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| 1 | Impact of metastatic lymph node ratio in node-positive colorectal cancer显示文摘Colorectal cancer(CRC) is one of the most common malignant diseases in the world.Presently,the most widely used staging system for CRC is the tumor nodes metastasis classification system,which classifies patients into prognostic groups according to the depth of the primary tumor,presence of regional lymph node(LN) metastases,and evidence of distant metastatic spread.The number of LNs with confirmed metastasis is related to the severity of the disease,but this number depends on the number of LNs retrieved,which varies depending on patient age,tumor grade,surgical extent,and tumor site.Numerous studies and a recent structured review have demonstrated associated improvements in the survival of CRC patients with increasing numbers of LNs retrieved for examination.Hence,the impact of lymph node ratio(LNR),defined as the number of metastatic LNs divided by the number of LNs retrieved,has been investigated in various malignancies,including CRC.In this editorial,we review the literature demonstrating the clinicopathological significance of LNR in CRC pati-ents.Some reports have indicated the advantage of considering the LNR compared to the number of LNs retrieved and/or LN status.When the LNR is taken into consideration for survival analysis,the number of LNs retrieved and/or the LN status is not always found to be a prognostic factor.The cut-off points for LNRs were proposed in numerous studies.However,optimal thresholds for LNRs have not yet received consensus.It is still unclear whether the LNR has more prognostic validity than N stage.For all these reasons,the potential advantages of LNRs in the staging system should be investigated in large prospective data sets. | Shingo Noura Masayuki Ohue Shingo Kano Tatsushi Shingai Terumasa Yamada Isao Miyashiro Hiroaki Ohigashi Masahiko Yano Osamu Ishikawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，3： | 7 |
| 2 | Endoscopic diagnosis for colorectal sessile serrated lesions显示文摘BACKGROUND Hyperplastic polyps are considered non-neoplastic, whereas sessile serrated lesions(SSLs) are precursors of cancer via the ‘‘serrated neoplastic pathway’’. The clinical features of SSLs are tumor size(> 5 mm), location in the proximal colon, coverage with abundant mucus called the ‘‘mucus cap’’, indistinct borders, and a cloud-like surface. The features in magnifying narrow-band imaging are varicose microvascular vessels and expanded crypt openings. However, accurate diagnosis is often difficult.AIM To develop a diagnostic score system for SSLs.METHODS We retrospectively reviewed consecutive patients who underwent endoscopic resection during colonoscopy at the Toyoshima endoscopy clinic. We collected data on serrated polyps diagnosed by endoscopic or pathological examination. The significant factors for the diagnosis of SSLs were assessed using logistic regression analysis. Each item that was significant in multivariate analysis was assigned 1 point, with the sum of these points defined as the endoscopic SSL diagnosis score. The optimal cut-off value of the endoscopic SSL diagnosis score was determined by receiver-operating characteristic curve analysis.RESULTS Among 1288 polyps that were endoscopically removed, we analyzed 232 diagnosed as serrated polyps by endoscopic or pathological examination. In the univariate analysis, the location(proximal colon), size(> 5 mm), mucus cap, indistinct borders, cloud-like surface, and varicose microvascular vessels were