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| 1 | Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo显示文摘 | Yanjing Song Chuan Tong Yao Wang Yunhe Gao Hanren Dai Yelei Guo Xudong Zhao Yi Wang Zizheng Wang Weidong Han Lin Chen | 2018 | Protein & Cell2018，9，10： | 11 |
| 2 | Investigation into the Formation, Structure, and Evolution of an EF4 Tornado in East China Using a High-Resolution Numerical Simulation显示文摘Devastating tornadoes in China have received growing attention in recent years, but little is known about their formation, structure, and evolution on the tornadic scale. Most of these tornadoes develop within the East Asian monsoon regime, in an environment quite different from tornadoes in the U.S. In this study, we used an idealized, highresolution(25-m grid spacing) numerical simulation to investigate the deadly EF4(Enhanced Fujita scale category 4)tornado that occurred on 23 June 2016 and claimed 99 lives in Yancheng, Jiangsu Province. A tornadic supercell developed in the simulation that had striking similarities to radar observations. The violent tornado in Funing County was reproduced, exceeding EF4(74 ms–1), consistent with the on-site damage survey. It was accompanied by a funnel cloud that extended to the surface, and exhibited a double-helix vorticity structure. The signal of tornado genesis was found first at the cloud base in the pressure perturbation field, and then developed both upward and downward in terms of maximum vertical velocity overlapping with the intense vertical vorticity centers. The tornado's demise was found to accompany strong downdrafts overlapping with the intense vorticity centers. One of the interesting findings of this work is that a violent surface vortex was able to be generated and maintained, even though the simulation employed a free-slip lower boundary condition. The success of this simulation, despite using an idealized numerical approach, provides a means to investigate more historical tornadoes in China. | Dan YAO Haile XUE Jinfang YIN Jisong SUN Xudong LIANG Jianping GUO | 2018 | Journal of Meteorological Research2018，32，2： | 10 |
| 3 | Advanced hydrogels for the repair of cartilage defects and regeneration显示文摘Cartilage defects are one of the most common symptoms of osteoarthritis(OA),a degenerative disease that affects millions of people world-wide and places a significant socio-economic burden on society.Hydrogels,which are a class of biomaterials that are elastic,and display smooth surfaces while exhibiting high water content,are promising candidates for cartilage regeneration.In recent years,various kinds of hydrogels have been developed and applied for the repair of cartilage defects in vitro or in vivo,some of which are hopeful to enter clinical trials.In this review,recent research findings and developments of hydrogels for cartilage defects repair are summarized.We discuss the principle of cartilage regeneration,and outline the requirements that have to be fulfilled for the deployment of hydrogels for medical applications.We also highlight the development of advanced hydrogels with tailored properties for different kinds of cartilage defects to meet the requirements of cartilage tissue engineering and precision medicine. | Wei Wei Yuanzhu Ma Xudong Yao Wenyan Zhou Xiaozhao Wang Chenglin Li Junxin Lin Qiulin He Sebastian Leptihn Hongwei Ouyang | 2021 | Bioactive Materials2021，6，4： | 8 |
| 4 | Importance of identifying tropical cyclone tornadoes in typhoon warning and defense systems显示文摘Tornadoes are highly localized severe weather phenomena and have been of increasing concern in China [1] in recent years, especially after the sinking of the Oriental Star in 2015 [2] and severe tornado damage in Yancheng in 2016 (3)Tornadoes induced by tropical cyclones, however, have received little attention.A recent study has shown that a large number of tornado-scale vortices can be produced at the inner edge of the intense eyewallconvection of tropical cyclones [4]. | Dan Yao Xudong Liang Qing Meng Jian Li Chong Wu Zhengshuai Xie Dandan Chen Jianping Guo | 2019 | Science Bulletin2019，64，3： | 7 |
