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| 1 | pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells显示文摘Infection with Chlamydia trachomatis induces inflammatory pathologies in the urogenital tract that can lead to infertility and ectopic pregnancy.Pathogenesis of infection has been mostly attributed to excessive cytokine production.However,precise mechanisms on how C.trachomatis triggers this production,and which protein(s) stimulate inflammatory cytokines remains unknown.In the present study,the C.trachomatis pORF5 protein induced tumor necrosis factor alpha(TNF-α),interleukin-1 beta(IL-1β) and interleukin-8(IL-8) in dose-and time-dependent manners in the THP-1 human monocyte cell line.We found that intracellular p38/mitogen-activated protein kinase(MAPK) and extracellular signal-regulated kinase(ERK)/MAPK signaling pathways were required for the induction of TNF-α,IL-1β and IL-8.Blockade of toll-like receptor 2(TLR2) signaling reduced induction levels of TNF-α,IL-8 and IL-1β.We concluded that the C.trachomatis pORF5 protein might contribute to the inflammatory processes associated with chlamydial infections. | ZHOU Hui HUANG QiuLin LI ZhongYu WU YiMou XIE XiaoBing MA KangKang CAO WenJuan ZHOU Zhou LU ChunXue ZHONG GuangMing | 2013 | Science China(Life Sciences)2013，56，5： | 26 |
| 2 | Structural basis of Zika virus helicase in recognizing its substrates显示文摘Zika 的最近的爆炸爆发病毒(ZIKV ) 感染在南方和中美洲和加勒比海被报导了。与 ZIKV 感染联系的新生的头小畸型已经引起了国际担心的一种公共健康紧急情况。没有特定的疫苗或药当前是可得到的治疗 ZIKV 感染。ZIKV helicase,在病毒的 RNA 复制起一个枢轴的作用,是为治疗的一个吸引人的目标。我们决定了 ZIKV helicase-ATP-Mn 2+ 和 ZIKV helicase-RNA 的水晶结构。这是到 ATP 的任何 flavivirus helicase 界限的第一结构。有相关 flavivirus helicases 的比较证明了尽管在活跃地点的批评 P 环在不同种类之中有可变符合构造,认出 ATP/Mn 2+ 采用一个相同模式。ZIKV helicase-RNA 的结构表明了在 RNA 绑定之上,马达领域的旋转能引起重要 conformational 变化。惊人地,尽管 ZIKV 和登革热病毒(DENV ) apo-helicases 份额为 RNA 绑定保存了残余,他们在为 RNA 识别的不同单个模式的马达域旋转结果的不同礼貌。它建议 flavivirus helicases 能发展了一台保存引擎为 RNA 放松,而是不同马达领域旋转从 nucleoside triphosphate 把化学能变换成机械精力在可变 RNA 识别的结果适应单个病毒的复制的模式。 | Hongliang Tian Xiaoyun Ji Xiaoyun Yang Zhongxin Zhang zuoku Lu Kailin Yang Cheng Chen Qi Zhao Heng Chi Zhongyu Mu Wei Xie Zefang Wang Huiqiang Lou Haitao Yang Zihe Rao | 2016 | Protein & Cell2016，7，8： | 3 |
| 3 | Simulated photo-degradation of dissolved organic matter in lakes revealed by three-dimensional excitation-emission matrix with regional integration and parallel factor analysis显示文摘Simulated photo-degradation of fluorescent dissolved organic matter(FDOM) in Lake Baihua(BH) and Lake Hongfeng(HF) was investigated with three-dimensional excitationemission matrix(3 DEEM) fluorescence combined with the fluorescence regional integration(FRI),parallel factor(PARAFAC) analysis,and multi-order kinetic models.In the FRI analysis,fulvic-like and humic-like materials were the main constituents for both BH-FDOM and HF-FDOM.Four individual components were identified by use of PARAFAC analysis as humic-like components(C1),fulvic-like components(C2),protein-like components(C3) and unidentified components(C4).The maximum 3 DEEM fluorescence intensity of PARAFAC components C1-C3 decreased by about 60%,70% and 90%,respectively after photo-degradation.The multi-order kinetic model was acceptable to represent the photo-degradation of FDOM with correlation coefficient(Radj2)(0.963-0.998).The photo-degradation rate constants(kn) showed differences of three orders of magnitude,from 1.09 × 10-6 to 4.02 × 10-4 min-1,and half-life of multi-order model(T1/2n)ranged from 5.26 to 64.01 min.The decreased values of fluorescence index(FI) and biogenic index(BI),the fact that of percent fluorescence response parameter of Region I(PⅠ,n) showed the greatest change ratio,followed by percent fluorescence response parameter of Region II(PⅡ,n,while the largest decrease ratio was found for C3 components,and the lowest T1/2n was observed for C3,indicated preferential degradation of protein-like materials/components derived from biological sources during photodegradation.This research on the degradation of FDOM by 3 DEEM/FRI-PARAFAC would be beneficial to understanding the photo-degradation of FD OM in natural environments and accurately predicting the environmental behaviors of contaminants in the presence of FDOM. | Jin Zhang Fanhao Song Tingting Li Kefu Xie Huiying Yao Baoshan Xing Zhongyu Li Yingchen Bai | 2020 | Journal of Environmental Sciences2020，32，4： | 3 |
