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| 1 | Genome-wide Scan for Seed Composition Provides Insights into Soybean Quality Improvement and the Impacts of Domestication and Breeding显示文摘优秀特点的复杂基因建筑学妨碍了努力在大豆修改种子营养素。染色体宽的协会研究为种子作文被进行,包括蛋白质,油,丰满的酸,和氨基酸,用有一个高密度的 SNP 数组的 313 多样的大豆 germplasm 就职 genotyped。87 个 chromosomal 区域的一个总数被识别与种子作文被联系,解释基因变化的 8%-89% 。已知的功能的候选人基因 GmSAT1, AK-HSDH, SACPD-C,和 FAD3A,和通常认为的 MtN21 nodulin, FATB,和 steroid-5 -- 涉及 N 2 固定,氨基酸生合成,和丰满的酸新陈代谢的 reductase 在主要效果的 loci 被发现。另外的 germplasm 就职的进一步的分析显示这些主要效果的 loci 受到了驯服或现代繁殖选择,并且突变而产生之遗传的变体和分布与地理区域相关。我们也表明与种子重量有关并且到全部的蛋白质的氨基酸集中有一个不同基因基础。这帮助揭开在种子之中的复杂关系的深入的基因机制加重。因此,我们的学习不仅为大豆营养素改进提供珍贵基因和标记,份量上和品质上,而且进在驯服期间优秀、引起的大豆的改变的提议卓见。 | Jiaoping Zhang Xianzhi Wang Yaming Lu Siddhi J. Bhusal Qijian Song Perry B. Cregan Yang Yen Michael Brown Guo-Liang Jiang | 2018 | Molecular Plant2018，11，3： | 12 |
| 2 | Highly Stretchable and Transparent Ionic Conductor with Novel Hydrophobicity and Extreme-Temperature Tolerance显示文摘Highly stretchable and transparent ionic conducting materials have enabled new concepts of electronic devices denoted as iontronics,with a distinguishable working mechanism and performances from the conventional electronics.However,the existing ionic conducting materials can hardly bear the humidity and temperature change of our daily life,which has greatly hindered the development and real-world application of iontronics.Herein,we design an ion gel possessing unique traits of hydrophobicity,humidity insensitivity,wide working temperature range(exceeding 100℃,and the range covered our daily life temperature),high conductivity(10^(-3)~10^(-5) S/cm),extensive stretchability,and high transparency,which is among the bestperforming ionic conductors ever developed for flexible iontronics.Several ion gel-based iontronics have been demonstrated,including large-deformation sensors,electroluminescent devices,and ionic cables,which can serve for a long time under harsh conditions.The designed material opens new potential for the real-world application progress of iontronics. | Lei Shi Kun Jia Yiyang Gao Hua Yang Yaming Ma Shiyao Lu Guoxin Gao Huaitian Bu Tongqing Lu Shujiang Ding | 2020 | Research2020，，1： | 7 |
| 3 | New insights into hepatitis B virus biology and implications for novel antiviral strategies显示文摘Hepatitis B virus(HBV), a small DNA virus with a unique replication mode, can cause chronic hepatitis(CHB), which is characterized by the persistence of the viral covalently closed circular DNA that serves as the template for HBV replication and the production of large amounts of secreted HBV surface antigen(HBs Ag) that is present in excess of the levels of infectious virus. Despite the success of currently approved antiviral treatments for CHB patients, including interferon and nucleotide analogs, which suppress HBV replication and reduce the risk of CHB-related liver diseases, these therapies fail to eradicate the virus in most of the patients. With the development of the cell and animal models for HBV study, a beter understanding of the HBV life cycle has been achieved and a series of novel antiviral strategies that target diferent stages of HBV replication have been designed to overcome the viral factors that contribute to HBV persistence. Such basic HBV research advancements and therapeutic developments are the subject of this review. | Jieliang Chen Min Wu Kuancheng Liu Wen Zhang Yaming Li Xiaohui Zhou Lu Bai Zhenghong Yuan | 2015 | National Science Review2015，2，3： | 6 |
| 4 | Single-cell RNA sequencing reveals Nestin+active neural stem cells outside the central canal after spinal cord injury显示文摘Neural stem cells(NSCs)in the spinal cord hold great potential for repair after spinal cord injury(SCI).The ependyma in the central canal(CC)region has been considered as the NSCs source in the spinal cord.However,the ependyma function as NSCs after SCI is still under debate.We used Nestin as a marker to isolate potential NSCs and their immediate progeny,and characterized the cells before and after SCI by single-cell RNA-sequencing(scRNA-seq).We identified two subgroups of NSCs:the subgroup located within the CC cannot prime to active NSCs after SCI,while the subgroup located outside the CC were activated and exhibited the active NSCs properties after SCI.We demonstrated the comprehensive dynamic transcriptome of NSCs from quiescent to active NSCs after SCI.This study reveals that Nestin+cells outside CC were NSCs that activated upon SCI and may thus serve as endogenous NSCs for regenerative treatment of SCI in the future. | Muya Shu Xiaoyu Xue Hu Nie Xianming Wu Minghan Sun Lianyong Qiao Xing Li Bai Xu Zhifeng Xiao Yannan Zhao Yongheng Fan Bing Chen Jixiang Zhang Ya Shi Yaming Yang Falong Lu Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
