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| 1 | Two RING-Finger Ubiquitin E3 Ligases Regulate the Degradation of SPX4, An Internal Phosphate Sensor, for Phosphate Homeostasis and Signaling in Rice显示文摘SPX-domain-containing proteins (SPXs) play an important role in inorganic phosphate (Pi) sensing,signaling,and transport in eukaryotes.In plants,SPXs are known to integrate cellular Pi status and negatively regulate the activity of Pi central regulators,the PHOSPATE STARVATION RESPONSE proteins (PHRs).The stability of SPXs,such as SPX4,is reduced under Pi-deficient conditions.However,the mechanisms by which SPXs are degraded remain unclear.In this study,using a yeast-twhybrid screen we iden.tified two RING-finger ubiquitin E3 ligases regulating SPX4 degradation,designated SDEL1 and SDEL2,which were post-transcriptionally induced by Pi starvation.We found that both SDELs were located in the nucleus and cytoplasm,had ubiquitin E3 ligase activity,and directly ubiquitinated the K^213 and K^299 lysine residues in SPX4 to regulate its stability.Furthermore,we found that PHR2,a Pi central regulator in rice,could compete with SDELs by interacting with SPX4 under Pi-sufficient conditions,which protected SPX4 from ubiquitination and degradation.Consistent with the biochemical function of SDEL1 and SDEL2,overexpression of SDEL1 or SDEL2 resulted in Pi overaccumulation and induced Pi-starvation signaling even under Pi-sufficient conditions.Conversely,their loss-of-function mutants displayed decreased Pi accumulation and reduced Pi-starvation signaling.Collectively,our study revealed that SDEL1 and SDEL2 facilitate the degradation of SPX4 to modulate PHR2 activity and regulate Pi homeostasis and Pi signaling in response to external Pi availability in rice. | Wenyuan Ruan Meina Guo Xueqing Wang Zhenhui Guo Zhuang Xu Lei Xu Hongyu Zhao Haiji Sun Chengqi Yan Keke Yi | 2019 | Molecular Plant2019，12，8： | 14 |
| 2 | Dietary supplementation with Clostridium butyricum improves growth performance of broilers by regulating intestinal microbiota and mucosal epithelial cells显示文摘Clostridium butyricum has been widely considered an antibiotic substitute in recent years.It can promote growth performance,improve the immune response and enhance the intestinal barrier function of the host.In the present study,1-d-old Arbor Acres(AA)broilers were fed C.butyricum(1×109 cfu/kg)for 28 d.The transcriptomic characteristics of epithelial cells of the cecal mucosa were determined by RNA-sequence,and the cecal microbiota composition was explored by 16 S ribosomal RNA gene sequencing.The changes in the intestinal mucosa of broilers were then analyzed by tissue staining.Gene Ontology(GO)annotations identified substance transport and processes and pathways that might participate in intestinal development and cell viability.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed that the differentially expressed genes are involved in numerous pathways related to amino acid and vitamin metabolism and antioxidant and defensive functions,among others.The relative expression of some genes associated with intestinal barrier function(claudins 2,15,19,and 23,tight junction proteins 1,2,and 3 and mucin 1)was significantly increased in the treatment group(P<0.05 or P<0.01).Moreover,the proportion of Firmicutes was higher in the C.butyricum-treated group,whereas the proportion of Proteobacteria was higher in the control group.At the genus level,the relative abundances of Butyricicoccus and Lactobacillus,among other bacteria,were increased after C.butyricum supplementation.The tissue staining analysis showed that the cecal mucosa of broilers was significantly ameliorated after the addition of C.butyricum(P<0.05 or P<0.01).These results showed that dietary supplementation with C.butyricum can enhance the antioxidant capacity,mucosal barrier function,and stabilize the cecal microbiota,resulting in improving the growth performance. | Laipeng Xu Xiangli Sun Xianhua Wan Keke Li Fuchun Jian Wenting Li Ruirui Jiang Ruili Han Hong Li Xiangtao Kang Yanbin Wang | 2021 | Animal Nutrition2021，，4： | 12 |
