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| 1 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 2 | Ultrathin defective high-entropy layered double hydroxides for electrochemical water oxidation显示文摘One of the fundamental driving forces in the materials science community is the hunt for new materials with specific properties that meet the requirements of rapidly evolving technology. | Kaizhi Gu Xiaoyan Zhu Dongdong Wang Nana Zhang Gen Huang Wei Li Peng Long Jing Tian Yuqin Zou Yanyong Wang Ru Chen Shuangyin Wang | 2021 | Journal of Energy Chemistry2021，30，9： | 1 |
| 3 | WTAP regulates postnatal development of brown adipose tissue by stabilizing METTL3 in mice显示文摘Brown adipocyte maturation during postnatal development is essential for brown adipose tissue(BAT)to protect animals against cold.Impaired maturation of brown adipocytes leads to cold intolerance.However,the molecular mechanisms that determine the maturation of brown adipocytes during postnatal development are not fully understood.Here,we identify Wilms’tumor 1-associating protein(WTAP)as an essential regulator in the postnatal development and maturation of BAT.BAT-specific knockout of Wtap(Wtap-BKO)severely impairs maturation of BAT in vivo by decreasing the expression of BAT-selective genes,leading to the whitening of interscapular BAT(iBAT).Single nucleus RNA-sequencing analysis shows the dynamic changes of cell heterogeneity in iBAT of Wtap-BKO mice.Adult mice with WTAP deficiency in BAT display hypothermic and succumb to acute cold challenge.Mechanistically,WTAP deficiency decreases m6A mRNA modification by reducing the protein stability of METTL3.BAT-specific overexpression of Mettl3 partially rescues the phenotypes observed in Wtap-BKO mice.These data demonstrate that WTAP/METTL3 plays an essential role in iBAT postnatal development and thermogenesis. | Yuqin Wang Xinzhi Li Cenxi Liu Liying Zhou Lei Shi Zhiguo Zhang Long Chen Ming Gao Lanyue Gao Yuanyuan Xu He Huang Jin Li Zheng Chen | 2022 | Life Metabolism2022，1，3： | 0 |
| 4 | Effects of anesthetic depth on postoperative pain and delirium:a meta-analysis of randomized controlled trials with trial sequential analysis显示文摘Background:Whether anesthetic depth affects postoperative outcomes remains controversial.This meta-analysis aimed to evaluate the effects of deepvs.light anesthesia on postoperative pain,cognitive function,recovery from anesthesia,complications,and mortality.Methods:PubMed,EMBASE,and Cochrane CENTRAL databases were searched until January 2022 for randomized controlled trials comparing deep and light anesthesia in adult surgical patients.The co-primary outcomes were postoperative pain and delirium(assessed using the confusion assessment method).We conducted a meta-analysis using a random-effects model.We assessed publication bias using the Begg’s rank correlation test and Egger’s linear regression.We evaluated the evidence using the trial sequential analysis and Grading of Recommendations Assessment,Development and Evaluation(GRADE)methodology.We conducted subgroup analyses for pain scores at different postoperative time points and delirium according to cardiac or non-cardiac surgery.Results:A total of 26 trials with 10,743 patients were included.Deep anesthesia compared with light anesthesia(a mean difference in bispectral index of-12 to-11)was associated with lower pain scores at rest at 0 to 1 h postoperatively(weighted mean difference=-0.72,95%confidence interval[CI]=-1.25 to-0.18,P=0.009;moderate-quality evidence)and an increased incidence of postoperative delirium(24.95%vs.15.92%;risk ratio=1.57,95%CI=1.28-1.91,P<0.0001;high-quality evidence).No publication bias was detected.For the exploratory secondary outcomes,deep anesthesia was associated with prolonged postoperative recovery,without affecting neurocognitive outcomes,major complications,or mortality.In the subgroup analyses,the deep anesthesia group had lower pain scores at rest and on movement during 24 h postoperatively,without statistically significant subgroup differences,and deep anesthesia was associated with an increased incidence of delirium after non-cardiac and cardiac surgeries,without statistically significant subgroup differences.Conclusions:Deep anesthesia reduced early postoperative pain but increased postoperative delirium.The current evidence does not support the use of deep anesthesia in clinical practice. | Yuqin Long Xiaomei Feng Hong Liu Xisheng Shan Fuhai Ji Ke Peng | 2022 | Chinese Medical Journal2022，135，23： | 0 |
| 5 | 6-5 Operation of HWRs for C-ADS Injector显示文摘There are two types of HWR cavities have been developed in IMP for C-ADS Injector.HWR010s have been used to accelerate proton from 2.1 MeV to 10 MeV.There are 12 HWR010s assembled in two CMs.The taper type HWR015s have been used to accelerate proton from 10MeV to 18.5 MeV.There are 5 HWRs assembled in the third CM.Proton beam has been accelerated to 26 MeV by HWR010,HWR015 and Spoke021 in June 2017.The beam has been accelerated to 18.5 MeV by HWR010 and HWR015.The CMs in the tunnel are shown in Fig.1. | Yue Weiming Zhang Shenghu Li Yongming Chang Wei Jiang Tiancai Zhang Shengxue Gao Zheng Wang Ruoxue Huang Shichun Pan Feng Chen Long Li Chunlong Song Yukun Guo Hao Xiong Pingran Cong Zhang Tan Teng Wan Yuqin Niu Xiaofei Bai Feng Hu Chuanfei Zhang Peng Liu Lubei Huang Yulu Zhao Yugang Guo Xiaohong You Zhiming Zhang Junhui Huang Guirong He Yuan | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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