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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Emerging role of deep learning-based artificial intelligence in tumor pathology显示文摘The development of digital pathology and progression of state-of-the-art algorithms for computer vision have led to increasing interest in the use of artificial intelligence(AI),especially deep learning(DL)-based AI,in tumor pathology.The DL-based algorithms have been developed to conduct all kinds of work involved in tumor pathology,including tumor diagnosis,subtyping,grading,staging,and prognostic prediction,as well as the identification of pathological features,biomarkers and genetic changes.The applications of AI in pathology not only contribute to improve diagnostic accuracy and objectivity but also reduce the workload of pathologists and subsequently enable them to spend additional time on high-level decision-making tasks.In addition,AI is useful for pathologists to meet the requirements of precision oncology.However,there are still some challenges relating to the implementation of AI,including the issues of algorithm validation and interpretability,computing systems,the unbelieving attitude of pathologists,clinicians and patients,as well as regulators and reimbursements.Herein,we present an overview on how AI-based approaches could be integrated into the workflow of pathologists and discuss the challenges and perspectives of the implementation of AI in tumor pathology. | Yahui Jiang Meng Yang Shuhao Wang Xiangchun Li Yan Sun | 2020 | Cancer Communications2020，40，4： | 15 |
| 3 | A review:Photonics devices,architectures,and algorithms for optical neural computing显示文摘The explosive growth of data and information has motivated various emerging non-von Neumann computational approaches in the More-than-Moore era.Photonics neuromorphic computing has attracted lots of attention due to the fascinating advantages such as high speed,wide bandwidth,and massive parallelism.Here,we offer a review on the optical neural computing in our research groups at the device and system levels.The photonics neuron and photonics synapse plasticity are presented.In addition,we introduce several optical neural computing architectures and algorithms including photonic spiking neural network,photonic convolutional neural network,photonic matrix computation,photonic reservoir computing,and photonic reinforcement learning.Finally,we summarize the major challenges faced by photonic neuromorphic computing,and propose promising solutions and perspectives. | Shuiying Xiang Yanan Han Ziwei Song Xingxing Guo Yahui Zhang Zhenxing Ren Suhong Wang Yuanting Ma Weiwen Zou Bowen Ma Shaofu Xu Jianji Dong Hailong Zhou Quansheng Ren Tao Deng Yan Liu Genquan Han Yue Hao | 2021 | Journal of Semiconductors2021，42，2： | 7 |
| 4 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 5 | Recent progress in organic solar cells(PartⅠmaterial science)显示文摘During past several years,the photovoltaic performances of organic solar cells(OSCs)have achieved rapid progress with power conversion efficiencies(PCEs)over 18%,demonstrating a great practical application prospect.The development of material science including conjugated polymer donors,oligomer-like organic molecule donors,fused and nonfused ring acceptors,polymer acceptors,single-component organic solar cells and water/alcohol soluble interface materials are the key research topics in OSC field.Herein,the recent progress of these aspects is systematically summarized.Meanwhile,the current problems and future development are also discussed. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，2： | 5 |
| 6 | Recent progress in organic solar cells(PartⅡdevice engineering)显示文摘1 Introduction Organic solar cells(OSCs)belong to a multidisciplinary field composed of chemistry,materials science,physics,engineering,etc.For a better reviewing of this field,we briefly divide the research field of OSCs into two parts:material science and device engineering.In our previous review,the material science part of OSCs,including conjugated polymer donors and acceptors,small molecular donors and acceptors. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yuqiang Liu Lei Meng Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，8： | 3 |