| 3 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 4 | A large carbon pool in lake sediments over the arid/semiarid region, NW China显示文摘Carbon burial in lake sediments is an important component of the global carbon cycle. However, little is known about the magnitude of carbon sequestered in lake sediments over the arid/semiarid region of China(ASAC).In this study, we estimate both organic and inorganic carbon burial since *AD 1800 based on nine lakes in ASAC,and discuss the most plausible factors controlling carbon burial. Our estimates show that the annual organic carbon burial rate(OCBR) ranges from 5.3 to 129.8 g cm-2year-1(weighted mean of 49.9 g cm-2year-1), leading to a standing stock of 1.1–24.0 kg cm-2(weighted mean of 8.6 kg cm-2)and a regional sum of *108 Tg organic carbon sequestered since *AD 1800. The annual inorganic carbon burial rate(ICBR) ranges from 11.4 to 124.0 g cm-2year-1(weighted mean of 48.3 g cm-2year-1), which is slightly lower than OCBR. The inorganic carbon standing stock ranges from2.4 to 26.0 kg cm-2(weighted mean of 8.1 kg cm-2),resulting in a sum of *101 Tg regional inorganic carbon burial since *AD 1800, which is slightly lower than the organic carbon sequestration. OCBR in ASAC shows a continuously increasing trend since *AD 1950, which is possibly due to the high autochthonous and allochthonous primary production and subsequently high sedimentation rate in the lakes. This increasing carbon burial is possibly related to both climatic changes and enhanced anthropogenic activities, such as land use change, deforestation, and eutrophication in the lake. Furthermore, OCBR and ICBR are expected to continuously increase under the scenario of increasing precipitation and runoff and enhanced anthropogenic activities.The results of this research show that the buried carbon in lake sediments of the ASAC region constitutes a significant and large carbon pool, which should be considered and integrated into the global carbon cycle. | Jianghu Lan Hai Xu Bin Liu Enguo Sheng Jiangtao Zhao Keke Yu | 2015 | Chinese Journal Of Geochemistry2015，34，3： | 10 |
| 5 | Non-injection gram-scale synthesis of cesium lead halide perovskite quantum dots with controllable size and composition显示文摘金属卤化物 perovskites 是为太阳的收获和轻射出应用被认为候选人好的新奇 optoelectronic 材料。在这研究,我们为综合开发一条可再现、便宜的途径 highquality 铯铅卤化物 perovskite (CsPbX 3, X = Cl, Br,并且我或 Cl/Br 和 I/Br ) 由在空中的在 octadecene 的先锋的直接加热的 nanocrystals (NC ) 。试验性的结果证明同样准备的 CsPbX 3 nanocrystals 的粒子尺寸和作文能被反应温度的一个简单变化成功地调节。同样准备的 nanocrystals 的排放山峰位置能方便地从 UV 被调节到 NIR (360-700 nm ) 区域,和同样获得的样品(绿、红的排出物) 的量收益罐头活动范围直到 87% 。结构和同样获得的 NC 的化学作文被传播电子显微镜学, X 光检查衍射,和元素的分析描绘。这建议合成线路能与一个批反应产出大量高质量的 NC,并且能为基于 perovskite 的轻射出、光电的太阳能电池的进一步的应用程序铺平道路,通常在克规模上。 | Xu Chen Lucheng Peng Keke Huang Zhan Shi Renguo Xie Wensheng Yang | 2016 | Nano Research2016，9，7： | 8 |
| 6 | Analyses of surrogate models for calculating thermophysical properties of aviation kerosene RP-3 at supercritical pressures显示文摘Aviation kerosene is commonly used in combustion and regenerative engine cooling processes in propulsion and power-generation systems,including rocket,scramjet,and advanced gas turbine engines.In this paper,many surrogate models proposed in the open literature are examined for their applicability and accuracy in calculating thermodynamic and transport properties of the China aviation kerosene RP-3 at supercritical pressures,based on the extended corresponding-states methods.The enthalpy change from endothermic decomposition and low heating value from combustion of the jet fuel are also evaluated.Results from a number of simple and representative surrogate models,which contain species components ranging from 1 to10,are analyzed in detail.Data analyses indicate that a surrogate model with four species is the best choice for thermophysical property calculations under the tested conditions,with fluid temperature up to 650 K at various supercritical pressures.The surrogate model is particularly accurate in predicting the pseudo-critical temperature of aviation kerosene RP-3 at a supercritical pressure.A simple surrogate model containing the n-decane species and a surrogate model containing 10 species are the other two acceptable options.The work conducted herein is of practical importance for theoretical analyses and numerical simulations of various physicochemical processes at engine operating conditions. | XU KeKe MENG Hua | 2015 | Science China(Technological Sciences)2015，58，3： | 6 |
