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| 1 | 亚太地区慢性乙型肝炎治疗共识(2012最新版)显示文摘自2008年至今,有大量关于慢性HBV感染的自然史和治疗的最新数据不断涌现。其中包括慢性HBV感染的无症状感染者,以社区为基础的队列研究,HBV基因型的作用,非药物诱导的自然HBV变异型毒株,无创性肝纤维化评估方法的应用,HBsAg定量在临床中的应用,更有效的新治疗药物和新治疗方案等等。来自亚太地区的专家审查和评估了相关数据,并共同商讨了近年来报道的最有意义的发现,基于此,对2008年版的亚太地区慢性乙型肝炎治疗共识进行修订,同时对2008年版治疗指南定义的关键词组进行了修订。修订后的指南包括以下几方面内容:一般治疗,肝纤维化评价适应证,何时开始治疗或停药,初始抗病毒治疗药物的选择,如何监测治疗中和治疗后的患者。关于特殊人群的治疗建议中包括了对妊娠妇女,已发生耐药,合并其他病毒感染,肝功能失代偿,接受免疫抑制治疗、化疗,肝移植或肝细胞癌患者的具体治疗建议。 | 廖运范 Jia-HorngKao Teerha Piratvisuth Henry Lik Yuen Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Wan-Long Chuang Laurentius A.Lesmana Jose D.Sollano Dong-Jin Suh Masao Omata 刘颖 徐莹 李芸 黄祖雄 樊蓉 李小溪 吕国涛 周彬 孙剑 侯金林 | 2012 | 临床肝胆病杂志2012，28，8： | 182 |
| 2 | Precise orbit determination of Beidou Satellites with precise positioning显示文摘Chinese Beidou satellite navigation system constellation currently consists of eight Beidou satellites and can provide preliminary service of navigation and positioning in the Asia-Pacific Region.Based on the self-developed software Position And Navigation Data Analysis(PANDA) and Beidou Experimental Tracking Stations (BETS),which are built by Wuhan University,the study of Beidou precise orbit determination,static precise point positioning (PPP),and high precision relative positioning,and differential positioning are carried out comprehensively.Results show that the radial precision of the Beidou satellite orbit determination is better than 10 centimeters.The RMS of static PPP can reach several centimeters to even millimeters for baseline relative positioning.The precision of kinematic pseudo-range differential positioning and RTK mode positioning are 2-4 m and 5-10 cm respectively,which are close to the level of GPS precise positioning.Research in this paper verifies that,with support of ground reference station network,Beidou satellite navigation system can provide precise positioning from several decimeters to meters in the wide area and several centimeters in the regional area.These promising results would be helpful for the implementation and applications of Beidou satellite navigation system. | SHI Chuang ZHAO QiLe LI Min TANG WeiMing HU ZhiGang LOU YiDong ZHANG HongPing NIU XiaoJi LIU JingNan | 2012 | Science China Earth Sciences2012，55，7： | 61 |
| 3 | Assessment of Waterlogging Risk in Lixiahe Region of Jiangsu Province Based on AVHRR and MODIS Image显示文摘Four images of 1991 AVHRR, 2003 and 2007 MODIS were used to extract waterlogging inundated water of three years, and three inundated water maps were overlaid to estimate waterlogging affected frequency. Based on wa-terlogging affected frequency, waterlogging hazard of pixel scale was assessed. According to the weighed score of area percentage of different waterlogging affected frequency in 13 counties/cities of Lixiahe region, waterlogging hazard rank of every county/city was assessed. Waterlogging affected frequency map and 1km×1km grid landuse map were used to assess waterlogging risk of pixel scale; and then waterlogging risk rank of every county/city was assessed by the similar method by which waterlogging hazard rank of every county/city was assessed. High risk region is located mainly in core zone of Lixiahe hinterland, medium risk region is adjacent to high risk region, and low risk region is located in the most outlying area of risk zone and mainly in south to middle part of Lixiahe region. Xinghua and Gaoyou belong to high risk city, Jiangyan belongs to medium risk city, and the other counties/cities have low or lower waterlogging risk. The method of assessing waterlogging risk in this paper is simple and applicable. This paper can provide guidance for the waterlogging risk analysis in broader area of Huaihe River Basin. | HUANG Dapeng LIU Chuang FANG Huajun PENG Shunfeng | 2008 | Chinese Geographical Science2008，18，2： | 11 |
