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| 1 | Experimental and numerical investigation on the thermal and mechanical behaviours of thermal barrier coatings exposed to CMAS corrosion显示文摘Calcium-magnesium-alumino-silicate(CMAS)corrosion is a critical factor which causes the failure of thermal barrier coating(TBC).CMAS attack significantly alters the temperature and stress fields in TBC,resulting in their delamination or spallation.In this work,the evolution process of TBC prepared by suspension plasma spraying(SPS)under CMAS attack is investigated.The CMAS corrosion leads to the formation of the reaction layer and subsequent bending of TBC.Based on the observations,a corrosion model is proposed to describe the generation and evolution of the reaction layer and bending of TBC.Then,numerical simulations are performed to investigate the corrosion process of free-standing TBC and the complete TBC system under CMAS attack.The corrosion model constructs a bridge for connecting two numerical models.The results show that the CMAS corrosion has a significant influence on the stress field,such as the peak stress,whereas it has little influence on the steady-state temperature field.The peak of stress increases with holding time,which increases the risk of the rupture of TBC.The Mises stress increases nonlinearly along the thick direction of the reaction layer.Furthermore,in the traditional failure zone,such as the interface of the top coat and bond coat,the stress obviously changes during CMAS corrosion. | Dongxu LI Peng JIANG Renheng GAO Fan SUN Xiaochao JIN Xueling FAN | 2021 | Journal of Advanced Ceramics2021，10，3： | 9 |
| 2 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression显示文摘OBJECTIVE: To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine.METHODS: A rat model of depression was established by chronic mild stress(CMS). Model rats received either Sini San, fluoxetine, a combination of the two drugs, or no drug treatment. Healthy naive rats were used as controls. Open field and sucrose preference tests were used to assess depression-like behavior. ELISA and immunohistochemistry were used to determine central and peripheral levels of 5-HT.RESULTS: In the group with no drug treatment,central 5-HT expression decreased while peripheral5-HT concentrations increased as CMS continued.Four weeks after CMS, Sini San alone was less effective in reducing depression-like behavior than fluoxetine alone or in combination with Sini San,but combined use was more effective than fluoxetine alone. Eight weeks after CMS, Sini San alone or in combination with fluoxetine was more effective in reducing depression-like behavior than fluoxetine alone. Furthermore Sini San and fluoxetine used alone or in combination notably increased central 5-HT expression and decreased peripheral 5-HT levels in the rat model.CONCLUSION:The results of the present study indicate that there is a synergistic action between the two medicines in the treatment of depression. Sini San exhibited a relatively long lag before its effects were observed; however, by eight weeks the Traditional Chinese Medicine appeared at least as effective as fluoxetine. We suggest that Sini San can replace fluoxetine in the later stages of depression treatment to minimize side effects observed with long-term fluoxetine administration. | Yubo Li Yuxiu Sun Xueling Ma Xiaoxing Xue Wenting Zhang Zhiqian Wu Yulin Ouyang Jianxin Chen Weiming Wang Shuzhen Guo Wei Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 3 | The Relationship Between the Gut Microbiome and Neurodegen-erative Diseases显示文摘Many recent studies have shown that the gut microbiome plays important roles in human physiology and pathology.Also,microbiome-based therapies have been used to improve health status and treat diseases.In addition,aging and neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s disease,have become topics of intense interest