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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Brown adipose tissue transplantation improves whole-body energy metabolism显示文摘 | Qingsheng Chi Dehua Wang Zhaoyun Zhang Chenzhong Li Yiming Li Yaoming Xue John R Speakma Wanzhu Jin Xiaomeng Liu Zongji Zhen Xiaoming Zhu Minghui Meng Lan Li Yanyan Shen | 2013 | Cell Research2013，23，6： | 11 |
| 3 | Synthesis of Z-scheme g-C3N4 nanosheets/Ag3PO4 photocatalysts with enhanced visible-light photocatalytic performance for the degradation of tetracycline and dye显示文摘Graphene-like C3N4/Ag3PO4 photocatalysts are synthesized by calcination and solutions precipitating method.The obtained g-C3N4/Ag3PO4 composites display excellent photocatalytic activity for the degradation of methylene orange(MO),rhodamine B(RhB)and tetracycline(TC)under visible light irradiation.The solutions containing RhB(10 mg/L)and MO(10 mg/L)can be efficiently degraded within15 min and 30 min.Especially,nearly 80%of TC(50 mg/L)is degraded within 20 min.which are much better than those of pure g-C3N4 nanosheets and Ag3PO4,implying that strong interaction and reasonable energy band alignment in the contact interface can effectively transfer the carries.Furthermore,the g-C3N4/Ag3PO4 composites exhibit the improved stability,and only a slight decrease is observed after three recycling runs.Moreover,the impact of inorganic ions and PH values on the degradation performance is rather small.The Z-scheme photocatalytic mechanism of the g-C3N4/Ag3PO4 composites based on the active species trapping experimental is proposed.This work demonstrates the promising applications of the g-C3N4/Ag3PO4 composites in environmental issues. | Meng Ding Juanjuan Zhou Hongcen Yang Ruya Cao Shouwei Zhang Minghui Shao Xijin Xu | 2020 | Chinese Chemical Letters2020，31，1： | 6 |
| 4 | Study on Architectural Concept of Environmental Adaptability of Vernacular Dwellings in Guanzhong-Tianshui Area显示文摘Vernacular dwellings are organic products adaptive to local climate and other natural conditions. From the perspective of climatic and geographical features, this study analyzed spatial layouts, outer appearance, courtyard layout and material structure of vernacular dwellings in Guanzhong-Tianshui area, and refined the ecological concepts and technologies adaptive to local environment. Vernacular dwellings are expected to develop sustainably in the evolution of natural environment, and adapt to the development needs of local human settlements. | MENG Xiangwu YE Minghui SHI Hongru | 2013 | Journal of Landscape Research2013，5，4： | 3 |
| 5 | Genome-wide association mapping of stress-tolerance traits in cotton显示文摘Environmental stresses severely impair cotton production worldwide. To identify the genetic basis of, and molecular markers associated with, environmental stresses such as salt, cold and Verticillium wilt, association mapping of salt-, cold-, and disease-tolerance traits was performed in a population of 503 upland cotton accessions using 179 polymorphic SSR markers and 11,975 array-derived SNP markers. Salt and cold tolerance was evaluated via the relative germination rate(RGR) of the seeds under seven and four environments, respectively. The disease index of Verticillium wilt was investigated for two years in the field in Xinjiang. These three traits showed large variation across environments. A genome-wide association study revealed that 31, 19, and 15 SSR markers were associated with RGR-Salt(the relative germination rates of seeds under salt stress),RGR-Cold(the relative germination rates of seeds under cold stress), and DIV(the disease index of Verticillium wilt), respectively. Six SNPs in seven environments and two SNPs in BLUP(best linear unbiased prediction) results were associated with RGR-Salt, and the phenotypic variance explained ranged from 3.96 to 5.00%. Two SNPs(i02237 Gh, i02243 Gh)on D01 were concluded to be stable genetic loci associated with RGR-Salt. A total of 223 genes were found in a candidate gene interval(D01, 37771–1942912). Of these four genes,GhPIP3A, GhSAG29, GhTZF4, and GhTZF4a, showed expression changes in sensitive and tolerant genotype accessions under salt stress, and were assigned as candidate genes associated with RGR-Salt. This study revealed the genetic basis of stress resistance in upland cotton and will facilitate stress-resistance breeding in cotton. | Heng Sun Minghui Meng Zhenhua Yan Zhongxu Lin Xinhui Nie Xiyan Yang | 2019 | The Crop Journal2019，7，1： | 3 |
