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| 1 | Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma显示文摘瞄准:在整个 Barretts 食管的前进调查 cyclooxygenase-2 (COX-2 ) 和上皮的生长因素受体(EGFR ) 的表示() 。方法:COX-2 和 EGFR 蛋白质表情被使用免疫检测组织化学的方法。详细 cytomorphological 改变的 A 是坚定的。COX-2 和 EGFR 表示的区域被使用计算机成像系统确定。结果:COX-2 和 EGFR 的表情与前进一起增加了从到食管腺癌(EAC ) 。积极关联在 COX-2 表示和 EGFR 表示之间被发现。结论:COX-2 和 EGFR 可能在逐步的前进从是合作的到 EAC,从而导致致癌作用。 | Yan Li John M Wo Mukunda B Ray Whitney Jones Ruifeng R Su Susan Ellis Robert C G Martin | 2006 | World Journal of Gastroenterology2006，12，6： | 14 |
| 2 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 3 | 超导量子比特应用到量子随机行走显示文摘将对多体物理现象模拟和通用量子计算产生影响创新点量子随机行走利用量子叠加态的特性,粒子在格点中的行走特性需要用量子力学来诠释,是经典随机行走在量子力学中的拓展。中国科学技术大学潘建伟、朱晓波、彭承志等实验团队,联合中国科学院物理研究所范桁等理论团队,开创性地将超导量子比特应用到量子随机行走的研究中,实验上首次在固态量子计算系统中演示了强关联纠缠体系的量子随机行走,将对未来多体物理现象的模拟以及利用量子随机行走进行通用量子计算研究产生重要影响。 | YAN Z ZHANG Y R GONG M | 2019 | 张江科技评论2019，0，3： | 7 |
| 4 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 5 | Tolllike receptor2 m ediates lipopolysaccharides induced cellular signaling显示文摘 | Yan R B Mark M R Gray A | 1998 | Nature1998，395，： | 2 |
| 6 | Characterization of high-molecular weight glutenin subunit genes from Elytrigia elongate显示文摘 | Wang J R Yan Z H Wei Y M | 2006 | Plant Breeding2006，125，： | 1 |
| 7 | The fundamental principle and eco-techniques of wastewater aquaculture显示文摘 | Yan J Wang R Wang M | 1998 | Eco Eng1998，10，2： | 1 |
| 8 | Characterization and expression pattern of zebrafish anti-Mullerian hormone (AMH) relative to sox9a, sox9b, and cyp191a, during gonad development 显示文摘 | Adriana R M Yan Y L Ruth A B | 2005 | Gene Expression Patterns2005，5，： | 1 |
| 9 | Preparation and comparison of supported gold nanocatalysts on anatase, brookite, rutile, and P25 polymorphs of TiO2 for catalytic oxidation of CO 显示文摘 | Yan Wenfu Chen Bei Mahurin S M Schwartz V Mullins D R Lupini R Andrew Pennycook S J Dai Sheng Overbury S H | 2005 | Journal of Physical Chemistry B2005，109，10： | 1 |
| 10 | IrrE, a global regulator of extreme radiation resistance inDeinococcus radiodurans, enhances salt tolerance in Escherichia coli and Brassica napus显示文摘 | Pan J Wang J Zhou Z Yan Y Zhang W Lu W Ping S Dai Q Yuan M Feng B Hou X Zhang Y Ma R Liu T Feng L Wang L Chen M Lin M | 2009 | PloS One2009，4，2： | 1 |
| 11 | The microstructure and properties of 17-4PH martensitie precipitation hardening stainless steel modified by plasma nitrocarburizing 显示文摘 | Liu R L Yan M F | 2010 | Surface and Coatings Technology2010，204，14： | 1 |
| 12 | Intrahepatic regulatory T cells in autoimmune hepatitis are as-sociated with treatment response and depleted with currenttherapies显示文摘 | TAUBERT R HARDTKE -WOLENSKI M NO YAN F | 2014 | J Hepatol2014，61，5： | 1 |
| 13 | Implementing the k-nearest Neighbour Rule via a Neural Network显示文摘 | Qiu Chen Yan Nixon M S Damper R I | 1995 | Proceedings of the IEEE International Conference on Neural Networks1995，，1： | 1 |
| 14 | Histone deacetylases modulate vascular smooth muscle cell migration induced by cyclic mechanical strain显示文摘 | Yan Z Q Yao Q P Zhang M L Qi Y X Guo Z Y Shen B R | 2009 | J Biomeeh2009，42，： | 1 |
| 15 | Involvement of the TCA cycle in the anaerobic metabolism of polyphosphate accumulating organisms (PAOs) 显示文摘 | ZHOU Yan PIJUAN M ZENG R J | 2009 | Water Research2009，43，5： | 1 |
| 16 | Expression of angiogenic factors is upregulated in DMBA-induced rat mammary pathologies显示文摘 | Yan M Schneider J Gear R | 2004 | Pathobiology2004，71，5： | 1 |
| 17 | The experimental research on antigastric cancer active peptide显示文摘 | Su X L Ke Y Yan M R | 1999 | Int J Modern Cancer Ther1999，2，2： | 1 |
| 18 | Fingerprint analysis of fruiting bodies of cultured Cordyceps rnilitaris by high- performance liquid chromatography-photodiode array de- tection 显示文摘 | Yu R M Ye B Yan C Y | 2007 | J Pharrn Biorned Anal2007，44，3： | 1 |
| 19 | Optimiza- tion of microwave-assisted extraction of phenolics from po- tato and its downstream waste using orthogonal array de- sign 显示文摘 | WU T YAN J LIU R H Marcone M F | 2012 | Food Chemistry2012，133，4： | 1 |
| 20 | Gender differences in brain activity and the re- latiomhip between brain activity and differences in prevalence rates between male and female major depressive disorder patients: A resting-state fMRI study显示文摘 | Yao Z Yan R Wei M | 2014 | CAin Neurophysiol2014，125，11： | 1 |
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