|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Global profiling of crotonylation on non-histone proteins显示文摘 | Weizhi Xu Junhu Wan Jun Zhan Xueying Li Huiying He Zhaomei Shi Hongquan Zhang | 2017 | Cell Research2017，27，7： | 7 |
| 2 | Triblock copolymer-assisted construction of 20 nm-sized ytterbium-doped TiO_2 hollow nanostructures for enhanced solar energy utilization efficiency显示文摘Rare-earth doped titania single-crystalline hollow nanoparticles of 20 nm are constructed via a simple sol-gel process. Amphiphilic ABA tri-block copolymers played a key role in assisting the formation of hollow structure, for which a hollow nanostructure growth mechanism is proposed. By introducing rare earth into the synthesis process, the as-prepared nanoparticles exhibit near-infrared light absorption properties. Photo-decomposition efficiency of Orange II azo dye can be successfully evaluated when using Yb3+-doped Ti O2 hollow nanoparticles as photocatalysts; it is more than two times higher than the pure Ti O2 hollow nanoparticles. The hollow nanostructured Yb3+-doped Ti O2 samples are exploited as photoanodes in N719- sensitized solar cells and prove able to improve the photoelectric conversion efficiency by measuring the solar cell parameters of dye-sensitized solar cells(DSSCs) under simulative sunlight. | Lin Cheng Xuefeng Xu Yuyan Fang Yan Li Jiaxi Wang Guojia Wan Xueying Ge Liangjie Yuan Keli Zhang Lei Liao Quan Yuan | 2015 | Science China Chemistry2015，58，5： | 2 |
| 3 | Pasteurella multocida capsular:lipopolysaccharide types D:L6 and A:L3 remain to be the main epidemic genotypes of pigs in China显示文摘Pasteurella multocida is a leading cause of respiratory disorders in pigs.This study was designed to understand the genotypical and antimicrobial resistant characteristics of P.multocida from pigs in China.To achieve this,we briefly investigated 158 P.multocida isolates from pigs with respiratory disorders in China between 2019 and 2020.Genotyping through multiplex PCR assays assigned these 158 isolates into capsular genotypes A(60.13%,95/158),D(35.44%,56/158),F(4.43%,7/158),and/or lipopolysaccharide(LPS)genotypes L3(28.48%,45/158)and L6(66.46%,105/158).In addition,eight isolates(5.06%,8/158)were found to be nontypable using the LPS genotyping method.When combining the capsular genotypes and the LPS genotypes,D:L6(34.81%,55/158)and A:L6(31.65%,50/158)were the predominant genotypes,followed by A:L3(24.05%,38/158).PCR detection of virulence factor-encoding genes showed that over 80%of the isolates were positive for exbB,tonB,exbD,ompH,ptfA,fimA,sodA,sodC,fur,ompA,oma87,plpB,hsf-2,nanH and hgbB,suggesting the presence of these genes were broad characteristics of P.multocida.We also found approximately 63.92%(101/158),51.27%(81/158),8.86%(14/158),7.59%(12/158),3.16%(5/158),0.63%(1/158),and 0.63%(1/158)of the isolates grew well in media with the presence of colistin(4μg/mL),tetracycline(16μg/mL),tigecycline(1μg/mL),ampicillin(32μg/mL),chloramphenicol(32μg/mL),cefepime(16μg/mL),and ciprofloxacin(1μg/mL),respectively.This study contributes to the understanding of genotypes and antimicrobial resistance profile of P.multocida currently circulation in pigs of China. | Songtao Liu Lin Lin Hao Yang Wenqing Wu Long Guo Yue Zhang Fei Wang Xueying Wang Wenbo Song Lin Hua Wan Liang Xibiao Tang Huanchun Chen Zhong Peng Bin Wu | 2021 | Animal Diseases2021，1，4： | 1 |
| 4 | Recent Advances in Fatigue Detection Algorithm Based on EEG显示文摘Fatigue is a state commonly caused by overworked,which seriously affects daily work and life.How to detect mental fatigue has always been a hot spot for researchers to explore.Electroencephalogram(EEG)is considered one of the most accurate and objective indicators.This article investigated the devel-opment of classification algorithms applied in EEG-based fatigue detection in recent years.According to the different source of the data,we can divide these classification algorithms into two categories,intra-subject(within the same sub-ject)and cross-subject(across different subjects).In most studies,traditional machine learning algorithms with artificial feature extraction methods were com-monly used for fatigue detection as intra-subject algorithms.Besides,deep learn-ing algorithms have been applied to fatigue detection and could achieve effective result based on large-scale dataset.However,it is difficult to perform long-term calibration training on the subjects in practical applications.With the lack of large samples,transfer learning algorithms as a cross-subject algorithm could promote the practical application of fatigue detection methods.We found that the research based on deep learning and transfer learning has gradually increased in recent years.But as afield with increasing requirements,researchers still need to con-tinue to explore efficient decoding algorithms,design effective experimental para-digms,and collect and accumulate valid standard data,to achieve fast and accurate fatigue detection methods or systems to further widely apply. | Fei Wang Yinxing Wan Man Li Haiyun Huang Li Li Xueying Hou Jiahui Pan Zhenfu Wen Jingcong Li | 2023 | Intelligent Automation & Soft Computing2023，，3： | 1 |
