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| 1 | Factors that associated with TB patient admission rate and TB inpatient service cost: a cross-sectional study in China显示文摘Background:China has recently adopted the“TB designated hospital model”to improve the quality of tuberculosis(TB)treatment and patient management.Considering that inpatient service often results in high patient financial burden,and therefore influences patient adherence to treatment,it is critical to better understand the TB patient admission rate and TB inpatient service cost,as well as their influential factors in this new model.Methods:Quantitative and qualitative studies were conducted in two cities,Hanzhong in Shaanxi Province and Zhenjiang in Jiangsu Province,in China.Quantitative data were obtained from a sample survey of 533 TB patients and TB inpatient records from 2010–2012 in six county designated hospitals.Qualitative information was obtained through interviews with key stakeholders(40 key informant interviews,14 focus group discussions)and reviews of health policy documents in study areas.Both univariate and multivariate statistical analyses were applied for the quantitative analysis,and the thematic framework approach was applied for the qualitative analysis.Results:The TB patient admission rates in Zhenjiang and Hanzhong were 54.8 and 55.9%,respectively.Qualitative analyses revealed that financial incentives,misunderstanding of infectious disease control and failure of health insurance regulations were the key factors associated with the admission rates and medical costs.Quantitative analyses found differences in hospitalization rate existed among patients with different health insurance and patients from different counties.Average medical costs for TB inpatients in Jurong and Zhenba were 7,215 CNY and 4,644 CNY,which was higher than the 5,500 CNY and 3,800 CNY limits set by the New Rural Cooperative Medical System.No differences in medical cost or length of stay were found between patients with and without comorbidities in county-level hospitals.Conclusions:TB patient admission rates and inpatient service costs were relatively high.Studies of related factors indicated that a package of interventions,including health education programs,reform of health insurance regulations and improvement of TB treatment guidelines,are urgently required to ensure that TB patients receive appropriate care. | Hongyan Hu Jiaying Chen Kaori DSato Yang Zhou Hui Jiang Pingbo Wu Hong Wang | 2016 | Infectious Diseases of Poverty2016，5，1： | 4 |
| 2 | Rapid Synthesis and Photoluminescence Properties of Eu-doped ZnO Nanoneedles via Facile Hydrothermal Method显示文摘 | LANG Jihui WANG Jiaying ZHANG Qi XU Songsong HAN Qiang ZHANG Yan ZHAI Hongju CAO Jian YAN Yongsheng YANG Jinghai | 2014 | Chemical Research in Chinese Universities2014，30，4： | 4 |
| 3 | Microstructure and mechanical properties of SiC_(f)/SiBCN ceramic matrix composites显示文摘SiC fiber reinforced SiBCN ceramic matrix composites(CMCs)have been prepared by mechanical alloying and consolidated by hot pressing.During the sintering process,amorphous SiC fibers crystallized seriously and transformed into-SiC.Meanwhile,the interfacial carbothermal reactions caused the strong bonding between the matrix and fibers.As a result,SiCf/SiBCN fractured in a typical catastrophic manner.Room-temperature mechanical properties reached the maximums for the CMC samples sintered at 1900℃/60 MPa/30 min.The density,flexural strength,Young’s modulus and fracture toughness are 2.56±0.02 g/cm^(3),284.3±17.9 MPa,183.5±11.1 GPa and 2.78±0.14 MPa·m^(1/2),respectively. | Jiaying WANG Zhihua YANG Xiaoming DUAN Dechang JIA Yu ZHOU | 2015 | Journal of Advanced Ceramics2015，4，1： | 3 |