significantly associated with the diagnosis of SSLs. In the multivariate analysis, size(> 5 mm;P = 0.033), mucus cap(P = 0.005), and indistinct borders(P = 0.033) were independently associated with the diagnosis of SSLs. Size > 5 mm, mucus cap, and indistinct borders were assigned 1 point each and the sum of these points was defined as the endoscopic SSL diagnosis score. The receiver-operating characteristic curve analysis showed an optimal cut-off score of 3, which predicted pathological SSLs with 75% sensitivity, 80% specificity, and 78.4% accuracy. The pathological SSL rate for an endoscopic SSL diagnosis score of 3 was significantly higher than that for an endoscopic SSL diagnosis score of 0, 1, or 2(P < 0.001).CONCLUSION Size > 5 mm, mucus cap, and indistinct borders were significant endoscopic features for the diagnosis of SSLs. Serrated polyps with these three features should be removed during colonoscopy. | Toshihiro Nishizawa Shuntaro Yoshida Akira Toyoshima Tomoharu Yamada Yoshiki Sakaguchi Taiga Irako Hirotoshi Ebinuma Takanori Kanai Kazuhiko Koike Osamu Toyoshima | 2021 | World Journal of Gastroenterology2021，27，13： | 7 |
| 3 | 劳力士学习中心显示文摘日本SANAA事务所设计的劳力士学习中心于2010年的2月22日开放。SANAA (Sejima And Nishizawa And Associates)是由建筑师妹岛和世和西泽立卫两人共同成立的建筑事务所,该事务所设计的劳力士学习中心建筑新颖大胆而且具有高度的实验性质,向人们展示了21世纪人类新的学习方式和交互性影响的意义。作为瑞士洛桑联邦理工学院(EPFL)的一部分, | Yumiko Yamada Rikiya Yamamoto Osamu Kato Naoto Noguchi Mizuko Kaji Takayuki Hasegawa Louis-Antoine Grego Tetsuo Kondo Matthias Haertel Catarina Canas 朱晓琳 | 2010 | 建筑技艺2010，16，5： | 6 |
| 4 | Feasibility and safety of laparoscopic and endoscopic cooperative surgery for gastric submucosal tumors, including esophagogastric junction tumors显示文摘 | Shu Hoteya Shusuke Haruta Hisashi Shinohara Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Daisuke Kikuchi Toshifumi Mitani Osamu Ogawa Akira Matsui Toshiro Iizuka Harushi Udagawa Mitsuru Kaise | 2014 | Digestive Endoscopy2014，，4： | 4 |
| 5 | Preoperative Gemcitabine-Based Chemoradiation Therapy for Resectable and Borderline Resectable Pancreatic Cancer显示文摘 | Hidenori Takahashi Hiroaki Ohigashi Kunihito Gotoh Shigeru Marubashi Terumasa Yamada Masayuki Murata Tatsuya Ioka Hiroyuki Uehara Masahiko Yano Osamu Ishikawa | 2013 | Annals of Surgery2013，，6： | 3 |
| 6 | Enlarged folds on endoscopic gastritis as a predictor for submucosal invasion of gastric cancers显示文摘BACKGROUND Accurate diagnosis of the depth of gastric cancer invasion is crucial in clinical practice.The diagnosis of gastric cancer depth is often made using endoscopic characteristics of the tumor and its margins;however,evaluating invasion depth based on endoscopic background gastritis remains unclear.AIM To investigate predicting submucosal invasion using the endoscopy-based Kyoto classification of gastritis.METHODS Patients with gastric cancer detected on esophagogastroduodenoscopy at Toyoshima Endoscopy Clinic were enrolled.We analyzed the effects of patient and tumor characteristics,including age,sex,body mass index,surveillance endoscopy within 2 years,current Helicobacter pylori infection,the Kyoto classification,and Lauren’s tumor type,on submucosal tumor invasion and curative endoscopic resection.The Kyoto classification included atrophy,intestinal metaplasia,enlarged folds,nodularity,and diffuse redness.Atrophy was characterized by non-reddish and low mucosa.Intestinal metaplasia was detected as patchy whitish or grayish-white flat elevations,forming an irregular uneven surface.An enlarged fold referred to a fold width≥5 mm in the greater curvature of the corpus.Nodularity was characterized