| 7 | Enhanced CO_(2)electroreduction to ethylene via strong metal-support interaction显示文摘The CuO/CeO_(2) composites with strong metal-support interaction were synthesised,which can efficiently electroreduct CO_(2)to C(2)H_(4).The Faradaic efficiency(FE)of C_(2)H_(4) could reach 50.5%with a current density of 18 mA cm^(-2).The strong metal-support interaction could not only enhance the adsorption and activation of CO_(2),but also can stablize the CuO. | Mengen Chu Chunjun Chen Yahui Wu Xupeng Yan Shuaiqiang Jia Ruting Feng Haihong Wu Mingyuan He Buxing Han | 2022 | Green Energy & Environment2022，7，4： | 3 |
| 8 | A New Quantum Algorithm for Computing RSA Ciphertext Period显示文摘Shor proposed a quantum polynomial-time integer factorization algorithm to break the RSA public-key cryptosystem.In this paper,we propose a new quantum algorithm for breaking RSA by computing the order of the RSA ciphertext C.The new algorithm has the following properties:1)recovering the RSA plaintext M from the ciphertext C without factoring n;2)avoiding the even order of the element;3)having higher success probability than Shor's;4)having the same complexity as Shor's. | WANG Yahui YAN Songyuan ZHANG Huanguo | 2017 | Wuhan University Journal of Natural Sciences2017，22，1： | 2 |
| 9 | Multiscale evolution mechanism of sandstone under wet-dry cycles of deionized water:From molecular scale to macroscopic scale显示文摘Water is the most abundant molecule found on the earth’s surface and is a key factor in multiscale rock destruction.However,given the fine-grained nature of rock and the complexity of its internal structure,the microstructural evolution of rock under the action of water has not yet been elucidated in detail,and little is understood about the relationship between the rock structure and solideliquid unit.A variety of techniques were used in this study to track the mechanical properties,pore and crack characteristics,and mineral structure degradation characteristics of sandstone at different stages under the action of deionized water,and the evolution mechanisms of the microstructure were analyzed at the molecular scale.The results showed that during the watererock interaction process,water was adsorbed onto the surface of dolomite minerals and the hydrophilic surface of clay minerals,forming a high-density hydrogen bond network.However,different mineral surface structures had different water adsorption structures,resulting in the strain of the dense clay mineral aggregates under expansion action.Stress concentrated at crack tips under the capillary force of dolomite minerals(very weak dolomite dissolution).These effects resulted in a substantial increase in the number of small pores and enhancements in poreecrack connectivity,and the rock strength exhibited varying degrees of decline at different stages of wet-dry cycles.In general,the results of this paper will help to further elucidate the internal connections between molecular-scale and macroscale processes in rock science. | Jie Meng Changdong Li Jia-Qing Zhou Zihan Zhang Shengyi Yan Yahui Zhang Dewei Huang Guihua Wang | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，5： | 1 |
| 10 | Control of numberof graphene layers using ultrasound in supercritical CO2 and theirapplication in lithium-ion batteries显示文摘 | Wang Wucong Wang Yan Gao Yahui | 2014 | Journal of SupercriticalFluids2014，85，95： | 1 |
| 11 | Algorithms of target detection on hyperspectral imagery显示文摘 | Yahui Yan Bingqi Liu | 2013 | Optik2013，，124： | 1 |
| 12 | Influence of surface free energy on the adhesion of marine benthic diatom Nitzsehia closterium MMDL533 显示文摘 | Li Yan Gao Yahui Li Xuesong | 2010 | Colloids Surf B: Biointerf2010，75，： | 1 |