| 4 | A novel vector of topological and structural information for amino acids and its QSAR applications for peptides and analogues显示文摘A new descriptor, called vector of topological and structural information for coded and noncoded amino acids (VTSA), was derived by principal component analysis (PCA) from a matrix of 66 topological and structural variables of 134 amino acids. The VTSA vector was then applied into two sets of peptide quantitative structure-activity relationships or quantitative sequence-activity modelings (QSARs/ QSAMs). Molded by genetic partial least squares (GPLS), support vector machine (SVM), and immune neural network (INN), good results were obtained. For the datasets of 58 angiotensin converting en-zyme inhibitors (ACEI) and 89 elastase substrate catalyzed kinetics (ESCK) , the R2, cross-validation R2, and root mean square error of estimation (RMSEE) were as follows: ACEI, R2cu≥0.82, Q2cu≥0.77, Ermse≤0.44 (GPLS+SVM); ESCK, R2cu≥0.84, Q2cu≥0.82, Ermse≤0.20 (GPLS+INN), respectively. | LI ZhiLiang LI GenRong SHU Mao SUN JiaYing YANG ShanBin MEI Hu ZHANG MengJun ZHOU Ping WU ShiRong CHEN GuoHua LU FengLin LU TingTing | 2008 | Science China Chemistry2008，51，10： | 2 |
| 5 | Epidemiological and Genetic Characteristics of the H3 Subtype Avian Influenza Viruses in China显示文摘Avian influenza viruses(AIVs)are naturally preserved in waterfowls and sometimes spill over to infect humans and mammalian animals.The H3 subtype is one of the most prevalent influenza virus subtypes in waterfowls.Since 2000,H3 subtype AIVs have been continuously isolated from poultry and wild birds in the mainland of China,which implied a dynamic spread in large-scale geography and multiple species.Combinations of H3 with N1–N8 subtypes were reported,among which H3N2 and H3N8 subtypes predominated. | Jiaying Yang Lei Yang Wenfei Zhu Dayan Wang Yuelong Shu | 2021 | China CDC weekly2021，3，44： | 2 |
| 6 | Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure显示文摘Heart failure(HF)patients in general have a higher risk of developing cancer.Several animal studies have indicated that cardiac remodeling and HF remarkably accelerate tumor progression,highlighting a cause-and-effect relationship between these two disease entities.Targeting ferroptosis,a prevailing form of non-apoptotic cell death,has been considered a promising therapeutic strategy for human cancers.Exosomes critically contribute to proximal and distant organ-organ communications and play crucial roles in regulating diseases in a paracrine manner.However,whether exosomes control the sensitivity of cancer to ferroptosis via regulating the cardiomyocyte-tumor cell crosstalk in ischemic HF has not yet been explored.Here,we demonstrate that myocardial infarction(MI)decreased the sensitivity of cancer cells to the canonical ferroptosis activator erastin or imidazole ketone erastin in a mouse model of xenograft tumor.Post-MI plasma exosomes potently blunted the sensitivity of tumor cells to ferroptosis inducers both in vitro in mouse Lewis lung carcinoma cell line LLC and osteosarcoma cell line K7M2 and in vivo with xenograft tumorigenesis model.The expression of miR-22-3p in cardiomyocytes and plasma-exosomes was significantly upregulated in the failing hearts of mice with chronic MI and of HF patients as well.Incubation of tumor cells with the exosomes isolated from post-MI mouse plasma or overexpression of miR-22-3p alone abrogated erastin-induced ferroptotic cell death in vitro.Cardiomyocyte-enriched miR-22-3p was packaged in exosomes and transferred into tumor cells.Inhibition of cardiomyocyte-specific miR-22-3p by AAV9 sponge increased the sensitivity of cancer cells to ferroptosis.ACSL4,a pro-ferroptotic gene,was experimentally established as a target of miR-22-3p in tumor cells.Taken together,our findings uncovered for the first time that MI suppresses erastin-induced ferroptosis through releasing miR-22-3p-enriched exosomes derived from cardiomyocytes.Therefore,targeting exosome-mediated cardiomyocyte/tumor pathological communication may offer a novel approach for the ferroptosis-based antitumor therapy. | Ye Yuan Zhongting Mei Zhezhe Qu Guanghui Li Shuting Yu Yingqi Liu Kuiwu Liu Zhihua Shen Jiaying Pu Yanquan Wang Changhao Wang Zhiyong Sun Qian Liu Xiaochen Pang Ao