| 5 | Single site catalyst with enzyme-mimic micro-environment for electroreduction of CO_(2)显示文摘Single site catalysts provide a unique platform for mimicking natural enzyme due to their tunable interaction between metal center and coordinated ligand.However,most works have focused on preparing structural and functional models of nature enzyme,with less reports also taking the local chemical environment,i.e.,functional/catalytic residues around the active site which is an essential feature of enzymes,into consideration.Herein,we report a Co-centered porphyrinic polymer containing the enzyme-mimic micro-environment,where the linker triazole over CoN4 site enables formation of hydrogen bond with the*COOH intermediate,thus promoting the electrocatalytic reduction of CO_(2).As-prepared catalyst achieves the CO_(2)-to-CO conversion of 5,788 h^(−1) turnover frequency value and near unit(~96%)faradaic efficiency at−0.61 V versus reversible hydrogen electrode.This strategy will bring new dimension of designing highly active single-site catalysts. | Chang Long Kaiwei Wan Xueying Qiu Xiaofei Zhang Jianyu Han Pengfei An Zhongjie Yang Xiang Li Jun Guo Xinghua Shi Hui Wang Zhiyong Tang Shaoqin Liu | 2022 | Nano Research2022，15，3： | 1 |
| 6 | Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23显示文摘Osteocytes act within a hypoxic environment to control key steps in bone formation.FGF23,a critical phosphate-regulating hormone,is stimulated by low oxygen/iron in acute and chronic diseases,however the molecular mechanisms directing this process remain unclear.Our goal was to identify the osteocyte factors responsible for FGF23 production driven by changes in oxygen/iron utilization.Hypoxia-inducible factor-prolyl hydroxylase inhibitors(HIF-PHI)which stabilize HIF transcription factors,increased Fgf23 in normal mice,as well as in osteocyte-like cells;in mice with conditional osteocyte Fgf23 deletion,circulating i FGF23 was suppressed.An inducible MSC cell line(‘MPC2’)underwent FG-4592 treatment and ATACseq/RNAseq,and demonstrated that differentiated osteocytes significantly increased HIF genomic accessibility versus progenitor cells.Integrative genomics also revealed increased prolyl hydroxylase Egln1(Phd2)chromatin accessibility and expression,which was positively associated with osteocyte differentiation.In mice with chronic kidney disease(CKD),Phd1-3 enzymes were suppressed,consistent with FGF23 upregulation in this model.Conditional loss of Phd2 from osteocytes in vivo resulted in upregulated Fgf23,in line with our findings that the MPC2 cell line lacking Phd2(CRISPR Phd2-KO cells)constitutively activated Fgf23 that was abolished by HIF1αblockade.In vitro,Phd2-KO cells lost iron-mediated suppression of Fgf23 and this activity was not compensated for by Phd1 or-3.In sum,osteocytes become adapted to oxygen/iron sensing during differentiation and are directly sensitive to bioavailable iron.Further,Phd2 is a critical mediator of osteocyte FGF23 production,thus our collective studies may provide new therapeutic targets for skeletal diseases involving disturbed oxygen/iron sensing. | Megan L.Noonan Pu Ni Emmanuel Solis Yamil G.Marambio Rafiou Agoro Xiaona Chu Yue Wang Hongyu Gao Xiaoling Xuei Erica L.Clinkenbeard Guanglong Jiang Sheng Liu Steve Stegen Geert Carmeliet William R.Thompson Yunlong Liu Jun Wan Kenneth E.White | 2023 | Bone Research2023，11，1： | 1 |
| 7 | Optimization of bike-sharing parking spot layout based on usage requirements显示文摘In this paper,two problems that exist in parking spot layout of bike-sharing which need to be solved are addressed.One is the size of parking spot,while another is the location of parking spot.First,the generation and attraction model of traffic travel is used to predict the usage requirements of bike-sharing,to acquire the parking requirements of bike-sharing.Then,we establish the best station spacing model to calculate the optimal quantity of parking spots.Moreover,the method of shortest distance clustering is applied to cluster the parking demand spots.Finally,the location optimization of bike-sharing parking spot is carried out by using gravity location model.In summary,the layout of bike-sharing parking spot is finished based on the abovementioned four steps. | Di Sun Jin Zhou Furong Wan Zhiqiang Sun Xueying Gao | 2020 | International Journal of Modeling, Simulation, and Scientific Computing2020，11，1： | 0 |
