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| 1 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 2 | Artificial photosynthesis bringing new vigor into plastic wastes显示文摘The accumulation of plastic wastes in landfills and the environment threatens our environment and public health,while leading to the loss of potential carbon resources.The urgent necessary lies in developing an energy-saving and environmentally benign approach to upgrade plastic into value-added chemicals.Artificial photosynthesis holds the ability to realize plastic upcycling by using endless solar energy under mild conditions,but remains in the initial stage for plastic upgrading.In this review,we aim to look critically at the photocatalytic conversion of plastic wastes from the perspective of resource reutilization.To begin with,we present the emerging conversion routes for plastic wastes and highlight the advantages of artificial photosynthesis for processing plastic wastes.By parsing photocatalytic plastic conversion process,we demonstrate the currently available routes for processing plastic,including plastic photodegradation,tandem decomposition of plastic and CO_(2) reduction,selective plastic oxidation,as well as photoreforming of plastic.This review concludes with a personal perspective for potential advances and emerging challenges in photocatalytic plastic conversion. | Sailei Kang Tao Sun Yingxin Ma Mengmeng Du Mingfu Gong Chunyu Zhou Yang Chai Bocheng Qiu | 2023 | SmartMat2023，4，4： | 1 |
| 3 | The contribution of photoinduced charge-transfer enhancement to the SERS of uranyl(Ⅵ) in a uranyl-Ag_2O complex显示文摘Charge-transfer(CT) is an important enhancement mechanism in the field of surface-enhanced Raman scattering(SERS) that typically increases the Raman intensity of molecules by as much as 10–100 times.Herein, a low-cost Ag_2O aggregates substrate was prepared via a facile chemical precipitation method,and the calculated CT-based enhancement factor of the uranyl ions adsorbed on it reached as high as 10~5, a metal-comparable value. The efficient photoinduced CT process from the valence band of Ag_2O to the LUMO of uranyl ions under appropriate excitation sources resulted in the repulsion of the axial oxygen atoms of the O=U=O bond, which enhanced its polarizability, creating a more intense Raman mode. To the best of our knowledge, this study firstly reports such a strong photoinduced CT enhancement of uranyl ions, with concentrations of 10^(-8) mol L^(-1) or lower being detected using this Ag_2O substrate. Most importantly, this research has shown that the photoinduced CT enhancement also contributes to the SERS of uranyl ions on pure Ag substrates which have often been ascribed to the electromagnetic enhancement in previous studies. In addition, Ag_2O can be used to selectively detect uranyl ions without interference from many other molecules or ions because of the energy matching rule of the photoinduced CT process, which was readily available for uranyl detection in the environmental aqueous solution. | Shaofei Wang Shanli Yang Haoxi Wu Jiaolai Jiang Lang Shao Yiming Ren Yingru Li Chuanhui Liang Mingfu Chu Xiaolin Wang | 2019 | Science Bulletin2019，64，5： | 1 |
| 4 | A Survey on Bit-parallelism Based Packet Classification显示文摘 | Han Xiaofei Wang Xueguang Yang Mingfu | 2003 | Journal of East China University of Science and Technology2003，29，5： | 1 |
| 5 | Antidiabetic activity of mung bean extracts in diabetic KK-Ay mice显示文摘 | YAO Yang CHEN Feng WANG Mingfu | 2008 | Journal of Agricultural and Food Chemistiy2008，56，19： | 1 |
| 6 | Antidiabetic activity ofmung bean extracts in diabetic KK-Ay mice显示文摘 | YAO Yang CHEN Feng WANG Mingfu | 2008 | Journal of Agriculturaland Food Chemistry2008，56，19： | 1 |
| 7 | Bonding Efficacy of a Self-adhesive Resin Cement to Enamel and Dentin显示文摘With the objective to evaluate the bonding efficacy of a new self-adhesive resin cement(RelyX Unicem, 3M ESPE) to enamel and dentin using a shear bonding strengths test with or without acid etching pretreatment, flat buccal dentin surface and mesial/distal enamel surface were made using a high-speed diamond bur. Copper rings were luted using Rely X Unicem(RU; 3M ESPE), Panavia F(PF; Kuraray) or Vitique(VI; DMG). For RU, the shear bonding strengths using GL(Gluma Etch, Heraeus) acid etching pretreatment were also tested. The teeth were placed into copper rings(inner diameter: 16 mm, height: 4mm) and embedded in methylmethacrylate resin. The specimens were stored for 24 h in distilled water at 37 ℃ prior to shear bonding strengths testing. In addition, bond failures were examined by optical microscope and categorized as 4 models such as different adhesive, cohesive, or mixed. Shear bonding strengths were calculated by dividing the maximum debonding force over the cross sectional area of each specimen. The