| 4 | Effect of Arctium lappa L.in the dextran sulfate sodium colitis mouse model显示文摘AIM:To analyze the possible protective role of Arctium lappa L.(AL)in a murine model of ulcerative colitis(UC).METHODS:BALB/c mice were administered 100 mg/kg AL powder orally each day.After 7 d,colitis was induced by administration of dextran sulfate sodium(DSS)(5% W/V)in drinking water for a further 8 consecutive days.Diarrhea and bloody stools as well as colonic histology were observed.The level of interleukin-6(IL-6)and tu-mor necrosis factor-α(TNF-α)in colonic sections were detected by immunohistochemistry.RESULTS:There were significant differences in mean body weight values and disease activity indices between controls and AL-treated animals.Moreover,the histological findings showed that AL treatment can prevent mucosal edema,submucosal erosions,ulceration,inflammatory cell infiltration and colon damage.In addition,immunohistochemistry analysis showed that the levels of the inflammatory cytokines,IL-6 and TNF-α were also decreased in AL-treated groups.CONCLUSION:We suggest that AL can prevent intestinal damage and decrease inflammatory cytokines in mice with DSS-induced colitis.Thus,AL could prove to be a useful food for UC. | Tzou-Chi Huang Shinn-Shyong Tsai Li-Fang Liu Yu Lin Liu Hung-Jen Liu Kuo Pin Chuang | 2010 | World Journal of Gastroenterology2010，16，33： | 10 |
| 5 | Dopamine D4 Receptor Gene Associated with the Frontal-Striatal-Cerebellar Loop in Children with ADHD: A Resting-State fMRI Study显示文摘Attention deficit hyperactivity disorder(ADHD)is a common childhood neuropsychiatric disorder that has been linked to the dopaminergic system. This study aimed to investigate the effects of regulation of the dopamine D4 receptor(DRD4) on functional brain activity during the resting state in ADHD children using the methods of regional homogeneity(Re Ho) and functional connectivity(FC). Resting-state functional magnetic resonance imaging data were analyzed in 49 children with ADHD. All participants were classified as either carriers of the DRD44-repeat/4-repeat(4 R/4 R) allele(n = 30) or the DRD42-repeat(2 R) allele(n = 19). The results showed that participants with the DRD4 2 R allele had decreased Re Ho bilaterally in the posterior lobes of the cerebellum, while Re Ho was increased in the left angular gyrus. Compared with participants carrying the DRD4 4 R/4 R allele, those with the DRD4 2 R allele showed decreased FC to the left angular gyrus in the left striatum, right inferior frontal gyrus, and bilateral lobes of the cerebellum. The increased FC regions included the left superior frontal gyrus, medial frontal gyrus, and rectus gyrus. These data suggest that the DRD4 polymorphisms are associated with localized brain activity and specific functional connections, including abnormality in the frontal-striatal-cerebellar loop. Our study not only enhances the understanding of the correlation between the cerebellar lobes and ADHD, but also provides an imaging basis for explaining the neural mechanisms underlying ADHD in children. | ANDan Qian Xin Wang Huiru Liu Jiejie Tao Jiejie Zhou Qiong Ye Jiance Li Chuang Yang Jingliang Cheng Ke Zhao Meihao Wang | 2018 | Neuroscience Bulletin2018，34，3： | 10 |
| 6 | Development and Future Challenges of Bio-Syncretic Robots显示文摘 | Chuang Zhang Wenxue Wang Ning Xi Yuechao Wang Lianqing Liu | 2018 | Engineering2018，4，4： | 10 |
| 7 | High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care显示文摘Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding Xue Bi Jing, a five-herb medicine, to antibioticbased sepsis care. Although adding Xue Bi Jing further reduced 28-day mortality via modulating the host response, pharmacokinetic herbedrug interaction is a widely recognized issue that needs to be studied.Building on our earlier systematic chemical and human pharmacokinetic investigations of Xue Bi Jing, we evaluated the degree of pharmacokinetic compatibility for Xue Bi Jing/antibiotic combination based on mechanistic evidence of interaction risk. Considering both Xue Bi Jing-antibiotic and antibiotic-Xue Bi Jing interaction potential, we integrated informatics-based approach with experimental approach and developed a compound pair-based method for data processing. To reflect clinical reality, we selected for study Xue Bi Jing compounds bioavailable for drug interactions and 45 antibiotics commonly used in sepsis care in China. Based on the data of interacting with drug metabolizing enzymes and transporters, no Xue Bi Jing compound could pair, as perpetrator, with the antibiotics. Although some antibiotics could,due to