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| 1 | Dopamine D4 Receptor Gene Associated with the Frontal-Striatal-Cerebellar Loop in Children with ADHD: A Resting-State fMRI Study显示文摘Attention deficit hyperactivity disorder(ADHD)is a common childhood neuropsychiatric disorder that has been linked to the dopaminergic system. This study aimed to investigate the effects of regulation of the dopamine D4 receptor(DRD4) on functional brain activity during the resting state in ADHD children using the methods of regional homogeneity(Re Ho) and functional connectivity(FC). Resting-state functional magnetic resonance imaging data were analyzed in 49 children with ADHD. All participants were classified as either carriers of the DRD44-repeat/4-repeat(4 R/4 R) allele(n = 30) or the DRD42-repeat(2 R) allele(n = 19). The results showed that participants with the DRD4 2 R allele had decreased Re Ho bilaterally in the posterior lobes of the cerebellum, while Re Ho was increased in the left angular gyrus. Compared with participants carrying the DRD4 4 R/4 R allele, those with the DRD4 2 R allele showed decreased FC to the left angular gyrus in the left striatum, right inferior frontal gyrus, and bilateral lobes of the cerebellum. The increased FC regions included the left superior frontal gyrus, medial frontal gyrus, and rectus gyrus. These data suggest that the DRD4 polymorphisms are associated with localized brain activity and specific functional connections, including abnormality in the frontal-striatal-cerebellar loop. Our study not only enhances the understanding of the correlation between the cerebellar lobes and ADHD, but also provides an imaging basis for explaining the neural mechanisms underlying ADHD in children. | ANDan Qian Xin Wang Huiru Liu Jiejie Tao Jiejie Zhou Qiong Ye Jiance Li Chuang Yang Jingliang Cheng Ke Zhao Meihao Wang | 2018 | Neuroscience Bulletin2018，34，3： | 10 |
| 2 | Evaluating ischemic stroke with diffusion tensor imaging显示文摘Objective:In recent years,diffusion tensor imaging (DTI) has emerged as a promising tool to study ischemic stroke. The aim of this study is to evaluate the anisotropic changes of cerebral white matter tracks in patients with ischemic stroke using DTI,and investigate the correlation between corticospinal tract damage and muscle strength in such patients during acute ischemia.Method:9 patients with acute ischemic stroke and 9 healthy subjects were examined with T1 weighted magnetic resonance imaging (MRI),T2 weighted MRI and DTI. Fractional anisotropy (FA) was measured and the three-dimensional fibrous band images of bilateral corticospinal tracts were reconstructed. The muscle strength of the affected hand was assessed by Brunnstorm standard[1],which is an internationally recognized measure of movement in hemiplegic patients.Results:①In the control group,there was no significant difference in FA between the bilateral corticospinal tracts,but FA in different white matter structure of the same side was significantly different (t=3.12,P < 0.05). FA of posterior limb of internal capsule was higher than that of knee and anterior limb of internal capsule,FA of anterior limb of internal capsule was the lowest. while in the patient group,FA of the infarcted sites was significantly lower than the contralateral ones (t=5.570,P < 0.01). ②The ipsilateral corticospinal tract demonstrated continuous interruption and the loss of consistent anatomic structure. The involved severity of corticospinal tract had significant correlation with that of muscle strength of the ipsilateral hand (r=0.83,P < 0.01).Conclusion:This study shows that DTI can be used to investigate ischemic stroke and assess ischemic stroke-induced damage. The damaged severity of corticospinal tracts is correlated with that of muscle strength. | Ziqian Chen Ping Ni Youqiang Ye Hui Xiao Gennian Qian Shangwen Xu Jingliang Wang Xizhang Yang Jinhua Chen Zhenshan Shi Biyun Zhang | 2008 | 福州总医院学报2008，15，3： | 6 |
| 3 | Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury显示文摘Spinal cord injury(SCI)involves diverse injury responses in different cell types in a temporally and spatially specific manner.Here,using single-cell transcriptomic analyses combined with classic anatomical,behavioral,electrophysiological analyses,we report,with single-cell resolution,temporal molecular and cellular changes in crush-injured adult mouse spinal cord.Data revealed pathological changes of 12 different major cell types,three of which infiltrated into the spinal cord at distinct times post-injury.We discovered novel microglia and astrocyte subtypes in the uninjured spinal cord,and their dynamic conversions into additional stage-specific