| 13 | RETRACTED ARTICLE:Thermal,mechanical,and tribological properties of sodium-montmorillonite-nanoparticle-reinforced polyethersulfone and polytetrafluoroethylene ternary composites显示文摘The Editor-in-Chief has retracted this article[1]because a large number of figures as well significant parts of the text overlap with the 2017 Ph.D.thesis by Zhen Zuo[2].All authors agree to this retraction.[1]Yan S C,Xue Y H,Hu Y H,Wang S J.Thermal,mechanical,and tribological properties of sodium-montmorillonite-nanoparticlereinforced polyethersulfone and polytetrafluoroethylene ternary composites.Friction(2020).http://gffzzd3cc09b8251d45dfs96kb9kuxnu696u6w.ffgz.tsg.suse.edu.cn/10.1007/s40544-019-0343-x.[2]Zuo Z.Research on tribological property and friction interface interaction of PES/PTFE composite.Ph.D Thesis.Qinhuangdao(China):Yanshan University,2017. | Shicheng YAN Yahong XUE Yahui HU Shoujun WANG | 2022 | Friction2022，10，7： | 1 |
| 14 | Research progress of tunnel-type sodium manganese oxide cathodes for SIBs显示文摘Among the large energy storage batteries,the sodium ion batteries(SIBs)are attracted huge interest due to the fact of its abundant raw materials and low cost,and has become the most promising secondary battery.Tunnel-type sodium manganese oxides(TMOs)are industrialized cathode materials because of their simple synthesis method and proficient electrochemical performance.Na_(0.44)MnO_(2)(NMO)is considered the best candidate material for all tunnel-type structural materials.In this paper,the research progress in charge and discharge of cathode materials for tunnel-type structural SIBs is reviewed,the redox mechanism and all sorts of synthesis methods and different coating methods lead to different morphology and electrochemical properties of materials and the classification of electrolytes and nonaqueous electrolytes.The development and utility of aqueous solutions are discussed,and the mechanism is analyzed.Summarized the cationic potential of the transition metal oxide for tunnel structure,plays a vital role in predicting and designing the cathode material of this structure.In addition,the future opportunities and challenges for such tunnel-type SIBs in this field are described in detail. | Jie Feng Shaohua Luo Kexing Cai Shengxue Yan Qing Wang Yahui Zhang Xin Liu | 2022 | Chinese Chemical Letters2022，33，5： | 1 |
| 15 | Novel P2-type layered medium-entropy ceramics oxide as cathode material for sodium-ion batteries显示文摘High-entropy oxides(HEOs)and medium-entropy oxides(MEOs)are new types of single-phase solid solution materials.MEOs have rarely been reported as positive electrode material for sodium-ion batteries(SIBs).In this study,we first proposed the concept of the application of MEOs in SIBs.P2-type 3-cation oxide Na_(2/3)Ni_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)and 4-cation oxide Na_(2/3)Ni_(1/3)Mn_(1/3)Fe_(1/3-x)Al_(x)O_(2)(NaNMFA)were prepared using the solid-state method,rather than the doping technology.In addition,the importance of the concept of entropy stabilization in material performance and battery cycling was demonstrated by testing 3-cation(NaNMF)and 4-cation(NaNMFA)oxides in the same system.Thus,NaNMFA can provide a reversible capacity of about 125.6 mAh-g”1 in the voltage range of 2-4.2 V,and has enhanced cycle stability.The capacity and decay law of the MEO batteries indicate that the configurational entropy(1.28 R(NaNMFA)>1.10 R(NaNMF))of the cationic system,is the main factor affecting the structural and cycle stability of the electrode material.This work emphasizes that the rational design of MEOs with novel structures and different electrochemically active elements may be the strategy for exploring high-performance SIB cathode materials in next-generation energy storage devices. | Shengxue YAN Shaohua LUO Liu YANG Jian FENG Pengwei LI Qing WANG Yahui ZHANG Xin LIU | 2022 | Journal of Advanced Ceramics2022，11，1： | 1 |
