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| 1 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 2 | A critical survey of technologies of large offshore wind farm integration: summary, advances, and perspectives显示文摘Offshore wind farms(OWFs)have received widespread attention for their abundant unexploited wind energy poten-tial and convenient locations conditions.They are rapidly developing towards having large capacity and being located further away from shore.It is thus necessary to explore effective power transmission technologies to connect large OWFs to onshore grids.At present,three types of power transmission technologies have been proposed for large OWF integration.They are:high voltage alternating current(HVAC)transmission,high voltage direct current(HVDC)transmission,and low-frequency alternating current(LFAC)or fractional frequency alternating current transmission.This work undertakes a comprehensive review of grid connection technologies for large OWF integration.Compared with previous reviews,a more exhaustive summary is provided to elaborate HVAC,LFAC,and five HVDC topologies,consisting of line-commutated converter HVDC,voltage source converter HVDC,hybrid-HVDC,diode rectifier-based HVDC,and all DC transmission systems.The fault ride-through technologies of the grid connection schemes are also presented in detail to provide research references and guidelines for researchers.In addition,a comprehensive evalu-ation of the seven grid connection technologies for large OWFs is proposed based on eight specific indicators.Finally,eight conclusions and six perspectives are outlined for future research in integrating large OWFs. | Bo Yang Bingqiang Liu Hongyu Zhou Jingbo Wang Wei Yao Shaocong Wu Hongchun Shu Yaxing Ren | 2022 | Protection and Control of Modern Power Systems2022，7，1： | 4 |
| 3 | Progress on major genes for high fecundity in ewes显示文摘The existence of major genes affecting fecundity in sheep flocks throughout the world has been demonstrated.Three major genes whose mutations can increase ovulation rate have been discovered,and all related to the transforming growth factorβ(TGF-β)superfamily.The mutant FecB of bone morphogenetic protein receptor 1B(BMPR1B)has an additive effect on ovulation rate.Six mutations(Fec^(XI),Fec^(XH),Fec^(XG),Fec^(XB),Fec^(XL),Fec^(XR))of bone morphogenetic protein 15(BMP15)related with fertility have been identified that share the same mechanism.All the mutants can increase ovulation rate in heterozygotes and cause complete sterility in homozygotes.Homozygous ewes with two new mutations(FecX^(Gr),FecX^(O))of BMP15 had increased ovulation rate without causing sterility.There are five mutations in growth differentiation factor 9(GDF9)associated with sheep prolificacy where FecG^(E) and FecG^(F) have additive an effect on ovulation rate and litter size.The newly identifiedβ-1,4-N-acetylgalactosaminyltransferase 2(B4GALNT2)gene of FecL is proposed as a new mechanism of ovulation rate regulation in sheep.Woodlands is an X-linked maternally imprinted gene which increases ovulation rate.In addition,several putative major genes need to be verified.This review is focused on the identification of the mutations and mechanisms whereby the major genes affecting ovulation rate. | Qiuyue LIU Zhangyuan PAN Xiangyu WANG Wenping HU Ran DI Yaxing YAO Mingxing CHU | 2014 | Frontiers of Agricultural Science and Engineering2014，1，4： | 3 |
| 4 | Application of intraoperative O-arm-assisted real-time navigation technique for spinal fixation显示文摘This study explored the combined use of the O-arm and real-time navigation during spinal fixation. The clinical data for 60 patients undergoing spinal fixation, at Beijing Tsinghua Chang Gung Hospital between May 5, 2015 and May 1, 2017, were retrospectively analyzed. Pre-, intra-, and postoperative imaging findings were assessed. The patients were classified into the occipitocervical fusion(32 cases) and thoracic/lumbar/sacral spine fixation(28 cases, including 6 cases of percutaneous pedicle screw) groups. Lesion resections were performed microscopically. An O-arm, combined with real-time navigation, was used to assess spinal fixation. Efficacy was evaluated using operative times, X-ray times, screw positioning, and complications. Within the occipitocervical fusion group, 182 screws were placed in the cervical spine and 96 in the occipital bone. However, 6 screws penetrated the bone cortex and were adjacent to the vertebral arteries, based on O-arm