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| 1 | Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty显示文摘童年肥胖和肥胖相关的新陈代谢的复杂并发症被一本高脂肪的出生后的食谱导致。然而,一个合适的动物模型的缺乏在肥胖研究仍然是可观的挑战。在当前的学习,我们在断奶以后在哺乳期间并且到小狗提供了高脂肪的饮食(HFD ) 给水坝。我们也与导致 HFD 的出生后的肥胖开发了 C57BL/6J 老鼠小狗的一个新奇模型。结果证明用 HFD 喂在小狗导致胖免职和肥胖。而且, HFD 更 potently 比女小狗增加了男性的身体重量(BW ) 。喂 HFD 的女小狗是肥胖的,经历了早熟的发身,并且显示出在视下丘的增加的 kisspeptin 表示。然而,父母肥胖和早熟的发身没在导致 HFD 的出生后的重量获得和小狗的发身发作上施加 synergistic 效果。有趣地,有正常 BW 的一些喂 HFD 的崽也展出了早熟的发身。这发现建议了那篇食谱作文然而并非 BW 扳机发身发作。我们的模型建议肥胖和早熟的发身的好构造有效性。而且,我们的模型能也被用来探索在 dietinduced 之间的相互的相互作用出生后的童年肥胖和发身。 | Rahim Ullah Yan Su Yi Shen Chunlu Li Xiaoqin Xu Jianwei Zhang Ke Huang Naveed Rauf Yang He Jingjing Cheng Huaping Qin Yu-Dong Zhou Junfen Fu | 2017 | Frontiers of Medicine2017，11，2： | 5 |
| 2 | COVID-19 vaccine development:milestones,lessons and prospects显示文摘With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern(VOC),the implementation of vaccination is critically important.Existing SARS-CoV-2 vaccines mainly include inactivated,live attenuated,viral vector,protein subunit,RNA,DNA,and virus-like particle(VLP)vaccines.Viral vector vaccines,protein subunit vaccines,and mRNA vaccines may induce additional cellular or humoral immune regulations,including Th cell responses and germinal center responses,and form relevant memory cells,greatly improving their efficiency.However,some viral vector or mRNA vaccines may be associated with complications like thrombocytopenia and myocarditis,raising concerns about the safety of these COVID-19 vaccines.Here,we systemically assess the safety and efficacy of COVID-19 vaccines,including the possible complications and different effects on pregnant women,the elderly,people with immune diseases and acquired immunodeficiency syndrome(AIDS),transplant recipients,and cancer patients.Based on the current analysis,governments and relevant agencies are recommended to continue to advance the vaccine immunization process.Simultaneously,special attention should be paid to the health status of the vaccines,timely treatment of complications,vaccine development,and ensuring the lives and health of patients.In addition,available measures such as mix-and-match vaccination,developing new vaccines like nanoparticle vaccines,and optimizing immune adjuvant to improve vaccine safety and efficacy could be considered. | Maochen Li Han Wang Lili Tian Zehan Pang Qingkun Yang Tianqi Huang Junfen Fan Lihua Song Yigang Tong Huahao Fan | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 2 |
| 3 | An investigation of the thermal degradation of the intumescent coating containing MoO3and Fe203 显示文摘 | LI Guoxin YANG Junfen HE Tingshu | 2008 | Surf Coat Technol2008，202，： | 1 |
| 4 | An investigation of the thermal degradation of the intumescent coating containing MoO3 and Fe2O3显示文摘 | LI GUOXIN YANG JUNFEN HE TINGSHU | 2008 | Surface & Coatings Technology2008，202，： | 1 |
| 5 | An Investigation of the Thermal Degradation of the Intumescent Coating Containing MoO3 and Fe2O3显示文摘 | Lin Guoxin Yang Junfen He Tingshu | 2008 | Surface & Coatings Technology2008，202，： | 1 |
| 6 | An efficient synthesis of 3, 4-dihydropyrimidin-2- ones catalyzed by NH2SO3 H under ultrasound irradiation 显示文摘 | LI Jitai HAN Junfen YANG Jinhui | 2003 | Ultrasonics Sonochemistry2003，10，3： | 1 |
| 7 | Effect of Pharmaceuti- cal Care interventions on Blood Pressure and Medication Adherence of Patients with Primary Hypertension, in China显示文摘 | Jinping Wang Jianlong Wu Junfen Yang | 2010 | Clinical Research and Regulatory Affairs2010，12，1： | 1 |
| 8 | miR-375 Is Down-Regulated in Squamous Cervical Cancer and Inhibits Cell Migration and Invasion via Targeting Transcription Factor SP1显示文摘 | Fenfen Wang Yang Li Jiansong Zhou Junfen Xu Chanjuan Peng Feng Ye Yuanming Shen Weiguo Lu Xiaoyun Wan Xing Xie | 2011 | The American Journal of Pathology2011，，5： | 1 |
| 9 | VEGF-A not Ang2 mediates endothelial-like differentiation of immatureDCs by ERK1/2 signaling in the microenvironment of human colon adenocarcinoma显示文摘 | Jing Lu Kangdong Liu Jimin Zhao Jun Zhao Junfen Ma Hongyan Yang Youtian Huang Zhenzhu Qin Ruihua Bai Lili Jiang Fengshou Lv Pei Li Wenhai Yan Mingyao Zhao Ziming Dong | 2011 | International Journal of Oncology2011，，6： | 1 |
