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| 1 | Posterior quadrantic disconnection maintains the activity of isolated temporal-parietal-occipital nerve tissue: neuroprotective measures in the surgical treatment of epilepsy显示文摘Extensive lesions involving the posterior quadrant of the cerebral hemisphere(temporal,parietal,and occipital lobes)induce intractable epilepsy.These patients are potential candidates for surgical treatment[1].Maintenance of isolated nerve tissue activity after surgery plays a crucial role in the neuroprotective effects of neurosurgery treatment.Disconnection surgery of the posterior quadrant is used to completely isolate nerve fibers,while blood supply at the isolated lobes is maintained.Subsequently,cavities caused by | Shaoya Yin Keke Feng Mei Feng Xueqing Zhang Yuqin Zhang | 2014 | Neural Regeneration Research2014，9，4： | 4 |
| 2 | Mg-Fe LDH sealed PEO coating on magnesium for biodegradation control,antibacteria and osteogenesis显示文摘Attempt of developing bio-safety and functional layered double hydroxides(LDHs)modifed plasma electrolytic oxidation(PEO)coatings,has become a hotspot in the protection of magnesium(Mg)based biomedical implants.In the present work,Mg-Fe LDH flms with different Fe contents were fabricated on PEO coating via a novel two-step method:frstly,the Fe OOH flms were prepared by immersing PEO sample in Fe^(2+)-containing solution,and then Mg-Fe LDH flms were formed by transforming the Fe OOH flms via a hydrothermal treatment in water.The highly-oriented LDH nano-sheets could enhance the anti-corrosion performance of PEO coating,which was proved by the results of electrochemical test,hydrogen evolution and corroded morphology.PEO/Mg-Fe LDH coatings showed a low hemolysis rate(less5%)than PEO coating.In addition,PEO/Mg-Fe LDH coatings were more favorable for cell adhesion and proliferation than PEO coating.Moreover,PEO/Mg-Fe LDH coatings showed good photothermal conversion property,which demonstrated the excellent rapid antibacterial effect under NIR light.In vitro culture of rat bone marrow stem cell(r BMSC)suggested that cells cultured in the extract of PEO/Mg-Fe LDH coatings had a better osteogenic activity.In vivo subcutaneous implantation test revealed that PEO/Mg-Fe LDH coatings exhibited good anti-corrosion and histocompatibility. | Dongdong Zhang Jielong Zhou Feng Peng Ji Tan Xianming Zhang Shi Qian Yuqin Qiao Yu Zhang Xuanyong Liu | 2022 | Journal of Materials Science & Technology2022，，10： | 3 |
| 3 | Peroxisome proliferator activated receptor-γ ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells显示文摘 | Jiajun Liu Huiling Lu Renwei Huang Dongjun Lin Xiangyuan Wu Qu Lin Xinyao Wu Jing Zheng Xianglin Pan Jun Peng Yuqin Song Maohong Zhang Ming Hou Feng Chen | 2005 | Cancer Chemotherapy and Pharmacology2005，，4： | 1 |
| 4 | Route choice model considering generalized travel cost based on game theory显示文摘 | FENG YUQIN LENG JUNQIANG XIE ZHONGYU | 2013 | Mathematical Problems in Engineering2013，，1： | 1 |
| 5 | Further Understanding of the Food Safety Problem显示文摘Frequent occurrence of food quality and safety proves that it is not effective to solve the Problem only from mechanism and supervision mechanism. Instead,it may expand solution ideas from external environment inducing changes of social institutions. Edible agricultural products are raw materials of foods,so their quality and safety are decisive for food quality and safety. Combining with concept of quality and safety of edible agricultural products,from social economy,science,technology and culture,environment cognition,this paper made a further understanding of food quality and safety. It found that the quality and safety of domestic edible agricultural products are not completely resulted from human factor,and not completely quality and safety problem in practical sense. Design of problem solutions should consider such external factors as economic level and consumption concept,dual character of science and technology,cultural quality of the masses,and moral trait of the masses,and enhance matching of building of regulation tools with external environment. | Xingxing MEI Zhongchao FENG Pinghua HE Yawen GAO Yuqin DAI | 2015 | Asian Agricultural Research2015，7，7： | 1 |
