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| 1 | Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes显示文摘Being infected by SARS-CoV-2 may cause damage to multiple organs in patients, such as the lung, liver and heart. Angiotensin-converting enzyme 2(ACE2), reported as a SARS-CoV-2 receptor, is also expressed in human male testes. This suggests a potential risk in human male reproductive system. However, the characteristics of ACE2-positive cells and the expression of other SARS-CoV-2 process-related genes are still worthy of further investigation. Here, we performed singlecell RNA seq(scRNA-seq) analysis on 853 male embryo primordial germ cells(PGCs) and 2,854 normal testis cells to assess the effects of the SARS-CoV-2 virus on the male reproductive system from embryonic stage to adulthood. We also collected and constructed the scRNA-seq library on 228 Sertoli cells from three non-obstructive azoospermia(NOA) patients to assess the effects at disease state. We found that ACE2 expressing cells existed in almost all testis cell types and Sertoli cells had highest expression level and positive cells ratio. Moreover, ACE2 was also expressed in human male PGCs. In adulthood, the level of ACE2 expression decreased with the increase of age. We also found that ACE2 positive cells had high expressions of stress response and immune activation-related genes. Interestingly, some potential SARS-CoV-2 process-related genes such as TMPRSS2, BSG, CTSL and CTSB had different expression patterns in the same cell type. Furthermore, ACE2 expression level in NOA donors’ Sertoli cells was significantly decreased. Our work would help to assess the risk of SARS-CoV-2 infection in the male reproductive system. | Xixi Liu Yidong Chen Wenhao Tang Li Zhang Wei Chen Zhiqiang Yan Peng Yuan Ming Yang Siming Kong Liying Yan Jie Qiao | 2020 | Science China(Life Sciences)2020，63，7： | 14 |
| 2 | Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner显示文摘As one of the hallmarks of cancer,metabolic reprogramming leads to cancer progression,and targeting glycolytic enzymes could be useful strategies for cancer therapy.By screening a small molecule library consisting of 1320 FDA-approved drugs,we found that penfluridol,an antipsychotic drug used to treat schizophrenia,could inhibit glycolysis and induce apoptosis in esophageal squamous cell carcinoma(ESCC).Gene profiling and Ingenuity Pathway Analysis suggested the important role of AMPK in action mechanism of penfluridol.By using drug affinity responsive target stability(DARTS)technology and proteomics,we identified phosphofructokinase,liver type(PFKL),a key enzyme in glycolysis,as a direct target of penfluridol.Penfluridol could not exhibit its anticancer property in PFKL-deficient cancer cells,illustrating that PFKL is essential for the bioactivity of penfluridol.High PFKL expression is correlated with advanced stages and poor survival of ESCC patients,and silencing of PFKL significantly suppressed tumor growth.Mechanistically,direct binding of penfluridol and PFKL inhibits glucose consumption,lactate and ATP production,leads to nuclear translocation of FOXO3a and subsequent transcriptional activation of BIM in an AMPK-dependent manner.Taken together,PFKL is a potential prognostic biomarker and therapeutic target in ESCC,and penfluridol may be a new therapeutic option for management of this lethal disease. | Cancan Zheng Xiaomei Yu Yiyao Liang Yidong Zhu Yan He Long Liao Dingkang Wang Yanming Yang Xingfeng Yin Ang Li Qingyu He Bin Li | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 4 |
| 3 | A review of real-time multi-GNSS precise orbit determination based on the filter method显示文摘Stable and reliable high-precision satellite orbit products are the prerequisites for the positioning services with high performance.In general,the positioning accuracy depends strongly on the quality of satellite orbit and clock products,especially for absolute positioning modes,such as Precise Point Positioning(PPP).With the development of real-time services,real-time Precise Orbit Determination(POD)is indispensable and mainly includes two methods:the ultra-rapid orbit prediction and the real-time filtering orbit determination.The real-time filtering method has a great potential to obtain more stable and reliable products than the ultra-rapid orbit prediction method and thus has attracted increasing attention in commercial companies and research institutes.However,several key issues should be resolved,including the refinement of satellite dynamic stochastic models,adaptive filtering for irregular satellite motions,rapid convergence,and real-time Ambiguity Resolution(AR).This paper reviews and summarizes the current research progress in real-time filtering POD with a focus on the aforementioned issues.In addition,the real-time filtering orbit determination software developed by our group is introduced,and some of the latest results are evaluated.The Three-Dimensional(3D)real-time orbit accuracy of GPS and Galileo satellites is better than 5 cm with AR.In terms of the convergence time and accuracy of kinematic PPP AR,the better performance of the filter orbit products is validated compared to the ultra-rapid orbit products. | Yidong Lou Xiaolei Dai Xiaopeng Gong Chenglong Li Yun Qing Yang Liu Yaquan Peng Shengfeng Gu | 2022 | Satellite Navigation2022，3，3： | 4 |