their inhibition of uridine 50-diphosphoglucuronosyltransferase 2 B15, organic anion transporters1/2 and/or organic anion-transporting polypeptide 1 B3, pair with senkyunolide I, tanshinol and salvianolic acid B, the potential interactions(resulting in increased exposure) are likely desirable due to these Xue Bi Jing compounds’ low baseline exposure levels. Inhibition of aldehyde dehydrogenase by 7 antibiotics probably results in undesirable reduction of exposure to protocatechuic acid from Xue Bi Jing.Collectively, Xue Bi Jing/antibiotic combination exhibited a high degree of pharmacokinetic compatibility at clinically relevant doses. The methodology developed can be applied to investigate other drug combinations. | Jian Li Olajide E.Olaleye Xuan Yu Weiwei Jia Junling Yang Chuang Lu Songqiao Liu Jingjing Yu Xiaona Duan Yaya Wanga Kai Dong Rongrong He Chen Cheng Chuan Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 10 |
| 8 | Comparison of OA-2000 and IOL Master 500 using in cataract patients with high myopia显示文摘This study was designed to compare optical biometry measurements and predicted refraction in cataract patients with high myopia [axial length(AL) ≥26 mm] using OA-2000 and IOL Master 500. Ocular biometry measurements were performed using both biometers before surgery. Uneventful cataract surgery was performed in all patients. Postoperative manifest refraction was obtained 3 wk after surgery or later. A total of 67 eyes were examined. The AL, keratometry(K), and anterior chamber depth(ACD) of the two biometers showed excellent agreement. Predicted errors were similar and a strong positive correlation was observed(r=0.909). Out of 21 eyes(31.34%) with unsuccessful AL readings using the IOL Master 500, 20 eyes of them could be measured using OA-2000. Therefore, the biometric parameters measured by the two biometers showed good agreement. However, OA-2000 had a lower AL measurement failure rate. | Ya-Li Du Geng Wang Hui-Chun Huang Li-Yu Lin Chuang Jin Li-Fang Liu Xiu-Ru Liu Ming-Zhi Zhang | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 10 |
| 9 | Lotus Leaf‑Derived Gradient Hierarchical Porous C/MoS2 Morphology Genetic Composites with Wideband and Tunable Electromagnetic Absorption Performance显示文摘Inspired by the nature,lotus leaf-derived gradient hierarchical porous C/MoS2 morphology genetic composites(GHPCM)were successfully fabricated through an in situ strategy.The biological microstructure of lotus leaf was well preserved after treatment.Different pores with gradient pore sizes ranging from 300 to 5μm were hierarchically distributed in the composites.In addition,the surface states of lotus leaf resulted in the Janus-like morphologies of MoS2.The GHPCM exhibit excellent electromagnetic wave absorption performance,with the minimum reflection loss of−50.1 dB at a thickness of 2.4 mm and the maximum effective bandwidth of 6.0 GHz at a thickness of 2.2 mm.The outstanding performance could be attributed to the synergy of conductive loss,polarization loss,and impedance matching.In particularly,we provided a brand-new dielectric sum-quotient model to analyze the electromagnetic performance of the non-magnetic material system.It suggests that the specific sum and quotient of permittivity are the key to keep reflection loss below−10 dB within a certain frequency range.Furthermore,based on the concept of material genetic engineering,the dielectric constant could be taken into account to seek for suitable materials with designable electromagnetic absorption performance. | Fei Pan Zhicheng Liu Baiwen Deng Yanyan Dong Xiaojie Zhu Chuang Huang Wei Lu | 2021 | Nano-Micro Letters2021，13，3： | 9 |
