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| 1 | Ultrasensitive biosensors based on long-range surface plasmon polariton and dielectric waveguide modes显示文摘An ultrasensitive biosensor based on hybrid structure and composed of long-range surface plasmon polariton(LRSPP) and dielectric planar waveguide(PWG) modes is proposed. Both PWG and LRSPP modes have strong resonances to form strong coupling between the two modes, and the two modes can couple to enhance sensitivity of sensors. In the hybrid structure, PWG is composed of cytop–Si–cytop multilayers and the LRSPP configuration is composed of cytop–metal–sensing medium multilayer slabs. The highest imaging sensitivities of 2264 and3619 RIU-1were realized in the proposed sensors based on Au and Al-monolayer graphene, respectively, which are nearly 1.2 and 1.9 times larger than the 1910 RIU-1sensitivity of the conventional LRSPR sensor(LRSPP sensor). Moreover, it is demonstrated that the PWG-coupled LRSPP biosensor is applicable to the sensing medium,with refractive index in the vicinity of 1.34. | Leiming Wu Jun Guo Hailin Xu Xiaoyu Dai Yuanjiang Xiang | 2016 | Photonics Research2016，4，6： | 4 |
| 2 | Regorafenib-loaded poly(lactide-co-glycolide) microspheres designed to improve transarterial chemoembolization therapy for hepatocellular carcinoma显示文摘Transarterial chemoembolization(TACE)has been widely introduced to treat hepatocellular carcinoma(HCC)especially for unresectable patients for decades.However,TACE evokes an angiogenic response due to the secretion of vascular endothelial growth factor(VEGF),resulting in the formation of new blood vessels and eventually tumor recurrence.Thus,we aimed to develop regorafenib(REGO)-loaded poly(lactide-co-glycolide)(PLGA)microspheres that enabled localized and sustained drug delivery to limit proangiogenic responses following TACE in HCC treatment.REGO-loaded PLGA microspheres were prepared using the emulsion-solvent evaporation/extraction method,in which DMF was selected as an organic phase co-solvent.Accordingly,we optimized the proportion of DMF,which the optimal ratio to DCM was 1:9(v/v).After preparation,the microspheres provided high drug loading capacity of 28.6%,high loading efficiency of 91.5%,and the average particle size of 149μm for TACE.IR spectra and XRD were applied to confirming sufficient REGO entrapment.The in vitro release profiles demonstrated sustained drug release of microspheres for more than 30 d To confirm the role of REGO-loaded microspheres in TACE,the cell cytotoxic activity on HepG2 cells and anti-angiogenic effects in HUVECs Tube-formation assay were studied in combination with miriplatin.Moreover,the microspheres indicated the potential of antagonizing miriplatin resistance of HepG2 cells in vitro.Pharmacokinetics preliminary studies exhibited that REGO could be sustainably released from microspheres for more than 30d after TACE in vivo.In vivo anti-tumor efficacy was further determined in HepG2 xenograft tumor mouse model,demonstrating that REGO microspheres could improve the antitumor efficacy of miriplatin remarkably compared with miriplatin monotherapy.In conclusion,the obtained REGO microspheres demonstrated promising therapeutic effects against HCC when combined with TACE. | Xiang Li Guangwei He Feng Su Zhaoxing Chu Leiming Xu Yazhong Zhang Jianping Zhou Yang Ding | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，6： | 4 |
| 3 | Association between arterial stiffness and risk of coronary artery disease in a community-based population显示文摘 | Zhang Yun Ye Ping Luo Leiming Bai Yongyi Xu Ruyi Xiao Wenkai Liu Dejun Wu Hongmei | 2014 | Chinese Medical Journal2014，，22： | 3 |
| 4 | All-optical logic devices based on black arsenic-phosphorus with strong nonlinear optical response and high stability显示文摘The Kerr nonlinearity in two-dimensional(2D)nanomaterials is emerging as an appealing and intriguing research area due to their prominent light processing,modulation,and manipulation abilities.In this contribution,2D black arsenic-phosphorus(B-AsP)nanosheets(NSs)were applied in nonlinear photonic devices based on spatial self-phase modula-tion(SSPM)method.By applying the Kerr nonlinearity in 2D B-AsP,an all-optical phase-modulated system is proposed to realize the functions of“on”and“off”in all-optical switching.By using the same all-optical phase-modulated system,another optical logic gate is proposed,and the logical“or”function is obtained based on the 2D B-AsP NSs dispersions.Moreover,by using the SSPM method,a 2D B-AsP/SnS_(2) hybrid structure is fabricated,and the result illustrates that the hybrid structure possesses the ability of the