| 7 | Cenozoic Evolution of Sediments and Climate Change and Response to Tectonic Uplift of the Northeastern Tibetan Plateau显示文摘Through a comprehensive study of magnetostratigraphy and sedimentology of several basins in the northeastern Tibetan Plateau, we reveal that the study area mainly experienced six tectonic uplift stages at approximately 52 Ma, 34–30 Ma, 24–20 Ma, 16–12 Ma, 8–6 Ma, and 3.6–2.6 Ma. Comprehensive analyses of pollen assemblages from the Qaidam, Linxia, Xining, and West Jiuquan Basins show that the northeastern Tibetan Plateau has undergone six major changes in vegetation types and climate: 50–40 Ma for the warm-humid forest vegetation, 40–23 Ma for the warm-arid and temperate-arid forest steppe vegetation, 23–18.6 Ma for the warm-humid and temperatehumid forest vegetation, 18.6–8.5 Ma for the warm-humid and cool-humid forest steppe vegetation, 8.6–5 Ma for the temperate sub-humid savanna steppe vegetation, and 5–1.8 Ma for the cold-arid steppe vegetation. Comprehensive comparisons of tectonic uplift events inferred from sedimentary records, climatic changes inferred from pollen, and global climate changes show that in the northeastern Tibetan Plateau the climate in the Paleogene at low altitude was mainly controlled by the global climate change, while that in the Neogene interval with high altitude landscapes of mountains and basins is more controlled by altitude and morphology. | LIANG Xia JI Junliang LU Jingfang KE Xue AI Keke XU Yadong SONG Bowen | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 5 |
| 8 | A general thermodynamic model for the long-period stacking ordered phases in magnesium alloys显示文摘A thermodynamic model Mg x(Xs,Mg)6(Xl,Mg)8(Xs and Xl are elements smaller and larger than Mg)for long-period stacking ordered phases(LPSOs)was proposed based on two key factors:the Xs 6 Xl 8-type L12 clusters and the variation of chemical compositions.In general,all available LPSOs can be described with this model.As a representative system,Mg-Y-Zn with three LPSOs was investigated using the CALPHAD(calculation of phase diagram)approach aided with first-principles calculations.Two new three-phase equilibria were predicted and were validated by key experiments.The model-based descriptions will be the basis for the research and development of magnesium alloys. | Kai Xu Shuhong Liu Keke Chang Yongpeng Liang Yong Du Zhanpeng Jin | 2021 | Journal of Magnesium and Alloys2021，9，1： | 4 |
| 9 | Model validation and parametric study of fluid flows and heat transfer of aviation kerosene with endothermic pyrolysis at supercritical pressure显示文摘The regenerative cooling technology is a promising approach for effective thermal protection of propulsion and power-generation systems.A mathematical model has been used to examine fluid flows and heat transfer of the aviation kerosene RP-3 with endothermic fuel pyrolysis at a supercritical pressure of 5 MPa.A pyrolytic reaction mechanism,which consists of 18 species and 24 elementary reactions,is incorporated to account for fuel pyrolysis.Detailed model validations are conducted against a series of experimental data,including fluid temperature,fuel conversion rate,various product yields,and chemical heat sink,fully verifying the accuracy and reliability of the model.Effects of fuel pyrolysis and inlet flow velocity on flow dynamics and heat transfer characteristics of RP-3 are investigated.Results reveal that the endothermic fuel pyrolysis significantly improves the heat transfer process in the high fluid temperature region.During the supercritical-pressure heat transfer process,the flow velocity significantly increases,caused by the drastic variations of thermophysical properties.Under all the tested conditions,the Nusselt number initially increases,consistent with the increased flow velocity,and then slightly decreases in the high fluid temperature region,mainly owing to the decreased heat absorption rate from the endothermic pyrolytic chemical reactions. | Keke Xu Hua Meng | 2015 | Propulsion and Power Research2015，4，4： | 3 |