Kruskal-Wallis test was used to determine pairwise statistical differences(P < 0.05) in SBS between the experimental groups. For dentin bonding strength, statistical analysis showed that there was no significant difference among RU(12.84 MPa), PF(14.93 MPa) and VI(11.03 MP); and the bonding strengths of them were higher than RU with acid etching pretreatment(9.12 MP). When bonded to enamel, PF(17.99 MP) and VI(17.58 MP) scored significantly higher than RU efficacy.The use of self-adhesive cement Rely X Unicem can obtain the bonding strengths to dentin similar to traditional resin cements. Phosphoric acid etching can improve the bonding strengths of the selfadhesive resin cement to enamel, but was negative for dentin. | 王林虎 XU Haixing LI Songyang 施斌 LI Rong YE Mingfu YANG Jing | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，6： | 1 |
| 8 | Hypoxia signaling in human health and diseases:implications and prospects for therapeutics显示文摘Molecular oxygen(O2)is essential for most biological reactions in mammalian cells.When the intracellular oxygen content decreases,it is called hypoxia.The process of hypoxia is linked to several biological processes,including pathogenic microbe infection,metabolic adaptation,cancer,acute and chronic diseases,and other stress responses.The mechanism underlying cells respond to oxygen changes to mediate subsequent signal response is the central question during hypoxia.Hypoxia-inducible factors(HIFs)sense hypoxia to regulate the expressions of a series of downstream genes expression,which participate in multiple processes including cell metabolism,cell growth/death,cell proliferation,glycolysis,immune response,microbe infection,tumorigenesis,and metastasis.Importantly,hypoxia signaling also interacts with other cellular pathways,such as phosphoinositide 3-kinase(PI3K)-mammalian target of rapamycin(mTOR)signaling,nuclear factor kappa-B(NF-κB)pathway,extracellular signal-regulated kinases(ERK)signaling,and endoplasmic reticulum(ER)stress.This paper systematically reviews the mechanisms of hypoxia signaling activation,the control of HIF signaling,and the function of HIF signaling in human health and diseases.In addition,the therapeutic targets involved in HIF signaling to balance health and diseases are summarized and highlighted,which would provide novel strategies for the design and development of therapeutic drugs. | Zhen Luo Mingfu Tian Ge Yang Qiaoru Tan Yubing Chen Geng Li Qiwei Zhang Yongkui Li Pin Wan Jianguo Wu | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 1 |
| 9 | NIR-Ⅱ fluorescence/photoacoustic imaging of ovarian cancer and peritoneal metastasis显示文摘Ovarian cancer is a global problem,and is typically diagnosed in the middle or late stages,with a mysterious abdominal mass or atypical abdominal metastases due to the lack of specific initial diagnostic methods.Dual-modal near-infrared Ⅱ(NIR-Ⅱ,1,000–1,700 nm)fluorescence/photoacoustic imaging has great potential in early ovarian cancer diagnosis and image-guided surgery due to its high sensitivity and deep penetration.Herein,we report a novel organic NIR-Ⅱ dye(H10)with excellent aggregation-induced-emission(AIE)characteristics(I/I0>1.6)utilizing a selenadiazolo-[3,4-f]benzo[c][1,2,5]thiadiazole(ST)-based building block.Then,water-soluble and biocompatible H10@follicle-stimulating hormone(H10@FSH)dots with superior optical/photoacoustic properties and a tenfold increase in ovarian-specific targeting ability were synthesized.Finally,for the first time,in vivo dual-mode NIR-Ⅱ fluorescent/photoacoustic(PA)imaging and image-guided surgery of patient-derived tumor xenograft(PDTX)and micro-metastatic abdominal ovarian cancer lesions were investigated.This novel strategy will establish a new method for early detection of ovarian cancer and significantly improve the prognosis of ovarian cancer patients. | Siyu Lu Liru Xue Meng Yang Jingjing Wang Yang Li Yuxin Jiang Xuechuan Hong Mingfu Wu Yuling Xiao | 2022 | Nano Research2022，15，10： | 0 |
| 10 | SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication显示文摘Viral infection in respiratory tract usually leads to cell death,impairing respiratory function to cause severe disease.However,the diversity of clinical manifestations of SARS-CoV-2 infection increases the complexity and difficulty of viral infection prevention,and especially the high-frequency asymptomatic infection increases the risk of virus transmission.Studying how SARS-CoV-2 affects apoptotic pathway may help to understand the pathological process of its infection.Here,we uncovered SARS-CoV-2 imployed a distinct anti-apoptotic mechanism via its N protein.We found SARS-CoV-2 virus-like particles(trVLP)suppressed cell apoptosis,but the trVLP lacking N protein didn’t.Further study verified that N protein repressed cell apoptosis in cultured cells,human lung organoids and