| 6 | Route choice model Considering generalized ravel cost based on game theory 显示文摘 | FENG Yuqin LENG Junqiang ZHANG Yaping | 2013 | Mathematical Problems in Engineer- ing2013，，2013： | 1 |
| 7 | A new method for the prediction of network security situations based on recurrent neural network with gated recurrent unit显示文摘Purpose-The purpose of this paper is to solve the shortage of the existing methods for the prediction of network security situations(NSS).Because the conventional methods for the prediction of NSS,such as support vector machine,particle swarm optimization,etc.,lack accuracy,robustness and efficiency,in this study,the authors propose a new method for the prediction of NSS based on recurrent neural network(RNN)with gated recurrent unit.Design/methodology/approach-This method extracts internal and external information features from the original time-series network data for the first time.Then,the extracted features are applied to the deep RNN model for training and validation.After iteration and optimization,the accuracy of predictions of NSS will be obtained by the well-trained model,and the model is robust for the unstable network data.Findings-Experiments on bench marked data set show that the proposed method obtains more accurate and robust prediction results than conventional models.Although the deep RNN models need more time consumption for training,they guarantee the accuracy and robustness of prediction in return for validation.Originality/value-In the prediction of NSS time-series data,the proposed internal and external information features are well described the original data,and the employment of deep RNN model will outperform the state-of-the-arts models. | Wei Feng Yuqin Wu Yexian Fan | 2020 | International Journal of Intelligent Computing and Cybernetics2020，13，1： | 1 |
| 8 | An oligodeoxynucleotide that induces differentiation of bonemarrow mesenchymal stem cells to osteoblasts in vitro and reduces alveolar bone loss in rats with periodontitis 显示文摘 | Yuqin Shen Zhiyuan Feng Chongtao Lin | 2012 | Int J Mol Sci2012，13，3： | 1 |
| 9 | An oligodeoxynucleotide with promising modulation activity for the proliferation and activation of osteoblast 显示文摘 | Zhiyuan Feng Yuqin Shen Liying Wang | 2011 | Int J Mol Sci2011，12，4： | 1 |
| 10 | Efficacy and safety of obinutuzumab for the first-line treatment of follicular lymphoma:a subgroup analysis of Chinese patients enrolled in the phase III GALLIUM study显示文摘Backgrounds:GALLIUM is a global phase Ⅲ study that demonstrated significant improvements in progression-free survival(PFS)for obinutuzumab plus chemotherapy(G-chemo)vs.rituximab plus chemotherapy(R-chemo)in previously untreated patients with follicular lymphoma(FL).This study aimed to report the results of a subgroup of patients in China.Methods:Patients were randomized to G-chemo or R-chemo.Responders received maintenance therapy for 2 years or until disease progression.The primary endpoint was investigator(INV)-assessed PFS.Secondary endpoints included the overall response rate(ORR)and complete response rate(CRR)at the end of induction chemotherapy,overall survival(OS),and safety.Results:Overall,58 patients with FL were randomized to the G-chemo(n=25)and R-chemo arms(n=33).The INV-assessed PFS rate at 3 years was 81.8%in the G-chemo arm,vs.70.2%in the R-chemo arm(hazard ratio 0.35;95%confidence interval:0.09-1.34;P=0.1120).The INV-assessed CRRs(without positron emission tomography[PET])in these arms were 24.0%and 21.2%,respectively,whereas the ORRs were 80.0%and 90.9%,respectively.INV-assessed CRR-PET was 52.6%in the G-chemo,vs.60.9%in the R-chemo.Median OS was not reached in either arm.Grade 3 to 5 adverse events were more frequent in the R-chemo arm(97.0%vs.88.0%).Conclusions:The results of this subgroup analysis were consistent with those of the global population,and they suggest that G-chemo has a positive benefit-risk profile in patients from China with FL.Trial registration:ClinicalTrials.gov,No.NCT01332968. | Xiaonan Hong Yuqin Song Yuankai Shi Qingyuan Zhang Wei Guo Gang Wu Junmin Li Jifeng Feng Anastasiia Kinkolykh Andrea Knapp Tongyu Lin | 2022 | Chinese Medical Journal2022，，4： | 1 |