three-dimensional imaging; therefore, the precision rate was 96.7%. Within the thoracic/lumbar/sacral spine fixation group, 148 pedicle screws were implanted, with 4 initially outside the vertebral body,yielding a precision rate of 97.3%. Ten percutaneous pedicle screws were implanted and well positioned. O-arm scans were performed 3 times/patient, with an average of 20–30 min/time. Screw implantation times were 5–7 min(cervical spine), 8–10 min(thoracic spine), and 6–8 min(lumbar spine). Intraoperative O-arm scans, combined with real-time navigation technology, allow real-time observation of screw angles and depths, improving the accuracy and safety of posterior screw fixations and reducing the radiation dose and frequency experienced by patients and surgeons. | Zhenxing Sun Dan Yuan Yaxing Sun Zhanquan Zhang Guihuai Wang Yi Guo Guoqin Wang Dongkang Liu Peng Chen Linkai Jing Feng Yang Peihai Zhang Huifang Zhang Youtu Wu Wei Shi James Wang | 2017 | Translational Neuroscience and Clinics2017，3，3： | 2 |
| 5 | A Spectral-element Time-Domain Solution of MAXWELL's Equations显示文摘 | Yaxing Liu Joon-Ho Lee Tian Xiao etc | 2006 | Microwave and Optical Technology Letters2006，48，4： | 1 |
| 6 | Use of grid computing for modeling virtual geospatial prod- ucts显示文摘 | Chen Aijun Di Liping Wei Yaxing Bai Yuqi and Liu Yang | 2009 | International Journal of Geographical Information Science2009，23，5： | 1 |
| 7 | Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation显示文摘One major strategy to generate genetically modified mouse models is gene targeting in mouse embryonic stem(ES)cells,which is used to produce gene-targeted mice for wide applications in biomedicine.However,a major bottleneck in this approach is that the robustness of germiine transmission of gene-targeted ES cells can be significantly reduced by their genetic and epigenetic instability after long-term culturing,which impairs the efficiency and robustness of mouse model generation.Recently,we have established a new type of pluripotent cells termed extended pluripotent stem(EPS)cells,which have superior developmental potency and robust germline competence compared to conventional mouse ES cells.In this study,we demonstrate that mouse EPS cells well maintain developmental potency and genetic stability after long-term passage.Based on gene targeting in mouse EPS cells,we established a new approach to directly and rapidly generate gene-targeted mouse models through tetraploid complementation,Haibo Li and Chaoran Zhao contributed equally to this work.Electronic supplementary material The online version of this article(http://gffzzd3cc09b8251d45dfsq955kqbcob9b6ukf.ffgz.tsg.suse.edu.cn/10.1007/s13238-018-0556-1)contains supplementary material,which is available to authorized users.which could be accomplished in approximately 2 months.Importantly,using this approach,we successfully constructed mouse models in which the human interleukin 3(IL3)or interleukin 6(IL6)gene was knocked into its corresponding locus in the mouse genome.Our study demonstrates the feasibility of using mouse EPS cells to rapidly generate mouse models by gene targeting,which have great application potential in biomedical research. | Haibo Li Chaoran Zhao Jun Xu Yaxing Xu Chunmei Cheng Yinan Liu Ting Wang Yaqin Du Liangfu Xie Jingru Zhao Yanchuang Han Xiaobao Wang Yun Bai Hongkui Deng | 2019 | Protein & Cell2019，10，1： | 1 |
| 8 | UranyI Phosphonates with Multiple UranyI Coordination Geometries and Low Temperature Phase Transition显示文摘Main observation and conclusion Two new uranium(VI)phosphonate compounds,namely K_(8)[N(C_(2)H_(5))_(4)]_(2)(UO_(2))_(17)(H_(2)O)_(4)[CH_(2)(PO_(3))_(2)]_(8)[CH_(2)(PO_(3))(PO_(3)H)]_(4)·16(H_(2)O)(1)and[N(C_(2)H_(5))_(4)]_(4)(H_(3)O)_(2)(UO_(2))_(10)[CH_(2)(PO_(3))_(2)]_(5)[CH_(2)(PO_(3))(PO_(3)H)]_(2)·10H_(2)O(2),have been synthesized under mild hydro/solvothermal condition.The structural analysis of the two compounds reveals that they both contain all three typical coordination geometries of the U(VI)ions,including UO;tetragonal,UO,pentagonal,and UOg hexagonal bipyramids.Moreover,compound 1 displays a tempera-ture-induced single crystal to single crystal phase transformation as confirmed by the Single-crystal X-ray diffraction data collected at different temperatures.Temperature-dependent fluorescence spectra presented herein illustrate the perturbation of the electronic structure of uranyl centers. | Lanhua Chen Yugang Zhang Zhehui Weng Zhiyong Liu Jiarong Zhang Yaxing Wang Shuao Wang | 2021 | Chinese Journal of Chemistry2021，39，3： | 1 |