subtypes/states.Most dynamic changes occur at 3-days post-injury and by day-14 the second wave of microglial activation emerged,accompanied with changes in various cell types including neurons,indicative of the second round of attacks.By day-38,major cell types are still substantially deviated from uninjured states,demonstrating prolonged alterations.This study provides a comprehensive mapping of cellular/molecular pathological changes along the temporal axis after SCI,which may facilitate the development of novel therapeutic strategies,including those targeting microglia. | Chen Li Zhourui Wu Liqiang Zhou Jingliang Shao Xiao Hu Wei Xu Yilong Ren Xingfei Zhu Weihong Ge Kunshan Zhang Jiping Liu Runzhi Huang Jing Yu Dandan Luo Xuejiao Yang Wenmin Zhu Rongrong Zhu Changhong Zheng Yi Eve Sun Liming Cheng | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 4 |
| 4 | Broadband rhenium disulfide optical modulator for solid-state lasers显示文摘Rhenium disulfide(ReS_2), a member of group Ⅶ transition metal dichalcogenides(TMDs), has attracted increasing attention because of its unique distorted 1T structure and electronic and optical properties, which are much different from those of group Ⅵ TMDs(MoS_2, WS_2, MoSe_2, WSe_2, etc.). It has been proved that bulk ReS_2 behaves as a stack of electronically and vibrationally decoupled monolayers, which offers remarkable possibilities to prepare a monolayer ReS_2 facilely and offers a novel platform to study photonic properties of TMDs. However,due to the large and layer-independent bandgap, the nonlinear optical properties of ReS_2 from the visible to midinfrared spectral range have not yet been investigated. Here, the band structure of ReS_2 with the introduction of defects is simulated by the ab initio method, and the results indicate that the bandgap can be reduced from 1.38 to 0.54 eV with the introduction of defects in a suitable range. In the experiment, using a bulk ReS_2 with suitable defects as the raw material, a few-layered broadband ReS_2 saturable absorber(SA) is prepared by the liquid phase exfoliation method. Using the as-prepared ReS_2 SA, passively Q-switched solid-state lasers at wavelengths of 0.64,1.064, and 1.991 μm are investigated systematically. Moreover, with cavity design, a femtosecond passively modelocked laser at 1.06 μm is successfully realized based on the as-prepared ReS_2 SA for the first time. The results present a promising alternative for a rare broadband optical modulator and indicate the potential of ReS_2 in generating Q-switched and mode-locked pulsed lasers. It is further anticipated that this work may be helpful for the design of 2D optoelectronic devices with variable bandgaps. | XIANCUI SU BAITAO ZHANG YIRAN WANG GUANBAI HE GUORU LI NA LIN KEJIAN YANG JINGLIANG HE SHANDE LIU | 2018 | Photonics Research2018，6，6： | 4 |
| 5 | Successful application of Shirasu porous glass (SPG) membrane system for microbubble aeration in a biofilm reactor treating synthetic wastewater显示文摘 | Chun Liu Hiroshi Tanaka Jing Zhang Lei Zhang Jingliang Yang Xia Huang Nobuhiko Kubota | 2013 | Separation and Purification Technology2013，，： | 2 |
| 6 | Nonlinear optical absorption properties of InP nanowires and applications as a saturable absorber显示文摘Indium phosphide(InP)nanowires(NWs)have attracted significant attention due to their exotic properties that are different from the bulk counterparts,and have been widely used for light generation,amplification,detection,modulation,and switching,etc.Here,high-quality InP NWs were directly grown on a quartz substrate by the Au-nanoparticle assisted vapor-liquid-solid method.We thoroughly studied their nonlinear optical absorption properties at 1.06μm by the open-aperture Z-scan method.Interestingly,a transition phenomenon from satu-rable absorption(SA)to reverse saturable absorption(RSA)was observed with the increase of the incident laser intensity.In the analysis,we found that the effective nonlinear absorption cofficient(βeff-10^2 cm/MW)under the SA process was 3 orders of magnitude larger than that during the RSA processes.Furthermore,the SA proper-ties of InP NWs were experimentally verified by using them as a saturable absorber for a passively Q-switched Nd:YVO4 solid-state laser at 1.06μm,where the shortest pulse width of 462 ns and largest single pulse energy of 1.32μJ were obtained.Moreover,the ultrafast carrier relaxation dynamics were basically studied,and the intraband and inter-band ultrafast carrier relaxation times of 8.1 and 63.8 ps,respectively,were measured by a degenerate pump-probe method with the probe laser of 800 nm.These results well demonstrate the nonlinear optical absorption properties,which show the excellent light manipulating capabilities of InP NWs and pave a way for their applications in ultrafast nanophotonic devices. | JUNTING LIU HONGKUN NIE BINGZHENG YAN KEJIAN YANG HE YANG VLADISLAV KHAYRUDINOV HARRI LIPSANEN BAITAO ZHANG JINGLIANG HE | 2020 | Photonics Research2020，8，6： | 2 |