| 5 | Dynamics and manipulation of ferroelectric domain walls in bismuth ferrite thin films显示文摘Ferroelectric domain walls differ from domains not only in their crystalline and discrete symmetry,but also in their electronic,magnetic,and mechanical properties.Although domain walls provide a degree of freedom to regulate the physical properties at the nanoscale;the relatively lower controllability prevents their practical applications in nano-devices.In this work;with the advantages of 3D domain configuration detection based on piezoresponse force microscopy;we find that the mobility of three types of domain walls(tail-to-tail,head-to-tail,head-to-head)in(001)BiFeO3 films varies with the applied electrical field.Under low voltages;head-to-tail domain walls are more mobile than other domain walls;while,under high voltages,tail-to-tail domain walls become rather active and possess relatively long average lengths.This is due to the high nucleation energy and relatively low growth energy for charged domain walls.Finally;we demonstrate the manipulation of domain walls through successive electric writings,resulting in well-aligned conduction paths as designed;paving the way for their application in advanced spintronic;memory and communication nano-devices. | Shuyu Xiao Yaming Jin Xiaomei Lu Sang-Wook Cheong Jiangyu Li Yang Li Fengzhen Huang Jinsong Zhu | 2020 | National Science Review2020，7，2： | 2 |
| 6 | HID-1 is a peripheral membrane protein primarily associated with the medial-and transGolgi apparatus显示文摘Caenorhabditis elegans hid-1 gene was first identified in a screen for mutants with a high-temperature-induced dauer formation(Hid)phenotype.Despite the fact that the hid-1 gene encodes a novel protein(HID-1)which is highly conserved from Caenorhabditis elegans to mammals,the domain structure,subcellular localization,and exact function of HID-1 remain unknown.Previous studies and various bioinformatic softwares predicted that HID-1 contained many transmembrane domains but no known functional domain.In this study,we revealed that mammalian HID-1 localized to the medial-and transGolgi apparatus as well as the cytosol,and the localization was sensitive to brefeldin A treatment.Next,we demonstrated that HID-1 was a peripheral membrane protein and dynamically shuttled between the Golgi apparatus and the cytosol.Finally,we verified that a conserved N-terminal myristoylation site was required for HID-1 binding to the Golgi apparatus.We propose that HID-1 is probably involved in the intracellular trafficking within the Golgi region. | Lifen Wang Yi Zhan Eli Song Yong Yu Yaming Jiu Wen Du Jingze Lu Pingsheng Liu Pingyong Xu Tao Xu | 2011 | Protein & Cell2011，2，1： | 1 |
| 7 | On the soulution of an equation involving the Smarandache function 显示文摘 | Lu Yaming | 2006 | Scientia Magna2006，2，1： | 1 |
| 8 | On the solutions of an equation involving the Smarandache function 显示文摘 | Lu Yaming | 2006 | Scientia Magna2006，2，1： | 1 |
| 9 | On the Solutions of an Equations Involving the Smarandache Function 显示文摘 | Lu Yaming | 2006 | Scientia Magna2006，1，2： | 1 |
| 10 | An ultrapotent pan-β-coronavirus lineage B(β-CoV-B)neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope显示文摘New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design.Here,we identified a receptorbinding domain(RBD)-binding antibody,XG014,which potently neutralizesβ-coronavirus lineage B(β-CoV-B),including SARS-CoV-2,its circulating variants,SARSCoV and bat SARSr-CoV WIV1.Interestingly,antibody family members competing with XG014 binding show reduced levels of cross-reactivity and induce antibodydependent SARS-CoV-2 spike(S)protein-mediated cellcell fusion,suggesting a unique mode of recognition by XG014.Structural analyses reveal that XG014 recognizes a conserved epitope outside the ACE2 binding site and completely locks RBD in the non-functional“down”conformation,while its family member XG005 directly competes with ACE2 binding and position the RBD“up”.Single administration of XG014 is effective in protection against and therapy of SARS-CoV-2 infection in vivo.Our findings suggest the potential to develop XG014 as pan-β-CoV-B therapeutics and the importance of the XG014 conserved antigenic epitope for designing broadly protective vaccines againstβ-CoV-B and newly emerging SARS-CoV-2 variants of concern. | Zezhong Liu Wei Xu Zhenguo Chen Wangjun Fu Wuqiang Zhan Yidan Gao Jie Zhou Yunjiao Zhou Jianbo Wu Qian Wang Xiang Zhang Aihua Hao Wei Wu Qianqian Zhang Yaming Li Kaiyue Fan Ruihong Chen Qiaochu Jiang Christian TMayer Till Schoofs Youhua Xie Shibo Jiang Yumei Wen Zhenghong Yuan Kang Wang Lu Lu Lei Sun Qiao Wang | 2022 | Protein & Cell2022，13，9： | 1 |