| 10 | Atorvastatin combined with low-dose dexamethasone for vascular endothelial cell dysfunction induced by chronic subdural hematoma显示文摘Atorvastatin has been shown to be a safe and effective non-surgical treatment option for patients with chronic subdural hematoma.However,treatment with atorvastatin is not effective in some patients,who must undergo further surgical treatment.Dexamethasone has anti-inflammatory and immunomodulatory effects,and low dosages are safe and effective for the treatment of many diseases,such as ankylosing spondylitis and community-acquired pneumonia.However,the effects of atorvastatin and low-dose dexamethasone for the treatment of chronic subdural hematoma remain poorly understood.Hematoma samples of patients with chronic subdural hematoma admitted to the General Hospital of Tianjin Medical University of China were collected and diluted in endothelial cell medium at 1:1 as the hematoma group.Atorvastatin,dexamethasone,or their combination was added to the culture medium.The main results were as follows:hopping probe ion conductance microscopy and permeability detection revealed that the best dosages to improve endothelial cell permeability were 0.1μM atorvastatin and 0.1μM dexamethasone.Atorvastatin,dexamethasone,or their combination could markedly improve the recovery of injured endothelial cells.Mice subcutaneously injected with diluted hematoma solution and then treated with atorvastatin,dexamethasone,or their combination exhibited varying levels of rescue of endothelial cell function.Hopping probe ion conductance microscopy,western blot assay,and polymerase chain reaction to evaluate the status of human cerebral endothelial cell status and expression level of tight junction protein indicated that atorvastatin,dexamethasone,or their combination could reduce subcutaneous vascular leakage caused by hematoma fluid.Moreover,the curative effect of the combined treatment was significantly better than that of either single treatment.Expression of Krüppel-like factor 2 protein in human cerebral endothelial cells was significantly increased,as was expression of the tight junction protein and vascular permeability marker vascular endothelial cadherin in each treatment group compared with the hematoma stimulation group.Hematoma fluid in patients with chronic subdural hematoma may damage vascular endothelial cells.However,atorvastatin combined with low-dose dexamethasone could rescue endothelial cell dysfunction by increasing the expression of tight junction proteins after hematoma injury.The effect of combining atorvastatin with low-dose dexamethasone was better than that of atorvastatin alone.Increased expression of Krüppel-like factor 2 may play an important role in the treatment of chronic subdural hematoma.The animal protocols were approved by the Animal Care and Use Committee of Tianjin Medical University of China on July 31,2016(approval No.IRB2016-YX-036).The study regarding human hematoma samples was approved by the Ethics Committee of Tianjin Medical University of China on July 31,2018(approval No.IRB2018-088-01). | Yue-Shan Fan Bo Wang Dong Wang Xin Xu Chuang Gao Ying Li Shu Zhang Gui-Li Yang Xiao Liu Rong-Cai Jiang Jian-Ning Zhang | 2021 | Neural Regeneration Research2021，16，3： | 9 |
| 11 | Resting state brain default network in patients with motor aphasia resulting from cerebral infarction显示文摘To explore the brain default mode network(DMN)in patients with motor aphasia resulting from cerebral infarction,we used resting state functional magnetic resonance imaging(fMRI)to investigate the possible neural mechanism.Thirteen patients with motor aphasia resulting from cerebral infarction and ten matched controls were selected in this study.All subjects were examined using resting state fMRI.We chose the posterior cingulate cortex as the region of interest and then used functional connectivity analysis to calculate the DMN functional connectivity and analyze differences in the functional connectivity between the two groups.Compared with normal controls,aphasia patient group showed a significantly decreased functional connectivity in bilateral medial frontal gyrus,superior frontal gyrus,middle frontal gyrus,middle temporal gyrus,precuneus and cuneus.The aphasia patient group showed increased functional connectivity mainly in bilateral medial frontal gyrus,middle frontal gyrus,inferior frontal gyrus,precentral gyrus,insula.The DMN in cerebral infarction motor aphasia patients showed significantly decreased functional connectivity in the resting state.The DMN most likely plays an important role in motor aphasia resulting from cerebral infarction.Furthermore,functional connectivity in the brain regions surrounding the left and right Broca’s areas was significantly enhanced due to compensatory mechanisms.This may be helpful for the recovery of language function in cerebral infarction patients with motor aphasia. | Xin Wang Meihao Wang Weizhuo Wang Huiru Liu Jiejie Tao Chuang Yang Jiance Li | 2014 | Chinese Science Bulletin2014，59，31： | 9 |