| 9 | Derivation of totipotent-like stem cells with blastocyst-like structure forming potential显示文摘It is challenging to derive totipotent stem cells in vitro that functionally and molecularly resemble cells from totipotent embryos.Here,we report that a chemical cocktail enables the derivation of totipotent-like stem cells,designated as totipotent potential stem(TPS)cells,from 2-cell mouse embryos and extended pluripotent stem cells,and that these TPS cells can be stably maintained long term in vitro.TPS cells shared features with 2-cell mouse embryos in terms of totipotency markers,transcriptome,chromatin accessibility and DNA methylation patterns.In vivo chimera formation assays show that these cells have embryonic and extraembryonic developmental potentials at the single-cell level.Moreover,TPS cells can be induced into blastocyst-like structures resembling preimplantation mouse blastocysts.Mechanistically,inhibition of HDAC1/2 and DOT1L activity and activation of RARγsignaling are important for inducing and maintaining totipotent features of TPS cells.Our study opens up a new path toward fully capturing totipotent stem cells in vitro. | Yaxing Xu Jingru Zhao Yixuan Ren Xuyang Wang Yulin Lyu Bingqing Xie Yiming Sun Xiandun Yuan Haiyin Liu Weifeng Yang Yenan Fu Yu Yu Yinan Liu Rong Mu Cheng Li Jun Xu Hongkui Deng | 2022 | Cell Research2022，32，6： | 1 |
| 10 | Binding energies, lifetimes and implications of bulk and interface solvated electrons in water 显示文摘 | SIEFERMANN K R LIU Yaxing LUGOVOY E | 2010 | Nature Chem2010，2，4： | 1 |
| 11 | Graphlike Manifolds显示文摘 | Liu Yaxing Li Qisheng | 1994 | Chinese Quart J Math1994，9，4： | 1 |
| 12 | Graphlike Manifolds with Contraction ×显示文摘Graphlike Manifolds with Contraction ×GraphlikeManifoldswithContraction×￥LiuYaxing;LiQisheng(Dept.ofMath.HenanUniversity,... | Liu Yaxing Li Qisheng(Dept.of Math. Henan University,Kaifeng, 475001 ) | 1996 | Chinese Quarterly Journal of Mathematics1996，11，1： | 1 |
| 13 | Transition towards carbon-neutral electrical systems for China:Challenges and perspectives显示文摘1Ambitious goal towards carbon-neutral power systems in China International Panel on Climate Change(IPCC)revealed the necessity to neutralize CO_(2) emissions from global energy systems by mid-century in order to contain the temperatureraise below1.5°Cby2100.China,accounting for over 30% of global CO_(2)emissions,represents the largest challenge globally for decarbonization.In September 2020,at the 75th United Nations General Assembly(UNGA),President Xi announced that China will strive to peak carbon emissions by 2030 and to achieve carbon neutrality by 2060.Following the commitment,policies have been advanced to achieve these goals. | Xinyu CHEN Yaxing LIU Michael MCELROY | 2022 | Frontiers of Engineering Management2022，9，3： | 1 |
| 14 | Research for length change of four seasons over China in recent 47 years显示文摘Using daily temperature data from 599 Chinese weather stations during 1961-2007, the length change trends of four seasons during the past 47 years were analyzed. Results show that throughout the region, four seasons' lengths are: spring becomes shorter (?0.8 d/10yrs), summer becomes longer (3.2 d/10yrs), autumn (?0.5 d/10yrs) and winter (?1.6 d/10yrs) becomes shorter. This trend is different in spatial distribution, namely it is very obvious in northern than southern China, and also remarkable in eastern than western China. Summer change is most obvious, but autumn has little change comparatively. This trend is highly obvious in North, East, Central and South China. In the Southwest starting in the 21st century, summer becomes longer and winter shortens. The trend in the Plateau region since the 1980s is that spring becomes longer and winter shortens. The average annual temperature increased during the past 47 years, and the change of the average annual temperature precedes seasons' length. Thus, the average annual temperature has a certain influence on the length change of seasons. | ZhenYan Yu GuangZhou Fan Wei Hua DingWen Zhou Xin Lai YaXing Liu | 2011 | Research in Cold and Arid Regions2011，3，6： | 1 |
