 |
| 3 | Clinical Significance of hTERC Gene Detection in Exfoliated Cervical Epithelial Cells for Cervical Lesions显示文摘 | Xiuhui Zheng Peihe Liang Yingru Zheng Ping Yi Qiang Liu Jian Han Yinhu Huang Yuanguo Zhou Jianxin Guo Li Li | 2013 | International Journal of Gynecological Cancer2013，，5： | 1 |
| 4 | Silver nanocubes monolayers as a SERS substrate for quantitative analysis显示文摘Surface-enhanced Raman scattering(SERS)is a powerful spectroscopic tool in quantitative analysis of molecules,where the substrate plays a critical role in determining the detection performance.Herein,a silver nanocubes/polyelectrolyte/gold film sandwich structure was prepared as a reproducible,highperformance SERS substrate by the wate r/oil inte rfacial assembly method.In addition to the hot spots on the nanocubes surface,the edge-to-edge interspace of the Ag nanocubes led to marked enhancement of the SERS intensity,with a limit of detection of 10~(11)mol/L and limit of quantitation of 10~(10)mol/L for crystal violet.When rhodamine 6 G and crystal violet were co-adsorbed on the Ag nanocube surfaces,the characteristic SERS peaks of the two molecules remained well resolved and separated,and the peak intensities varied with the respective concentration,which could be exploited for concurrent detection of dual molecules.Results from this work indicate that organized ensembles of Ag nanocubes can serve as effective SERS substrate can for sensitive analysis for complex molecular systems. | Ziang Zhou Xiuhui Bai Peishen Li Changzheng Wang Ming Guo Yang Zhang Peiren Ding Shaowei Chen Yunyun Wu Qiang Wang | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 5 | POSITIVITY-PRESERVING LOCAL DISCONTINUOUS GALERKIN METHOD FOR PATTERN FORMATION DYNAMICAL MODEL IN POLYMERIZING ACTIN FLOCKS显示文摘In this paper,we apply local discontinuous Galerkin(LDG)methods for pattern formation dynamical model in polymerizing actin focks.There are two main dificulties in designing effective numerical solvers.First of all,the density function is non-negative,and zero is an unstable equilibrium solution.Therefore,negative density values may yield blow-up solutions.To obtain positive numerical approximations,we apply the positivitypreserving(PP)techniques.Secondly,the model may contain stif source.The most commonly used time integration for the PP technique is the strong-stability-preserving Runge-Kutta method.However,for problems with stiff source,such time discretizations may require strictly limited time step sizes,leading to large computational cost.Moreover,the stiff source any trigger spurious filament polarization,leading to wrong numerical approximations on coarse meshes.In this paper,we combine the PP LDG methods with the semi-implicit Runge-Kutta methods.Numerical experiments demonstrate that the proposed method can yield accurate numerical approximations with relatively large time steps. | Xiuhui Guo Lulu Tian Yang Yang Hui Guo | 2023 | Journal of Computational Mathematics2023，41，4： | 0 |
| 6 | Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau显示文摘The uplift of the Tibetan Plateau significantly altered the geomorphology and climate of the Euroasia by creating large mountains and rivers.Fishes are more likely to be affected relative to other organisms,as they are largely restricted to river systems.Faced with the rapidly flowing water in the Tibetan Plateau,a group of catfish has evolved greatly enlarged pectoral fins with more numbers of fin-rays to form an adhesive apparatus.However,the genetic basis of these adaptations in Tibetan catfishes remains elusive.In this study,we performed comparative genomic analyses based on the chromosome-level genome of Glyptosternum maculatum in family Sisoridae and detected some proteins with conspicuously high evolutionary rates in particular in genes involved in skeleton development,energy metabolism,and hypoxia response.We found that the hoxd12a gene evolved faster and a loss-of-function assay of hoxd12a supports a potential role for this gene in shaping the enlarged fins of these Tibetan catfishes.Other genes with amino acid replacements and signatures of positive selection included proteins involved in low temperature(TRMU)and hypoxia(VHL)responses.Functional assays reveal that the G.maculatum TRMU allele generates more mitochondrial ATP than the ancestral allele found in low-altitude fishes.Functional assays of VHL alleles suggest that the G.maculatum allele has lower transactivation activity than the low-altitude forms.These findings provide a window into the genomic underpinnings of physiological adaptations that permit G.maculatum to survive in the harsh environment of the Tibetan Himalayas that mirror those that are convergently found in other vertebrates such as humans. | Liandong Yang Ning Sun Honghui Zeng Ying Wang Wenjun Chen Zufa Ding Yang Liu Jing Wang Minghui Meng Yanjun Shen Jingliang Kang Xiuhui Ma Wenqi Lv Juan Chen Axel Meyer Baocheng Guo Shunping He | 2023 | Science China(Life Sciences)2023，66，7： | 0 |
| 7 | A local discontinuous Galerkin method for the pattern formation dynamical model in polymerizing action flocks显示文摘In this paper,we apply local discontinuous Galerkin methods to the pattern formation dynamical model in polymerizing action flocks.Optimal error estimates for the density and filament polarization in different norms are established.We use a semi-implicit spectral deferred correction time method for time discretization,which allows a relative large time step and avoids computation of a Jacobian matrix.Numerical experiments are presented to verify the theoretical analysis and to show the capability for simulations of action wave formation. | Lulu Tian Xiuhui Guo Hui Guo Maosheng Jiang Yang Yang Jiansong Zhang | 2022 | Science China Mathematics2022，65，4： | 0 |
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