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| 1 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 2 | Clinical significance of immunohistochemica study of P53 protein in colorectal carcinoma显示文摘AIMS To determine the clinical significance of P53 protein ex-pression in colorectal carcinoma.METHODS The expression of P53 protein in 92 colorectal car-cinomas was examined using the monoclonal antibody PAb 1801.Correlation between P53 protein expression and prognosis in col-orectal carcinoma was analyzed using log-rank test.RESULTS The frequency of P53 protein expression was 57.61%,corresponding with Dukes’ staging.Analysis of survivordata demonstrated that the survival rate of colorectal carcinomawith positive P53 protein group was lower than that of negativeP53 protein group.CONCLUSIONS We conclude that the expression of P53 pro-tein is correlated with poor prognosis in colorectal carcinoma. | CHEN Da-Wei WANG Yuan-He CHEN Xue-Yun WANG Qiang GAO Han Dr.CHEN Da-Wei, Surgeon-in-Charge,Having 12 papers published.Department of General Surgery,Changzheng Hospital,Second Military Medical University,415 Feng Yang Road,Shanghai 200003 China.Correspondence to Dr.CHEN Da-Wei. | 1996 | World Journal of Gastroenterology1996，2，1： | 3 |
| 3 | MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma显示文摘 | Changzheng Liu Jia Yu Shuangni Yu Robert M. Lavker Lei Cai Wei Liu Kegong Yang Xiaodong He Songsen Chen | 2010 | Journal of Hepatology2010，，1： | 2 |
| 4 | MXR7 facilitates liver cancer metastasis via epithelial-mesenchymal transition显示文摘MXR7 is a cell-surface protein and highly expressed in hepatocellular carcinoma(HCC). The aim of this study is to determine the expression profile of MXR7 in HCC and investigate the influence of MXR7 on invasion and metastasis of HCC cells. For this purpose, immunohistochemical assay was used to identify the differential expression of MXR7 in 94 HCC specimens. Expression of MXR7 in 4 pairs of HCC and portal vein tumor thrombus(PVTT) was also tested. The motility of HCC cells were characterized by transwell migration and matrigel invasion assays. In vivo metastasis potential was determined via tail vein injection assay.Moreover, compared with noninvasive HCC tumors or human HCC cell lines with low metastatic potential, invasive HCC samples and HCC cell lines with high metastatic potential exhibited higher MXR7 expression. Furthermore, forced expression of MXR7 in SMMC-7721 promoted cell proliferation, migration and invasion in vitro and accelerated tumor growth and metastasis in vivo. Conversely, knockdown of MXR7 expression in HuH7 cells inhibited proliferation and motility of cells. Mechanically,overexpression of MXR7 promoted epithelial-mesenchymal transition(EMT) progress, and MXR7 depletion repressed the EMT phenotype. In conclusion, MXR7 is a mediator of EMT and metastasis in HCC and may serve as a novel therapeutic target. | guishuai lv yexiong tan hongwei lv tian fang changzheng wang ting li yanting yu congli hu wen wen hongyang wang wen yang | 2017 | Science China(Life Sciences)2017，60，11： | 2 |
| 5 | The R1947X mutation of NF1 causing autosomal dominant neurofibromatosis type 1 in a Chinese family显示文摘Neurofibromatosis type 1 is a common autosomal dominant disorder with a high rate of penetrance. It is caused by the mutation of the tumor suppressor gene NF1, which encodes neurofibromin. The main function of neurofibromin is down-regulating the biological activity of the proto-oncoprotein Ras by acting as a Ras-specific GTPase activating protein. In this study, we identified a Chinese family affected with neurofibromatosis type 1. The known gene NF1 associated with NF1 was studied by linkage analysis and by direct sequencing of the entire coding region and exon-intron boundaries of the NF1 gene. The R1947X mutation of NF1 was identified, which was co-segregated with affected individuals in the Chinese family, but not present in unaffected family members. This is the first report, which states that the R1947X mutation of NF1 may be one of reasons for neurofibromatosis type 1 in Chinese population. | Qinbo Yang Changzheng Huang Xiaoying Yang Yinfu Feng Qing Wang Mugen Liu | 2008 | Journal of Genetics and Genomics2008，35，2： | 2 |
