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| 1 | Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy显示文摘Treatment strategies,whether as follow-up or'total incisional biopsy'for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic treatment.Based on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive tumors.Therefore,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during follow-up.Recent advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade neoplasms.Future studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness. | Tsutomu Nishida Shusaku Tsutsui Motohiko Kato Takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 18 |
| 2 | Clinical outcomes of ampullary neoplasms in resected margin positive or uncertain cases after endoscopic papillectomy显示文摘BACKGROUND Endoscopic papillectomy(EP) for benign ampullary neoplasms could be a lessinvasive alternative to pancreatoduodenectomy(PD). There are some problems and limitations with EP. The post-EP resection margins of ampullary tumors are often positive or uncertain because of the burning effect of EP. The clinical outcomes of resected margin positive or uncertain cases after EP remain unknown.AIM To investigate the clinical outcomes of resected margin positive or uncertain cases after EP.METHODS Between January 2007 and October 2018, all patients with ampullary tumors who underwent EP at Kobe University Hospital were included in this study. The indications for EP were as follows: adenoma, as determined by preoperative endoscopic biopsy, without bile/pancreatic duct extension, according to endoscopic ultrasound or intraductal ultrasound. The clinical outcomes of resected margin positive or uncertain cases after EP were retrospectively investigated.RESULTS Of the 45 patients, 29 were male, and 16 were female. The mean age of the patients was 65 years old. Forty-one patients(89.5%) underwent en bloc resection,and 4 patients(10.5%) underwent piecemeal resection. After EP, 33 tumors were histopathologically diagnosed as adenoma, and 12 were diagnosed as adenocarcinoma. The resected margins were positive or uncertain in 24 patients(53.3%). Of these cases, 15 and 9 were diagnosed as adenoma and adenocarcinoma, respectively. Follow-up observation was selected for all adenomas and 5 adenocarcinomas. In the remaining 4 adenocarcinoma cases,additional PD was performed. Additional PD was performed in 4 cases, and residual carcinoma was found after the additional PD in 1 of these cases. In the follow-up period, local tumor recurrence was detected in 3 cases. Two of these cases involved primary EP-diagnosed adenoma. The recurrent tumors were also adenomas detected by biopsy. The remaining case involved primary EPdiagnosed adenocarcinoma. The recurrent tumor was also an adenocarcinoma.All of the recurrent tumors were successfully treated with argon plasma coagulation(APC). There was no local or lymph node recurrence after the APC.The post-APC follow-up periods lasted for 57.1 to 133.8 mo. No ampullary tumor-related deaths occurred in all patients.CONCLUSION Resected margin positive or uncertain cases after EP could be managed by endoscopic treatment including APC, even in cases of adenocarcinoma. EP could become an effective less-invasive first-line treatment for early stage ampullary tumors. | Arata Sakai Masahiro Tsujimae Atsuhiro Masuda Takao Iemoto Shigeto Ashina Kohei Yamakawa Takeshi Tanaka Shunta Tanaka Yasutaka Yamada Ryota Nakano Yu Sato Manabu Kurosawa Takuya Ikegawa Seiji Fujigaki Takashi Kobayashi Hideyuki Shiomi Yoshifumi Arisaka Tomoo Itoh Yuzo Kodama | 2019 | World Journal of Gastroenterology2019，25，11： | 9 |