in biomedical research.Several researchers have explored the links between these topics to study the potential pathogenic or therapeutic effects of intestinal microbiota in disease.But the exact relationship between neurodegenerative diseases and gut microbiota remains unclear.As technology advances,new techniques for studying the microbiome will be developed and refined,and the relationship between diseases and gut microbiota will be revealed.This article summarizes the known interactions between the gut microbiome and neurodegenerative diseases,highlighting assay techniques for the gut microbiome,and we also discuss the potential therapeutic role of microbiome-based therapies in diseases. | Xueling Zhu Bo Li Pengcheng Lou Tingting Dai Yang Chen Aoxiang Zhuge Yin Yuan Lanjuan Li | 2021 | Neuroscience Bulletin2021，37，10： | 6 |
| 4 | Seismic hazard assessment of the Three Gorges Project显示文摘Seismic monitoring data for the past 50 years in the Three Gorges Reservoir area show that the reservoir head area is a typical weak seismic region with low seismicity before impoundment and that the epicenters were concentrated in the east and west sides of the Zigui Basin,most of which were natural tectonic earthquakes.After impoundment,the seismic activity shifted to the segment between Badong and Zigui along the Yangtze River,mainly within 5 km of the reservoir bank.The seismogenesis was categorized into four types:Karst collapse earthquakes,earthquakes caused by Karst gas explosion,mining tunnel collapse earthquakes,and rock (terrane) slip earthquakes,all of which are related to the lithology,structure,and tectonics of near-surface geological bodies of the area.Compared with the seismicity before impoundment,the seismic frequency increase was remarkable,with most of the magnitudes below Ms2.0.Therefore,the intensity of the earthquakes remained at a low level.On November 22,2008,a magnitude 4.1 earthquake,the largest earthquake recorded since impoundment,occurred in Quyuan Town,Zigui County.The intensity and PGA of reservoir-induced earthquakes are higher than those of tectonic earthquakes with equal magnitude,but the peak intensity of reservoir-induced earthquakes is not likely to go beyond that of the estimated range from earlier studies. | Yao Yunsheng Wang Qiuliang Li Jinggang Shen Xueling Kong Yuyang | 2013 | Geodesy and Geodynamics2013，4，2： | 4 |
| 5 | The enhanced protective effects of salvianic acid A: A functionalized nanoparticles against ischemic stroke through increasing the permeability of the blood-brain barrier显示文摘Ischemic stroke is the leading cause of disability and death worldwide. Currently, the only proven treatment for ischemic stroke is restoring the cerebral blood supply. In addition, some of the tissue is damaged during the subsequent reperfusion because of the overproduction of reactive oxygen species (ROS). Furthermore, antioxidant therapies have shown promise in preclinical studies for the treatment of ischemia-reperfusion injury. However, their therapeutic efficacy has been limited because of their low bioavailability in brain. To resolve this issue, we synthesized ROS-responsive, fan-shaped dendrimer nanoparticles (NPs) and conjugated them with a blood-brain barrier (BBB)-targeting peptide, COG1410, and salvianic acid A (SA), which is an effective antioxidant in ischemic stroke. The BBB targeting peptide acts as a ligand of the nanocarrier system and penetrates the BBB through the endocytosis of the ligand receptor. The results showed that T-SA-NPs not only target and accumulate in the infarct area, they also reduce over 2 times of the infarct area and reverse the behavioral deficits in MCAO mice, which illustrates that these NPs have an effective therapeutic effect on the ischemic stroke. In addition, these NPs had no toxicity in any organs of the body. Importantly, the present study provides an alternative strategy for delivering antioxidants to the brain and achieving targeted therapy of ischemic stroke. | Yaru Li Xiaojie Zhang Zhifeng Qi Xueling Guo Xiaopeng Liu Wenjuan Shi Yang Liu Libo Du | 2020 | Nano Research2020，13，10： | 4 |