| 6 | On the technologies of Hα imaging spectrograph for the CHASE mission显示文摘The Hα imaging spectrograph(HIS) is the scientific payload of the first solar space mission, the Chinese Hα solar explorer(CHASE), supported by the China National Space Administration(CNSA). The CHASE/HIS achieves, for the first time in space, Hα spectroscopic observations with high spectral and temporal resolutions. Separate channels for the raster scanning mode(RSM) and continuum imaging mode(CIM) are integrated into one, and a highly integrated design is achieved through multiple folding of the optical path and ultra-light miniaturized components. The design of HIS implements a number of key technologies such as high-precision scanning of the optical field of view(FOV), high-precision integrated manufacturing inspection, a large-tolerance pre-filter window, and full-link solar radiation calibration. The HIS instrument has a pixel spectral resolution of 0.024 ? and can complete a full-Sun scanning within 46 s. | Qiang Liu Hongjiang Tao Changzheng Chen Chengshan Han Zhe Chen Gui Mei Liang Yang Qinglong Hu Hongwei Xin Xiansheng Li Hongyu Guan Donglin Xue Mingchao Zhu Changhong Hu Qinghua Ha Yukun He Cheng Fang Chuan Li Zhen Li | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 2 |
| 7 | 显示文摘 | Chen Lei Yu Xuehai Yang Changzheng | 1996 | Chinese Journal of Polymer Science1996，14，4： | 1 |
| 8 | Synthesis of cobalt disulfide nanopartlcles in polymer matrix 显示文摘 | BI Hong JIANG Xiqun YANG Changzheng | 2003 | Materials Letters2003，57，： | 1 |
| 9 | Cloning and Expression of Human Stem Cell Factor Fused with Thrombopoietin Mimetic Peptide in Escherichia coli显示文摘 | Lin Su Songsen Chen Kegong Yang Changzheng Liu Zhiquan Liang | 2006 | Biotechnology Letters2006，，12： | 1 |
| 10 | High dielectric constant composite of p (vdftrfe ) with grafted copper phthalocyanine oligomer显示文摘 | Wang Jingwen Shen Qundong Yang Changzheng | 2004 | Macromolecules2004，37，6： | 1 |
| 11 | New-phasedmetastable V203 porous urchin-like micronanostructures , Facilesynthesis and application in aqueous lithium ion batteries显示文摘 | Xu Yang Zheng Lei Wu Changzheng | 2011 | Chemistry-A European Journal2011，1，17： | 1 |
| 12 | Silver nanocubes monolayers as a SERS substrate for quantitative analysis显示文摘Surface-enhanced Raman scattering(SERS)is a powerful spectroscopic tool in quantitative analysis of molecules,where the substrate plays a critical role in determining the detection performance.Herein,a silver nanocubes/polyelectrolyte/gold film sandwich structure was prepared as a reproducible,highperformance SERS substrate by the wate r/oil inte rfacial assembly method.In addition to the hot spots on the nanocubes surface,the edge-to-edge interspace of the Ag nanocubes led to marked enhancement of the SERS intensity,with a limit of detection of 10~(11)mol/L and limit of quantitation of 10~(10)mol/L for crystal violet.When rhodamine 6 G and crystal violet were co-adsorbed on the Ag nanocube surfaces,the characteristic SERS peaks of the two molecules remained well resolved and separated,and the peak intensities varied with the respective concentration,which could be exploited for concurrent detection of dual molecules.Results from this work indicate that organized ensembles of Ag nanocubes can serve as effective SERS substrate can for sensitive analysis for complex molecular systems. | Ziang Zhou Xiuhui Bai Peishen Li Changzheng Wang Ming Guo Yang Zhang Peiren Ding Shaowei Chen Yunyun Wu Qiang Wang | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 13 | Surface etching induced ultrathin sandwich structure realizing enhanced photocatalytic activity显示文摘Photocatalytic conversion efficiency is limited by serious charge carrier recombination. Efficient carrier separation is usually achieved by elegantly-designed multi-component structures connected by directional electric field. Herein, we developed a twodimensional(2 D) sandwich structure, as a new photocatalytic system, to realize high-efficiency carrier separation. This strategy integrated multifunction into a single structure for the first time, which successfully introduces a stable built-in electric field,realizing high-effective carrier separation. Besides, the carrier concentration is dramatically increased due to dimensional confinement. Benefiting from above synergic advantages, 2 D sandwich photocatalyst achieves the highest nitrogen fixation rate(435 μmol g^(-1) h^(-1)) in inorganic solid photocatalysts under visible light irradiation. We anticipate that 2 D sandwich photocatalyst holds promises for the application and expansion of 2 D materials in photocatalysis research. | Bo Yang Wentuan Bi Yangyang Wan Xiaogang Li Mingcan Huang Ruilin Yuan Huanxin Ju Wangsheng Chu Xiaojun Wu Linghui He Changzheng Wu Yi Xie | 2018 | Science China Chemistry2018，61，12： | 1 |
| 14 | Microemulsion polymerization of siloxane with nonionic surfactants as emulsifiers显示文摘 | Dunming Zhang Xiqun Jiang Changzheng Yang | 2003 | Journal of Applied Polymer Science2003，89，： | 1 |
| 15 | Microemulsion pol- ymerization of siloxane with nonionic surfactants as emulsifiers 显示文摘 | Dunming Zhang Xiqun Jiang Changzheng Yang | 2003 | J Appl Polym Sci2003，89，： | 1 |
