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| 1 | Advances in 3D bioprinting technology for cardiac tissue engineering and regeneration显示文摘Cardiovascular disease is still one of the leading causes of death in the world,and heart transplantation is the current major treatment for end-stage cardiovascular diseases.However,because of the shortage of heart donors,new sources of cardiac regenerative medicine are greatly needed.The prominent development of tissue engineering using bioactive materials has creatively laid a direct promising foundation.Whereas,how to precisely pattern a cardiac structure with complete biological function still requires technological breakthroughs.Recently,the emerging three-dimensional(3D)bioprinting technology for tissue engineering has shown great advantages in generating micro-scale cardiac tissues,which has established its impressive potential as a novel foundation for cardiovascular regeneration.Whether 3D bioprinted hearts can replace traditional heart transplantation as a novel strategy for treating cardiovascular diseases in the future is a frontier issue.In this review article,we emphasize the current knowledge and future perspectives regarding available bioinks,bioprinting strategies and the latest outcome progress in cardiac 3D bioprinting to move this promising medical approach towards potential clinical implementation. | Nanbo Liu Xing Ye Bin Yao Mingyi Zhao Peng Wu Guihuan Liu Donglin Zhuang Haodong Jiang Xiaowei Chen Yinru He Sha Huang Ping Zhu | 2021 | Bioactive Materials2021，6，5： | 4 |
| 2 | Oxidation behaviors of carbon fiber reinforced multilayer SiC–Si_(3)N_(4) matrix composites显示文摘Oxidation behaviors of carbon fiber reinforced SiC matrix composites(C/SiC)are one of the most noteworthy properties.For C/SiC,the oxidation behavior was controlled by matrix microcracks caused by the mismatch of coefficients of thermal expansion(CTEs)and elastic modulus between carbon fiber and SiC matrix.In order to improve the oxidation resistance,multilayer SiC–Si_(3)N_(4) matrices were fabricated by chemical vapor infiltration(CVI)to alleviate the above two kinds of mismatch and change the local stress distribution.For the oxidation of C/SiC with multilayer matrices,matrix microcracks would be deflected at the transition layer between different layers of multilayer SiC–Si_(3)N_(4) matrix to lengthen the oxygen diffusion channels,thereby improving the oxidation resistance of C/SiC,especially at 800 and 1000℃.The strength retention ratio was increased from 61.9%(C/SiC–SiC/SiC)to 75.7%(C/SiC–Si_(3)N_(4)/SiC/SiC)and 67.8%(C/SiC–SiC/Si_(3)N_(4)/SiC)after oxidation at 800℃for 10 h. | Xiaolin DANG Donglin ZHAO Tong GUO Xiaomeng FAN Jimei XUE Fang YE Yongsheng LIU Laifei CHENG | 2022 | Journal of Advanced Ceramics2022，11，2： | 1 |
| 3 | Data-Driven Discovery of Stochastic Differential Equations显示文摘Stochastic differential equations(SDEs)are mathematical models that are widely used to describe complex processes or phenomena perturbed by random noise from different sources.The identification of SDEs governing a system is often a challenge because of the inherent strong stochasticity of data and the complexity of the system’s dynamics.The practical utility of existing parametric approaches for identifying SDEs is usually limited by insufficient data resources.This study presents a novel framework for identifying SDEs by leveraging the sparse Bayesian learning(SBL)technique to search for a parsimonious,yet physically necessary representation from the space of candidate basis functions.More importantly,we use the analytical tractability of SBL to develop an efficient way to formulate the linear regression problem for the discovery of SDEs that requires considerably less time-series data.The effectiveness of the proposed framework is demonstrated using real data on stock and oil prices,bearing variation,and wind speed,as well as simulated data on well-known stochastic dynamical systems,including the generalized Wiener process and Langevin equation.This framework aims to assist specialists in extracting stochastic mathematical models from random phenomena in the natural sciences,economics,and engineering fields for analysis,prediction,and decision making. | Yasen Wang Huazhen Fang Junyang Jin Guijun Ma Xin He Xing Dai Zuogong Yue Cheng Cheng Hai-Tao Zhang Donglin Pu Dongrui Wu Ye Yuan Jorge Gonçalves Jürgen Kurths Han Ding | 2022 | Engineering2022，，10： | 1 |
| 4 | Multiplex network reconstruction for the coupled spatial diffusion of infodemic and pandemic of COVID-19显示文摘The pandemic of COVID-19 witnessed a massive infodemic with the public being bombarded with vast quantities of information.The spreading of neutral and highly accurate reports can guide the public to self-protect and reduce the pandemic.Mis-and dis-information would intrigue panic and high exposure risk to epidemic.Although the infodemic has attracted attentions from the academia,it is still not known to what degree and in which direction the information flows contribute to the COVID-19 pandemic.To fill the gap,we apply network reconstruction techniques to rebuild the hidden multiplex network of information and COVID-19 spreading by which we aim at quantifying the interaction between the propagation of information and the spatial outbreak of COVID-19,and delineate between the positive and negative impact of information on the pandemic.By differentiating the types of media that participated in the information process,we find that in the early stage of COVID-19 pandemic,infodemic does play a critical role to amplify the risk of virus outbreak in China and the risk is even larger for those highly developed regions.Compared to the old-fashion media,the new mobile platforms impose a greater risk to reinforce the positive feedback between infodemic and COVID-19 pandemic. | Xiaoqi Zhang Zi-Ke Zhang Wenbo Wang Donglin Hou Jiajing Xu Xinyue Ye Shengwen Li | 2021 | International Journal of Digital Earth2021，14，4： | 1 |