| 6 | The prognostic value of programmed cell death ligand 1expression in non-Hodgkin lymphoma:a meta-analysis显示文摘Objective: Although the prognostic value of programmed cell death-ligand 1(PD-L1) expression in non-Hodgkin lymphoma(NHL) has been evaluated in many studies, the results remain controversial. To investigate the prognostic role of PD-L1 expression and the association between PD-L1 expression and clinicopathological features of NHL, we performed a meta-analysis.Methods: The Pub Med, EMBASE, and Cochrane Library databases were searched up to November 30, 2017. The hazard ratio(HR), 95% confidence interval(CI), and odds ratios(OR) with 95% CIs were combined to evaluate the association of PD-L1 expression with overall survival(OS) and clinicopathological features. Review manager 5.3 and STATA 12.0 were used in this meta-analysis.Results: A total of 2,005 patients across nine studies were enrolled in our meta-analysis, and the pooled results showed that high PD-L1 expression was associated with a poor prognosis(HR=2.04, 95% CI: 1.18–3.54, P=0.01). In the subgroup analysis according to histology types, pooled results demonstrated that an increased PD-L1 expression was an unfavorable prognostic factor for diffuse large B-cell lymphoma(HR=1.92, 95% CI: 1.06–3.48, P=0.03) but not for natural killer/T-cell lymphoma(HR=2.41, 95%CI: 0.47–12.22, P=0.29). Pooled ORs indicated that PD-L1 expression was higher in NHL with international prognostic indices of≥3. However, PD-L1 expression had no correlation with gender, age, disease stage, lactate dehydrogenase level, B symptoms, and germinal center B-cell-like lymphoma.Conclusions: High PD-L1 expression was a poor prognostic biomarker in patients with NHL. Because of our limited sample size,high-quality studies with larger sample sizes are needed to validate our results. | Shu Zha Minghui Zhang Yu Zhang Hongxue Meng Yan Wang Yupeng Liu Jing Jing Lan Huang Mengqi Sun Yue Zhang Qingyuan Zhang | 2018 | Cancer Biology & Medicine2018，15，3： | 2 |
| 7 | Musk secretion in muskrats(Ondatra zibethicus L.):association with lipid and cholesterol metabolism-related pathways显示文摘Male muskrats(Ondatra zibethicus L.)secrete musk from their scent glands during musk secretion season.Musk plays an important role as a communication pheromone during the breeding season.In this study,gas chromatography–mass spectrometry(GC–MS)was used to analyze the main components of musk.The GC–MS results after methyl esterification showed that 71.55%of the musk is composed of fatty acids.The other components of muskrat musk include cholesterol(9.31%)and other organics.Transcriptome comparison between musk secretion and non-secretion seasons showed significant changes in the scent glands for 53 genes involved in fatty acid and cholesterol synthesis and metabolism regulatory pathways,which include fatty acid biosynthesis,elongation,and metabolism;steroid biosynthesis;steroid hormone biosynthesis pathways.A reverse transcription–polymerase chain reaction analysis confirmed these detected changes.Overall,our results indicated that lipid synthesis and metabolism play important roles in musk compound synthesis by providing energy for musk production,and the produced musk provides a mechanism for male muskrats to communicate with females during the breeding season. | TIANXIANG ZHANG MEISHAN ZHANG MINGHUI SHI WEIJIANG JIN SHUMIAO ZHANG MENGYUAN FAN YIMENG LI YUPING MENG XUELIN TIAN SHUQIANG LIU DEFU HU | 2021 | BIOCELL2021，45，2： | 2 |
| 8 | Reactive oxygen species generation is essential for cisplatininduced accelerated senescence in hepatocellular carcinoma显示文摘因为这个过程涉及肿瘤抑制并且被许多化学疗法的代理人导致了,加速的老朽是重要的。基于铂的化学疗法的代理人 cisplatin 显示大量 antitumor 活动。然而,在 hepatocellular 癌(HCC ) 的导致 cisplatin 的加速的老朽的分子的机制仍然保持不清楚。在现在的学习,生长 HepG2 和 SMMC-7721 细胞上的 cisplatin 的禁止的效果被 3-(4,5-dimethylthiazol-2-yl ) 检测 -2,5-diphenyltetrazolium 溴化物试金。细胞的老朽然后被牛乳糖试金估计。包括 p53, p21,和 p16,老朽相关的因素被量的反向的抄写聚合酶链反应评估。反应的氧种类(ROS ) 被流动 cytometry 分析。我们的结果表明 cisplatin 在一个剂量依赖者和时间依赖者举止减少了 HepG2 和 SMMC-7721 房间的增长。在 cisplatintreated hepatoma 房间观察的衰老的显型依赖于 p53 和 p21 激活然而并非在 p16 激活上。而且, cisplatininduced 加速了取决于的老朽细胞内部的 ROS 产生。ROS scavenger N-acetyl-L-cysteine 显著地也压制了 HepG2 和 SMMC-7721 房间的导致 cisplatin 的老朽。在结论,我们的结果揭示了在细胞内部的 ROS 产生和导致 cisplatin 的加速的老朽之间的一个功能的连接,并且这个连接可以被用作 HCC 的一个潜在的目标。 | Kai Qu Ting Lin Zhixin Wang Sinan Liu Hulin Chang Xinsen Xu Fandi Meng Lei Zhou Jichao Wei Minghui Tai Yafeng Dong Chang Liu | 2014 | Frontiers of Medicine2014，8，2： | 2 |