| 16 | Structural insight into EV-A713A protein and its interaction with a peptide inhibitor显示文摘Dear Editor,Hand,foot,and mouth disease(HFMD)is a common illness among children that is usually mild and self-limiting.However,in some severe cases,patients may rapidly develop neurological and systemic complications that can be fatal(Ooi et al.,2010).HFMD is caused by a few serotypes of human enterovirus A(HEV-A)species(Yu and Cowling,2019),with enterovirus A71(EV-A71)and coxsackievirus A16(CV-A16)being the most typical causative agents(Yu and Cowling,2019).Furthermore,severe neurological sequelae are more common in cases with EV-A71 serotype infection than other serotypes(Ooi et al.,2010;Yu and Cowling,2019).There has been a significant increase in EV-A71 epidemic activity throughout the Asia–Pacific region(McMinn,2002)since EV-A71 was first isolated from a patient with central nervous system(CNS)disease in 1969(Schmidt et al.,1974).EV-A71 is a small non-enveloped virus belonging to HEV-A species of the genus Enterovirus in the family Picornaviridae(Nasri et al.,2007).Its genome is a single-stranded positive-sense RNA of approximately 7400 bp in length and contains only one complete open reading frame(ORF),which encodes a large polyprotein(Solomon et al.,2010). | Yahui Liu Panjing Lv Wei Wang Jiahai Zhang Xi Zhou Yang Qiu Kun Cai Haoran Zhang Yuan Fang Yan Li | 2023 | Virologica Sinica2023，38，6： | 0 |
| 17 | A post-GWAS replication study confirming the association of C14H8orf33 gene with milk production traits in dairy cattle显示文摘Genome-wide association studies with an Illumina Bovine50K chip have detected 105 SNPs associated with one or multiple milk production traits in the Chinese Holstein population.Of these,38 significant SNPs detected with high confidence by both L1-TDT and MMRA methods were selected to further mine potential key genes affecting milk yield and milk composition.By blasting the flanking sequences of these 38 SNPs with the bovine genome sequence combined with comparative genomics analysis,26 genes were found to contain or be near to such SNPs.Among them,the C14H8orf33 gene is merely 87 bp away from the significant SNP,Hapmap30383-BTC-005848.Hence,we report herein genotype-phenotype associations to further validate the genetic effects of the C14H8orf33 gene.By pooled DNA sequencing of 14 unrelated Holstein sires,a total of 18 with seven novel SNPs were identified.Among them,nine SNPs were in the 5′regulatory region,one in exon 6 and the other in the 3′UTR and 3′regulatory region.A total of nine of these identified SNPs were successfully genotyped and analyzed by mass spectrometry for association with five milk production traits in an independent resource population.The results showed that these SNPs were statistically significant for more than two traits[P<(0.0001–0.0267)].In addition,mRNA expression analyses revealed that C14H8orf33 was ubiquitous in eight different tissues,with a relatively higher expression level in the mammary gland than in other tissues.These findings,therefore,provide strong evidence for association of C14H8orf33 variants with milk yield and milk composition traits and may be applied in Chinese Holstein breeding programs. | Shaohua YANG Chao QI Yan XIE Xiaogang CUI Yahui GAO Jianping JIANG Li JIANG Shengli ZHANG Qin ZHANG Dongxiao SUN | 2014 | Frontiers of Agricultural Science and Engineering2014，1，4： | 0 |
| 18 | Red/NIR emission carbonized polymer dots based on citric acid-benzoylurea and their application in lymph nodes imaging显示文摘Identification of lymph nodes(LNs)is critical for studies of the structure,the role in disease development,and the efficacy of disease treatment.Carbonized polymer dots(CPDs)are expected to be potential LNs-targeted imaging agents due to their excellent properties with special structure,better photoluminescence(PL)and great biocompatibility.Herein,a red/near infrared(NIR)emission CPDs(RCPDs)with one and two-photon bioimaging based on citric acid(CA)and benzoylurea(BU)are prepared.Notably,the RCPDs are capable of targeting LNs for imaging.Lymphocyte homing has been demonstrated to be the cellular mechanism of RCPDs target LNs imaging.This work has developed a new nanomaterial for targeted imaging of LNs,while the biological applications of CPDs have been expanded and deepened. | Feishi Shan Tingrui Zhang Chengshuang Liao Xue Yue Jing Zhang Li Yan Yanman Liu Zhixing Cao Min Wang Yahui Zhang Leyong Wang Zhouyu Wang Xiaoqi Yu | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 19 | Chromosome-scale genome assembly of Prunus pusilliflora provides novel insights into genome evolution, disease resistance, and dormancy release in Cerasus L.