| 12 | Using repeated precise gps campaigns for research of present-day crustal movement and strain in the Qinghai-Tibetan Plateau显示文摘The problem of crustal movement in the Qing-hai-Tibetan Plateau is a hotstopic of the present-day international geodetic world. GPS observations in 1993, 1995 and 1997 are used to survey the three-dimensional displacement of GPS monitoring station in the Qinghai-Tibetan Plateau, and to calculate and analyze the present-day crustal movement and strain in the Qinghai-Tibetan Plateau. The result of repeated campaign shows that the crustal movement in the Qinghai-Tibetan Plateau is still compressing in the north and south directions, extending in the west and east directions, and uplifting in the vertical direction. The relative convergence velocity of the Himalayan block is approximately (19.5±1.7)mm/a, the strain velocity is about (5.5±6.0) mm/a, and the uplifting velocity is some (7.6±5.2) mm/a. The compression velocity of the Tibet block relative to Golmud in the north and south directions is (9.3±4.6) mm/a, the strain velocity of the middle part in the west and east directions is (15.6±6.3) mm/a, | LIU Jingnan XU Caijun SONG Chenghua SHI Chuang JIANG Weiping DONG Lixiang | 2001 | Chinese Science Bulletin2001，46，8： | 8 |
| 13 | Composition formulas of Ti alloys derived by interpreting Ti-6Al-4V显示文摘Titanium alloys are composed ofαandβphases and are classified as nearα,dual-phaseα+β,andβtypes.This study attempts to derive their general composition formulas within the cluster-plus-glue-atom model by interpreting Ti-6A1-4V and other popular dual-phaseα+βTi alloy s with well-established chemical compositions.Our model identifiedαmolecule-like structural unit that covers onlyαnearest-neighbor cluster along withαfew next-neighbor glue atoms,which can be represented as'[cluster](glue atoms)x'.The structural units of theαandβphases in Ti-6Al-4V,α-[Al-Ti_(12)](AlTi_(2)),andβ-[Al-Ti_(14)](V2Ti),were derived first and were in an unusual unit ratio of about 2.33:1.To obtain an alloy composition formula that satisfied this unit ratio,the two clusters were treated as hard spheres of different radii and packed according to the clusterplusglueatom model.Our calculations determined that the Ti-6A1-4V alloy unit is composed of 12α-[Al-Ti_(12)](AlTi_(2))and 5β-[Al-Ti_(14)](V2Ti)units(Ti-6.05A1-3.94V wt.%),with the fractional volume of theβphase being 32.5 vol.%,which is in agreement with experimental data.Finally,we describe how the chemical formulas of theαand p phases explain the high temperature near-a alloys(such as Ti-1100,[Al-(Ti_(0.97)Zr_(0.03))_(12)](Al_(0.67)Si_(0.12)Sn_(0.18)Mo_(0.03))_(1.01)Ti_(1.99))and high-strengthβ-Ti alloys(such as Ti-5553,[Al-Ti_(14)](Al_(0.24)Fe_(0.03)Cr_(0.20)-Mo_(0.18)V0.35)_(2.45)Ti_(0.55)),respectively. | LIU TianYu ZHANG Shuang WANG Qing MIN XiaoHua DONG Chuang | 2021 | Science China(Technological Sciences)2021，64，8： | 8 |
| 14 | Development of micro-and nanorobotics: A review显示文摘Micro-and nanorobotic is an emerging field of research arising from the cross-fusion of micro/nano technology and robotics and has become an important part of robotics. Micro-and nanorobots have the advantages of small size, low weight, large thrust-toweight ratio, high flexibility, and high sensitivity. Due to the characteristics distinguishing from macroscopic robots, micro-and nanorobots have stimulated the research interest of the scientific community and opened up numerous application fields such as drug delivery and disease diagnosis. In the past 30 years, research on micro-and nanorobots has made considerable progress.This article provides a comprehensive overview of the development of these robots. First, the application of the robots is reviewed. Then, the key components of the robots are discussed separately, covering their actuation, design, fabrication and control. In addition, from the perspectives of intelligence and sensing, clinical applications, materials and performance, the challenges that may be encountered in the development of such robots in the future are discussed. Finally, the entire article is summarized, and concepts for future micro-and nanorobots are described. | YANG Jia ZHANG Chuang WANG XiaoDong WANG WenXue XI Ning LIU LianQing | 2019 | Science China(Technological Sciences)2019，62，1： | 7 |