unidirectional nonlinear excitation,which helps in obtaining the function of spatial asymmetric light propagation.This function is considered an important prerequisite for the realization of diode functionalization,which is believed to be a factor in important basis for the design of isolators as well.The initial investig-ations indicate that 2D B-AsP is applicable for designing optical logical devices,which can be considered as an import-ant development in all-optical information processing. | Leiming Wu Taojian Fan Songrui Wei Yijun Xu Ye Zhang Dingtao Ma Yiqing Shu Yuanjiang Xiang Jun Liu Jianqing Li Krassimir Panajotov Yuwen Qin Han Zhang | 2022 | Opto-Electronic Advances2022，5，1： | 3 |
| 5 | miR-200b is involved in intestinal fibrosis of Crohn’s disease显示文摘 | Yingwei Chen Wensong Ge Leiming Xu Chunying Qu Mingjie Zhu Wenzhu Zhang Yongtao Xiao | 2012 | International Journal of Molecular Medicine2012，，4： | 2 |
| 6 | High-throughput RNA sequencing reveals the anti-inflammatory mechanism of baicalin on Propionibacterium acnes-induced acne in rabbits显示文摘Objective:Propionibacterium acnes(P.acnes)plays an important role in the development of acne,an inflammatory skin disease with a high-incidence.In this study,we used high-throughput RNA sequencing(RNA-seq)to reveal the anti-inflammatory mechanism of baicalin on P.acnes-induced acne in rabbits.Methods:The Kligman method was used to induce acne in the ears of New Zealand rabbits.The effect of baicalin on the acne model was evaluated by the number of acne lesions and hematoxylin and eosin(H&E)staining of acne tissues.Enzyme-linked immunoabsorbent assay was used to measure the protein expression levels of tumor necrosis factor a(TNFA),interleukin-1 b(IL1B),IL6,and IL8 in the serum of rabbits.RNA-seq was performed to investigate the mechanism of anti-inflammatory activities of baicalin on acne.Immunohistochemical analysis and Western blot were used to validate the expression levels of related proteins in acne tissues.Results:Baicalin treatment significantly reduced the number of acne lesions and lesions of the ear as well as levels of serum inflammatory cytokines.RNA-seq data showed that baicalin treatment globally suppressed inflammation,especially the TNF signaling pathway and Staphylococcus aureus infection pathway,in the rabbit acne model.Conclusion: Baicalin effectively ameliorates P. acnes-induced acne in rabbits by suppressingthe inflammatory response in rabbits. | Xingzhe Yang Guangrui Huang Leiming You Honghao Sheng Yuxiu Sun Yuyin Feng Qingyi Lu Anlong Xu | 2019 | Journal of Traditional Chinese Medical Sciences2019，6，3： | 2 |
| 7 | Controllable Fabrication of TiO2 1D‐Nano/Micro Structures: Solid, Hollow, and Tube‐in‐Tube Fibers by Electrospinning and the Photocatalytic Performance显示文摘 | Leiming Lang Di Wu Zheng Xu | 2012 | Chem. Eur. J2012，，34： | 1 |
| 8 | On-demand multicast routing protocol with multipoint relay (ODMRP-MPR) in mobile ad-hoc network显示文摘 | Zhao Yao Xu Leiming Shi Meilin | 2003 | Communication Technology Proceedings2003，2，： | 1 |
| 9 | Automated hydraulic correction technology for CBM horizontal wellbore显示文摘 | Guojun Wen Wei Liu Chao Xu Leiming Li Xiaohao Liu | 2010 | International Journal of Coal Geology2010，，2： | 1 |
| 10 | A novel tumor metastasis suppressor gene LASS2/TMSG1 interacts with vacuolar ATPase through its homeodomain显示文摘 | Wenjuan Yu Leiming Wang Yuewei Wang Xiaoyan Xu Pengcheng Zou Miaozi Gong Jie Zheng Jiangfeng You Hua Wang Fang Mei Fei Pei | 2013 | J Cell Biochem2013，，3： | 1 |
| 11 | miR-200b is involved in intestinal fibrosis of Crohn’s disease显示文摘 | Yingwei Chen Wensong Ge Leiming Xu Chunying Qu Mingjie Zhu Wenzhu Zhang Yongtao Xiao | 2012 | International Journal of Molecular Medicine2012，，4： | 1 |
| 12 | Serum protein profiles suggest a possible link between qi deficiency constitution and Pi-qi-deficiency syndrome of chronic superficial gastritis显示文摘Objective:To identify potential serum protein candidates involved in linking the traditional Chinese medicine(TCM)-defined qi deficiency constitution(QDC)to Pi-qi-deficiency syndrome(PQDS)of chronic superficial gastritis(CSG).Methods:Using participants with the TCM-defined balanced constitution as a control population,labelfree quantitative proteomics was adopted to identify differentially expressed proteins(DEPs)in serum samples from two case populations:case population 1(participants with QDC)and case population 2(patients with PQDS of CSG).The DEPs discovered in both case populations were analyzed to identify common DEPs as potential candidates for proteins involved in the link between QDC and PQDS.Based on Kyoto Encyclopedia