| 9 | Integration of magnetically stabilized bed and amorphous nickel alloy catalyst for CO methanation显示文摘 | Pan Zhiyong Dong Minghui Meng Xiangkun Zhang Xiaoxing Mu Xuhong Zong Baoning | 2007 | Chemical Engineering Science2007，62，： | 1 |
| 10 | On the rumpling mechanism in nanocrystalline coatings:Improved by reactive magnetron sputtering with oxygen显示文摘Surface rumpling is detrimental to high temperature protective coatings as it shortens their lifetime and leads to adhesion losses and unexpected corrosion degradation.The driving force and mass transport mechanism behind of rumpling remains to be clarified.In the present investigation,we subjected two types of nanocrystalline coating systems to avoid the influence of interdiffusion on rumpling study.One group was an ordinary nanocrystalline coating,and the other group was designed and prepared with trace oxygen by reactive magnetron sputtering.Systematic cyclic oxidation test at 1100°C was also car-ried out.Results show the ordinary nanocrystalline coating oxidized rapidly,which leads to the fast consumption of Al and the acceleration of phase transition in the coating.Meanwhile,severe surface rumpling is observed due to the stress release of nanocrystals through plastic deformation.Besides,the reactive doping of oxygen can significantly reduce the consumption process of Al in nanocrystalline coat-ing.The rumpling is controlled due to the improvement of coefficient of thermal expansion and Young’s modulus of the coating.Thereafter,the cyclic oxidation resistance is improved. | Bo Meng Jinlong Wang Lanlan Yang Minghui Chen Shenglong Zhu Fuhui Wang | 2023 | Journal of Materials Science & Technology2023，，1： | 1 |
| 11 | Research on the construction technique of super-large diameter rock-socketed piles in karst areas 显示文摘 | Haofeng Xing Minghui Meng Wanxue Long | 2012 | Trans Tech Publications Switzerland2012，1486，： | 1 |
| 12 | Satellite record of the transition of air quality over China显示文摘The rapid development of atmospheric satellite instruments since 1990s provides unprecedented large amount of observational datasets concerning global atmospheric pollutants.The continu-ous and long-term large-scale satellite products such as aerosol optical depth,tropospheric NO 2 and SO 2 enable effective and objective evaluation of air quality.Satellite columnar aerosol opti-cal parameters can be used to indicate particle pollution near surface after correction.By contrast,satellite results of trace gas pollutants such as NO 2 and SO 2 from fossil fuel combustion with short lifetime around half one day are used to estimate anthro-pogenic emissions.It is shown that the overall anthropogenic emissions in China have largely declined since strict emission reduction policy implemented since 2013.However,coarse pixel resolution of the trace gases,limited information and retrieval bias of aerosol properties tend to hinder further application of satellite in air quality research.Recently launched satellite missions with advanced detection abilities will greatly enhance global atmo-spheric observations with much more datasets available. | Liangfu Chen Minghui Tao Zifeng Wang Jinhua Tao Chao Yu Ying Zhang Meng Fan Jinabin Gu Lin Su | 2018 | Big Earth Data2018，2，2： | 0 |
| 13 | Space view of the decadal variation for typical air pollutants in the Pearl River Delta (PRD) region in China显示文摘 | Zifeng WANG Min SHAO Liangfu CHEN Minghui TAO Liuju ZHONG Duohong CHEN Meng FAN Yang WANG Xinhui WANG | 2016 | Frontiers of Environmental Science & Engineering2016，10，5： | 0 |
| 14 | Improved performance and prolonged lifetime of titania-based materials: sequential use as adsorbent and photocatalyst显示文摘Lifetime is a key index in the evaluation of environmentally functional materials. Although it is well known that adsorption is the first step in photocatalysis, very little work has been done on the sequential use of materials as both adsorbents and photocatalysts. In this work, two titania-based materials, Ti O2 xerogel and Ti O2 photocatalyst nanoparticles, were fabricated and evaluated as adsorbent and photocatalyst for the remediation of contaminated water with an azo dye, Acid Orange 7(AO7), as the modeling pollutant. The Ti O2 xerogel showed a high adsorption capacity to AO7(769 mg/g) and could be regenerated easily with diluted Na OH solution(0.01 mol/L) for several cycles. The exhausted xerogel was calcined at 400 °C for 3 h and used as a photocatalyst for the degradation of AO7. Compared to the nanoparticles directly prepared from fresh Ti O2 xerogel, the Ti O2 nanoparticles from adsorption exhausted xerogel showed a much higher photocatalytic activity upon both UV and visible light irradiation. Thus the titania-based materials were endowed with improved performance as well as prolonged lifetime. | Yan Peng Minghui Li Shujuan Zhang Guangze Nie Meng Qi Bingcai Pan | 2015 | Science China Chemistry2015，58，7： | 0 |