| 10 | Treatment of Skin Reaction Induced by Nivolumab Combined with Radiotherapy in Non-small Cell Lung Cancer:A Case Report显示文摘Skin reaction or dermatological toxicities induced by immunotherapy is common.It usually manifests skin rash or erythema and can be cured by skin lotion or steroid.Nivolumab,a human IgG4 programmed cell death protein 1(PD-1)inhibitor,blocks T cells activation preventing signal and allows the immune system to clear cancer cells.Nivolumab was approved in the second-line therapy in squamous cell lung cancer by FDA,with less than 10%unusual skin reaction,like sensory neuropathy,peeling skin,erythema multiforme,vitiligo,and psoriasis.Radiotherapy could aggravate this skin reaction through inflammatory response and promotion of immunity.The combined treatment of anti-PD-1 and radiotherapy represented a new promising therapeutic approach in many studies,but the risk of side effects may be high.We reported a patient with advanced squamous cell lung cancer who suffered from serious skin immune-related adverse events when he was treated with nivolumab and radiotherapy.The immune overreaction of the treatment of anti-PD-1 treatment and radiotherapy might cause these serious skin adverse events.Our report warranted careful workup to reduce the risk of side effects by combinative therapy with anti-PD-1 and radiotherapy. | Zhimei Zhao Shichao Liu Xiajuan Xu Zhongfa Zhang Keke Nie Youxin Ji | 2018 | Chinese Medical Sciences Journal2018，33，3： | 3 |
| 11 | Late Holocene hydroclimatic variations and possible forcing mechanisms over the eastern Central Asia显示文摘Hydroclimatic variations over the eastern Central Asia are highly sensitive to changes in hemispheric-scale atmospheric circulation systems. To fully understand the long-term variability and relationship between hydroclimate and atmospheric circulation system, we present a high-resolution lascustrine record of late Holocene hydroclimate from Lake Sayram, Central Tianshan Mountains, China, based on the total organic carbon, total nitrogen, and carbonate contents, carbon/nitrogen ratios, and grain size. Our results reveal four periods of substantially increased precipitation at the interval of 4000–3780, 3590–3210, 2800–2160, and 890–280 cal yr BP, and one period of slightly increased precipitation from 1700–1370 cal yr BP. These wetter periods broadly coincide with those identified in other records from the mid-latitude Westerlies-dominated eastern Central Asia, including the northern Tibetan Plateau. As such, a similar hydroclimatic pattern existed over this entire region during the late Holocene. Based on a close similarity of our record with reconstruction of North Atlantic Oscillation indices and solar irradiance, we propose that decreased solar irradiance and southern migration of the entire circum-North Atlantic circulation system, particularly the main pathway of the mid-latitude Westerlies, significantly influenced hydroclimate in eastern Central Asia during the late Holocene. Finally, the inferred precipitation at Lake Sayram has increased markedly over the past 100 years, although this potential future changes in hydroclimate in Central Asia need for further investigation. | Jianghu LAN Hai XU Keke YU Enguo SHENG Kangen ZHOU Tianli WANG YuANDa YE Dongna YAN Huixian WU Peng CHENG Waili ABULIEZI Liangcheng TAN | 2019 | Science China Earth Sciences2019，62，8： | 3 |
| 12 | Design of novel NiSiAlY alloys in marine salt-spray environment:PartⅡ.Al-Ni-Si-Y thermodynamic dataset显示文摘The NiSiAlY material is a promising candidate to replace NiCrAlY,which can withstand the harsh saltspray conditions in marine environment.To efficiently design novel NiSiAlY alloys,this work establishes a thermodynamic dataset of the Al-Ni-Si-Y quaternary system using the CALPHAD(CALculation of PHAse Diagrams)approach.We employ this database to calculate and predict the phase constitutions and solidification behaviors of different NiSiAlY alloys concerning the content variations of Al and Si.We have further proposed the selection of the NiSiAlY alloys for serving in marine salt-spray environment with three constraints:(i)outstanding mechanical property;(ii)good high-temperature anti-oxidation;(iii)excellent corrosion resistance.This results in a compositional range of the NiSiAlY alloys with 1 wt% | Kai Xu Keke Chang Miao Yu Dapeng Zhou Yong Du Liping Wang | 2021 | Journal of Materials Science & Technology2021，，30： | 3 |