| 15 | Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons显示文摘The expression of linear DNA sequence is precisely regulated by the three-dimensional(3D)architecture of chromatin.Morphine-induced aberrant gene networks of neurons have been extensively investigated;however,how morphine impacts the 3D genomic architecture of neurons is still unknown.Here,we applied digestion-ligation-only high-throughput chromosome conformation capture(DLO Hi-C)technology to investigate the effects of morphine on the 3D chromatin architecture of primate cortical neurons.After receiving continuous morphine administration for 90 days on rhesus monkeys,we discovered that morphine re-arranged chromosome territories,with a total of 391 segmented compartments being switched.Morphine altered over half of the detected topologically associated domains(TADs),most of which exhibited a variety of shifts,followed by separating and fusing types.Analysis of the looping events at kilobase-scale resolution revealed that morphine increased not only the number but also the length of differential loops.Moreover,all identified differentially expressed genes from the RNA sequencing data were mapped to the specific TAD boundaries or differential loops,and were further validated for changed expression.Collectively,an altered 3D genomic architecture of cortical neurons may regulate the gene networks associated with morphine effects.Our finding provides critical hubs connecting chromosome spatial organization and gene networks associated with the morphine effects in humans. | Liang Wang Xiaojie Wang Chunqi Liu Wei Xu Weihong Kuang Qian Bu Hongchun Li Ying Zhao Linhong Jiang Yaxing Chen Feng Qin Shu Li Qinfan Wei Xiaocong Liu Bin Liu Yuanyuan Chen Yanping Dai Hongbo Wang Jingwei Tian Gang Cao Yinglan Zhao Xiaobo Cen | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 16 | A uranyl based coordination polymer showing response to low-dosage ionizing radiations down to 10^(−5) Gy显示文摘Radiation detection material is a central component of nuclear technology finding applications in many critical fields.Developing a highly radiation-sensitive material that shows a facilely detectable response to ultra-low dosage of radiation is a long-term research target and remains to be a challenge.Previously reported most optimal chemical radiation dosimeter can detect low-dosage X-andγ-ray radiations down to 10^(−4) Gy.We document here a new photoresponsive coordination polymer showing upgraded radiation detection capabilities with the detection limit on the radiation dose one order of magnitude lower than the previous record.The radiation induced photoluminescence quenching process was elucidated by multiple spectroscopic characterizations. | Jian Xie Yaxing Wang Wei Liu Chengyu Liang Yugang Zhang Lanhua Chen Daopeng Sheng Zhifang Chai Shuao Wang | 2020 | Science China Chemistry2020，63，11： | 0 |
| 17 | TiO_(2) nanorods based self-supported electrode of 1T/2H MoS_(2) nanosheets decorated by Ag nano-particles for efficient hydrogen evolution reaction显示文摘Molybdenum disulfide(MoS_(2))has shown significant promise as an economic hydrogen evolution reaction(HER)catalyst for hydrogen generation,but its catalytic performance is still lower than noble metalbased catalysists.Herein,a silver nanoparticles(Ag NPs)-decorated 1T/2H phase layered MoS_(2) electrocatalyst grown on titanium dioxide nanorod arrays(Ag NPs/1T(2H)MoS_(2)/TNRs)was prepared through acid-tunable ammonium ion intercalation.Taking advantage of MoS_(2) layered structure and crystal phase controllability,as-prepared Ag NPs/1T(2H)MoS_(2)/TNRs exhibited ultrahigh HER activity.As-proposed strategy combines facile hydrogen desorption(Ag NPs)with efficient hydrogen adsorption(1T/2H MoS_(2))effectively circumventes the kinetic limitation of hydrogen desorption by 1T/2H MoS_(2).The as-prepared Ag NPs/1T(2H)MoS_(2)/TNRs electrocatalyst exhibited excellent HER activity in 0.5 mol/L H2SO4 with low overpotential(118 mV vs.reversible hydrogen electrode(RHE))and small Tafel slope(38.61 mV/dec).The overpotential exhibts no obvious attenuation after 10 h of constant current flow.First-principles calculation demonstrates that as-prepared 1T/2H MoS_(2) exhibit a large capacity to store protons.These protons can be subsequently transferred to Ag NPs,which significantly increases the hydrogen coverage on the surface of Ag NPs in HER process and thus change the rate-determining step of HER on Ag NPs from water dissociation to hydrogen recombination.This study provides a unique strategy to improve the catalytic activity and stability for MoS_(2)-based electrocatalyst. | Changzheng Lin Yunpeng Liu Yaxing Sun Zhenyu Wang Hao Xu Mingtao Li Jiangtao Feng Bo Hou Wei Yan | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 18 | Benefit-based cost allocation for residentially distributed photovoltaic