| 6 | Research progress on properties of pre-gelatinized starch and its application in wheat flour products显示文摘Starch is the most abundant organic compound in nature,second only to cellulose.However,the conserved structure of native starches limits their properties and applications.Therefore,it is often necessary to modify them to obtain specific properties.As a common green and safe physical modification method,pre-gelatinization can improve the cold water solubility and swelling power of starch.The typical preparation methods of pre-gelatinized starch include spray drying,extrusion,and drum drying.Spray-dried pre-gelatinized starch still had good granule shape,but the increase of cold water solubility and cold paste viscosity was relatively small.Extruded and drum-dried pre-gelatinized starch showed serious structure destruction,significant increases in cold water solubility and cold paste viscosity,but relatively low hot paste viscosity.The properties of pre-gelatinized starch obtained by different methods are different,so do their effects on the quality of flour products.Wheat flour products,as one of the leading staple food for the people all over the world,play a vital role in people's daily life.With the improvement of people's living standards,more and more special flour products with unique features have received attentions of consumers and researchers.However,the sensory characteristics of special flour products are often inferior to traditional flour products,which limits its development.The unique functional characteristics of pre-gelatinized starch make it expected to play an essential role in the quality improvement of featured flour products.In this paper,the granule morphology,crystal structure,hydration and gelatinization properties of pre-gelatinized starch prepared by three common methods and their application in flour products were reviewed,which provides a theoretical basis for the application of pre-gelatinized starch in food industry. | Hao Ma Mei Liu Ying Liang Xueling Zheng Le Sun Wenqian Dang Jie Li Limin Li Chong Liu | 2022 | Grain & Oil Science and Technology2022，5，2： | 3 |
| 7 | 18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs显示文摘Hepatic stellate cells(HSCs)are essential drivers of fibrogenesis.Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis.18beta-glycyrrhetinic acid(18b-GA)is a natural compound that exists widely in herbal medicines,such as Glycyrrhiza uralensis Fisch,which is used for treating multiple liver diseases,especially in Asia.In the present study,we demonstrated that 18b-GA decreased hepatic fibrosis by inducing the apoptosis in activated HSCs.18b-GA inhibited the expression of a-smooth muscle actin and collagen type Ⅰ alpha-1.Using a chemoproteomic approach derived from activity-based protein profiling,together with cellular thermal shift assay and surface plasmon resonance,we found that 18b-GA covalently targeted peroxiredoxin 1(PRDX1)and peroxiredoxin 2(PRDX2)proteins via binding to active cysteine residues and thereby inhibited their enzymatic activities.18b-GA induced the elevation of reactive oxygen species(ROS),resulting in the apoptosis of activated HSCs.PRDX1 knockdown also led to ROS-mediated apoptosis in activated HSCs.Collectively,our findings revealed the target proteins and molecular mechanisms of 18b-GA in ameliorating hepatic fibrosis,highlighting the future development of 18b-GA as a novel therapeutic drug for hepatic fibrosis. | Qian Zhang Piao Luo Liuhai Zheng Jiayun Chen Junzhe Zhang Huan Tang Dandan Liu Xueling He Qiaoli Shi Liwei Gu Jiahao Li Qiuyan Guo Chuanbin Yang Yin Kwan Wong Fei Xia Jigang Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，4： | 3 |