| 16 | Synthesis of cobalt disulfide nanopartieles in polymer matrix 显示文摘 | Bi Hong Jiang Xiqun Yang Changzheng | 2003 | Materials Letters2003，57，： | 1 |
| 17 | Photocatalytic fuel cell for simultaneous antibiotic wastewater treatment and electricity production by anatase TiO_(2) nanoparticles anchored on Ni foam显示文摘Photocatalytic fuel cell (PFC) holds great potential for the sustainable production of electricity and degradation of organic pollutants for solving global energy and environmental problems.However,the efficient photodegradation of organic dyes and antibiotic drugs,such as ciprofloxacin (CIP) and methylene blue(MB),remains challenging.Aiming at improving the separation efficiency of hole and electron for electricity generation in the PFC system,TiO_(2)-NPs@NF-x photoanode was fabricated by a cost-effective and laborsaving hydrothermal approach.The as-fabricated photoanode demonstrated abundant active sites,enhanced light harvesting capacity and photogenerated charge carrier separation.At a CIP-HCl concentration of 10 mg/L and p H value of about 7,85%of CIP-HCl can be efficiently removed after 3 h irradiation by 300 W Xe lamp.TiO_(2)-NPs@NF-20 photoelectrode based PFC system exhibited an impressed ability to simultaneously degrade ciprofloxacin and generate electricity under light irradiation with an open circuit voltage of 1.021 V,short circuit current density and maximum power density of 2.4 mA/cm^(2),0.357 mW/cm^(2),respectively.This work provided a cost-effective method for the treatment of organic waste and generation of electrical power. | Jinhan Li Xicheng Li Shaobin Yu Shuai Gao Yang Zhang Yan Li Changzheng Wang Qiang Wang | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 18 | Electromagnetic interference and shielding of valve hall in HVDC converter station显示文摘The electromagnetic interference(EMI)from the valve hall as an important consideration in the design of high voltage direct current(HVDC)converter stations is analyzed by electromagnetic field numerical method and measurements.By using moment method,the EMI filed strength level as well as radio interference level(RIL)of the valve hall during the normal operation are computed after an antenna model is built for the valve tower.According to the character of EMI obtained,the practical shielding measures for valve hall are discussed to satisfy the relative standards.The test results for the500 kV converter station show that both the numerical method and shielding technique used in this paper are practical. | Changzheng GAO Lin LI Zhibin ZHAO Yang LIU | 2010 | Frontiers of Electrical and Electronic Engineering in China2010，5，1： | 0 |
| 19 | Temporal patterns of energy intake and cognitive function and its decline:a community-based cohort study in China显示文摘Dear Editor,Worldwide,around 55 million people had prevalent dementia in 2019,which is expected to triple by 2050,especially in low-and middle-income countries[1].Lacking timely diagnosis and limited effective treatment for dementia make identifying risk factors crucial for its early prevention,among which dietary factors have received increasing attention[1].Recently,accumulating evidence from population-based studies has linked the temporal patterns of energy intake(TPEI),usually defined as the temporal distribution of energy intake during a day,to mortality and metabolic diseases[2],such as diabetes and hypertension.In vitro and in vivo studies also revealed that meal timing could drive metabolic alterations and circadian regulation[3],and disrupted meal timing altered the peripheral circadian clocks in the hippocampus and consequently affected cognitive function[4]. | Hui Chen Yang Tao Min-Dian Li Yuxuan Gu Jiaxi Yang You Wu Dongmei Yu Changzheng Yuan | 2022 | Life Metabolism2022，1，1： | 0 |
| 20 | Retina cell atlases of multiple species and an online platform for retina cell-type markers显示文摘The retina is a complex visual tissue that perceives light signals because of an exquisite orchestration of high cellular complexity(Fig. 1A). It is of great significance to explore the transcriptome diversity of each cell type for comprehensive understanding(Voigt et al.,2020b). Unlike conventional sequencing methods, single-cell RNAsequencing(scRNA-seq) and single-nucleus RNA-sequencing(snRNA-seq) accurately profile transcriptomic characterization of individual whole cells and nuclei, respectively. | Zaoxu Xu Changzheng Wang Min Chen Yuting Yuan Linzhou Li Zhen Huang Yue Yuan Huanming Yang Qi Wang Xingliang Zhang | 2022 | Journal of Genetics and Genomics2022，49，3： | 0 |
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