| 3 | Choroidal and cutaneous metastasis from gastric adenocarcinoma显示文摘Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of men, and cutaneous metastasis occurs in 0.8% of all gastric cancers. We report a patient with gastric adenocarcinoma who presented with visual disorder in his left eye and skin pain on his head as his initial symptoms. These symptoms were diagnosed to be caused by choroidal and cutaneous metastasis of gastric adenocarcinoma. Two cycles of chemotherapy consisted of oral S-1 and intravenous cisplatin (SPIRITS regimen); this was markedly effective to reduce the primary gastric lesion and almost all the metastatic lesions. | Shoichiro Kawai Tsutomu Nishida Yoshito Hayashi Hisao Ezaki Takuya Yamada Shinichiro Shinzaki Masanori Miyazaki Kei Nakai Takayuki Yakushijin Kenji Watabe Hideki Iijima Masahiko Tsujii Kohji Nishida Tetsuo Takehara | 2013 | World Journal of Gastroenterology2013，19，9： | 6 |
| 4 | Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection显示文摘 | Mika Kurokawa Naoki Hiramatsu Tsugiko Oze Takayuki Yakushijin Masanori Miyazaki Atsushi Hosui Takuya Miyagi Yuichi Yoshida Hisashi Ishida Tomohide Tatsumi Shinichi Kiso Tatsuya Kanto Akinori Kasahara Sadaharu Iio Yoshinori Doi Akira Yamada Masahide Oshita | 2012 | Journal of Gastroenterology2012，，5： | 4 |
| 5 | Overexpression of c-met in the early stage of pancreatic carcinogenesis; altered expression is not sufficient for progression from chronic pancreatitis to pancreatic cancer显示文摘瞄准:在早胰腺的致癌作用期间调查遇见 c 的表示。方法:我们使用了 46 体积纸巾和 36 件微把样品,包括正常的胰,慢性胰炎,和胰腺的癌症,为量的即时反向的抄写聚合酶链反应。结果:大批,组织分析,胰腺的癌症纸巾显著地表示了高水平比遇见 c 做了慢性胰炎和正常的胰纸巾。遇见 c 的层次没在慢性胰炎和正常的胰纸巾之间不同。在基于 microdissection 的分析,遇见 c 比在正常管的上皮细胞在微把的胰腺的癌症房间和影响胰腺炎的上皮细胞在高水平被表示(两, P <
0.01 ) 。有趣地,影响胰腺炎的上皮细胞表示了层次遇见 c 类似于那些胰腺的癌症房间。结论:Overexpression 遇见 c 在胰腺的致癌作用的早阶段期间发生,并且遇见 c 的表示的单个改变不为到胰腺的癌症房间的长期的影响胰腺炎的上皮细胞的前进是足够的。 | Kenoki Ohuchida Kazuhiro Mizumoto Nami Ishikawa Yasuhiro Ogura Daisuke Yamada Takuya Egami Hayato Fujita Seiji Ohashi Eishi Nagai Masao Tanaka | 2006 | World Journal of Gastroenterology2006，12，24： | 4 |
| 6 | A novel videoendoscopy system by using autofluorescence and reflectance imaging for diagnosis of esophagogastric cancers <ce:link locator='fx1'/>显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Takuya Yamada Hideharu Ogiyama Kazuho Imanaka Naotoshi Sugimoto Koji Higashino Ryu Ishihara Hiroyuki Narahara Shingo Ishiguro | 2005 | Gastrointestinal Endoscopy2005，，4： | 2 |
| 7 | Partial gastrectomy using natural orifice translumenal endoscopic surgery (NOTES) for gastric submucosal tumors: early experience in humans显示文摘 | Kiyokazu Nakajima Toshirou Nishida Tsuyoshi Takahashi Yoshihito Souma Johji Hara Takuya Yamada Toshiyuki Yoshio Tateki Tsutsui Takeshi Yokoi Masaki Mori Yuichiro Doki | 2009 | Surgical Endoscopy2009，，12： | 2 |
| 8 | Longterm outcomes after endoscopic mucosal resection for early gastric cancer显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Ryu Ishihara Koji Higashino Yoji Takeuchi Kazuho Imanaka Takuya Yamada Sachiko Yamamoto Shunsuke Yamamoto Hideaki Tsukuma Shingo Ishiguro | 2006 | Gastric Cancer2006，，2： | 2 |
| 9 | Longterm outcomes after endoscopic mucosal resection for early gastric cancer显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Ryu Ishihara Koji Higashino Yoji Takeuchi Kazuho Imanaka Takuya Yamada Sachiko Yamamoto Shunsuke Yamamoto Hideaki Tsukuma Shingo Ishiguro | 2006 | Gastric Cancer2006，，2： | 2 |