| 13 | OsCYCP4s coordinate phosphate starvation signaling with cell cycle progression in rice显示文摘Phosphate starvation leads to a strong reduction in shoot growth and yield in crops.The reduced shoot growth is caused by extensive gene expression reprogram-ming triggered by phosphate deficiency,which is not itself a direct consequence of low levels of shoot phosphorus.However,how phosphate starvation inhibits shoot growth in rice is still unclear.In this study,we determined the role of OsCYCP4s in the regulation of shoot growth in response to phosphate starvation in rice.We demonstrate that the ex-pression levels of OsCYCP4s,except OsCYCP4;3,were induced by phosphate starvation.Overexpression of the phosphate starvation induced OsCYCP4s could compete with the other cyclins for the binding with cyclin-dependent kinases,therefore suppressing growth by reducing cell proliferation.The phosphate starvation induced growth inhibition in the loss-of-function mutants cycp4;1,cycp4;2,and cycp4;4 is par-tially compromised.Furthermore,the expression of some phosphate starvation inducible genes is negatively modu-lated by these cyclins,which indicates that these OsCYCP4s may also be involved in phosphate starvation signaling.We conclude that phosphate starvation induced OsCYCP4s might coordinate phosphate starvation signaling and cell cycle progression under phosphate starvation stress. | Lei Xu Fang Wang Ruili Li Minjuan Deng Meilan Fu Huiying Teng Keke Yi | 2020 | Journal of Integrative Plant Biology2020，62，7： | 2 |
| 14 | Deficiency of two-pore segment channel 2 contributes to systemic lupus erythematosus via regulation of apoptosis and cell cycle显示文摘Background:Systemic lupus erythematosus(SLE)is a complex autoimmune disease,and the mechanism of SLE is yet to be fully elucidated.The aim of this study was to explore the role of two-pore segment channel 2(TPCN2)in SLE pathogenesis.Methods:Quantitative reverse transcription polymerase chain reaction(qRT-PCR)was used to detect the expression ofTPCN2 in SLE.We performed a loss-of-function assay by lentiviral construct in Jurkat and THP-1 cell.Knockdown ofTPCN2 were confirmed at the RNA level by qRT-PCR and protein level by Western blotting.Cell Count Kit-8 and flow cytometry were used to analyze the cell proliferation,apoptosis,and cell cycle ofTPCN2-deficient cells.In addition,gene expression profile ofTPCN2-deficient cells was analyzed by RNA sequencing(RNA-seq).Results:TPCN2 knockdown with short hairpin RNA(shRNA)-mediated lentiviruses inhibited cell proliferation,and induced apoptosis and cell-cycle arrest of G2/M phase in both Jurkat and THP-1 cells.We analyzed the transcriptome of knockdown-TPCN2-Jurkat cells,and screened the differential genes,which were enriched for the G2/M checkpoint,complement,and interleukin-6-Janus kinase-signal transducer and activator of transcription pathways,as well as changes in levels of forkhead box O,phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin,and T cell receptor pathways;moreover,TPCN2 significantly influenced cellular processes and biological regulation.Conclusion:TPCN2 might be a potential protective factor against SLE. | Keke Li Jingkai Xu Ke Xue Ruixing Yu Chengxu Li Wenmin Fei Xiaoli Ning Yang Han Ziyi Wang Jun Shu Yong Cui | 2022 | Chinese Medical Journal2022，，4： | 2 |
| 15 | Microstructure, mechanical properties and tribological behavior of tribofilm generated from natural serpentine mineral powders as lubricant additive显示文摘 | Helong Yu Yi Xu Peijing Shi Hongmei Wang Min Wei Keke Zhao Binshi Xu | 2013 | Wear (-)2013，，1： | 2 |
| 16 | Injectable silk/hydroxyapatite nanocomposite hydrogels with vascularization capacity for bone regeneration显示文摘Localized and sustained osteogenic-angiogenic stimulation to bone defects is critical for effective bone repair.Here,desferrioxamine(DFO)was loaded on silk fibroin nanofibers and blended with hydroxyapatite nanorods(HA),forming injectable DFO-loaded silk fibroin-HA nanocomposite hydrogels.The composite hydrogels remained homogeneous distribution of HA with high ratio(60%)and also higher stiffness than that of pure silk fibroin nanofiber hydrogels,which provided stable osteogenic stimulation niches for tissue regeneration.Without the scarify of injectability,the hydrogels achieved slow delivery of DFO for above 60 days,resulting in suitable angiogenesis in vitro and in vivo and better osteogenesis than DFO-free systems.Compared to previous injectable silk fibroin-HA hydrogels,the introduction of vascularization capacity further stimulated the osteogenic differentiation of stem cells and accelerated new bone formation.Quicker and better bone healing were detected at defect sites after the injection of DFO-loaded nanocomposite hydrogels,indicating the effective synergistic effect of osteogenic and angiogenic cues.This work provides a simple and effective strategy of introducing angiogenic cues to bone matrices.We believe that the injectable nanocomposite hydrogels are suitable for the regeneration of bone tissues. | Keke Wang Weinan Cheng Zhaozhao Ding Gang Xu Xin Zheng Meirong Li Guozhong Lu Qiang Lu | 2021 | Journal of Materials Science & Technology2021，，4： | 2 |