of Genes and Genomes pathway(KEGG)and Gene Ontology(GO)enrichment analysis and analysis of proteineprotein interaction networks,we evaluated the possible functions of these potential serum candidates.Results:We discovered 24 and 28 proteins that were differentially expressed in case populations 1 and 2,respectively,compared with the control population.Hierarchical clustering analysis showed that the expression profile of DEPs of individuals from the same population clustered well,while those from different populations were segregated.Furthermore,GO analysis revealed the 10 DEPs that were common to both case populations to be mainly associated with negative regulation of cellular metabolic and immune system processes while KEGG analysis indicated these proteins to be associated with complement and coagulation cascades and peroxisome proliferator-activated receptor signaling.Notably,serum levels of C4b-binding protein beta chain,glycosylphosphatidylinositol-specific phospholipase D1 and MS-F1 light chain variable region proteins were notably higher in the two case populations compared with the control,particularly in the case of CSG with PQDS.Conclusion:The results presented here provide new insights into the molecular mechanisms underlying development of PQDS of CSG from QDC,and suggest candidate serum biomarkers for future application in integrative medicine. | Xinhui Gao Leiming You Aijie Liu Xiaopu Sang Ting’an Li Shen Zhang Kunyu Li Guangrui Huang Ting Wang Anlong Xu | 2019 | Journal of Traditional Chinese Medical Sciences2019，6，4： | 1 |
| 13 | StarIn:An Approach to Predict the Popularity of GitHub Repository显示文摘The popularity of repository in GitHub is an important indicator to evaluate its quality.Exploring the trend of popularity is a crucial guideline to study its development potential.Herein,StarIn,a stargazer-influence based approach is proposed to predict the popularity of GitHub repository.Using the followers in GitHub as a basic dataset,stargazer-following based network was established.The indicator,stargazer influence,was measured from three aspects of basic influence,network dynamic influence and network static influence.Experiments was conducted,and the correlation of StarIn was analyzed with the popularity of repository from the perspective of six characteristics.The experimental evaluation provides an interesting approach to predict the popularity of repositories in GitHub from a new perspective.StarIn achieves an excellent performance of predicting the popularity of repositories with a high accurate rate under two different classifiers. | Leiming Ren Shimin Shan Xiujuan Xu Yu Liu | 2020 | 国际计算机前沿大会会议论文集2020，，2： | 0 |
| 14 | Clinical Observation on 34 Cases of Chronic Atrophic Gastritis Treated with Shenlian Twelve Flavors显示文摘[Objectives]The research aimed to observe the curative effect of Shenlian Twelve Flavors in treating CAG patients with spleen deficiency and blood stasis toxin.[Methods]66 cases of CAG patients with spleen deficiency and blood stasis toxin were selected,32 cases in the control group and 34 cases in the observation group were generated according to the random number table method.The control group was treated with Moluodan;the observation group was treated with Shenlian Twelve Flavors.After treatment,the effective rate,TCM symptom score,gastroscopic score,pathological score,serum gastrin 17(G-17)level,and adverse reactions were compared between the two groups.[Results]The total effective rates of control group and observation group were 84.37%and 91.18%,respectively,and there was no statistical significance between the two groups(P>0.05).For the improvement of TCM symptom score,both groups were improved significantly compared with that before treatment,and observation group was better than control group(P<0.05).For the improvement of gastroscopic score,both groups were improved compared with that before treatment,and observation group was better than control group(P<0.05).For the improvement of pathological scores,both groups were improved compared with that before treatment,but there was no statistical significance between the two groups(P>0.05).[Conclusions]Shenlian Twelve Flavors has definite clinical efficacy in the treatment of CAG with spleen deficiency and blood stasis toxin.It could improve clinical symptoms,delay pathological progress,and regulate the level of G-17.There is no obvious adverse reaction,and it is worthy of clinical reference. | Jincheng WANG Sufang ZHOU Leiming MAO Jiao XU Chuang LIU | 2022 | Medicinal Plant2022，13，4： | 0 |