| 4 | USP22 promotes the G1/S phase transition by upregulating FoxM1 expressionvia β-catenin nuclear localization and is associated with poor prognosis in stageII pancreatic ductal adenocarcinoma显示文摘 | Zhen Ning Aman Wang Jinxiao Liang Yunpeng Xie Jiwei Liu Lu Feng Qiu Yan Zhongyu Wang | 2014 | International Journal of Oncology2014，，4： | 1 |
| 5 | USP22 promotes epithelial-mesenchymal transition via the FAK pathwayin pancreatic cancer cells显示文摘 | Zhen Ning Aman Wang Jinxiao Liang Yunpeng Xie Jiwei Liu Qiu Yan Zhongyu Wang | 2014 | Oncology Reports2014，，4： | 1 |
| 6 | 无人机遥感在植物生态学中的应用与挑战显示文摘无人机为获取高时空分辨率的遥感数据提供了经济灵活的工具,为植物生态学家开展从个体到区域尺度的生态学研究提供了新的机遇和手段。但作为一种新兴的技术手段,当前无人机遥感在植物生态学中的应用仍充满了挑战,植物生态学的科研需求与无人机遥感的生态应用需要更为深入的融合。本文综述了无人机遥感技术在植物生态学中的应用,展望了无人机在植物生态学研究中的应用前景。在所综述的400篇文献中,59%的文章发表于非植物生态学领域的遥感类期刊,遥感学者与生态学者的关注点存在较大差异。当前的研究集中在无人机遥感的技术层面,如数据处理和遥感反演方法等,对生态学问题本身的关注较少。综述的文献中,61%的研究案例集中在群落尺度,可见光(RGB)相机和多光谱相机是最常用的传感器类型(75%)。无人机遥感数据中蕴藏着诸多待挖掘的、有重要意义的生态参数,这些参数有助于我们识别林窗的几何特征,构建林冠的化学组合,更好地了解林冠表面的不规则性和群落的异质性。无人机遥感技术在植物生态学研究中的深入应用,需要集植物生态学家和遥感专家之合力共同推进。 | Zhongyu Sun Xiaonian Wang Zhihui Wang Long Yang Yichun Xie Yuhui Huang | 2021 | Journal of Plant Ecology2021，14，6： | 1 |
| 7 | Effects of Pre-Deforming and Isothermal Treatment on Structural Granular Transformation of as Cast ZA27 Alloy显示文摘 | Xie Hui (谢辉) Xu Lijun (许丽君) Yuan Zhongyue(袁中岳) | 2001 | The Chinese Journal of Nonferrous Metals(中国有色金属学报)2001，11，： | 1 |
| 8 | Route choice model considering generalized travel cost based on game theory显示文摘 | FENG YUQIN LENG JUNQIANG XIE ZHONGYU | 2013 | Mathematical Problems in Engineering2013，，1： | 1 |
| 9 | SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways显示文摘 | Jeongsoon Park Yue Chen Daniel X. Tishkoff Chao Peng Minjia Tan Lunzhai Dai Zhongyu Xie Yi Zhang Bernadette M.M. Zwaans Mary E. Skinner David B. Lombard Yingming Zhao | 2013 | Molecular Cell2013，，6： | 1 |
| 10 | Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis显示文摘As the major cell precursors in osteogenesis, mesenchymal stem cells(MSCs) are indispensable for bone homeostasis and development. However, the primary mechanisms regulating osteogenic differentiation are controversial. Composed of multiple constituent enhancers, super enhancers(SEs) are powerful cis-regulatory elements that identify genes that ensure sequential differentiation. The present study demonstrated that SEs were indispensable for MSC osteogenesis and involved in osteoporosis development. Through integrated analysis, we identified the most common SE-targeted and osteoporosis-related osteogenic gene,ZBTB16. ZBTB16, positively regulated by SEs, promoted MSC osteogenesis but was expressed at lower levels in osteoporosis.Mechanistically, SEs recruited bromodomain containing 4(BRD4) at the site of ZBTB16, which then bound to RNA polymerase IIassociated protein 2(RPAP2) that transported RNA polymerase Ⅱ(POL Ⅱ) into the nucleus. The subsequent synergistic regulation of POL Ⅱ carboxyterminal domain(CTD) phosphorylation by BRD4 and RPAP2 initiated ZBTB16 transcriptional elongation, which facilitated MSC osteogenesis via the key osteogenic transcription factor SP7. Bone-targeting ZBTB16 overexpression had a therapeutic effect on the decreased bone density and remodeling capacity of Brd4^(fl/fl)Prx1-cre mice and osteoporosis(OP) models.Therefore, our study shows that SEs orchestrate the osteogenesis of MSCs by targeting ZBTB16 expression, which provides an attractive focus and therapeutic target for osteoporosis. | Wenhui Yu Zhongyu Xie Jinteng Li Jiajie Lin Zepeng Su Yunshu Che Feng Ye Zhaoqiang Zhang Peitao Xu Yipeng Zeng Xiaojun Xu Zhikun Li Pei Feng Rujia Mi Yanfeng Wu Huiyong Shen | 2023 | Bone Research2023，11，3： | 1 |
| 11 | Characterization of Botryosphaeria dothidea, the causal agent of grapevine canker in China显示文摘 | Jiye Yan Yue Xie Shengwei Yao Zhongyue Wang Xinghong Li | 2012 | Australasian Plant Pathology2012，，4： | 1 |