| 17 | Effect of Dietary Vitamin E on the Sperm Quality of Turbot(Scophthalmus maximus)显示文摘A 3-month feeding experiment was conducted in an in-door seawater system to investigate the effect of dietary vitamin E(Ve) on the sperm quality of turbot(Scophthalmus maximus). D-α-tocopherol acetate was supplemented to the basal(control) diet(65.14 mg kg–1 Ve) to obtain low and high levels of dietary Ve(244.60 mg kg–1, LVe; 721.60 mg kg–1, HVe). Compared with the control, sperm concentration was significantly increased in Ve-supplemented groups(LVe and HVe); while relative sperm volume and testis-somatic index were significantly increased in group HVe only. Sperm motility duration was significantly longer in group HVe than in the control, but no significant difference was observed in percent motility among groups. Sperm size, the uniformity of mitochondrial size, and the integrity of mitochondria cristae and plasma membrane were improved by dietary Ve, especially in HVe. The content of Ve in testis and liver as well as polyunsaturated fatty acids in sperm increased with dietary Ve. These results suggested that dietary Ve, especially at the high level(721.60 mg kg–1), significantly improved sperm concentration and motility duration and maintained normal sperm morphology of turbot. | XU Houguo HUANG Lina LIANG Mengqing ZHENG Keke WANG Xinxing | 2015 | Journal of Ocean University of China2015，14，4： | 2 |
| 18 | Design of novel NiSiAlY alloys in marine salt-spray environment:PartⅠ.Al-Si-Y and Ni-Si-Y subsystems显示文摘MCrAlY(M=Ni,Co,NiCo)alloys have been widely used as a bond layer for thermal barrier coatings(TBCs).However;oxides form discontinuously on MCrAlY surface in the marine environment since Cr_(2)O_(3)can react with NaCl and H_(2)O at temperatures above 500℃.Replacing Cr with other alloying elements(such as Si)might prevent severe salt-spray corrosion effectively.To save time and efforts in materials design of the Ni-Si-Al-Y system;we obtained the thermodynamic descriptions of the ternary compounds by coupling the CALPHAD(CALculation of PHAse Diagrams)approach and first-principles calculations.Seven and eighteen ternary compounds were evaluated and calculated in the Al-Si-Y and Ni-Si-Y systems;respectively.Phase diagrams of the two systems were depicted after a series of experimental Al/Ni-Si-RE(RE denotes rare earth elements,including La,Ce,Pr,Nd,Sm,Gd,Dy,Ho,and Er)systems being analyzed.It is found that the RE elements with the same reference states tend to form ternary compounds with the same crystal structures.The model-based descriptions are the basis for the research and development of novel NiSiAlY alloys in resisting high-temperature corrosion. | Kai Xu Keke Chang Yong Du Liping Wang | 2021 | Journal of Materials Science & Technology2021，，29： | 2 |
| 19 | Switching Optimally Balanced Fe-N Interaction Enables Extremely Stable Energy Storage显示文摘The interaction between electrode materials and charge carriers is one of the central issues dominating underlying energy storage mechanisms.To address the notoriously significant volume changes accompanying intercalation or formation of alloy/compounds,we aim to introduce and utilize a weak,reversible Fe-N interaction during the(de)intercalation of ammonium ions(NH_(4)^(+))within iron(Ⅲ)hexacyanoferrate(FeHCF),inspired by manipulating the electrostatic adsorption between N and Fe in the early stages of ammonia synthesis(Bosch-Harber Process,Chemical Engineering)and steel nitriding processes(Metal Industry).Such strategy of switching well-balanced Fe-N interaction is confirmed in between the nitrogen of ammonium ions and highspin Fe in FeHCF,as observed by using X-ray absorption spectroscopy.The resulting material provided an extremely stable energy storage(58 mAh g^(-1) after 10000 cycles at current density of 1 A g^(-1))as well as high-rate performance(23.6 mAh g^(-1) at current density of 10 A g^(-1)). | Zhenzhen Zhao Wei Zhang Miao Liu Dong Wang Xiyang Wang Lirong Zheng Xu Zou Zizhun Wang Dabing Li Keke Huang Weitao Zheng | 2023 | Energy & Environmental Materials2023，6，2： | 1 |
| 20 | Palladium-phosphi- nous Acid-catalyzed Cross-coupling of Aliphatic and Aromatic Acyl Chlorides with Boronie Acids 显示文摘 | KEKELI E K XU H WOLF C | 2008 | Tetrahedron Lett2008，49，40： | 1 |
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