显示文摘Prunus pusilliflora is a wild cherry germplasm resource distributed mainly in Southwest China.Despite its ornamental and economic value,a high-quality assembled P.pusilliflora genome is unavailable,hindering our understanding of its genetic background,population diversity,and evolutionary processes.Here,we de novo assembled a chromosome-scale P.pusilliflora genome using Oxford Nanopore,Illumina,and chromosome conformation capture sequencing.The assembled genome size was 309.62 Mb,with 76 scaffolds anchored to eight pseudochromosomes.We predicted 33035 protein-coding genes,functionally annotated 98.27%of them,and identified repetitive sequences covering 49.08%of the genome.We found that P.pusilliflora is closely related to Prunus serrulata and Prunus yedoensis,having diverged from them∼41.8 million years ago.A comparative genomic analysis revealed that P.pusilliflora has 643 expanded and 1128 contracted gene families.Furthermore,we found that P.pusilliflora is more resistant to Colletotrichum viniferum,Phytophthora capsici,and Pseudomonas syringae pv.tomato(Pst)DC3000 infections than cultivated Prunus avium.P.pusilliflora also has considerably more nucleotide-binding site-type resistance gene analogs than P.avium,which explains its stronger disease resistance.The cytochrome P450 and WRKY families of 263 and 61 proteins were divided into 42 and 8 subfamilies respectively in P.pusilliflora.Furthermore,81 MADS-box genes were identified in P.pusilliflora,accompanying expansions of the SVP and AGL15 subfamilies and loss of the TM3 subfamily.Our assembly of a high-quality P.pusilliflora genome will be valuable for further research on cherries and molecular breeding. | Songtao Jiu Baozheng Chen Xiao Dong Zhengxin Lv Yuxuan Wang Chunjin Yin Yan Xu Sen Zhang Jijun Zhu Jiyuan Wang Xunju Liu Wanxia Sun Guoqian Yang Meng Li Shufeng Li Zhuo Zhang Ruie Liu Lei Wang Muhammad Aamir Manzoor Quero-García José Shiping Wang Yahui Lei Ling Yang Elisabeth Dirlewanger Yang Dong Caixi Zhang | 2023 | Horticulture Research2023，10，5： | 0 |
| 20 | Post-hepatoportoenterostomy Acoustic Radiation Force Impulse Elastography to Predict Two-year Outcome of Biliary Atresia显示文摘Background and Aims: Early identification of prognostic factors to predict transplant/death outcome of biliary atresia (BA) is challenging. We aimed to investigate the longitudinal changes and predictive value of dynamic changes in acoustic radiation force impulse elastography with shear wave speed (SWS) quantification and other parameters within three months after hepatoportoenterostomy (HPE) for 2-year BA outcomes. Methods: Seventy-four patients who underwent HPE between July 2016 and June 2019 were prospectively enrolled. Outcomes were classified into native liver survival and transplant/death groups. Acoustic radiation force im-pulse elastography was performed sequentially at 3 months intervals post-HPE. Cox regression analysis was used to de-termine the superior SWS values and other predictors of liver transplantation or death. Results: Among patients 2 years of age, 36 survived with a native liver, nine died, and 29 underwent liver transplantation. The trend in SWS levels in the transplant/death group was significantly different from that in the native liver survival group. ΔSWS at 1-3 months post-HPE and total bilirubin at 1 month post-HPE were se-lected as superior predictors of liver transplantation or death using multivariate Cox regression models: hazard ratio (HR)=1.927;95% confidence interval (CI): 1.475-2.661;p<0.001 and HR=1.010;95% CI: 1.003-1.017;p=0.007, respectively. The combination of the selected ΔSWS and total bilirubin had good predictive power, with an area under the receiver operating characteristics curve of 0.89, specificity 94.44% and sensitivity 73.68%. Conclusions: Our results suggest that early postoperative bilirubin levels and SWS changes were reliable predictors of 2-year BA outcomes. | Dongying Zhao Yahui Li Wei Xie Wenjie Wu Yan Chen Yongjun Zhang | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 0 |
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