| 5 | Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas显示文摘The limited molecular classifications and disease signatures of osteoarthritis(OA)impede the development of prediagnosis and targeted therapeutics for OA patients.To classify and understand the subtypes of OA,we collected three types of tissue including cartilage,subchondral bone,and synovium from multiple clinical centers and constructed an extensive transcriptome atlas of OA patients.By applying unsupervised clustering analysis to the cartilage transcriptome,OA patients were classified into four subtypes with distinct molecular signatures:a glycosaminoglycan metabolic disorder subtype(C1),a collagen metabolic disorder subtype(C2),an activated sensory neuron subtype(C3),and an inflammation subtype(C4).Through ligand-receptor crosstalk analysis of the three knee tissue types,we linked molecular functions with the clinical symptoms of different OA subtypes.For example,the Gene Ontology functional term of vasculature development was enriched in the subchondral bone-cartilage crosstalk of C2 and the cartilage-subchondral bone crosstalk of C4,which might lead to severe osteophytes in C2 patients and apparent joint space narrowing in C4 patients.Based on the marker genes of the four OA subtypes identified in this study,we modeled OA subtypes with two independent published RNA-seq datasets through random forest classification.The findings of this work contradicted traditional OA diagnosis by medical imaging and revealed distinct molecular subtypes in knee OA patients,which may allow for precise diagnosis and treatment of OA. | Chunhui Yuan Zongyou Pan Kun Zhao Jun Li Zixuan Sheng Xudong Yao Hua Liu Xiaolei Zhang Yang Yang Dongsheng Yu Yu Zhang Yuzi Xu Zhi-Yong Zhang Tianlong Huang Wanlu Liu Hongwei Ouyang | 2020 | Bone Research2020，8，4： | 4 |
| 6 | An effective method to screen sodium-based layered materials for sodium ion batteries显示文摘Due to the high cost and insufficient resource of lithium,sodium-ion batteries are widely investigated for large-scale applications.Typically,insertion-type materials possess better cyclic stability than alloy-type and conversion-type ones.Therefore,in this work,we proposed a facile and effective method to screen sodium-based layered materials based on Materials Project database as potential candidate insertion-type materials for sodium ion batteries.The obtained Na-based layered materials contains 38 kinds of space group,which reveals that the credibility of our screening approach would not be affected by the space group.Then,some important indexes of the representative materials,including the average voltage,volume change and sodium ion mobility,were further studied by means of density functional theory computations.Some materials with extremely low volume changes and Na diffusion barriers are promising candidates for sodium ion batteries.We believe that our classification algorithm could also be used to search for other alkali and multivalent ion-based layered materials,to accelerate the development of battery materials. | Xu Zhang Zihe Zhang Sai Yao An Chen Xudong Zhao Zhen Zhou | 2018 | npj Computational Materials2018，，1： | 4 |
| 7 | A novel minimally invasive percutaneous nephrolithotomy technique: safety and efficacy report显示文摘 | Guanghui Hu Zhuifeng Guo Huan Liu Ming Luo Min Liu Peng Lai Haimin Zhang Jing Yuan Xudong Yao Junhua Zheng Yunfei Xu | 2014 | Scandinavian Journal of Urology2014，，2： | 2 |
| 8 | Simple non-fullerene electron acceptors with unfused core for organic solar cells显示文摘Two simple electron acceptors based on unfused bithiophene core and 1,1-dicyanomethylene-3-indanone end group were easily prepared via three synthetic steps. These acceptors exhibited broad absorption in the range of 300 nm to 800 nm, aligned energy levels and high crystallinity. When combined with a wide band gap donor polymer in non-fullerene solar cells, an initial power conversion efficiency of 2.4% was achieved. The relatively low efficiencies were due to the large phase separation in blended thin films, which is originated from their high aggregation tendency in thin films. Our results suggest that these electron acceptors with unfused core are promising candidates for commercial application of solar cells due to the low cost starting materials and facile synthesis. | Yao Li Yunhua Xu Fan Yang Xudong Jiang Cheng Li Shengyong You Weiwei Li | 2019 | Chinese Chemical Letters2019，30，1： | 2 |
| 9 | Hidden Blood Loss After Total Hip Arthroplasty显示文摘 | Xudong Liu Xianlong Zhang Yunsu Chen Qi Wang Yao Jiang Bingfang Zeng | 2011 | The Journal of Arthroplasty2011，，7： | 2 |