| 15 | Semi-asynchronous personalized federated learning for short-term photovoltaic power forecasting显示文摘Accurate forecasting for photovoltaic power generation is one of the key enablers for the integration of solar photovoltaic systems into power grids.Existing deep-learning-based methods can perform well if there are sufficient training data and enough computational resources.However,there are challenges in building models through centralized shared data due to data privacy concerns and industry competition.Federated learning is a new distributed machine learning approach which enables training models across edge devices while data reside locally.In this paper,we propose an efficient semi-asynchronous federated learning framework for short-term solar power forecasting and evaluate the framework performance using a CNN-LSTM model.We design a personalization technique and a semi-asynchronous aggregation strategy to improve the efficiency of the proposed federated forecasting approach.Thorough evaluations using a real-world dataset demonstrate that the federated models can achieve significantly higher forecasting performance than fully local models while protecting data privacy,and the proposed semi-asynchronous aggregation and the personalization technique can make the forecasting framework more robust in real-world scenarios. | Weishan Zhang Xiao Chen Ke He Leiming Chen Liang Xu Xiao Wang Su Yang | 2023 | Digital Communications and Networks2023，9，5： | 0 |
| 16 | QTL Mapping for Plant Height of Wheat under Different Irrigation Modes显示文摘In order to mine gene loci associated with drought resistance and water use efficiency,and provide guidance for the breeding of drought-resistant wheat varieties,quantitative trait loci(QTLs)for plant height(PH)and stem height(SH)of wheat were evaluated using a population of 302 recombinant inbred lines(RILs)derived from a cross between drought-tolerant cultivar Luohan 2 and water-sensitive cultivar Weimai 8 under different water regimes in six environments.Totally 17 additive QTLs for PH and SH were identified and distributed on chromosomes 2B,3A,3B,4A,5A,5D,6B,7A and 7B,respectively,which explained3.3%to 26.95%phenotypic variations,with additive effect of 1.919 6 to 5.382 8 cm.Among them,14 QTLs,24 times and 5 QTLs,7 times were detected in three irrigation environments and three drought stress environments,respectively.Both the number of QTLs for PH and the times detected in drought stress environments were significantly less than those in irrigation environments.Of all the 17 QTLs for PH,12 were detected only in irrigation environment,three QTLs were detected only in drought stress environment,and two QTLs were detected in both environments,suggesting that the expression of the genes is greatly influenced by environmental condition.QPh-WL-7A.3 detected between maker Xbarc049 and Xgwm273 on chromosome 7A in all the three drought stress environments,can enhance2.481 5-3.697 2 cm of PH,explain 8.6%-10.0%additive effect,so it is useful for the genetic improvement of drought tolerance and molecular marker-assisted selection in wheat. | Yanyun REN Ling HUANG Minmin SHAO Leiming SUN Kai ZHAO Jinping WANG Xingke XU Weiying FENG Jifeng WANG Lu YAN Shichong WANG Lin WANG | 2017 | Agricultural Biotechnology2017，6，4： | 0 |
| 17 | Construction and expression of hepatitis B virus vector encoding TC-tagged core protein显示文摘Virus tagged with greenfluorescent protein(GFP)contributes to the visualization and study of the virus in living cells.However,the hepatitis B virus(HBV)particle,which is a compact virion with limited internal space,cannot be incorporated with GFP tag as a large fragment.It was recently reported that protein genetically inserted with a smaller size tetracysteine(TC)tag could be specially labeled by a biarsenicalfluorescent dye in living cells.In this study,we constructed a recombinant HBV vector encoding TC-tagged core protein for biarsenical labeling of HBV virion.TC tag was genetically inserted near the immunodominant c/e1 site of HBV core protein by mutagenesis.Western blot and enzyme-linked immu-nosorbent assay(ELISA)analysis showed that the TC-tagged core protein,hepatitis B surface antigen(HBsAg)and hepatitis B e antigen(HBeAg)could be expressed in cells transfected with the recombinant HBV vector,which is similar to the cells transfected with wild-type HBV vector.Reverse transcription-polymerase chain reaction(RT-PCR)and Southern blot analysis showed that HBV virion formation was affected by the genetic insertion of TC tag into core protein in some degree,but cells transfected with the HBV vector could still produce HBV virions incorporated with TC-tagged core proteins.Taken together,the recombinant HBV vector can serve as a useful tool to produce HBV virions incorporated with TC-tagged core proteins to befluorescently labeled by biarsencial dye for visualizing and studying HBV in living cells. | Yuanyuan LIN Xiaoming CHENG Yuhu SONG Li ZHOU Peiyuan LI Ying CHANG Leiming XU Jinjian YAO Jusheng LIN | 2009 | Frontiers of Medicine2009，3，4： | 0 |