Wang Zijing Ren Tong Wang Ying Liu Jinhuan Hong Jiajie Xie Xin Li Zhonghua Wang Weijie Du Baofeng Yang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 7 | Deformation field around a thrust fault:A comparison between laboratory results and GPS observations of the 2008 Wenchuan earthquake显示文摘On May 12,2008,an Mw7.9 earthquake occurred in Wenchuan County,Sichuan Province,China.Movement of Yingxiu–Beichuan Fault in the Longmenshan Fault Zone was considered to be the main cause of the earthquake.Earthquakes are closely related to fault activities.Therefore,studying the strain distribution and evolution process around active fault zones is important to the understanding of seismic activities.In this study,we conduct laboratory experiments with uniaxial compression applied to marble sheets with intentionally fabricated cracks.The speckle patterns of the rock samples under different loading conditions are recorded in real time by a digital camera.To calculate the deformation fields of the deliberately cracked marble sheets during different stages of the loading processes,the recorded images are processed by the digital image correlation method.The distribution and variation of the displacement and strain are further analyzed in order to understand the strain localization of and observed damage in the experimental fracture zones.Finally,we compare these laboratory results with the GPS-observed coseismic displacements during the 2008 Wenchuan earthquake,to assess the consistency between our laboratory observations and the field observations of the earthquake,but also to suggest how laboratory results can improve thinking about how earthquake patterns do and do not reflect fault patterns. | Ru Liu YongHong Zhao JiaYing Yang Qi Zhang AnDong Xu | 2019 | Earth and Planetary Physics2019，3，6： | 2 |
| 8 | Architecture engineering of carbonaceous anodes for high-rate potassium-ion batteries显示文摘The limited lithium resource in earth's crust has stimulated the pursuit of alternative energy storage technologies to lithium-ion battery.Potassium-ion batteries(KIBs)are regarded as a kind of promising candidate for large-scale energy storage owing to the high abundance and low cost of potassium resources.Nevertheless,further development and wide application of KIBs are still challenged by several obstacles,one of which is their fast capacity deterioration at high rates.A considerable amount of effort has recently been devoted to address this problem by developing advanced carbonaceous anode materials with diverse structures and morphologies.This review presents and highlights how the architecture engineering of carbonaceous anode materials gives rise to high-rate performances for KIBs,and also the beneficial conceptions are consciously extracted from the recent progress.Particularly,basic insights into the recent engineering strategies,structural innovation,and the related advances of carbonaceous anodes for high-rate KIBs are under specific concerns.Based on the achievements attained so far,a perspective on the foregoing,and proposed possible directions,and avenues for designing high-rate anodes,are presented finally. | Tianlai Wu Weicai Zhang Jiaying Yang Qiongqiong Lu Jing Peng Mingtao Zheng Fei Xu Yingliang Liu Yeru Liang | 2021 | Carbon Energy2021，3，4： | 2 |
| 9 | Measurement of hydrogen peroxide and organic hydroperoxide concentrations during autumn in Beijing, China显示文摘Gaseous peroxides play important roles in atmospheric chemistry. To understand the pathways of the formation and removal of peroxides, atmospheric peroxide concentrations and their controlling factors were measured from 7:00 to 20:00 in September, October, and November 2013 at a heavily trafficked residential site in Beijing, China, with average concentrations of hydrogen peroxide(H_2O_2) and methyl hydroperoxide(MHP) at 0.55 ppb and 0.063 ppb, respectively. H_2O_2 concentrations were higher in the afternoon and lower in the morning and evening, while MHP concentrations did not exhibit a