| 15 | GATA2^(−/−) human ESCs undergo attenuatedendothelial to hematopoietic transition andthereafter granulocyte commitment显示文摘Background: Hematopoiesis is a progressive process collectively controlled by an elaborate network of transcriptionfactors (TFs). Among these TFs, GATA2 has been implicated to be critical for regulating multiple steps of hematopoiesisin mouse models. However, whether similar function of GATA2 is conserved in human hematopoiesis, especially duringearly embryonic development stage, is largely unknown.Results: To examine the role of GATA2 in human background, we generated homozygous GATA2 knockout humanembryonic stem cells (GATA2^(−/−) hESCs) and analyzed their blood differentiation potential. Our results demonstratedthat GATA2^(−/−) hESCs displayed attenuated generation of CD34^(+)CD43^(+) hematopoietic progenitor cells (HPCs), due tothe impairment of endothelial to hematopoietic transition (EHT). Interestingly, GATA2^(−/−) hESCs retained the potentialto generate erythroblasts and macrophages, but never granulocytes. We further identified that SPI1 downregulationwas partially responsible for the defects of GATA2^(−/−) hESCs in generation of CD34^(+)CD43^(+) HPCs and granulocytes.Furthermore, we found that GATA2^(−/−) hESCs restored the granulocyte potential in the presence of Notch signaling.Conclusion: Our findings revealed the essential roles of GATA2 in EHT and granulocyte development throughregulating SPI1, and uncovered a role of Notch signaling in granulocyte generation during hematopoiesis modeled byhuman ESCs. | Ke Huang Juan Du Ning Ma Jiajun Liu Pengfei Wu Xiaoya Dong Minghui Meng Wenqian Wang Xin Chen Xi Shi Qianyu Chen Zhongzhou Yang Shubin Chen Jian Zhang Yuhang Li Wei Li Yi Zheng Jinglei Cai Peng Li Xiaofang Sun Jinyong Wang Duanqing Pei Guangjin Pan | 2015 | Cell Regeneration2015，4，1： | 0 |
| 16 | Original State of Grotto Eaves of the Daxiang Mountain Grottoes of Gangu County显示文摘Located in the east of Gansu Province, Gangu County in Tianshui City is the only way that people went to the Central Plains from the western regions in ancient times, and it's also an important node of the Grotto Culture Corridor of the Silk Road. Daxiang Mountain Giant Buddha Grottoes is the landmark of Gangu County. The giant Buddha statue stands among cliffs 200 meters high above the ground, and it is the second largest stone-base clay-sculpture Buddha in China. After going through thousands of years, the Giant Buddha Grottoes needs effective and scientific protection. This article was originated from the actual project—The Research on the Construction Technology of Wooden-structure Grotto Eaves in the Daxiang Mountain. This article f inished the rebuilding plan for the Buddha Grotto Eaves on the basis of analyzing historical documents, hole traces, morphological evolution and image demonstration. | YE Minghui MENG Xiangwu | 2015 | Journal of Landscape Research2015，7，6： | 0 |
| 17 | Long-term outcomes of intraoperative radiotherapy for early-stage breast cancer in China: amulticenter real-world study显示文摘Dear Editor,Intraoperative radiotherapy(IORT)is an accelerated par-tial breast irradiation(APBI)treatment that is accom-plished intraoperatively.Numerous clinical trials indicate that IORT is safe and effective,non-inferior to standard whole-breast external beam radiotherapy(EBRT)for low-risk patients who receive breast-conserving surgery[1-3].Nevertheless,these studies mainly included non-Asians and thus lack adequate evidence to support the value of IORT in Asian patients with breast cancer. | Xin Wang Kexin Feng Wenyan Wang Xiangzhi Meng Jiaqi Liu Yang Yang Yuting Zhong Jingruo Li Shikai Wu Minghui Li Pan Ma Qinfu Feng Hongmei Zeng Yuanting Gu Xiru Li Zhaoqing Fan Xiang Wang | 2022 | Cancer Communications2022，42，3： | 0 |