| 18 | Effect of Irrigation and Fertilization on Population Structure and Yield of Wheat显示文摘[Objectives] This study was conducted to investigate the effects of irrigation and fertilization on population structure and yield of wheat.[Methods]With Shannong 29 as an experimental material,the effects of irrigation and fertilization on population,dry matter accumulation and yield of wheat were studied.[Results]Integrated water-saving irrigation and fertilization of ridged field was the best with the highest population,dry matter accumulation and yield of wheat.[Conclusions]This study provides a theoretical basis for high-yield and high-efficiency wheat production with saved water and fertilizers. | Minmin SHAO Leiming SUN Xingke XU Kai ZHAO Ling HUANG Weiying FENG Jifeng WANG Lu YAN Lin WANG | 2020 | Agricultural Biotechnology2020，9，2： | 0 |
| 19 | Effects of Different Line Spacing and Seedling Belt Width on Yield Formation of Broad-Width Fine Sowing Wheat显示文摘In order to explore the interaction effects of line spacing and seedling belt width on wheat yield formation and improve the cultivation techniques of broadwidth and fine seeding of wheat,a high-yielding winter wheat cultivar Shannong 28 was selected as material. Using the split plot design,the main plot was set with line spacing as 20,25 and 30 cm,respectively,and the sub-plot was set with seedling belt width as 3,5,7,9 and 11 cm,respectively. Then,the population dynamics,dry matter accumulation and translocation and yield of wheat were studied under the experimental conditions. The results showed that under the line spacing of 20 cm,the dry matter accumulation and yield of winter wheat were higher with the seedling belt width of 5 cm. When the line spacing was 25 cm,the dry matter accumulation and yield under the seedling belt width of 9 cm reached a high level. Under the line spacing of 30 cm,Shannong 28 achieved higher dry matter accumulation and yield with the seedling belt width of 11 cm. Comprehensive analysis revealed that the suitable treatment for Shannong 28 was 25 cm of line spacing with 9 cm of seedling belt width,which could realize the coordination of the three factors of yield composition and get higher yield. Therefore,the reasonable line spacing and seedling belt width were the important technical ways to realize high yield of wheat. | Minmin SHAO Leiming SUN Kai ZHAO Xingke XU Ling HUANG Lin WANG Lu YAN Zhengchun JU | 2020 | Agricultural Biotechnology2020，9，3： | 0 |
| 20 | Formation and Development of a Mountain-induced Secondary Center inside Typhoon Morakot(2009)显示文摘The structural evolution of Typhoon Morakot(2009) during its passage across Taiwan was investigated with the WRF model. When Morakot approached eastern Taiwan, the low-level center was gradually filled by the Central Mountain Range(CMR), while the outer wind had flowed around the northern tip of the CMR and met the southwesterly monsoon to result in a strong confluent flow over the southern Taiwan Strait. When the confluent flow was blocked by the southern CMR, a secondary center(SC) without a warm core formed over southwestern Taiwan. During the northward movement of the SC along the west slope of the CMR, the warm air produced within the wake flow over the northwestern CMR was continuously advected into the SC, contributing to the generation of a warm core inside the SC. Consequently, a well-defined SC with a warm core, closed circulation and almost symmetric structure was produced over central western Taiwan, and then it coupled with Morakot's mid-level center after crossing the CMR to reestablish a new and vertically stacked typhoon. Therefore, the SC inside Morakot was initially generated by a dynamic interaction among the TC's cyclonic wind, southwesterly wind and orographic effects of the CMR, while the thermodynamic process associated with the downslope adiabatic warming effect documented by previous studies supported its development to be a well-defined SC. In summary, the evolution of the SC in this study is not in contradiction with previous studies, but just a complement, especially in the initial formation stage. | Xuwei BAO Leiming MA Jianyong LIU Jie TANG Jing XU | 2018 | Advances in Atmospheric Sciences2018，35，9： | 0 |
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