regular diurnal pattern. Both H_2O_2 and MHP concentrations increased at dusk in most cases. Both peroxides displayed monthly variations with higher concentrations in September. These results suggested that photochemical activity was the main controlling factor on variations of H_2O_2 concentrations during the measurement period. Increasing concentrations of volatile organic compounds emitted by motor vehicles were important contributors to H_2O_2 and MHP enrichment. High levels of H_2O_2 and MHP concentrations which occurred during the measurement period probably resulted from the transport of a polluted air mass with high water vapor content passing over the Bohai Bay, China. | Qingyu Zhang Jiaoyu Liu Youjiang He Jiaying Yang Jian Gao Houfeng Liu Wei Tang Yizhen Chen Wenhao Fan Xuan Chen Fahe Chai Shiro Hatakeyama | 2018 | Journal of Environmental Sciences2018，30，2： | 2 |
| 10 | A large insert Thellungiella halophila BIBAC library for genomics and identification of stress tolerance genes显示文摘 | Weiquan Wang Yaorong Wu Yin Li Jiaying Xie Zhonghui Zhang Zhiyong Deng Yiyue Zhang Cuiping Yang Jianbin Lai Huawei Zhang Hongyan Bao Sanyuan Tang Chengwei Yang Peng Gao Guixian Xia Huishan Guo Qi Xie | 2010 | Plant Molecular Biology (-)2010，，1： | 1 |
| 11 | Green‑Solvent Processed Blade‑Coating Organic Solar Cells with an Efficiency Approaching 19%Enabled by Alkyl‑Tailored Acceptors显示文摘Power-conversion-efficiencies(PCEs)of organic solar cells(OSCs)in laboratory,normally processed by spin-coating technology with toxic halogenated solvents,have reached over 19%.However,there is usually a marked PCE drop when the bladecoating and/or green-solvents toward large-scale printing are used instead,which hampers the practical development of OSCs.Here,a new series of N-alkyl-tailored small molecule acceptors named YR-SeNF with a same molecular main backbone are developed by combining selenium-fused central-core and naphthalene-fused endgroup.Thanks to the N-alkyl engineering,NIR-absorbing YR-SeNF series show different crystallinity,packing patterns,and miscibility with polymeric donor.The studies exhibit that the molecular packing,crystallinity,and vertical distribution of active layer morphologies are well optimized by introducing newly designed guest acceptor associated with tailored N-alkyl chains,providing the improved charge transfer dynamics and stability for the PM6:L8-BO:YRSeNF-based OSCs.As a result,a record-high PCE approaching 19%is achieved in the blade-coating OSCs fabricated from a greensolvent o-xylene with high-boiling point.Notably,ternary OSCs offer robust operating stability under maximum-power-point tracking and well-keep>80%of the initial PCEs for even over 400 h.Our alkyl-tailored guest acceptor strategy provides a unique approach to develop green-solvent and blade-coating processed high-efficiency and operating stable OSCs,which paves a way for industrial development. | Hairui Bai Ruijie Ma Wenyan Su Top Archie Dela Pea Tengfei Li Lingxiao Tang Jie Yang Bin Hu Yilin Wang Zhaozhao Bi Yueling Su Qi Wei Qiang Wu Yuwei Duan Yuxiang Li Jiaying Wu Zicheng Ding Xunfan Liao Yinjuan Huang Chao Gao Guanghao Lu Mingjie Li Weiguo Zhu Gang Li Qunping Fan Wei Ma | 2023 | Nano-Micro Letters2023，15，12： | 1 |
| 12 | Modified Energy - Aware AODV Routing for Ad hoc Networks显示文摘 | Jiaying Chen Yang Zhen | 2004 | Journal of Nanjing University of Posts and Telecommunication2004，24，3： | 1 |
| 13 | Structural Characteristics and Thermal Properties of Plasticized Poly (Lqactide)-silica Nanocomposites Synthesized by Sobgel Method显示文摘 | Yan Shifeng Yin Jingbo Yang Jiaying | 2007 | Materials Letters2007，61，： | 1 |
| 14 | An optimized relevancy Context Graph based on social network显示文摘 | Hu Qiang Du Yajun Yang Jiaying | 2014 | Journal of Information and Computational Science2014，11，6： | 1 |
| 15 | Somatic mutation analysis of EGFR, KRAS, BRAF and PIK3CA in 861patients with non-small cell lung cancer显示文摘 | Jianping Xu Jiaying He Huiyi Yang Xiaodi Luo Zhangmin Liang Jiaxin Chen Zhiping Cai Jiasen Xu Lifen Ren-Heidenreich | 2012 | Cancer Biomarkers2012，，： | 1 |