| 8 | 2 - 30 Progress in Analyzing RIBLL1 17F+p Experimental Data显示文摘 | He Jianjun Hu Jun Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Zhang Xueheng Su Jun Li Ertao Hu Zhengguo Guo Zhongyan Xu Xing Yuan Xiaohua Lu Wan Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu Hushan | 2010 | IMP & HIRFL Annual Report2010，，1： | 0 |
| 9 | Interface-enhanced thermoelectric output power in CrN/SrTiO_(3-x) heterostructure显示文摘Thermoelectric devices enable direct conversion between thermal and electrical energy.Recent studies have indicated that the thin film/substrate heterostructure is effective in achieving high thermoelectric performance via decoupling the Seebeck coefficient and electrical conductivity otherwise adversely inter-dependent in homogenous bulk materials.However,the mechanism underlying the thin film/substrate heterostructure thermoelectricity remains unclear.In addition,the power output of the thin film/substrate heterostructure is limited to the nanowatt scale to date,falling short of the practical application requirement.Here,we fabricated the CrN/SrTiO_(3-x) heterostructures with high thermoelectric output power and outstanding thermal stability.By varying the CrN film thickness and the reduction degree of CrN/SrTiO_(3-x) substrate,the optimized power output and the power density have respectively reached 276μWand 10^(8) mW/cm^(2) for the 30 nm CrN film on a highly reduced surface of CrN/SrTiO_(3-x) under a temperature difference of 300 K.The performance enhancement is attributed to the CrN/CrN/SrTiO_(3-x) heterointerface,corroborated by the band bending as revealed by the scanning Kelvin probe microscopy.These results will stimulate further research efforts towards interface thermoelectrics. | Xueying Wan Xiaowei Lu Lin Sun Mingyu Chen Na Ta Wei Liu Qi Chen Liwei Chen Jian He Peng Jiang Xinhe Bao | 2022 | Journal of Energy Chemistry2022，31，1： | 0 |
| 10 | Carboxylesterase genes in nitenpyram-resistant brown planthoppers,Nilaparvata lugens显示文摘Carboxylesterases(CarEs)represent one of the major detoxification enzyme families involved in insecticide resistance.However,the function of specific CarE genes in insecticide resistance is still unclear in the insect Nilaparvata lugens(Stål),a notorious rice crop pest in Asia.In this study,a total of 29 putative CarE genes in N.lugens were identified,and they were divided into seven clades;further,theβ-esterase clade was significantly expanded.Tissue-specific expression analysis found that 17 CarE genes were abundantly distributed in the midgut and fat body,while 12 CarE genes were highly expressed in the head.The expression of most CarE genes was significantly induced in response to the challenge of nitenpyram,triflumezopyrim,chlorpyrifos,isoprocarb and etofenprox.Among these,the expression levels of NlCarE2,NlCarE4,NlCarE9,NlCarE17 and NlCarE24 were increased by each insecticide.Real-time quantitative polymerase chain reaction and RNA interference assays revealed the NlCarE1 gene to be a candidate gene mainly involved in nitenpyram resistance,while simultaneously silencing NlCarE1 and NlCarE19 produced a stronger effect than silencing either one individually,suggesting a cooperative relationship in resistance formation.These findings lay the foundation for further clarification of insecticide resistance mediated by CarE in N.lugens. | Kaikai Mao Zhijie Ren Wenhao Li Tingwei Cai Xueying Qin Hu Wan Byung Rae Jin Shun He Jianhong Li | 2021 | Insect Science2021，28，4： | 0 |
| 11 | Creation of cytochrome P450 catalysis depending on a non-natural cofactor for fatty acid hydroxylation显示文摘Cytochrome P450 enzymes catalyze diverse oxidative transformations at the expense of reduced nicotinamide adenine dinucleotide phosphate(NADPH),however,their applications remain limited largely because NADPH is cost-prohibitive for biocatalysis at scale yet tightly regulated in host cells.A highly challenging task for P450 catalysis has been to develop an alternative and biocompatible electrondonating system.Here we engineered P450 BM3 to favor reduced nicotinamide cytosine dinucleotide(NCDH)and created non-natural cofactor-dependent P450 catalysis.Two outstanding mutants were identified with over 640-fold NCDH preference improvement and good catalytic efficiencies of over15,000 M^(-1)s^(-1)for the oxidation of the fatty acid probe 12-(para-nitrophenoxy)-dodecanoate.Molecular docking analysis indicated that these mutants bear a compacted cofactor entrance.Upon fusing with an NCD-dependent formate dehydrogenase,fused proteins functioned