systems in China:A cooperative game theory approach显示文摘Distributed photovoltaic(PV)systems have constantly been the key to achieve a low-carbon economy in China.However,the development of Chinese distributed PV systems has failed to meet expectations because of their irrational profit and cost allocations.In this study,the methodology for calculating the levelized cost of energy(LCOE)for PV is thoroughly discussed to address this issue.A mixed-integer linear programming model is built to determine the optimal system operation strategy with a benefit analysis.An externality-corrected mathematical model based on Shapley value is established to allocate the cost of distributed PV systems in 15 Chinese cities between the government,utility grid and residents.Results show that(i)an inverse relationship exists between the LCOEs and solar radiation levels;(ii)the government and residents gain extra benefits from the utility grid through net metering policies,and the utility grid should be the highly subsidized participant;(iii)the percentage of cost assigned to the utility grid and government should increase with the expansion of battery bank to weaken the impact of demand response on increasing theoretical subsidies;and(iv)apart from the LCOE,the local residential electricity prices remarkably impact the subsidy calculation results. | Xi LUO Xiaojun LIU Yanfeng LIU Jiaping LIU Yaxing WANG | 2021 | Frontiers of Engineering Management2021，8，2： | 0 |
| 19 | Three-dimensional-printed collagen/chitosan/secretome derived from HUCMSCs scaffolds for efficient neural network reconstruction in canines with traumatic brain injury显示文摘The secretome secreted by stem cells and bioactive material has emerged as a promising therapeutic choice for traumatic brain injury(TBI).We aimed to determine the effect of 3D-printed collagen/chitosan/secretome derived from human umbilical cord blood mesenchymal stem cells scaffolds(3D-CC-ST)on the injured tissue regeneration process.3D-CC-ST was performed using 3D printing technology at a low temperature(20C),and the physical properties and degeneration rate were measured.The utilization of low temperature contributed to a higher cytocompatibility of fabricating porous 3D architectures that provide a homogeneous distribution of cells.Immediately after the establishment of the canine TBI model,3D-CC-ST and 3D-CC(3D-printed collagen/chitosan scaffolds)were implanted into the cavity of TBI.Following implantation of scaffolds,neurological examination and motor evoked potential detection were performed to analyze locomotor function recovery.Histological and immunofluorescence staining were performed to evaluate neuro-regeneration.The group treated with 3D-CC-ST had good performance of behavior functions.Implanting 3D-CC-ST significantly reduced the cavity area,facilitated the regeneration of nerve fibers and vessel reconstruction,and promoted endogenous neuronal differentiation and synapse formation after TBI.The implantation of 3D-CC-ST also markedly reduced cell apoptosis and regulated the level of systemic inflammatory factors after TBI. | Xiaoyin Liu Guijun Zhang Pan Wei Lin Zhong Yaxing Chen Jianyong Zhang Xuyi Chen Liangxue Zhou | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 20 | Proof of retrievability based on LDPC codes显示文摘In order to reduce the computational overhead of proof of retrievability(POR) scheme, a new POR scheme based on low-density parity-check(LDPC) codes is proposed, noted as LDPC-POR. In the model of PORs scheme, the client preprocesses the data and sends it to an untrusted server for storage, only keeping some metadata. Then, the client sends a challenge to the server to prove that the data stored at the server has neither been tampered nor deleted. In the setup phase of this scheme, the client uses LDPC code to encode the data, and blinds data with permutation and pseudo-random stream. In the challenge phase, the server generates the proof completely based on exclusive OR(XOR), after that the client makes use of the LDPC code to prove the validity of proof. The theoretical analysis shows that this scheme not only reduces the computational overhead, but also saves storage space compared with the classical scheme. In the meantime security proof is also provided in this paper showing that this scheme is feasible. | Bian Jianchao Liu Huixia Luo Shoushan Zha Yaxing Li Wei | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，4： | 0 |
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