| 16 | TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO显示文摘Sensing of pathogenic nucleic acids by pattern recognition receptors(PRR)not only initiates anti-microbe defense but causes inflammatory and autoimmune diseases.E3 ubiquitin ligase(s)critical in innate response need to be further identified.Here we report that the tripartite motif-containing E3 ubiquitin ligase TRIM41 is required to innate antiviral response through facilitating pathogenic nucleic acids-triggered signaling pathway.TRIM41 deficiency impairs the production of inflammatory cytokines and type I interferons in macrophages after transfection with nucleic acid-mimics and infection with both DNA and RNA viruses.In vivo,TRIM41 deficiency leads to impaired innate response against viruses.Mechanistically,TRIM41 directly interacts with BCL10(B cell lymphoma 10),a core component of CARD proteins-BCL10—MALT1(CBM)complex,and modifies the Lys63-linked polyubiquitylation of BCL10,which,in turn,hubs NEMO for activation of NF-kB and TANK-binding kinase 1(TBK1)—interferon regulatory factor 3(IRF3)pathways.Our study suggests that TRIM41 is the potential universal E3 ubiquitin ligase responsible for Lys63 linkage of BCL10 during innate antiviral response,adding new insight into the molecular mechanism for the control of innate antiviral response. | Zhou Yu Xuelian Li Mingjin Yang Jiaying Huang Qian Fang Jianjun Jia Zheng Li Yan Gu Taoyong Chen Xuetao Cao | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 17 | Semi-interpenetrating polymer networks toward sulfonated poly(ether ether ketone) membranes for high concentration direct methanol fuel cell显示文摘Low methanol permeability of proton exchange membranes (PEMs) is greatly important for direct methanol fuel cells (DMFCs). Here, sulfonated poly (ether ether ketone) (SPEEK) based semiinterpenetrating polymer networks (semi-IPNs) are successfully prepared by interpenetrating SPEEK into the in-situ synthesized crosslinking networks. The polymeric networks are formed by the covalent bonds between bromobenzyl groups of bro mo methylated poly (phenylene oxide) and amine groups of diamine linkers as well as the ionic bonds between amine species and sulfonated groups. Two linkers without and with sulfonated groups are applied to fabricate the semi-IPNs. The core properties of the membranes, like phase separation, water uptake, proton conductivity and methanol permeability, are systematically studied and compared. The DMFCs assembled by using the semi-IPN membranes display better performance than Nafion 117 in high concentration methanol solutions. The present work provides a facile way to prepare PEMs with enhanced DMFC performance. | Xupo Liu Yunfeng Zhang Shaofeng Deng Cuicui Li Jiaming Dong Jiaying Wang Zehui Yang Deli Wang Hansong Cheng | 2019 | Chinese Chemical Letters2019，30，2： | 1 |
| 18 | The loss of function of HEL,which encodes a cellulose synthase interactive protein,causes helical and vine-like growth of tomato显示文摘Helical growth is an economical way for plant to obtain resources.The classic microtubule–microfibril alignment model of Arabidopsis helical growth involves restriction of the appropriate orientation of cellulose microfibrils appropriately in the cell walls.However,the molecular mechanism underlying tomato helical growth remains unknown.Here,we identified a spontaneous tomato helical(hel)mutant with right-handed helical cotyledons and petals but left-handed helical stems and true leaves.Genetic analysis revealed that the hel phenotype was controlled by a single recessive gene.Using map-based cloning,we cloned the HEL gene,which encodes a cellulose interacting protein homologous to CSI1 of Arabidopsis.We identified a 27 bp fragment replacement that generated a premature stop codon.Transgenic experiments showed that the helical growth phenotype could be restored by the allele of this gene from wild-type Pyriforme.In contrast,the knockout mutation of HEL in Pyriforme via CRISPR/Cas9 resulted in helical growth.These findings shed light on the molecular control of the helical growth of tomato. | Qihong Yang Xiaoshuai Wan Jiaying Wang Yuyang Zhang Junhong Zhang Taotao Wang Changxian Yang Zhibiao Ye | 2020 | Horticulture Research2020，7，1： | 1 |