mice.Mechanistically,N protein specifically interacted with anti-apoptotic protein MCL-1,and recruited a deubiquitinating enzyme USP15 to remove the K63-linked ubiquitination of MCL-1,which stabilized this protein and promoted it to hijack Bak in mitochondria.Importantly,N protein promoted the replications of IAV,DENV and ZIKV,and exacerbated death of IAV-infected mice,all of which could be blocked by a MCL-1 specific inhibitor,S63845.Altogether,we identifed a distinct anti-apoptotic function of the N protein,through which it promoted viral replication.These may explain how SARS-CoV-2 effectively replicates in asymptomatic individuals without cuasing respiratory dysfunction,and indicate a risk of enhanced coinfection with other viruses.We anticipate that abrogating the N/MCL-1-dominated apoptosis repression is conducive to the treatments of SARS-CoV-2 infection as well as coinfections with other viruses. | Pan Pan Weiwei Ge Zhiwei Lei Wei luo Yuqing Liu Zhanwen Guan Lumiao Chen Zhenyang Yu Miaomiao Shen Dingwen Hu Qi Xiang Wenbiao Wang Pin Wan Mingfu Tian Yang Yu Zhen Luo Xulin Chen Heng Xiao Qiwei Zhang Xujing Liang Xin Chen Yongkui Li Jianguo Wu | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 11 | Central nervous system injury meets nanoceria:opportunities and challenges显示文摘Central nervous system(CNS)injury,induced by ischemic/hemorrhagic or traumatic damage,is one of the most common causes of death and long-term disability worldwide.Reactive oxygen and nitrogen species(RONS)resulting in oxidative/nitrosative stress play a critical role in the pathological cascade of molecular events after CNS injury.Therefore,by targeting RONS,antioxidant therapies have been intensively explored in previous studies.However,traditional antioxidants have achieved limited success thus far,and the development of new antioxidants to achieve highly effective RONS modulation in CNS injury still remains a great challenge.With the rapid development of nanotechnology,novel nanomaterials provided promising opportunities to address this challenge.Within these,nanoceria has gained much attention due to its regenerative and excellent RONS elimination capability.To promote its practical application,it is important to know what has been done and what has yet to be done.This review aims to present the opportunities and challenges of nanoceria in treating CNS injury.The physicochemical properties of nanoceria and its interaction with RONS are described.The applications of nanoceria for stroke and neurotrauma treatment are summarized.The possible directions for future application of nanoceria in CNS injury treatment are proposed. | Wang Yang Maoting Zhang Jian He Mingfu Gong Jian Sun Xiaochao Yang | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 12 | Advances in Studies of Genetic Improvement of Sugarcane显示文摘Sugarcane(Saccharum spp.) is a large perennial herbaceous plant that is cultivated in tropical and subtropical regions of the world,and it is also one of the most efficient crops in the world in converting energy from sunlight into chemical energy. As an essential sugar crop and energy crop,sugarcane is receiving an increasing concern for its variety improvement. Traditional breeding and cultivation techniques have contributed a lot to increasing sugarcane yield and sucrose content. In recent years,development and application of biotechnology provide much help for genetic improvement of sugarcane. For convenience of breeders fully knowing advances in studies of sugarcane genetic improvement,this paper elaborated conventional breeding,genomics,GM technology,and molecular marker assisted breeding. | Mingfu WEN Junxian YANG Fangyin PAN Wenlong WU Yuegui CHEN Jinyan GUAN | 2016 | Asian Agricultural Research2016，8，11： | 0 |
| 13 | EFFECT OF ACUPUNCTURE ANALGESIA ON SYNAPSFS OF NUCLEUS CENTRO—MEDIANUS OBSERVED WITH ELECTRO—MICROSCOPE显示文摘The present study was aimed at the investigation of the ultrastructuralchanges of nucleus centromedianus(CM)of nuclei intralaminares under acupuncture analge-sia.The results of the observations on 18 healthy and adult rats were as follows.1.Thesynapses of the CM belong mainly to the axodendricular synapses and also with some suc-cessive or juxtaposing synapses.2.The presynaptic sac contains a lot of round and clearvesicles,some granular vesicles also spread among clear vesicles in a few synapses.3.Theround clear synaptic vesicles of CM in the electroacupuncture analgesia(EA)group are de-creased significantly than that in the control group.It is suggested that CM plays a role inacupuncture analgesia. | Luo Mingfu Wang Pingping Yang Youmi Institute of Acupuncture and Moxibustion,China Academy of Traditional Chinese Medicine.Beijing 100700 China | 1992 | World Journal of Acupuncture-Moxibustion1992，2，3： | 0 |
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