| 10 | Intent defined optical network with artificial intelligence-based automated operation and maintenance显示文摘Traditionally,the operation and maintenance of optical networks rely on the experience of engineers to configure network parameters,involving command-line interface,middle-ware scripting,and troubleshooting.However,with the emerging of newly B5 G applications,the traditional configuration cannot meet the requirement of real-time automatic configuration.Operators need a new configuration way without manual intervention at an underlying optical transport network.To cope with this issue,we propose an intent defined optical network(IDON)architecture toward artificial intelligence-based optical network automated operation and maintenance against service objective,by introducing a self-adapted generation and optimization(SAGO)policy in a customized manner.The IDON platform has three key innovations including intent-orient configuration translation,self-adapted generation and optimization policy,and close-loop intent guarantee operation.Focusing specifically on communication requirements,the IDON uses natural language processing to construct semantic graphs to understand,interact,and create the required network configuration.Then,deep reinforcement learning(DRL)is utilized to find the composition policy that satisfies the requirement of intent through the dynamic integration of fine-grained policies.Finally,the deep neural evolutionary network(DNEN)is introduced to achieve the intent guarantee at the milliseconds level.The feasibility and efficiency are verified on enhanced SDN testbed.Finally,we discuss several related challenges and opportunities for unveiling a promising upcoming future of intent defined optical network. | Hui YANG Kaixuan ZHAN Qiuyan YAO Xudong ZHAO Jie ZHANG Young LEE | 2020 | Science China(Information Sciences)2020，63，6： | 2 |
| 11 | Treatment planning optimization by quasi Newton and simulated annealig methods for gammma unit treatment system显示文摘 | SHU Huazhong YAN Yulong BAO Xudong FU Yao LUO Limin | 1998 | Physics on Medical Biology1998，43，10： | 1 |
| 12 | Interaction of curcumin with intravenous immunoglobulin: A fluorescence quenching and Fourier transformation infrared spectroscopy study显示文摘 | Yongchun Liu Zhengyin Yang Juan Du Xiaojun Yao Ruixia Lei Xudong Zheng Jianning Liu Huaisheng Hu Hong Li | 2008 | Immunobiology2008，，： | 1 |
| 13 | Thermodynamic mechanisms of mechanical crystallization of amorphous显示文摘 | Liu Li Si Lun Liu Shue Zhao Xudong Yao Bin Su Wenhui | | 0，，： | 1 |
| 14 | Band structure design of semiconductors for enhanced photocatalytic activity: The case of TiO_2显示文摘General strategies are proposed by passivated co-doping in present paper to improve the photocatalytic activity of semiconductors for degradation of environmental pollutants.The ideal band gap of semiconductors for enhancement of photocatalytic activity can be lowered to match with visible light absorption and the location of the Conduction Band(CB) should be raised to meet the reducing capacity.Then we apply the strategy to anatase TiO2.It is predicted that nonmetal–metal co-doping TiO2can modify the catalyst band edges by raising the valence band(VB) edge signifcantly and making the CB edge increased 0.24 eV.Therefore,the band gap for co-doping system should be narrowed to about2.72 eV.(N,Ta) is predicted to be the target donor–acceptor combination with the band gap of 2.71 eV,which red-shifts the TiO2absorption edge to 457.6 nm in visible range.The band engineering principle will be ft to other wide-band-gap semiconductors for enhanced photocatalytic activity. | Hui Yan Xudong Wang Man Yao Xiaojie Yao | 2013 | Progress in Natural Science:Materials International2013，23，4： | 1 |
| 15 | General Growth of Carbon Nanotubes for Cerium Redox Reactions in High-Efficiency Redox Flow Batteries显示文摘Carbon nanotubes(CNTs)possess remarkable mechanical,electrical,thermal,and optical properties that predestine them for numerous potential applications.The conventional chemical vapor deposition(CVD)route for the production of CNTs,however,suffers from costly and complex issues.Herein,we demonstrate a general and high-yield strategy to grow nitrogendoped CNTs(NCNTs)on three-dimensional(3D)graphite felt(GF)substrates,through a direct thermal pyrolysis process simply using a common tube furnace,instead of the costly and complex CVD method.Specifically,the NCNTs-decorated GF(NCNT-GF)electrode possesses enhanced electrocatalytic performance towards cerium redox reactions,mainly due to the catalytic effect of N atoms doped into NCNTs,and ingenious and hierarchical 3D architecture of the NCNT-GF.As a result,the cell with the NCNT-GF serving as a positive electrode shows the improved energy efficiency with increases of about 53.4%and 43.8%over the pristine GF and the acidly treated GF at a high charge/discharge rate of 30 mA cm^(-2),respectively.Moreover,the as-prepared NCNT catalyst-enhanced electrode is found to be highly robust and should enable a long-term cycle without detectable efficiency loss after 500 cycles.The viable synthetic strategy reported in this study will contribute to the further development of more active heteroatom-doped CNTs for redox flow batteries. | Zhaolin Na Ruifang Yao Qing Yan Xudong Sun Gang Huang | 2019 | Research2019，，1： | 1 |