| 11 | Biomechanical evaluation of two fusion techniques based on finite element analysis:Percutaneous endoscopic and minimally invasive transforaminal lumbar interbody fusion显示文摘As a novel minimally invasive technique,percutaneous endoscopic transforaminal lumbar interbody fusion(PETLIF)has been widely used in the treatment of lumbar degenerative diseases.The purpose of this study was to analyze these two operation types’biomechanical performances of PE-TLIF and traditional minimally invasive transforaminal lumbar interbody fusion(MIS-TLIF)using the finite element(FE)method.The intact FE models of L4-L5 were established and validated based on the CT images.On this basis,the FE models of MIS-TLIF and PETLIF were established and analyzed.It is demonstrated that for lumbar interbody fusion with the oblique asymmetrically implanted cage under bilateral pedicle screws and rods fixation,such as MIS-TLIF and PE-TLIF,different degrees of articular process resection have no significant effect on the cage subsidence,and the surgical segment can achieve similar stability.In addition,the maximum stress of the L4 inferior endplate of MIS-TLIF and PE-TLIF is greater than that of the L5 superior endplate,which indicates that MIS-TLIF and PE-TLIF can cause cage subsidence in the L4 inferior endplate. | Yang Yan Jiarui Li Jianhao Yu Yan Wang Hao Dong Yuqin Sun Xiaogang Wu Liming He Weiyi Chen Haoyu Feng | 2022 | Medicine in Novel Technology and Devices2022，，4： | 1 |
| 12 | The effect of carbon sources on nitrogen removal performance in bioelectrochemical systems显示文摘 | Huajun Feng Baocheng Huang Yuqin Zou Na Li Meizhen Wang Ju Yin Yanqing Cong Dongsheng Shen | 2013 | Bioresource Technology2013，，： | 1 |
| 13 | PEGylated BODIPY assembling fluorescent nanoparticles for photodynamic therapy显示文摘Two amphiphilic macromolecules were synthesized from polyethylene glycol monomethylether(PEG)and borondipyrrolmethene(BODIPY) via one-pot multicomponent Passerini reaction,and they could self-assemble into stable nanoparticles(NPs) in aqueous media.The optical properties,including fluorescence resonance energy transfer(FRET) were studied in detail.The obtained NPs possess good cytocompatibility,and could be used for living cell imaging and effective photodynamic therapy(PDT).These results shed light on one-pot synthesis of PEGylated fluorescent nanoparticles via multicomponent reaction for biomedical application. | Yu Zhu Wenhai Lin Wei Zhang Yuqin Feng Zhineng Wu Li Chen Zhigang Xie | 2017 | Chinese Chemical Letters2017，28，9： | 1 |
| 14 | Microenvironment-responsive electrocution of tumor and bacteria by implants modified with degenerate semiconductor film显示文摘Implantable biomaterials are widely used in the curative resection and palliative treatment of various types of cancers.However,cancer residue around the implants usually leads to treatment failure with cancer reoccurrence.Postoperation chemotherapy and radiation therapy are widely applied to clear the residual cancer cells but induce serious side effects.It is urgent to develop advanced therapy to minimize systemic toxicity while maintaining efficient cancer-killing ability.Herein,we report a degenerate layered double hydroxide(LDH)film modified implant,which realizes microenvironment-responsive electrotherapy.The film can gradually transform into a nondegenerate state and release holes.When in contact with tumor cells or bacteria,the film quickly transforms into a nondegenerate state and releases holes at a high rate,rendering the“electrocution”of tumor cells and bacteria.However,when placed in normal tissue,the hole release rate of the film is much slower,thus,causing little harm to normal cells.Therefore,the constructed film can intelligently identify and meet the physiological requirements promptly.In addition,the transformation between degenerate and nondegenerate states of LDH films can be cycled by electrical charging,so their selective and dynamic physiological functions can be artificially adjusted according to demand. | Donghui Wang Shun Xing Feng Peng Xianming Zhang Ji Tan Xueqing Hao Yuqin Qiao Naijian Ge Xuanyong Liu | 2023 | Bioactive Materials2023，，2： | 0 |