| 8 | Glycomolecules in Echinococcus granulosus cyst fluid inhibit TLR4-mediated inflammatory responses via c-Raf显示文摘Cystic echinococcosis,which is caused by larval infection of Echinococcus granulosus(E.granulosus)sensu lato,is a widespread chronic cyst-forming helminthic disease that affects up to 3 million people.1 E.granulosus can actively divert the host immune response towards anergy and anti-inflammatory pathways.2 Previous studies have shown that E.granulosus can escape host immunosurveillance by modulating the maturation of dendritic cells(DCs).3,4 Nevertheless,how E.granulosus,an extracellular pathogen,modulates the inflammatory response in DCs remains poorly understood.In this study,we investigated the effects of E.granulosus cyst fluid(EgCF)on bone marrow-derived DCs(BMDCs)exposed to LPS,an inflammatory stimulus,and the mechanisms involved in the EgCF–DCs immune modulation. | Jun Hou Linlin Li Dan Dong Lianghai Wang Xian Wang Kun Yang Xiaodan Xu Congzhe Chen Xiangwei Wu Xueling Chen | 2020 | Cellular & Molecular Immunology2020，17，4： | 3 |
| 9 | Development of Biomimetic Needle-like Apatite Nanocrystals by a Simple New Method显示文摘A new method of calcium nitrate and sodium phosphate as reactants was employed to prepare biomimetic apatite nanocrystals by a simple heating treatment in water. The structure and properties of the apatite crystals were investigated by TEM, XRD, IR, ICP and TG. It is found that the apatite nanocrystals contain OH-, CO32-, Na+ and HPO^- ions in their crystal structure. The crystal water is removed during heating from 200℃ to 400℃. CO32-and HPO^- are decomposed at 600℃ to 800℃, also there is lattice water lost at this temperature stage. The morphology of the apatite nanocrystals is needle-like with a length less than 80 nm. The size and crystallinity of the apatite nanocrystals increase with water treatment temperature and time. Compared to the apatite crystals sintered at 800℃, water treated apatite nanocrystals are poorly crystallized apatite. The results indicate that the apatite nanocrystals have similarity in composition, structure, morphology and crystallinity to that of bone apatite crystals. It can be used to make apatite crystals/polymer biomimetic bone repair materials or for other biomedical applications. | Jie WEI, Yubao LI, Yi ZUO, Xueling PENG and Li ZHANGResearch Center for Nano-Biomaterials, Sichuan University, Chengdu 610064, China | 2004 | Journal of Materials Science & Technology2004，20，6： | 2 |
| 10 | Optimization for quantification of sorghum tannins by Ferric ammonium citrate assay显示文摘Due to the complexity of structure,it is difficult to determine the content of sorghum tannins.The current method for the determination of sorghum tannins is the Ferric ammonium citrate assay described in ISO 9648.However,the standard tannic acid(TA)used in the ISO 9648 method is significantly different in both structure and dynamics from sorghum tannins,resulting in inaccurate quantitative result.Furthermore,the extraction solvent,75%dimethylformamide(DMF),used in each step of this method had large toxicity to human.Hence,the objective of this study is to optimize the ISO 9648 method by selecting proper standard and extraction solvents so as to enhance the accuracy and safety.In this study,Sephadex LH-20 chromatography combined with high pressure liquid chromatography was used to purify and identify the extracted sorghum tannin(ST).Then,commercial TA,epicatechin(EA),grape seed procyanidin(PA)were selected as the standard and ST was used as reference for Ferric ammonium citrate assay to compare the effects of the three standards.Furthermore,the extraction rates of sorghum tannins in the presence of several low toxic solvents,such as absolute ethanol,absolute methanol,70%ethanol solution,70%methanol solution and 70%acetone solution,were compared to determine the alternative solvents of 75%DMF solution.The results showed that PA was superior to TA and