by goosebump-like multiple nodules in the antrum.Diffuse redness was characterized by uniform reddish nonatrophic mucosa in the greater curvature of the corpus.RESULTS A total of 266 gastric cancer patients(mean age,66.7 years;male sex,58.6%;mean body mass index,22.8 kg/m2)were enrolled.Ninety-three patients underwent esophagogastroduodenoscopy for surveillance within 2 years,and 140 had current Helicobacter pylori infection.The mean Kyoto score was 4.54.Fifty-eight cancers were diffuse-type,and 87 cancers had invaded the submucosa.Multivariate analysis revealed that low body mass index(odds ratio 0.88,P=0.02),no surveillance esophagogastroduodenoscopy within 2 years(odds ratio 0.15,P<0.001),endoscopic enlarged folds of gastritis(odds ratio 3.39,P=0.001),and Lauren’s diffuse-type(odds ratio 5.09,P<0.001)were independently associated with submucosal invasion.Similar results were obtained with curative endoscopic resection.Among cancer patients with enlarged folds,severely enlarged folds(width≥10 mm)were more related to submucosal invasion than mildly enlarged folds(width 5-9 mm,P<0.001).CONCLUSION Enlarged folds of gastritis were associated with submucosal invasion.Endoscopic observation of background gastritis as well as the lesion itself may help diagnose the depth of cancer invasion. | Osamu Toyoshima Shuntaro Yoshida Toshihiro Nishizawa Akira Toyoshima Kosuke Sakitani Tatsuya Matsuno Tomoharu Yamada Takashi Matsuo Hayato Nakagawa Kazuhiko Koike | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，9： | 2 |
| 7 | Successful embolization assisted by covered stents for a pseudoaneurysm following pancreatic surgery显示文摘Delayed intra-abdominal hemorrhage after pancreatic surgery is a potentially lethal complication.Transarterial coil embolization and/or the placing of an endovascular stent are minimally invasive and effective procedures.An artery that is extensively eroded and rendered friable due to operative skeletonization or postoperative inflammation sometimes contributes to delayed intra-abdominal hemorrhage or rebleeding after coil embolization.This report presents a case of successful management of postoperative hemorrhage in a-74-year-old Japanese male.He experienced bleeding from a pseudoaneurysm of the brittle hepatic artery following total pancreatectomy.Initially the pseudoaneurysm was successfully treated with covered coronary stent-grafts,but rebleeding occurred 1 mo later due to the brittleness of the artery.Rebleeding was definitively managed by the complete packing of the stent by coil embolization.He remains stable at 18 mo following the f inal embolization.A stent graft can be used for protecting a brittle artery to avoid injury by coil embolization. | Koji Tanaka Hiroaki Ohigashi Hidenori Takahashi Kunihito Gotoh Terumasa Yamada Isao Miyashiro Masahiko Yano Osamu Ishikawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，9： | 2 |
| 8 | Usefulness of Magnifying Endoscopy with Narrow-Band Imaging for Determining Tumor Invasion Depth in Early Gastric Cancer显示文摘 | Daisuke Kikuchi Toshiro Iizuka Shu Hoteya Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Kaoru Domon Masanori Nakamura Akira Matsui Toshifumi Mitani Osamu Ogawa Sumio Watanabe Mitsuru Kaise Guido Schumacher | 2013 | Gastroenterology Research and Practice2013，，： | 2 |
| 9 | Endoscopic submucosal dissection for nonampullary large superficial adenocarcinoma/adenoma of the duodenum: feasibility and long-term outcomes显示文摘 | Shu Hoteya Naohisa Yahagi Toshiro Iizuka Daisuke Kikuchi Toshifumi Mitani Akira Matsui Osamu Ogawa Satoshi Yamashita Tsukasa Furuhata Akihiro Yamada Ryusuke Kimura Kosuke Nomura Yasutaka Kuribayashi Mitsuru Kaise | 2013 | EIO2013，，01： | 2 |
