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| 1 | 华北克拉通西部陆块北缘新生代岩石圈地幔特征的初步研究显示文摘凉城、四子王旗、三义堂和大同的地幔包体的岩石学和矿物的主、微量元素成分显示华北克拉通中、西部北缘总体为过渡型岩石圈地幔,为原始地幔经过不同程度的熔体抽取和后期交代富集作用的残留。凉城岩石圈地幔经历的熔体抽取程度最低,后期交代富集作用比较强烈,这与其橄榄岩中尖晶石的Cr#较低,并且共存的单斜辉石的Mg#较低一致。三义堂岩石圈地幔经历的熔体抽取程度最高,后期交代富集作用最强烈,不同样品甚至同一样品中不同单斜辉石颗粒的La/Yb和LREE配分模式变化范围非常大,且矿物边部比核部更富集微量元素。大同、四子王旗岩石圈地幔经历的熔体抽取程度介于凉城和三义堂之间,但后期的交代富集作用明显不如凉城和三义堂强烈。研究区的岩石圈地幔主要受硅酸盐熔体交代作用的影响,只有三义堂岩石圈地幔还可能也受到了碳酸盐交代作用的影响。 | 王亚妹 William L GRIFFIN 韩宝福 WANG YaMei HAN BaoFu | 2011 | 岩石学报2011，27，10： | 9 |
| 2 | Consensus Control of Multi-Agent Systems Using Fault-Estimation-in-the-Loop:Dynamic Event-Triggered Case显示文摘The paper develops a novel framework of consensus control with fault-estimation-in-the-loop for multi-agent systems(MASs)in the presence of faults.A dynamic event-triggered protocol(DETP)by adding an auxiliary variable is utilized to improve the utilization of communication resources.First,a novel estimator with a noise bias is put forward to estimate the existed fault and then a consensus controller with fault compensation(FC)is adopted to realize the demand of reliability and safety of addressed MASs.Subsequently,a novel consensus control framework with fault-estimation-in-the-loop is developed to achieve the predetermined consensus performance with the l_(2)-l_(∞)constraint by employing the variance analysis and the Lyapunov stability approaches.Furthermore,the desired estimator and controller gains are obtained in light of the solution to an algebraic matrix equation and a linear matrix inequality in a recursive way,respectively.Finally,a simulation result is employed to verify the usefulness of the proposed design framework. | Yamei Ju Derui Ding Xiao He Qing-Long Han Guoliang Wei | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，8： | 4 |
| 3 | Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells for severe aplastic anemia: Successful engraftment and mild GVHD显示文摘 | Yamei Wu Yongbin Cao Xiaohong Li Lixin Xu Zhihong Wang Pei Liu Pei Yan Zhouyang Liu Jing Wang Shuang Jiang Xiaoxiong Wu Chunji Gao Wanming Da Zhongchao Han | 2014 | Stem Cell Research2014，，1： | 3 |
| 4 | Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2显示文摘Constitutive activation of RAS-RAF-MEK-ERK signaling pathway(MAPK pathway)frequently occurs in many cancers harboring RAS or RAF oncogenic mutations.Because of the paradoxical activation induced by a single use of BRAF or MEK inhibitors,dual-target RAF and MEK treatment is thought to be a promising strategy.In this work,we evaluated erianin is a novel inhibitor of CRAF and MEK1/2 kinases,thus suppressing constitutive activation of the MAPK signaling pathway induced by BRAF V600E or RAS mutations.KinaseProfiler enzyme profiling,surface plasmon resonance(SPR),isothermal titration calorimetry(ITC),cellular thermal shift assay,computational docking,and molecular dynamics simulations were utilized to screen and identify erianin binding to CRAF and MEK1/2.Kinase assay,luminescent ADP detection assay,and enzyme kinetics assay were investigated to identify the efficiency of erianin in CRAF and MEK1/2 kinase activity.Notably,erianin suppressed BRAF V600E or RAS mutant melanoma and colorectal cancer cell by inhibiting MEK1/2 and CRAF but not BRAF kinase activity.Moreover,erianin attenuated melanoma and colorectal cancer in vivo.Overall,we provide a promising leading compound for BRAF V600E or RAS mutant melanoma and colorectal cancer through dual targeting of CRAF and MEK1/2. | Penglei Wang Xuechao Jia Bingbing Lu Han Huang Jialin Liu Xuejiao Liu Qiong Wu Yamei Hu Pan Li Huifang Wei Tingting Liu Dengyun Zhao Lingwei Zhang Xueli Tian Yanan Jiang Yan Qiao Wenna Nie Xinli Ma Ruihua Bai Cong Peng Zigang Dong Kangdong Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 5 | Optimization of PCR System in EST-SSR Analysis of Phytophthora infestans显示文摘Late blight caused by the oomycete Phytophthora infestans Montagne de Bary is a devastating disease on potato production. A total of six parameters affecting the PCR system in P. infestans were investigated based on the template DNA of the isolate HH06-23 and EST-SSR primer pair Pi08N. The results showed that the optimal annealing temperature was 63℃, and the optimum PCR system of EST-SSR was 25 ng template DNA, 0.5 mmol·L-1 dNTPs, 2 μL 10×Buffer (Mg 2+ free), 1.75 mmol·L-1 MgCl 2 , 15 pmol primer, and 1.2 U Taq DNA polymerase in total 20 μL reaction system. The PCR program was initial denaturation at 94℃ for 2 min, followed by 35 cycles of 94℃ for 30 s, 63℃ for 30 s, and 72℃ for 30 s, then a final extension step was 72℃ for 7 min, and held at 4℃. In addition, using the optimal PCR system, a total of 20 isolates of P. infestans were used for testing the stability and polymorphism of the PCR amplification. The clarity and abundant polymorphism indicated that this system was stable and suitable for researching the genetic diversity of P. infestans population. | WANG Jianan LU Wenhe JIN Guanghui BAI Yamei LI Wenxia HAN Yingpeng | 2010 | Journal of Northeast Agricultural University(English Edition)2010，17，1： | 0 |