| 12 | Ratiometric recognition of humidity by a europium-organic framework equipped with quasi-open metal site显示文摘Open metal site(OMS)seated in a luminescent lanthanide(Ln)metal center offers an opportunity for rationally tuning the spectroscopic behavior of lanthanide-organic frameworks aiming for a wide range of sensing applications.However,given the spherical nature of common coordination geometries of trivalent lanthanides and the generally strong Ln–O bonds,the lanthanide based OMS is rarely reported and difficult to be functionalized.We report here a unique europium-organic framework containing abundant quasi-OMS that is protected by an abnormal weak Eu–O bond.These quasi-OMSs offer reversible direct binding sites for water molecules probed by X-ray crystallography,leading to sensitive,visible,and ratiometric luminescent sensing toward humidity and water content in organic solvents.The specific recognition of water based on quasi-luminescentOMSs gives rise to a superior water detection limit down to 0.0003%v/v,which is one order of magnitude lower than that of Karl Fischer method. | Wei Zhang Jian Xie Zhuyin Sui Zhijun Xu Xiaoze Wang Min Lei Hongfa Zhang Zhongyue Li Yanlong Wang Wei Liu Wei Du Shuao Wang | 2021 | Science China Chemistry2021，64，10： | 1 |
| 13 | Galangin mitigates glucocorticoid-induced osteoporosis by activating autophagy of BMSCs via triggering the PKA/CREB signaling pathway显示文摘Glucocorticoid-induced osteoporosis(GIOP),one of the most common and serious adverse effects associated with glucocorticoid administration,manifests as decreased bone formation and increased bone resorption,eventually culminating in bone loss.Galangin(GAL)is a flavonoid extracted from the medicinal herbal galangal that possesses a variety of pharmacological activities and can inhibit osteoclastogenesis.However,the effects of GAL on GIOP remain unclear.Our study aims to explore the effects of GAL on GIOP in mice and the underlying mechanism.Our results show that GAL markedly mitigates the severity of dexamethasone(Dex)-induced osteoporosis in mice and potentiates osteogenic differentiation in mouse bone marrow-derived mesenchymal stem cells(BMSCs).Furthermore,GAL also significantly counteracts Dex-mediated suppression of osteogenic differentiation and autophagy in human BMSCs.GAL augments PKA/CREB-mediated autophagic flux in BMSCs and the bones of osteoporotic mice.GAL-mediated osteogenic differentiation in Dex-treated BMSCs is significantly decreased by the PKA inhibitor H89 and autophagy inhibitor 3-methyladenine.Collectively,our data indicate that GAL can ameliorate GIOP,partly by augmenting the mineralization of BMSCs by potentiating PKA/CREB-mediated autophagic flux,highlighting its potential therapeutic use in treating glucocorticoid-related osteoporosis. | Chenying Zeng Shan Wang Huimin Gu Fenglei Chen Ziming Wang Jinteng Li Zhongyu Xie Pei Feng Huiyong Shen Yanfeng Wu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 14 | Injectable hydrogels for spinal cord injury repair显示文摘Spinal cord injury(SCI)often causes severe functional impairment of body,which leads to a huge burden to the patient and the whole society.Many strategies,especially biomaterials,have been employed for SCI repair.Among various biomaterials,injectable hydrogels have attracted much attention because of their ability to load functional components and be injected into the lesioned area without surgeries.In this review,we summarize the recent progress in injectable hydrogels for SCI repair.We firstly introduce the pathophysiology of SCI,which reveals the mechanism of clinical manifestations and determines the therapeutic schedule.Then,we describe the original sources of polymers and the crosslinking manners in forming hydrogels.After that,we focus on the in vivo therapeutic strategies and effects of injectable hydrogels.Finally,the recent challenges and future outlook of injectable hydrogel for SCI repair are concluded and discussed.We believe this review can be helpful and inspire the further development of injectable hydrogels for SCI repair. | Huan Wang Hui Zhang Zhongyu Xie Keng Chen Mengjun Ma Yuejiao Huang Minli Li Zhaopeng Cai Peng Wang Huiyong Shen | 2022 | Engineered Regeneration2022，3，4： | 0 |
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