| 10 | miR-375 Is Down-Regulated in Squamous Cervical Cancer and Inhibits Cell Migration and Invasion via Targeting Transcription Factor SP1显示文摘 | Fenfen Wang Yang Li Jiansong Zhou Junfen Xu Chanjuan Peng Feng Ye Yuanming Shen Weiguo Lu Xiaoyun Wan Xing Xie | 2011 | The American Journal of Pathology2011，，5： | 1 |
| 11 | An investigation of the thermal degradation of the intumescent coating containing MoO3 and Fe2O3 显示文摘 | LI GUOXIN YANG JUNFEN HE TINGSHU | 2008 | Surface & Caotings Technology2008，202，： | 1 |
| 12 | An Investigation of the thermal degradation of the intumescent coating containing MoO3 and Fe2O3显示文摘 | Guoxin Li a Junfen Yang Tingshu He | 2008 | Surface & Coatings TechnoLogy2008，202，： | 1 |
| 13 | Microwave assisted synthesis of PQ-GDY@NH_(2)-UIO-66(Zr) for improved photocatalytic removal of NOx under visible light显示文摘Pyrazinoquinoxaline-based graphdiyne (PQ-GDY) contains a fixed number of sp-sp2hybridized carbon atoms and pyrazine-like sp2hybridized N atoms.In this paper,NH_(2)-UIO-66(Zr) on PQ-GDY substrate was successfully constructed with the help of microwaveassisted heating.PQ-GDY surface acts as a microwave antenna under microwave irradiation to rapidly absorb microwave energy and form hot spots (hot spot effect),which facilitates the formation of well-dispersed NH2-UIO-66(Zr) with good crystallinity.Transient absorption spectra show that high hole transport property of PQ-GDY can accelerate the migration of photogenerated holes from NH2-UIO-66(Zr) to PQ-GDY and greatly reduce the recombination rate of photogenerated electrons and holes due to the strong interaction between PQ-GDY and NH2-UIO-66(Zr).Under visible light (λ≥420 nm),PQ-GDY@NH_(2)-UIO-66(Zr) shows high photocatalytic stability and high NO_(x)removal rate up to 74%,which is 44% higher than that of primitive NH_(2)-UIO-66(Zr).At the same time,it inhibits the formation of toxic byproducts (NO2) and limits its concentration to a low level. | Qingyu Yang Shuangjun Li Rui Liang Lei Gao Shao Zhang Junfen Jia Yiran Liu Rundong Lyv Guisheng Li Shengxiong Xiao Dieqing Zhang | 2023 | Journal of Environmental Sciences2023，，12： | 0 |
| 14 | Chinese herbal medicine and COVID-19: quality evaluation of clinical guidelines and expert consensus and analysis of key recommendations显示文摘Objective:To systematically review the clinical practice guidelines(CPGs)for the treatment of patients with coronavirus disease 2019(COVID-19)using Chinese herbal medicine(CHM),assess the methodological quality as well as clinical credibility and implementability of specific recommendations,and summarize key recommendations.Methods:As of April 2022,we conducted a comprehensive search on major electronic databases,guideline websites,academic society websites,and government websites to assess the methodological quality and clinical applicability of the included CPGs using the Appraisal of Guidelines for Research and Evaluation(AGREE)II tool and Evaluation-Recommendations EXcellence(AGREE-REX)instructions,respectively.Results:The search yielded 61 CPGs,which were mostly published in 2020;moreover,98.4%of the CPGs were published in China.Only five CPGs achieved a high-quality AGREE II rating;further,six CPGs could be directly recommended,with most of the CPGs still showing much room for improvement.CPGs had a low overall score in the AGREE-REX evaluation,with the domains of clinical applicability,values and preferences,and implementability being standardized in 21.80%±12.56%,16.00%±11.81%,and 31.33%±14.55%of the CPGs,respectively.Five high-quality CPGs mentioned 56 Chinese herbal formulas.Half of the recommendations had moderate or strong evidence level in the GRADE evaluation.The most frequently recommended herbal medicines were Lianhua Qingwen granule/capsule and Jinhua Qinggan granule;however,the strength of recommendation for each prescription varied across CPGs and populations.Conclusions:The overall quality of current CPGs for COVID-19 for CHM still needs to be improved;moreover,the strength of the evidence remains to be standardized across CPGs. | Qingyong Zheng Ya Gao Lu Xiong Hengyi Huang Junfen Li Guoyuan OuYang WulayinSaimire Jingjing Yang Yu Zhang Xiaopeng Wang Xiaofeng Luo | 2022 | Acupuncture and Herbal Medicine2022，2，3： | 0 |
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