| 15 | Long-term survival benefit of anti-PD-1 therapy in patients with relapsed or refractory classical Hodgkin lymphoma显示文摘Anti-programmed cell death-1(anti-PD-1)therapies have shown a favorable efficacy and good tolerance for relapsed or refractory(r/r)classical Hodgkin lymphoma(cHL).However,there are limited data on long-term outcomes among patients with r/r cHL who achieve an objective response to anti-PD-1 therapies.A total of 260 responders from four,phase 2 clinical trials were included in this study.The median age was 32 years with a male/female ratio of 1.3:1.After a median follow-up period of 31.1 months,116(44.6%)responders experienced disease progression and 18(6.9%)died. | Weiping Liu Ningjing Lin Xinqin Feng Yan Xie Chong You Xiaohua Zhou Yuqin Song Jun Zhu | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 16 | Impact of ENSO on MJO Pattern Evolution over the Maritime Continent显示文摘The modulation of Madden–Julian oscillation(MJO)pattern evolution over the Maritime Continent(MC)by El Nino–Southern Oscillation(ENSO)was investigated through a combined observational and modeling study.MJO convective branches shifted south of the equator over the MC during eastern Pacific(EP)El Nino winters,while it became relatively symmetric about the equator during La Ni?a winters.The impact of central Pacific(CP)El Ninos to MJO pattern,on the other hand,is not statistically significant.The cause of the distinctive MJO pattern evolutions is likely attributed to the ENSO-induced changes of the background moisture and vertical shear over the MC.Idealized numerical experiments with a 2.5-layer model were carried out,and the result revealed that the background moisture change played a dominant role.An observational diagnosis of column-integrated moist static energy(MSE)budgets was further conducted.The result indicated that the MJO pattern difference was attributed to the MSE tendency asymmetry in front of MJO convection between EP El Nino and La Ni?a,caused by the advection of the mean MSE by anomalous meridional wind.The difference in the MJO-scale anomalous meridional wind was ultimately controlled by the change of the background meridional moisture gradient associated with EP El Nino and La Ni?a. | Jia LIU Yuqin DA Tim LI Feng HU | 2020 | Journal of Meteorological Research2020，34，6： | 0 |
| 17 | Emergence of hypervirulent Pseudomonas aeruginosa pathotypically armed with co-expressed T3SS effectors ExoS and ExoU显示文摘Pseudomonas aeruginosa is a significant pathogen mainly causing healthcare-associated infections(HAIs).Newly emerging high-risk clones of P.aeruginosa with elevated virulence profiles furtherly cause severe community-acquired infections(CAIs).Usually,it is not common for P.aeruginosa to co-carry exoU and exoS genes,encoding two type III secretion system(T3SS)effectors.The pathogenicity mechanism of exoS+/exoU+strains of P.aeruginosa remains unclear.Here,we provide detailed evidence for a subset of hypervirulent P.aeruginosa strains,which abundantly co-express and secrete the T3SS effectors ExoS and ExoU.The exoS+/exoU+P.aeruginosa strains were available to cause both HAIs and CAIs.The CAI-associated strains could elicit severe inflammation and hemorrhage,leading to higher death rates in a murine acute pneumonia model,and had great virulence potential in establishing chronic infections,demonstrating hypervirulence when compared to PAO1(exoS+/exoU-)and PA14(exoS-/exoU+).Both ExoS and ExoU were co-expressed and co-secreted in abundance in exoS+/exoU+strains.Their abundant protein secretion could boost exoS+/exoU+strains’potentials for cytotoxicity in vitro and pathogenicity in vivo.Genomic evidence indicates that exoU acquisition is likely mediated by horizontal gene transfer(HGT)of the pathogenicity island PAPI-2,while deletion of exoU was sufficient to mitigate virulence in the exoS+/exoU+strains.Furthermore,bioinformatics analysis showed that such exoS+/exoU+P.aeruginosa strains turned out to be widely distributed across the globe.Overall,the research provide detailed evidence for the high virulence and epidemicity of exoS+/exoU+strains of P.aeruginosa,highlighting an urgent need for surveillance against these high-risk hypervirulent strains. | Yuqin Song Yongqi Mu Nai-Kei Wong Zhuo Yue Juan Li Min Yuan Xiong Zhu Jinshu Hu Gang Zhang Dawei Wei Chao Wang Weihui Wu Fang Bai Jie Feng | 2023 | hLife2023，1，1： | 0 |