| 5 | Covalent Organic Frameworks:Chemistry of Pore Interface and Wall Surface Perturbation and Impact on Functions显示文摘CONSPECTUS:Porous structures are ubiquitous,discovered in nature ranging from biological channels in animals and plants to various pores in sediments and minerals and playing vital roles in maintaining biological activities and ecosystems.Synthetic pores have been known for over 100 years and currently continue to be a central subject in the fields of chemistry,physics,materials science,and technology.A fundamental key issue is how to develop specific functions with pores.Pores are determined by three parameters,including pore shape,size,and environment;how to design these parameters in a controlled manner is a key subject.Covalent organic frameworks(COFs)are a distinct class of crystalline porous polymers as they combine covalent and noncovalent chemistries to result in long-range-ordered polygonal skeletons and discrete pores.The topological diagramthe principle for designing COFsenables the predesign of not only skeletons but also pores,offering a powerful molecular platform for constructing tailor-made organic/polymeric materials.Over the past decade,progress in chemistry has greatly enhanced our capability to synthesize COFs to achieve different structures.Especially,the pores in COFs are constructed with lightweight elements,covalent bonds,and organic components,which offer numerous combinations to design and synthesize pore shapes,sizes,and interfaces.These parameters control the interplay with guest molecules and ions to determine the property and function of pores.Among various synthetic porous materials,COFs are unique in that these pore parameters are topologically designable and synthetically controllable.Two complementary strategies,i.e.,topology diagram and pore surface engineering,have been developed for pore chemistry,in which the first one emphasizes the in situ approach to design and control pores and the second one highlights the postsynthetic way to tune the pore structures finely yet precisely.These two different chemistries offer individual ways to explore different pores,properties,and functional materials and systems.Looking at the features of COFs,a basic common structure of the pores is the well-defined pore interface,which is constituted by aligned surface atoms and side units at a proximate distance along the pore long-axial direction and distributed periodically over the pores.These features of pore interfaces are specific to COFs and predetermine their functions.In this Account,we scrutinize the chemistry of pore interfaces by focusing on the pore shape,pore size,and aligned atoms and units on pore walls to design unique properties and functions.We highlight pore wall perturbation with surface atoms and side units to demonstrate their decisive roles in structural formation and functional expression.We summarize perspectives,key issues to be addressed,and opportunities with the aim of showing a promising way to next-stage materials and functional designs. | Lejian Deng Zhichao Ding Xingyao Ye Donglin Jiang | 2022 | Accounts of Materials Research2022，3，8： | 0 |
| 6 | Effect of chemical metallurgical factors on contents of S and P in weld metal during SAW显示文摘EffectofchemicalmetallurgicalfactorsoncontentsofSandPinweldmetalduringSAWXUESongbai;YEDonglin;HAOHemingandLIUWei(HarbinResear... | XUE Songbai YE Donglin HAO Heming and LIU Wei(sineior engineer,Harbin Research Institute of Welding. Harbin. 150080.) | 1996 | China Welding1996，5，1： | 0 |
| 7 | Electrical properties of Si/Si bonded wafers based on an amorphous Ge interlayer显示文摘An amorphous Ge(a-Ge) intermediate layer is introduced into the Si bonded interface to lower the annealing temperature and achieve good electrical characteristics. The interface and electrical characteristics of nSi/n-Si and p-Si/n-Si junctions manufactured by low-temperature wafer bonding based on a thin amorphous Ge are investigated. It is found that the bubble density tremendously decreases when the a-Ge film is not immersed in DI water. This is due to the decrease of the –OH groups. In addition, when the samples are annealed at 400 °C for20 h, the bubbles totally disappear. This can be explained by the appearance of the polycrystalline Ge(absorption of H_2) at the bonded interface. The junction resistance of the n-Si/n-Si bonded wafers decreases with the increase of the annealing temperature. This is consistent with the recrystallization of the a-Ge when high-temperature annealing is conducted. The carrier transport of the Si-based PN junction annealed at 350 °C is consistent with the trap-assisted tunneling model and that annealed at 400 °C is related to the carrier recombination model. | Shaoming Lin Shaoying Ke Yujie Ye Donglin Huang Jinyong Wu Songyan Chen Cheng Li Jianyuan Wang Wei Huang | 2018 | Journal of Semiconductors2018，39，11： | 0 |