as NCDH-specific P450catalysts by using formate as the electron donor.Importantly,these mutants and fusions catalyzed NCDH-dependent hydroxylation of fatty acids with similar chain length preference to those by natural P450 BM3 in the presence of NADPH and also similar regioselectivity for subterminal hydroxylation of lauric acid.As P450 BM3 and its variants are catalytically powerful to take diverse substrates and convey different reaction paths,our results offer an exciting opportunity to devise advanced cell factories that convey oxidative biocatalysis with an orthogonal reducing power supply system. | Qing Li Xiaojia Guo Xueying Wang Junting Wang Li Wan Haizhao Xue Zongbao K.Zhao | 2023 | Journal of Energy Chemistry2023，，4： | 0 |
| 12 | Whole-exome sequencing of a multicenter cohort identifies genetic changes associated with clinical phenotypes in pediatric nephrotic syndrome显示文摘Understanding the association between the genetic and clinical phenotypes in children with nephrotic syndrome(NS)of different etiologies is critical for early clinical guidance.We employed whole-exome sequencing(WES)to detect monogenic causes of NS in a multicenter cohort of 637 patients.In this study,a genetic cause was identified in 30.0%of the idiopathic steroid-resistant nephrotic syndrome(SRNS)patients.Other than congenital nephrotic syndrome(CNS),there were no significant differences in the incidence of monogenic diseases based on the age at manifestation.Causative mutations were detected in 39.5%of patients with focal segmental glomerulosclerosis(FSGS)and 9.2%of those with minimal change disease(MCD).In terms of the patterns in patients with different types of steroid resistance,a single gene mutation was identified in 34.8%of patients with primary resistance,2.9%with secondary resistance,and 71.4%of children with multidrug resistance.Among the various intensified immunosuppressive therapies,tacrolimus(TAC)showed the highest response rate,with 49.7%of idiopathic SRNS patients achieving complete remission.Idiopathic SRNS patients with monogenic disease showed a similar multidrug resistance pattern,and only 31.4%of patients with monogenic disease achieved a partial remission on TAC.During an average 4.1-year follow-up,21.4%of idiopathic SRNS patients with monogenic disease progressed to end-stage renal disease(ESRD).Collectively,this study provides evidence that genetic testing is necessary for presumed steroid-resistant and idiopathic SRNS patients,especially those with primary and/or multidrug resistance. | Jia Jiao Li Wang Fenfen Ni Mo Wang Shipin Feng Xiaojie Gao Han Chan Xueying Yang Hao Lee Huan Chi Xuelan Chen Daoqi Wu Gaofu Zhang Baohui Yang Anshuo Wang Qin Yang Junli Wan Sijie Yu Xiaoqin Li Mei Wang Xiaofeng Chen Xianying Mai Xiongzhong Ruan Haiping Yang Qiu Li | 2022 | Genes & Diseases2022，9，6： | 0 |
| 13 | Palladium single atoms from melting nanoparticles on WO_(3-x)for boosted hydrogen evolution reaction显示文摘Surface-supported isolated atoms in single-atom catalysts(SACs)grant maximum utilization of metals in heterogeneous catalysis.Herein,we report a feasible pyrolysis strategy to synthesize Pd single atoms by thermally melting Pd nanoparticles on an oxygen-vacancy-rich tungsten-oxide matrix at reduction atmosphere.Near ambient pressure X-ray photoelectron spectroscopy was used to monitor the formation of zero-valence Pd single atoms and the increased metallic feature of WO_(3-x)substrate.Accordingly,the as-obtained zero-valence Pd single-atom catalyst exhibits a markedly boosted HER activity with a low overpotential(η_(10)=70 mV)at the current density of 10 mA/cm2and a small Tafel slope(b=68 mV/dec),nearly 150 mV and a 3,0-fold enhancement than those of Pd nanoparticles(η_(10)=220 mV,b=133 mV/dec)under the same conditions.In addition,quasi in situ XPS results suggest the hydrogen spillover effect is more likely to occur on Pd single atoms during the electrochemical process.Our work may pave an interesting route for the rational design of highly-efficient single-atom catalysts,and the elucidation of corresponding enhanced reaction mechanisms by the utilization of advanced characterization techniques. | Zhongmiao Gong Zhigang Chen Hao Li Guang Yang Min Yuan Zhiyun Li Xueying Wan Yi Cui | 2024 | Journal of Energy Chemistry2024，91，4： | 0 |
| 14 | Investigation of Proton Resonant Properties in laNe via 17F+p and Its Astrophysical Implications for 14O(α,p)17F Stellar Reaction显示文摘 | Hu Jun He Jianjun Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Yuan Xiaohua Lu Wan Zhang Xueheng SuJun Li Ertao Hu Zhengguo Guo Zhongya n Xu Xing Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu Hushan | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员