| 11 | On the solutions of an equation involving the Smarandache function 显示文摘 | Lu Yaming | 2006 | Scientia Magna2006，2，1： | 1 |
| 12 | On the solutions of an equation involving the Smarandache function 显示文摘 | Lu Yaming | 2006 | Scientia Magna2006，2，1： | 1 |
| 13 | Over-expression of heme oxygenase-1 in peripheral blood predicts the progression and relapse risk of chronic myeloid leukemia显示文摘 | Wei Sixi Wang Yating Chai Qixiang Fang Qin Zhang Yaming Lu Yinghao Wang Jishi | 2014 | Chinese Medical Journal2014，，15： | 0 |
| 14 | Fractal analysis of small-micro pores and estimation of permeability of loess using mercury intrusion porosimetry显示文摘Many popular models have been proposed to study the fractal properties of the pores of porous materials based on mercury intrusion porosimetry(MIP).However,most of these models do not directly apply to the small-micro pores of loess,which have a significant impact on the throat pores and tunnels for fluid flow.Therefore,in this study we used a combination of techniques,including routine physical examination,MIP analysis,and scanning electron microscope(SEM)image analysis,to study these small-micro pores and their saturated water permeability properties.The techniques were used to determine whether the fractal dimensions of six MIP fractal models could be used to evaluate the microstructure types and permeability properties of loess.The results showed that the Neimark model is suitable for analysis of small-micro pores.When applied to saturated water permeability,the results from this model satisfied the correlation significance test and were consistent with those from SEM analysis.A high clay content and density cause an increase in the number of small-micro pores,leading to more roughness and heterogeneity of the pore structure,and an increase in the fractal dimensions.This process further leads to a decrease in the content of macro-meso pores and saturated water permeability.Furthermore,we propose new parameters:the*Ellipse and its area ratios(*EAR).These parameters,coupled with 2D-SEM and 3D-MIP fractal dimensions,can effectively and quantitatively be used to evaluate the types of loess microstructures(from typeⅠto typeⅢ)and the saturated water permeability(magnitude from 1×10^(-4)cm/s to 1×10^(-5)cm/s). | Tuo LU Yaming TANG Yongbo TIE Bo HONG Wei FENG | 2023 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2023，24，7： | 0 |
| 15 | Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat显示文摘Neural stem progenitor cell(NSPC)transplantation has been regarded as a promising therapeutic method for spinal cord injury(SCI)repair.However,different NSPCs may have different therapeutic effects,and it is therefore important to identify the optimal NSPC type.In our study,we compared the transcriptomes of human fetal brain-derived NSPCs(BNSPCs),spinal cord-derived NSPCs(SCNSPCs)and H9 embryonic stem-cell derived NSPCs(H9-NSPCs)in vitro and subsequently we transplanted each NSPC type on a collagen scaffold into a T8-9 complete SCI rat model in vivo.In vitro data showed that SCNSPCs had more highly expressed genes involved in nerve-related functions than the other two cell types.In vivo,compared with BNSPCs and H9-NSPCs,SCNSPCs exhibited the best therapeutic effects;in fact,SCNSPCs facilitated electrophysiological and hindlimb functional recovery.This study demonstrates that SCNSPCs may be an appropriate candidate cell type for SCI repair,which is of great clinical significance. | Bai Xu Man Yin Yaming Yang Yunlong Zou Wenbin Liu Lianyong Qiao Jixiang Zhang Zhan Wang Yayu Wu He Shen Minghan Sun Weiyuan Liu Weiwei Xue Yongheng Fan Qi Zhang Bing Chen Xianming Wu Ya Shi Falong Lu Yannan Zhao Zhifeng Xiao Jianwu Dai | 2023 | Bioactive Materials2023，，5： | 0 |
| 16 | Mean Value of Kloosterman Sums over Short Intervals显示文摘This paper is concerned with a kind of mean value problem of Kloosterman sums, which will lead to a sum of Kloosterman sums over short intervals. | Yaming LU | 2016 | Chinese Annals of Mathematics,Series B2016，37，5： | 0 |
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