| 18 | Innovations of Agricultural Scientific Research Institutions in Management of Special Materials显示文摘In recent years,the Ministry of Agriculture has increased input in agricultural scientific research projects.As a result,the procurement amount and quantity of special materials are increasing gradually,and the management of special materials becomes more standardized.In order to do well in management of special materials,the authors made exploration and thinking about further strengthening management of special materials in combination with actual conditions,including establishing regulations and systems,enhancing procurement process,strengthening requisition and safekeeping,and reinforcing general ledger management of special materials. | Yonghua LIU Haifang CHEN Lixin CUI Chunyang MENG Ran HUO Minghui HU | 2013 | Asian Agricultural Research2013，5，12： | 0 |
| 19 | Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau显示文摘The uplift of the Tibetan Plateau significantly altered the geomorphology and climate of the Euroasia by creating large mountains and rivers.Fishes are more likely to be affected relative to other organisms,as they are largely restricted to river systems.Faced with the rapidly flowing water in the Tibetan Plateau,a group of catfish has evolved greatly enlarged pectoral fins with more numbers of fin-rays to form an adhesive apparatus.However,the genetic basis of these adaptations in Tibetan catfishes remains elusive.In this study,we performed comparative genomic analyses based on the chromosome-level genome of Glyptosternum maculatum in family Sisoridae and detected some proteins with conspicuously high evolutionary rates in particular in genes involved in skeleton development,energy metabolism,and hypoxia response.We found that the hoxd12a gene evolved faster and a loss-of-function assay of hoxd12a supports a potential role for this gene in shaping the enlarged fins of these Tibetan catfishes.Other genes with amino acid replacements and signatures of positive selection included proteins involved in low temperature(TRMU)and hypoxia(VHL)responses.Functional assays reveal that the G.maculatum TRMU allele generates more mitochondrial ATP than the ancestral allele found in low-altitude fishes.Functional assays of VHL alleles suggest that the G.maculatum allele has lower transactivation activity than the low-altitude forms.These findings provide a window into the genomic underpinnings of physiological adaptations that permit G.maculatum to survive in the harsh environment of the Tibetan Himalayas that mirror those that are convergently found in other vertebrates such as humans. | Liandong Yang Ning Sun Honghui Zeng Ying Wang Wenjun Chen Zufa Ding Yang Liu Jing Wang Minghui Meng Yanjun Shen Jingliang Kang Xiuhui Ma Wenqi Lv Juan Chen Axel Meyer Baocheng Guo Shunping He | 2023 | Science China(Life Sciences)2023，66，7： | 0 |
| 20 | Aspect-based sentiment analysis of online peer reviews and prediction of paper acceptance results显示文摘Peer reviews of academic articles contain reviewers’ overall impressions and specific comments on the contributed articles,which have a lot of sentimental information.By exploring the fine-grained sentiments in peer reviews,we can discover critical aspects of interest to the reviewers.The results can also assist editors and chairmen in making final decisions.However,current research on the aspects of peer reviews is coarse-grained,and mostly focuses on the overall evaluation of the review objects.Therefore,this paper constructs a multi-level fine-grained aspect set of peer reviews for further study.First,this paper uses the multi-level aspect extraction method to extract the aspects from peer reviews of ICLR conference papers.Comparative experiments confirm the validity of the method.Secondly,various Deep Learning models are used to classify aspects’ sentiments automatically,with LCFS-BERT performing best.By calculating the correlation between sentimental scores of the review aspects and the acceptance result of papers,we can find the important aspects affecting acceptance.Finally,this paper predicts acceptance results of papers(accepted/rejected) according to the peer reviews.The optimal acceptance prediction model is XGboost,achieving a Macro_F1 score of 87.43%. | Minghui Meng Ruxue Han Jiangtao Zhong Haomin Zhou Chengzhi Zhang | 2023 | Data Science and Informetrics2023，3，1： | 0 |
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