| 10 | Kyoto classification in patients who developed multiple gastric carcinomas after Helicobacter pylori eradication显示文摘BACKGROUND Endoscopic Kyoto classification predicts gastric cancer risk;however,the score in the patients with primary gastric cancer after Helicobacter pylori(H.pylori)eradication therapy is unknown.AIM To elucidate the Kyoto classification score in patients with both single gastric cancer and multiple gastric cancers developed after H.pylori eradication.METHODS The endoscopist recorded the Kyoto classification at the endoscope and the Kyoto classification score at the time of the first diagnosis of gastric cancer after H.pylori eradication.The score was compared between single gastric cancer group and multiple gastric cancers group.RESULTS The Kyoto score at the time of diagnosis of 45 cases of gastric cancer after H.pylori eradication was 4.0 points in average.The score was 3.8 points in the single gastric cancer group,and 5.1 points in the multiple gastric cancers group.The multiple group had a significantly higher score than the single group(P=0.016).In the multiple gastric cancers group,all the patients(7/7)had 5 or higher Kyoto score,while in single gastric cancer group,the proportion of patients with a score of 5 or higher was less than half,or 44.7%(17/38).CONCLUSION Patients diagnosed with gastric cancer after H.pylori eradication tended to have advanced gastritis.In particular,in cases of multiple gastric cancers developed after H.pylori eradication,the endoscopic Kyoto classification score tended to be 5 or higher in patients with an open type atrophic gastritis and the intestinal metaplasia extended to the corpus. | Kosuke Sakitani Toshihiro Nishizawa Akira Toyoshima Shuntaro Yoshida Tatsuya Matsuno Tomoharu Yamada Masatoshi Irokawa Yoshiyuki Takahashi Yousuke Nakai Osamu Toyoshima Kazuhiko Koike | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，9： | 2 |
| 11 | Delayed bleeding after endoscopic submucosal dissection for non‐ampullary superficial duodenal neoplasias might be prevented by prophylactic endoscopic closure: Analysis of risk factors显示文摘 | Shu Hoteya Mitsuru Kaise Toshiro Iizuka Osamu Ogawa Toshifumi Mitani Akira Matsui Daisuke Kikuchi Tsukasa Furuhata Satoshi Yamashita Akihiro Yamada Ryusuke Kimura Kousuke Nomura Yasutaka Kuribayashi Yoshifumi Miyata Naohisa Yahagi | 2015 | Digestive Endoscopy2015，，3： | 2 |
| 12 | Real-Time Intraoperative Assessment of Residual Liver Functional Reserve Using Pulse Dye Densitometry显示文摘 | Hirofumi Akita Yo Sasaki Terumasa Yamada Kunihito Gotoh Hiroaki Ohigashi Hidetoshi Eguchi Masahiko Yano Osamu Ishikawa Shingi Imaoka | 2008 | World Journal of Surgery2008，，12： | 1 |
| 13 | Telomerase overexpression in K562 leukemia cells protects against apoptosis by serum deprivation and double-stranded DNA break inducing agents, but not against DNA synthesis inhibitors显示文摘 | Masaharu Akiyama Osamu Yamada Naotoshi Kanda Shinobu Akita Takeshi Kawano Tsuneya Ohno Hideaki Mizoguchi Yoshikatsu Eto Kenneth C Anderson Hisashi Yamada | 2002 | Cancer Letters2002，，2： | 1 |
| 14 | Prospective Study about the Utility of Endoscopic Ultrasound for Predicting the Safety of Endoscopic Submucosal Dissection in Early Gastric Cancer (T-HOPE 0801)显示文摘 | Daisuke Kikuchi Toshiro Iizuka Shu Hoteya Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Kaoru Domon Masanori Nakamura Akira Matsui Toshifumi Mitani Osamu Ogawa Mitsuru Kaise Everson L. A. Artifon | 2013 | Gastroenterology Research and Practice2013，，： | 1 |