| 18 | 6-31 Progress of Cryogenic System in 2014显示文摘During the year of 2014, the work of cryogenic group was mainly focused on operation of refrigerator system,test of TCM1, design and machining of HCM6. At the end of 2014 refrigerator system has achieved closed-loopoperation and recycle of helium gas, which did great contribution to superconducting cavity and superconductingmagnet test. Since the refrigerator was put into use(Fig. 1), it has operated continuously and reliably for more than5 110 h, reached helium lique ed capacity 270 L/h at 850 W. | Zhang Junhui Guo Xiaohong Jin Tao Zhao Yugang Niu Xiaofei Wan Yuqin Su Hailin Han Yanning Yang Yonghui Bai Feng Jiang Ziyun Hu Chuanfei Zhang Peng Guo Wanhong Yin Yukui Liu Zuohui Hu Yongping Wang Xianjin | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 19 | Effects of anesthetic depth on postoperative pain and delirium:a meta-analysis of randomized controlled trials with trial sequential analysis显示文摘Background:Whether anesthetic depth affects postoperative outcomes remains controversial.This meta-analysis aimed to evaluate the effects of deepvs.light anesthesia on postoperative pain,cognitive function,recovery from anesthesia,complications,and mortality.Methods:PubMed,EMBASE,and Cochrane CENTRAL databases were searched until January 2022 for randomized controlled trials comparing deep and light anesthesia in adult surgical patients.The co-primary outcomes were postoperative pain and delirium(assessed using the confusion assessment method).We conducted a meta-analysis using a random-effects model.We assessed publication bias using the Begg’s rank correlation test and Egger’s linear regression.We evaluated the evidence using the trial sequential analysis and Grading of Recommendations Assessment,Development and Evaluation(GRADE)methodology.We conducted subgroup analyses for pain scores at different postoperative time points and delirium according to cardiac or non-cardiac surgery.Results:A total of 26 trials with 10,743 patients were included.Deep anesthesia compared with light anesthesia(a mean difference in bispectral index of-12 to-11)was associated with lower pain scores at rest at 0 to 1 h postoperatively(weighted mean difference=-0.72,95%confidence interval[CI]=-1.25 to-0.18,P=0.009;moderate-quality evidence)and an increased incidence of postoperative delirium(24.95%vs.15.92%;risk ratio=1.57,95%CI=1.28-1.91,P<0.0001;high-quality evidence).No publication bias was detected.For the exploratory secondary outcomes,deep anesthesia was associated with prolonged postoperative recovery,without affecting neurocognitive outcomes,major complications,or mortality.In the subgroup analyses,the deep anesthesia group had lower pain scores at rest and on movement during 24 h postoperatively,without statistically significant subgroup differences,and deep anesthesia was associated with an increased incidence of delirium after non-cardiac and cardiac surgeries,without statistically significant subgroup differences.Conclusions:Deep anesthesia reduced early postoperative pain but increased postoperative delirium.The current evidence does not support the use of deep anesthesia in clinical practice. | Yuqin Long Xiaomei Feng Hong Liu Xisheng Shan Fuhai Ji Ke Peng | 2022 | Chinese Medical Journal2022，135，23： | 0 |
| 20 | 2017年低温系恒温器系统显示文摘ADS Injector-II linear accelerator is mainly composed of ECR ion source,LEBT,RFQ,MEBT,a superconducting accelerating segment and HEBT.The superconducting accelerating segment is composed of two HWR010 cavity cryomodules,a taper cavity cryomodule and a spoke cavity cryomodule(CM1+CM2+CM3+CM4),which has accelerated the proton beam to 25 MeV in Jun.2017. | Zhang Junhui Guo Xiaohong Bai Feng Wan Yuqin Hu Chuanfei Niu Xiaofei Zhang Peng Zhao Yugang Yin Yukui Guo Wanhong Hu Jianjun Wang Xianjin Han Yanning | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
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