| 15 | Straw layer burial to alleviate salt stress in silty loam soils: Impacts of straw forms显示文摘Salt stress can be alleviated by straw layer burial in the soil, but little is known of the appropriate form of the straw layer for optimal regulation of soil water and salinity because of the uncontrollability of field tests. Here, the following four straw forms with compaction thickness of 5 cm buried 40–45 deep were studied: no straw layer(CK), segmented straw(SL, 5 cm in length), straw pellet(SK), and straw powder(SF). The three straw forms(SL, SK and SF) significantly delayed the infiltration of irrigation water down the column profile by 71.20–134.3 h relative to CK and the migration velocity of the wetting front under SF was the slowest. It took longer for the wetting front to transcend SK than SL but shorter for it to reach the bottom of soil column after water crossed the straw layer. Compared with CK, the average volumetric water content in the 0–40 cm soil layer increased by 6.45% under SL, 1.77% under SK and 5.39% under SF. The desalination rates at the 0–40 and 0–100 cm soil layers increased by 5.85 and 3.76% under SL, 6.64 and 1.47% under SK and 5.97 and 4.82% under SF. However, there was no significant difference among straw forms in the 0–40 cm soil layer. Furthermore, the salt leaching efficiency(SLE, g mm^–1 h^–1) above the 40 cm layer under SL was 0.0097, being significantly higher than that under SF(0.0071) by 37.23%. Salt storage under SL, SK and SF in the 40–45 cm layer accounted for 4.50, 16.92 and 7.43% of total storage in the 1-m column profile. Cumulative evaporation under SL and SF decreased significantly by 41.20 and 49.00%, with both treatments having the most significant inhibition of salt accumulation(resalinization rate being 36.06 and 47.15% lower than CK) in the 0–40 cm soil layer. In conclusion, the different forms of straw layers have desalting effects under high irrigation level(446 mm). In particular, SL and SF performed better than SK in promoting deep salt leaching and inhibiting salt accumulation on the soil surface. However, SL was simpler to implement and its SLE was higher. Therefore, the segmented 5 cm straw can be recommended as an optimum physical form for establishing a straw layer for managing saline soils for crop production. | ZHANG Hong-yuan LU Chuang PANG Huan-cheng LIU Na ZHANG Xiao-li LI Yu-yi | 2020 | Journal of Integrative Agriculture2020，19，1： | 7 |
| 16 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update显示文摘 | Yun-Fan Liaw Jia-Horng Kao Teerha Piratvisuth Henry Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Jin-Lin Hou Wan-Long Chuang Laurentius Lesmana Jose | 2012 | Hepatology International2012，，3： | 6 |
| 17 | Characterization of a LAL-type regulator NemR in nemadectin biosynthesis and its application for increasing nemadectin production in Streptomyces cyaneogriseus显示文摘Nemadectin, a macrocyclic lactone antibiotic, is produced by Streptomyces cyaneogriseus ssp. noncyanogenus. A methoxime derivative of nemadectin, moxdectin, has been widely used to control insect and helminth in animal health. Despite the importance of nemadectin, little attention has been paid to the regulation of nemadectin biosynthesis, which has hindered efforts to improve nemadectin production via genetic manipulation of regulatory genes. Here, we characterize the function of nemR, the cluster-situated regulatory gene encoding a LAL-family transcriptional regulator, in the nemadectin biosynthesis gene cluster of S. cyaneogriseus ssp. noncyanogenus NMWT1. NemR is shown to be essential for nemadectin production and found to directly activate the transcription of nemA1-1/A1-2/A2, nemC and nemA4/A3/E/D operons, but indirectly activate that of nemG and nemF. A highly conserved sequence 5′-TGGGGTGKATAGGGGGTA-3′(K=T/G) is verified to be essential for NemR binding.Moreover, four novel targets of NemR, including genes encoding an SsgA-like protein(TU94_12730), a methylmalonyl-CoA mutase(TU94_19950), a thioesterase of oligomycin biosynthesis(TU94_22425) and a MFS family transporter(TU94_24835)are identified. Overexpression of nemR significantly increased nemadectin production by 79.9%, in comparison with NMWT1,suggesting that nemR plays an important role in the nemadectin biosynthesis. | Chuang Li Hairong He Jiabin Wang Hui Liu Haiyan Wang Yajie Zhu Xiangjing Wang Yanyan Zhang Wensheng Xiang | 2019 | Science China(Life Sciences)2019，62，3： | 6 |