| 15 | CEA-Antigen and SCC-Antigen mRNA Expression in Peripheral Blood Predict Hematogenous Recurrence After Resection in Patients with Esophageal Cancer显示文摘 | Koji Tanaka Masahiko Yano Masaaki Motoori Kentaro Kishi Isao Miyashiro Tatsushi Shingai Kunihito Gotoh Shingo Noura Hidenori Takahashi Masayuki Ohue Terumasa Yamada Hiroaki Ohigashi Takashi Yamamoto Tomoyuki Yamasaki Yuichiro Doki Osamu Ishikawa | 2010 | Annals of Surgical Oncology2010，，： | 1 |
| 16 | Texture and color enhancement imaging in magnifying endoscopic evaluation of colorectal adenomas显示文摘BACKGROUND Olympus Corporation has developed texture and color enhancement imaging(TXI)as a novel image-enhancing endoscopic technique.AIM To investigate the effectiveness of TXI in identifying colorectal adenomas using magnifying observation.METHODS Colorectal adenomas were observed by magnified endoscopy using white light imaging(WLI),TXI,narrow band imaging(NBI),and chromoendoscopy(CE).This study adopted mode 1 of TXI.Adenomas were confirmed by histological examination.TXI visibility was compared with the visibility of WLI,NBI,and CE for tumor margin,and vessel and surface patterns of the Japan NBI expert team(JNET)classification.Three expert endoscopists and three non-expert endoscopists evaluated the visibility scores,which were classified as 1,2,3,and 4.RESULTS Sixty-one consecutive adenomas were evaluated.The visibility score for tumor margin of TXI(3.47±0.79)was significantly higher than that of WLI(2.86±1.02,P<0.001),but lower than that of NBI(3.76±0.52,P<0.001),regardless of the endoscopist’s expertise.TXI(3.05±0.79)had a higher visibility score for the vessel pattern of JNET classification than WLI(2.17±0.90,P<0.001)and CE(2.47±0.87,P<0.001),but lower visibility score than NBI(3.79±0.47,P<0.001),regardless of the experience of endoscopists.For the visibility score for the surface pattern of JNET classification,TXI(2.89±0.85)was superior to WLI(1.95±0.79,P<0.01)and CE(2.75±0.90,P=0.002),but inferior to NBI(3.67±0.55,P<0.001).CONCLUSION TXI provided higher visibility than WLI,lower than NBI,and comparable to or higher than CE in the magnified observation of colorectal adenomas. | Osamu Toyoshima Toshihiro Nishizawa Shuntaro Yoshida Tomoharu Yamada Nariaki Odawara Tatsuya Matsuno Miho Obata Ken Kurokawa Chie Uekura Mitsuhiro Fujishiro | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，2： | 1 |
| 17 | Risk of Recurrence in a Long-term Follow-up After Surgery in 417 Patients With Hepatitis B- or Hepatitis C-Related Hepatocellular Carcinoma显示文摘 | Yo Sasaki Terumasa Yamada Hideo Tanaka Hiroaki Ohigashi Hidetoshi Eguchi Masahiko Yano Osamu Ishikawa Shingi Imaoka | 2006 | Annals of Surgery2006，，5： | 1 |
| 18 | Generation of hydrogen gas by reforming biomass with superheated steam 显示文摘 | Osamu Yamada | 2006 | Thin Solid Films2006，509，1： | 1 |
| 19 | The LDH (lactate dehydrogenase) method: a new technique to measure human natural killer activity 显示文摘 | Kita Masakazu Yamada Osamu Yamaji Masahiro | 1987 | Kyoto Pasuturu Kenkyusho Kenkyu Hokoku1987，1，： | 1 |
| 20 | Clinical features of isolated noncompaction of the ventricular myocardium显示文摘 | Fukiko Ichida Yuji Hamamichi Toshio Miyawaki Yasuo Ono Tetsuro Kamiya Teiji Akagi Hiromichi Hamada Osamu Hirose Takeshi Isobe Katsuhiko Yamada Shunji Kurotobi Hiroshi Mito Toshiharu Miyake Yasuo Murakami Takeshi Nishi Makoto Shinohara Masashi Seguchi Shin | 1999 | Journal of the American College of Cardiology1999，，1： | 1 |
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