| 6 | Research Progress of Different Acupuncture and Moxibustion Methods in the Treatment of GERD(Gastro Esophageal Reflux Disease)显示文摘Over the past decade,there have been many clinical reports on acupuncture and moxibustion in the treatment of gastro esophageal reflux disease,which has been an increasing trend year by year.The authors use'acupuncture','acupuncture and moxibustion'or'electric acupuncture'and'GERD'or'gastro esophageal reflux disease'as key words for retrieval.Through the clinical articles on acupuncture and moxibustion methods in the treatment of GERD indexed by China CNKI academic literature database,VPCS database and Wanfang database from 2006 to 2016,we find that:acupuncture and moxibustion methods in the treatment of GERD has definite curative effect and outstanding advantages.It can better improve the symptoms of patients and can effectively improve their quality of life.At present,in clinical applications,there are treatment ideas such as the method of acupuncture on governor vessel back segment,the old ten needles,and compatibility of five meridians in the aspect of acupoint selection;there are treatment ideas such as fire acupuncture,thread-embedding,and electric acupuncture in the aspect of method of needling and moxibustion;there are treatment ideas such as acupuncture and moxibustion combined with pinellia ternate Xiexin Decoction,Chinese herb bath,deanxit(flupentixol and melitracen tablets)in the aspect of acupuncture and medicinal treatment.This paper comb integration of the current variety of therapies,in order to allow readers to obtain a more comprehensive clinical diagnosis and treatment ideas of gastro esophageal reflux disease. | Yamei Han Xianbing Hou Tie Wang | 2018 | Journal of Advances in Medicine Science2018，1，2： | 0 |
| 7 | Kinetochore protein MAD1 participates in the DNA damage response through ataxia-telangiectasia mutated kinase-mediated phosphorylation and enhanced interaction with KU80显示文摘Objective:Mitotic arrest-deficient protein 1(MAD1)is a kinetochore protein essential for the mitotic spindle checkpoint.Proteomic studies have indicated that MAD1 is a component of the DNA damage response(DDR)pathway.However,whether and how MAD1 might be directly involved in the DDR is largely unknown.Methods:We ectopically expressed the wild type,or a phosphorylation-site--mutated form of MAD1 in MAD1 knockdown cells to look for complementation effects.We used the comet assay,colony formation assay,immunofluorescence staining,and flow cytometry to assess the DDR,radiosensitivity,and the G2/M checkpoint.We employed co-immunoprecipitation followed by mass spectrometry to identify MAD1 interacting proteins.Data were analyzed using the unpaired Student'st-test.Results:We showed that MAD1 was required for an optimal DDR,as knocking down MAD1 resulted in impaired DNA repair and hypersensitivity to ionizing radiation(IR).We found that IR-induced serine 214 phosphorylation was ataxia-telangiectasia mutated(ATM)kinase-dependent.Mutation of serine 214 to alanine failed to rescue the phenotypes of MAD1 knockdown cells in response to IR.Using mass spectrometry,we identified a protein complex mediated by MAD1 serine 214 phosphorylation in response to IR.Among them,we showed that KU80 was a key protein that displayed enhanced interaction with MAD1 after DNA damage.Finally,we showed that MAD1 interaction with KU80 required serine 214 phosphorylation,and it was essential for activation of DNA protein kinases catalytic subunit(DNA-PKcs).Conclusions:MAD1 serine 214 phosphorylation mediated by ATM kinase in response to IR was required for the interaction with KU80 and activation of DNA-PKCs. | Mingming Xiao Xuesong Li Yang Su Zhuang Liu Yamei Han Shuai Wang Qinghua Zeng Hong Liu Jianwei Hao Bo Xu | 2020 | Cancer Biology & Medicine2020，17，3： | 0 |
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