| 18 | Lead-free thermochromic perovskites with tunable transition temperatures for smart window applications显示文摘The structural flexibility of hybrid perovskite materials allows for phase transition and consequently thermochromic properties.Here we investigate the thermochromic performance in a series of copper-based layered perovskites with organic cations having different alky chain lengths. Their transition temperature is found to be dependent on the organic cations due to molecular motion and hydrogen bond interaction, providing possibilities to prepare thermochromic semiconductors near room temperature for smart window applications. | Jingwen Li Xiaolong Liu Peixin Cui Junmeng Li Tao Ye Xi Wang Chuang Zhang Yong Sheng Zhao | 2019 | Science China Chemistry2019，62，9： | 6 |
| 19 | WUSCHEL-related homeobox1(WOX1)regulates vein patterning and leaf size in Cucumis sativus显示文摘In plants,WUSCHEL-related homeobox1(WOX1)homologs promote lamina mediolateral outgrowth.However,the downstream components linking WOX1 and lamina development remain unclear.In this study,we revealed the roles of WOX1 in palmate leaf expansion in cucumber(Cucumis sativus).A cucumber mango fruit(mf)mutant,resulting from truncation of a WOX1-type protein(CsWOX1),displayed abnormal lamina growth and defects in the development of secondary and smaller veins.CsWOX1 was expressed in the middle mesophyll and leaf margins and rescued defects of the Arabidopsis wox1 prs double mutant.Transcriptomic analysis revealed that genes involved in auxin polar transport and auxin response were highly associated with leaf development.Analysis of the cucumber mf rl(round leaf)double mutant revealed that CsWOX1 functioned in vein development via PINOID(CsPID1)-controlled auxin transport.Overexpression of CsWOX1 in cucumber(CsWOX1-OE)affected vein patterning and produced‘butterfly-shaped’leaves.CsWOX1 physically interacted with CsTCP4a,which may account for the abnormal lamina development in the mf mutant line and the smaller leaves in the CsWOX1-OE plants.Our findings demonstrated that CsWOX1 regulates cucumber leaf vein development by modulating auxin polar transport;moreover,CsWOX1 regulates leaf size by controlling CIN-TCP genes. | Hu Wang Huanhuan Niu Chuang Li Guoyan Shen Xiaofeng Liu Yiqun Weng Tao Wu Zheng Li | 2020 | Horticulture Research2020，7，1： | 6 |
| 20 | Recent Advances in Space-Deployable Structures in China显示文摘Deployable space structure technology is an approach used in building spacecraft,especially when realizing deployment and folding functions.Once in orbit,the structures are released from the fairing,deployed,and positioned.With the development of communication,remote-sensing,and navigation satellites,space-deployable structures have become cutting-edge research topics in space science and technology.This paper summarizes the current research status and development trend of spacedeployable structures in China,including large space mesh antennas,space solar arrays,and deployable structures and mechanisms for deep-space exploration.Critical technologies of space-deployable structures are addressed from the perspectives of deployable mechanisms,cable-membrane form-finding,dynamic analysis,reliable environmental adaptability analysis,and validation.Finally,future technology developments and trends are elucidated in the fields of mesh antennas,solar arrays,deployable mechanisms,and on-orbit adjustment,assembly,and construction. | Xiaofei Ma Tuanjie Li Jingya Ma Zhiyi Wang Chuang Shi Shikun Zheng Qifeng Cui Xiao Li Fan Liu Hongwei Guo Liwu Liu Zuowei Wang Yang Li | 2022 | Engineering2022，，10： | 6 |
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