| 16 | Micro-electro-mechanical systems (MEMS)-based microscale direct methanol fuel cell development 显示文摘 | Yao Shi-Chune Tang Xudong Hsieh Cheng-Chieh | 2006 | Energy2006，31，5： | 1 |
| 17 | Hidden Blood Loss After Total Hip Arthroplasty显示文摘 | Xudong Liu Xianlong Zhang Yunsu Chen Qi Wang Yao Jiang Bingfang Zeng | 2011 | The Journal of Arthroplasty2011，，7： | 1 |
| 18 | Time-Modulated Transmissive Programmable Metasurface for Low Sidelobe Beam Scanning显示文摘Programmable metasurfaces have great potential for the implementation of low-complexity and low-cost phased arrays.Due to the difficulty of multiple-bit phase control,conventional programmable metasurfaces suffer a relatively high sidelobe level(SLL).In this manuscript,a time modulation strategy is introduced in the 1-bit transmissive programmable metasurface for reducing the SLLs of the generated patterns.After the periodic time modulation,harmonics are generated in each reconfigurable unit and the phase of the first-order harmonic can be dynamically controlled by applying different modulation sequences onto the corresponding unit.Through the high-speed modulation of the real-time periodic coding sequences on the metasurface by the programmable bias circuit,the equivalent phase shift accuracy to each metasurface unit can be improved to 6-bit and thus the SLLs of the metasurface could be reduced remarkably.The proposed time-modulated strategy is verified both numerically and experimentally with a transmissive programmable metasurface,which obtains an aperture efficiency over 34%and reduced SLLs of about-2o dB.The proposed design could offer a novel approach of a programmable metasurface framework for radar detection and secure communication applications. | Xudong Baio Fuli Zhang Li Sun Anjie Cao Jin Zhang Chong He Longhai Liu Jianquan Yao Weiren Zhu | 2022 | Research2022，，4： | 1 |
| 19 | Proteolytic ^18O Labeling for Comparative Proteomics:Model Studies With Two Serotypes of Adenovirus显示文摘 | Yao Xudong Fenselau C Reynolds KJ | 2001 | Anal Chem2001，73，13： | 1 |
| 20 | Seamless and early gap healing of osteochondral defects by autologous mosaicplasty combined with bioactive supramolecular nanofiber-enabled gelatin methacryloyl(BSN-GelMA)hydrogel显示文摘Autologous mosaicplasty is a common approach used to treat osteochondral defects in clinical practice.Gap integration between host and transplanted plugs requires bone tissue reservation and hyaline cartilage regeneration without uneven surface,graft necrosis and sclerosis.However,poor gap integration is a serious concern,which eventually leads to deterioration of joint function.To deal with such complications,this study has developed a strategy to effectively enhance integration of the gap region following mosaicplasty by applying injectable bioactive supramolecular nanofiber-enabled gelatin methacryloyl(GelMA)hydrogel(BSN-GelMA).A rabbit osteochondral defect model demonstrated that BSN-GelMA achieved seamless osteochondral healing in the gap region between plugs of osteochondral defects following mosaicplasty,as early as six weeks.Moreover,the International Cartilage Repair Society score,histology score,glycosaminoglycan content,subchondral bone volume,and collagen II expression were observed to be the highest in the gap region of BSN-GelMA treated group.This improved outcome was due to bio-interactive materials,which acted as tissue fillers to bridge the gap,prevent cartilage degeneration,and promote graft survival and migration of bone marrow mesenchymal stem cells by releasing bioactive supramolecular nanofibers from the GelMA hydrogel.This study provides a powerful and applicable approach to improve gap integration after autologous mosaicplasty.It is also a promising off-the-shelf bioactive material for cell-free in situ tissue regeneration. | Hongwei Wu Yuna Shang Wei Sun Xinyi Ouyang Wenyan Zhou Jieji Lu Shuhui Yang Wei Wei Xudong Yao g Xiaozhao Wang Xianzhu Zhang Yishan Chen Qiulin He Zhimou Yang Hongwei Ouyang | 2023 | Bioactive Materials2023，，1： | 1 |
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