| 10 | Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan显示文摘 | Ryu Ishihara Hiroyasu Iishi Noriya Uedo Yoji Takeuchi Sachiko Yamamoto Takuya Yamada Eriko Masuda Koji Higashino Motohiko Kato Hiroyuki Narahara Masaharu Tatsuta | 2008 | Gastrointestinal Endoscopy2008，，6： | 2 |
| 11 | A novel videoendoscopy system by using autofluorescence and reflectance imaging for diagnosis of esophagogastric cancers <ce:link locator='fx1'/>显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Takuya Yamada Hideharu Ogiyama Kazuho Imanaka Naotoshi Sugimoto Koji Higashino Ryu Ishihara Hiroyuki Narahara Shingo Ishiguro | 2005 | Gastrointestinal Endoscopy2005，，4： | 1 |
| 12 | Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection显示文摘 | Mika Kurokawa Naoki Hiramatsu Tsugiko Oze Takayuki Yakushijin Masanori Miyazaki Atsushi Hosui Takuya Miyagi Yuichi Yoshida Hisashi Ishida Tomohide Tatsumi Shinichi Kiso Tatsuya Kanto Akinori Kasahara Sadaharu Iio Yoshinori Doi Akira Yamada Masahide Oshita | 2012 | Journal of Gastroenterology2012，，5： | 1 |
| 13 | Inhalable sustained-release formulation of long-acting vasoactive intestinal peptide derivative alleviates acute airway inflammation显示文摘 | Satomi Onoue Takuya Matsui Kazuki Kuriyama Kumiko Ogawa Yoshiki Kojo Takahiro Mizumoto Shin-ichiro Karaki Atsukazu Kuwahara Shizuo Yamada | 2012 | Peptides2012，，2： | 1 |
| 14 | Oily grime formed on hard surfaces of kitchen appliances:Chemical composition and oxidation mechanism显示文摘 | Tsutsui Takuya Natsuhara Masahiko Yamada Kaoru | 2007 | Journal of Surfactants and Detergents2007，10，1： | 1 |
| 15 | Experimental Studies to Estimate the Intestinal Viability in a Rat Strangulated Ileus Model Using a Dielectric Parameter显示文摘 | Hiroshi Matsuo Hajime Hirose Yoshio Mori Hisato Takagi Hisashi Iwata Takuya Yamada Ken-Ichi Sakamoto Mikio Yasumura | 2004 | Digestive Diseases and Sciences2004，，4： | 1 |
| 16 | Local Resection by Combined Laparoendoscopic Surgery for Duodenal Gastrointestinal Stromal Tumor显示文摘 | Motohiko Kato Kiyokazu Nakajima Toshirou Nishida Makoto Yamasaki Tsutomu Nishida Shusaku Tsutsui Hideharu Ogiyama Shunsuke Yamamoto Takuya Yamada Masaki Mori Yuichiro Doki Norio Hayashi Isidoro Di Carlo | 2011 | Diagnostic and Therapeutic Endoscopy2011，，： | 1 |
| 17 | Coconut left atrium显示文摘 | Akira Funada Hideaki Kanzaki Suzu Kanzaki Hiroyuki Takahama Makoto Amaki Takuya Hasegawa Naoaki Yamada Masafumi Kitakaze | 2011 | International Journal of Cardiology2011，，2： | 1 |
| 18 | A novel videoendoscopy system by using autofluorescence and reflectance imaging for diagnosis of esophagogastric cancers 显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Takuya Yamada Hideharu Ogiyama Kazuho Imanaka Naotoshi Sugimoto Koji Higashino Ryu Ishihara Hiroyuki Narahara Shingo Ishiguro | 2005 | Gastrointestinal Endoscopy2005，，4： | 1 |
| 19 | Hepatitis B Virus Reactivation in a Case of Non-Hodgkin’s Lymphoma Treated with Chemotherapy and Rituximab: Necessity of Prophylaxis for Hepatitis B Virus Reactivation in Rituximab Therapy显示文摘 | Yutaka Tsutsumi Takahito Kawamura Shin Saitoh Masahiro Yamada Shinji Obara Takuya Miura Hiroe Kanamori Junji Tanaka Masahiro Asaka Masahiro Imamura Nobuo Masauzi | 2004 | Leukemia & Lymphoma2004，，3： | 1 |
| 20 | A novel endoscopic submucosal dissection technique with robust and adjustable tissue traction显示文摘 | Masashi Hirota Motohiko Kato Makoto Yamasaki Naoki Kawai Yasuhiro Miyazaki Takuya Yamada Tsuyoshi Takahashi Tetsuo Takehara Masaki Mori Yuichiro Doki Kiyokazu Nakajima | 2014 | Endoscopy2014，，： | 1 |
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