| 19 | Step‑by‑Step Modulation of Crystalline Features and Exciton Kinetics for 19.2%Efficiency Ortho‑Xylene Processed Organic Solar Cells显示文摘With plenty of popular and effective ternary organic solar cells(OSCs)construction strategies proposed and applied,its power conversion efficiencies(PCEs)have come to a new level of over 19%in single-junction devices.However,previous studies are heavily based in chloroform(CF)leaving behind substantial knowledge deficiencies in understanding the influence of solvent choice when introducing a third component.Herein,we present a case where a newly designed asymmetric small molecular acceptor using fluoro-methoxylated end-group modification strategy,named BTP-BO-3FO with enlarged bandgap,brings different morphological evolution and performance improvement effect on host system PM6:BTP-eC9,processed by CF and ortho-xylene(o-XY).With detailed analyses supported by a series of experiments,the best PCE of 19.24%for green solvent-processed OSCs is found to be a fruit of finely tuned crystalline ordering and general aggregation motif,which furthermore nourishes a favorable charge generation and recombination behavior.Likewise,over 19%PCE can be achieved by replacing spin-coating with blade coating for active layer deposition.This work focuses on understanding the commonly met yet frequently ignored issues when building ternary blends to demonstrate cutting-edge device performance,hence,will be instructive to other ternary OSC works in the future. | Bosen Zou Weiwei Wu Top Archie Dela Pena Ruijie Ma Yongmin Luo Yulong Hai Xiyun Xie Mingjie Li Zhenghui Luo Jiaying Wu Chuluo Yang Gang Li He Yan | 2024 | Nano-Micro Letters2024，16，2： | 0 |
| 20 | Conserved profiles of digestion by double restriction endonucleases in insect genomes facilitate the design of dd RAD显示文摘Double-digested Restriction Site Associated DNA Sequencing(ddRAD) through next-generation sequencing(NGS) generates large numbers of loci for characterizing genomewide variation among multiple samples using next-generation sequencing. Different combinations of restriction endonucleases(REs) may produce varying size distributions of digested fragments, which affect the number of genotyped loci. Understanding digestion profiles across different species will help in selecting REs for digestion in a particular organism. In this study, we use of genome sequences to compare the in silico digestion profile of 26 combinations of REs in 131 insect species with two simulation programs. The number of digested fragments in the 300–450 bp range increases linearly with the size of the genome. Different species and insect orders showed similar profiles when digested by different combinations of REs in silico, indicating the conservation of digestion by double enzymes in insect genomes. Combinations with Nla III or TaqαI usually produced higher number of fragments in the range 300–450 bp, while combinations with EcoRI or MluCI produced fewer fragments. The proportion of fragments with the same overhangs at the two ends of digested DNA was higher than those with different overhangs. The two four-base enzyme pairs produced more fragments in the 300–450 bp range than pairs of four-base + six-base enzymes. Experimental digestion of three species from Hymenoptera, Lepidoptera and Thysanoptera showed profiles congruent with in silico expectations. Our results shed light on understanding the digestion profiles of insect genomes and provide guidance on selecting REs for ddRAD projects. | Bingyan Li Qiao Gao Lijun Cao Ary Anthony Hoffmann Qiong Yang Jiaying Zhu Shujun Wei | 2018 | Zoological Systematics2018，43，4： | 0 |
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