| 8 | Theoretical study of a group IV p–i–n photodetector with a flat and broad response for visible and infrared detection显示文摘We report a theoretical study of a broadband Si/graded-SiGe/Ge/Ge0.9Sn0.1 p–i–n photodetector with a flat response based on modulating thickness of the layers in the active region.The responsivity of the photodetector is about 0.57 A/W in the range of 700 to 1800 nm.This structure is suitable for silicon-based epitaxial growth.Annealing is technically applied to form the graded-SiGe.The photodetector reaches a cut-off wavelength at^2300 nm and a low dark-current density under 3 V reverse bias about 0.17 mA/cm^2 is achieved theoretical at room temperature.This work is of great significance for silicon-based detection and communication,from visible to infrared. | Jinyong Wu Donglin Huang Yujie Ye Jianyuan Wang Wei Huang Cheng Li Songyan Chen Shaoying Ke | 2020 | Journal of Semiconductors2020，41，12： | 0 |
| 9 | Composition,function,and timing:exploring the early‑life gut microbiota in piglets for probiotic interventions显示文摘Background The establishment of a robust gut microbiota in piglets during their early developmental stage holds the potential for long-term advantageous effects.However,the optimal timeframe for introducing probiotics to achieve this outcome remains uncertain.Results In the context of this investigation,we conducted a longitudinal assessment of the fecal microbiota of 63 piglets at three distinct pre-weaning time points.Simultaneously,we gathered vaginal and fecal samples from 23 sows.Employing 16S rRNA gene and metagenomic sequencing methodologies,we conducted a comprehensive analysis of the fluctuation patterns in microbial composition,functional capacity,interaction networks,and colonization resistance within the gut microbiota of piglets.As the piglets progressed in age,discernible modifications in intestinal microbial diversity,composition,and function were observed.A source-tracking analysis unveiled the pivotal role of fecal and vaginal microbiota derived from sows in populating the gut microbiota of neonatal piglets.By D21,the microbial interaction network displayed a more concise and efficient configuration,accompanied by enhanced colonization resistance relative to the other two time points.Moreover,we identified three strains of Ruminococcus sp.at D10 as potential candidates for improving piglets’weight gain during the weaning phase.Conclusions The findings of this study propose that D10 represents the most opportune juncture for the introduction of external probiotic interventions during the early stages of piglet development.This investigation augments our comprehension of the microbiota dynamics in early-life of piglets and offers valuable insights for guiding forthcoming probiotic interventions. | Jianping Quan Cineng Xu Donglin Ruan Yong Ye Yibin Qiu Jie Wu Shenping Zhou Menghao Luan Xiang Zhao Yue Chen Danyang Lin Ying Sun Jifei Yang Enqin Zheng Gengyuan Cai Zhenfang Wu Jie Yang | 2024 | Journal of Animal Science and Biotechnology2024，15，2： | 0 |
| 10 | Skeletal muscle cell apoptosis following motor nerve injury versus sensory nerve injury显示文摘Skeletal muscle atrophy inevitably occurs in denervated skeletal muscle,and cell apoptosis plays an important role in skeletal muscle atrophy and degeneration.The present study established rat models of simple nerve injury by transecting the ventral or dorsal spinal nerve root and observed rat skeletal muscle cell apoptosis following simple motor nerve injury versus simple sensory nerve injury.Following skeletal muscle denervation for 10 weeks,cell apoptosis was detected in skeletal muscle,which was accompanied by obvious changes in rat behavior and electrophysiological responses.In addition,changes in cross-sectional area and average gray-scale of motor endplates of the gastrocnemius muscle were analyzed following sciatic nerve injury and motor nerve injury.Cell nuclei in denervated skeletal muscle tissue were more densely arranged than in normal skeletal muscle tissue.Cell nuclei were most dense in the sciatic nerve injury group,followed by the motor nerve injury group and the sensory nerve injury group.Fas/FasL expression and the number of apoptotic cells increased in denervated skeletal muscle,and apoptosis-related changes were observed.These findings suggested that motor and sensory nerves provided trophic actions following skeletal muscle and motor nerve injury,resulting in a greater influence on skeletal muscle atrophy than sensory nerve injury.Therefore,reconstruction of motor nerves should be preferentially considered for treating denervation-induced skeletal muscle atrophy. | Zhao, Lei Xu, Ruisheng Jiang, Shenyang Lue, Guangming Yan, Zhiqiang Sun, Junming Wang, Ling Xue, Ye Jiang, Donglin | 2011 | Neural Regeneration Research2011，6，3： | 0 |
| 11 | DUB3通过去泛素化BRD4促进BET抑制剂抗性和癌症进展显示文摘文章简介BRD4是Bromo结构域和末端结构域(BET)蛋白家族的成员。除了与乙酰化组蛋白相互作用外,BRD4还被证明通过以癌症类型特异性方式与转录因子物理和/或功能相互作用来促进癌症进展。这些发现强调BRD4是一种有前景的癌症治疗靶点。 | Xin Jin Yuqian Yan Dejie Wang Donglin Ding Tao Ma Zhenqing Ye Rafael Jimenez Liguo Wang 吴河水 Haojie Huang | 2019 | 科学新闻2019，0，2： | 0 |
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