EA in structure,with satisfactory color yield close to ST,and higher accuracy than TA.In terms of the extraction solvent,70%acetone solution was selected to replace 75%DMF solution because of its higher extraction yield(only next to 75%DMF)and low toxicity.Verification experiment results showed that both the recovery rate and the repeatability of the optimized method met the requirements of AOCO.Moreover,the optimized method,with higher accuracy and safety than the ISO 9648 method,can be applied widely in laboratory. | Xujuan Wang Xiaoxian Han Limin Li Xueling Zheng | 2020 | Grain & Oil Science and Technology2020，3，4： | 2 |
| 11 | A Critical Role of Activin A in Maturation of Mouse Peritoneal Macrophages in vitro and in vivo显示文摘Activin A,转变生长因素贝它(TGF-) 的一个多功能的因素总科,被 microglia 和巨噬细胞主要生产,并且它的反煽动性并且支持 inflammatory 活动是与巨噬细胞功能有关的两个。然而,在 vivo 的剩余的巨噬细胞上的 activin A 的直接效果仍然保持不清楚。在现在的学习,结果显示出那 activin A 不仅不增加了并且 IL-1 版本,而且在 vitro 并且在 vivo 的鼠标腹巨噬细胞的支持的吞噬细胞的能力,而它没影响 MHC 我和 MHC II 表示。而且,我们显著地发现那 activin A upregulated CD14 和 CD68 的表情,成熟巨噬细胞的标记,在在 vitro 并且在 vivo 的巨噬细胞的表面上。这些数据建议 activin A 能在 vitro 并且在 vivo 导致主要巨噬细胞成熟,但是不能经由调整涉及抗原的表示的 MHC 分子的表示触发获得的有免疫力的反应。 | Yinan Wang Xueling Cui Guixiang Tai Jingyan Ge Nan Li Fangfang Chen Fang Yu Zhonghui Liu | 2009 | Cellular & Molecular Immunology2009，6，5： | 2 |
| 12 | Resveratrol suppresses P-selectin, PSGL-1, and VWF through SIRT1 signaling pathway显示文摘 | Zhenkai Lou Kaili Du Tingting Wang Xueling Zhao Xingguo Li Bing Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，9： | 2 |
| 13 | Finite-time stabilization of switched linear systems with nonlinear saturating actu- ators 显示文摘 | Lin Xiangze Li Xueling Zou Yun | 2014 | Journal of the Franklin Institute2014，351，6： | 1 |
| 14 | Erratum to Simultaneous inhibition of PI3Kα and CDK4/6synergistically suppresses KRAS-mutated non-small cell lung cancer显示文摘In the published Figure 11,errors appeared in Figure 1B on page 69.In Figure 1B,bands for p-Akt S473,Akt,and Actin in H1355 cells were mistakenly placed.Here,we have updated Figure 1B to correct the mistake above.The errors do not impact the conclusions of this article.We apologize for the errors and for any confusion it may have caused. | Yuxiang Wang Xian Li Xueling Liu Yi Chen Chunhao Yang Cun Tan Bobo Wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding Linghua Meng | 2019 | Cancer Biology & Medicine2019，16，4： | 1 |
| 15 | Inheritance and mapping of male sterility restoration gene in upland japonica restorer lines显示文摘 | Dayun Tao Peng Xu Jing Li Fengyi Hu Youqiong Yang Jiawu Zhou XueLing Tan Monty P. Jones | 2004 | Euphytica2004，，3： | 1 |
| 16 | Compressive behavior and rate-controlling mechanisms of ultrafine grained copper over wide temperature and strain rate ranges显示文摘 | Tao Suo Yulong Li Feng Zhao Xueling Fan Weiguo Guo | 2013 | Mechanics of Materials2013，，： | 1 |
| 17 | Equilibrium, thermodynam- ics and breakthrough studies for adsorption of solanesol ontomacroporous resins显示文摘 | Du Xueling Yuan Qipeng Li Ye | 2008 | Chem Eng Processing2008，47，8： | 1 |
| 18 | Preparation of CaO–Al 2 O 3 –SiO 2 glass ceramics from coal gangue显示文摘 | Mei Yang Zhixing Guo Yinsheng Deng Xueling Xing Kehui Qiu Jianping Long Junfeng Li | 2011 | International Journal of Mineral Processing2011，，： | 1 |
| 19 | Inhibition of Sca-1-Positive Skeletal Stem Cell Recruitment by Alendronate Blunts the Anabolic Effects of Parathyroid Hormone on Bone Remodeling显示文摘 | Xiangwei Wu Lijuan Pang Weiqi Lei William Lu Jun Li Zhaoyang Li Frank J. Frassica Xueling Chen Mei Wan Xu Cao | 2010 | Cell Stem Cell2010，，5： | 1 |
| 20 | Genotypic and Phenotypic Characterization of HIV-1 CRF01_AE env Molecular Clones From Infections in China显示文摘 | Jianhui Nie Chuntao Zhang Wei Liu Xueling Wu Feng Li Suting Wang Fuxiong Liang Aijing Song Youchun Wang | 2010 | JAIDS Journal of Acquired Immune Deficiency Syndromes2010，，4： | 1 |
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