| 7 | Diode-pumped passively Qswitched intraeavity frequency doubled Nd:GdVO4/ KTP green laser显示文摘 | Jie Liu Jimin Yang Jingliang He | 2004 | Optics & Laser Technology2004，36，1： | 1 |
| 8 | Study on a novel non-dissolved redox mediator catalyzing biological deni- trification (RMBDN) technology显示文摘 | GUO Jianbo KANG Li YANG Jingliang | 2010 | Bioresource Technolo- gy2010，101，11： | 1 |
| 9 | Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3Cpro显示文摘Enteroviruses(EVs) 3C proteins suppress type I interferon(IFN) responses mediated by retinoid acid-inducible gene I(RIG-I), while an E3 ubiquitin ligase, tripartite motif protein 25(TRIM25)-mediated RIG-I ubiquitination is essential for RIG-I antiviral activity. Therefore, whether the effect of EVs 3C on RIG-I is associated with TRIM25 expression is worth to be further investigated. Here, we demonstrate that 3C proteins of EV71 and coxsackievirus B3(CVB3) reduced not only RIG-I expression but also TRIM25 expression through protease cleavage activity, while overexpression of TRIM25 restored RIG-I expression and IFN-b production reduced by 3C proteins. Further investigation confirmed that the two amino acids and functional domains in TRIM25 required for RIG-I ubiquitination and TRIM25 structural conformation were essential for the recovery of RIG-I expression. Moreover, we also observed that TRIM25 could rescue RIG-I expression reduced by 3C proteins of CVA6 and EV-D68 but not CVA16. Our findings provide an insightful interpretation of 3C-mediated host innate immune suppression and support TRIM25 as an attractive target against multiple EVs infection. | Huimin Xiao Jingliang Li Xu Yang Zhaolong Li Ying Wang Yajuan Rui Bin Liu Wenyan Zhang | 2021 | Virologica Sinica2021，36，6： | 1 |
| 10 | Diode-pumped passively Q-switched c - cut Nd: GdVO4 laser显示文摘 | Jie Liu Jimin Yang Jingliang He | 2003 | Optics Communications2003，219，： | 1 |
| 11 | Diode-pumped passively Qswitched intracavity frequency doubled Nd: GdVO4/KTP green laser 显示文摘 | Jie Liu Jimin Yang Jingliang He | 2004 | Optics & Laser Technology2004，36，1： | 1 |
| 12 | High repetition rate passively Q-switched diode-pumped Nd:YVO4 laser显示文摘 | Jimin Yang Jingliang He | 2003 | Optics & Laser Technology2003，5，6： | 1 |
| 13 | Studies on the electrochemical degradation of Acid OrangeⅡwastewater with cathodes modified by quinones显示文摘 | Lin Yue Jianbo Guo Jingliang Yang | 2014 | Journal of Industrial and Engineering Chemistry2014，20，： | 1 |
| 14 | Study on a novel non-dissolved redox mediator catalyzing biological denitrification (RMBI)N) technology显示文摘 | GUO Jianbo KANG Li YANG Jingliang | 2010 | Bioresource Technology2010，101，11： | 1 |
| 15 | Diode-pumped Nd:YxGd1-xVO4 crystal continuous-wave laser显示文摘 | Jie Liu Qianqian Peng Jimin Yang Qiuxia Jiang Jingliang He Lianjie Qin Xianlin Meng | | CHINESE OPTICS LETTERS0，，： | 1 |
| 16 | The CFD Approach to Analyse Transport Phenomena- Coupled Chemical Reactions Relevant for Methane Re- formers 显示文摘 | YUAN Jingliang YANG Guogang Bengt S | 2009 | International Journal of Nuclear Hydrogen Production and Applications2009，2，： | 1 |
| 17 | Estimation of dominant microbial population sizes in the anaerobic granular sludge of a full-scale UASB treating streptomycin wastewater by PCR-DGGE 显示文摘 | LIU Chun YANG Jingliang WU Gen | 2010 | World Journal of Microbiology and Biotechnology2010，26，2： | 1 |
| 18 | High repetition rate passively Q-switched diode-pumped Nd:YVO4 laser显示文摘 | Liu Jie Yang Jimin He Jingliang | 2003 | Opt & Laser Tech2003，35，： | 1 |
| 19 | Diode-pumped passively Q-switched c-cut Nd:GdVO4 laser显示文摘 | Liu Jie Yang Jimin He Jingliang | 2003 | Opt Commun2003，219，： | 1 |
| 20 | Upper Bound for Unequal Zig-Zag Network with Small Downstream显示文摘We consider the problem of characterizing network capacity in the presence of adversarial errors on network links,focusing in particular on the effect of small downstream links,where the downstream link is the directed link of feedback links across the cut of network.In this paper,we present a family of zigzag networks where the inner bound and the outer bound coincide.We also establish tight condition for this family of zig-zag network,and develop encoding scheme and detection and decoding strategy. | YANG Yanbo GAO Jingliang | 2014 | Wuhan University Journal of Natural Sciences2014，19，3： | 0 |
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