| 4 | Simultaneous diffusion of cation and anion to access N,S cocoordinated Bi-sites for enhanced CO_(2) electroreduction显示文摘Developing highly active single-atom sites catalysts for electrochemical reduction of CO_(2) is an effective and environmental-friendly strategy to promote carbon-neutral energy cycle and ameliorate global climate issues.Herein,we develop an atomically dispersed N,S co-coordinated bismuth atom sites catalyst(Bi-SAs-NS/C)via a cation and anion simultaneous diffusion strategy for electrocatalytic CO_(2) reduction.In this strategy,the bonded Bi cation and S anion are simultaneously diffused into the nitrogen-doped carbon layer in the form of Bi2S3.Then Bi is captured by the abundant N-rich vacancies and S is bonded with carbons.support at high temperature,formed the N,S co-coordinated Bi sites.Benefiting from the simultaneous diffusion of Bi and S,different electronegative N and S can be effectively co-coordinated with Bi,forming the uniform Bi-N_(3)S/C sites.The synthesized.Bi-SAs-NS/C exhibits a high selectivity towards CO with over 88%Faradaic efficiency in a wide potential range,and achieves a maximum FE_(CO)of 98.3%at-0.8 V vs.RHE with a current density of 10.24 mA·cm^(-2),which can keep constant with negligible degradation in 24 h continuous electrolysis.Experimental results and theoretical calculations reveal that the significantly improved catalytic performance of Bi-SAs-NS/C than Bi-SAs-N/C is ascribed to the replacement of one coordinated-N with low electronegative S in Bi-N_(4)C center,which can greatly reduce the energy barrier of the intermediate formation in rate-limiting step and increase the reaction kinetics.This work provides an effective strategy for rationally designing highly active single-atom sites;catalysts for efficient electrocatalysis with optimized electronic structure. | Zhiyuan Wang Chun Wang Yidong Hu Shuai Yang Jia Yang Wenxing Chen Huang Zhou Fangyao Zhou Lingxiao Wang Junyi Du Yafei Li Yuen Wu | 2021 | Nano Research2021，14，8： | 2 |
| 5 | Polyhexamethylene biguanide chemically modified cotton with desirable hemostatic,inflammation-reducing,intrinsic antibacterial property for infected wound healing显示文摘Medical cotton dressing is cheap and widely used in diversified fields,but in the application of promoting wound healing,the continuous research of multifunctional medical cotton dressing is still of great significance.Here,we developed a fresh type of antibacterial cotton dressing through a succinct strategy based on chemically anchoring polyhexamethylene biguanide(PHMB).Intriguingly,after PHMB modification,the cotton dressing exhibited outstanding antibacterial performance which could maintain>99.99%antibacterial rate after several treatments,including washing 50 times,repeated use 10 times,UV irradiation for 7 days,cationic dyes dying,and conditioned under 90℃water bath for 2 h.In addition,the water contact angle of cotton dressing increased dramatically from 0°to 111°,which could facilitate bacterial adhesion,thus further enhance the antibacterial efficiency,and easily remove the bacterial debris.Apart from that,the developed cotton dressing showed good cytocompatibility,promoted blood clotting and expression of platelets,and promoted the wound healing process in the infection intervened skin wound model.Taken together,this antibacterial cotton dressing with desirable blood clotting,sustained protection against bacterial infection and bacterial removal features shows the potential to be a candidate for infected skin wound healing. | Chuan Guo Jie Zhang Xiaojun Feng Zhenggui Du Yuanzhang Jiang Yidong Shi Guanghui Yang Lin Tan | 2022 | Chinese Chemical Letters2022，33，6： | 2 |
| 6 | Interpopulation variability of rhizome essential oils in Rhodiola crenulata from Tibet and Yunnan, China显示文摘 | Yidong Lei Peng Nan Tashi Tsering Li Wang Shiping Liu Yang Zhong | 2003 | Biochemical Systematics and Ecology2003，，6： | 1 |
| 7 | Photonic amorphous topological insulator显示文摘The current understanding of topological insulators and their classical wave analogs,such as photonic topological insulators,is mainly based on topological band theory.However,standard band theory does not apply to amorphous phases of matter,which are formed by non-crystalline lattices with no long-range positional order but only shortrange order,exhibiting unique phenomena such as the glass-to-liquid transition.Here,we experimentally investigate amorphous variants of a Chern number-based photonic topological insulator.By tuning the disorder strength in the lattice,we demonstrate that photonic topological edge states can persist into the amorphous regime prior to the glass-to-liquid transition.After the transition to a liquid-like lattice configuration,the signatures of topological edge states disappear.This interplay between topology and short-range order in amorphous lattices paves the way for new classes of non-crystalline topological photonic bandgap materials. | Peiheng Zhou Gui-Geng Liu Xin Ren Yihao Yang Haoran Xue Lei Bi Longjiang Deng Yidong Chong Baile Zhang | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 8 | Genetic diversity of sea buckthorn (Hippophae rhamnoides) populations in northeastern and northwestern China as revealed by ISSR markers显示文摘 | Chunjie Tian Yidong Lei Suhua Shi Peng Nan Jiakuan Chen Yang Zhong | 2004 | New Forests2004，，3： | 1 |
| 9 | CmRAV1 shows differential expression in two melon (Cucumis melo L.) cultivars and enhances salt tolerance in transgenic Arabidopsis plants显示文摘The growth and development of melon(Cucumis melo L.)are severely affected by soil salinization in many areas of the world,but the understanding of the molecular mechanisms underlying salt tolerance in melon remains limited.In this study,a new RAV(related to ABI3/VP1)gene,CmRAV1,was identified in melon.Protein structure homology analysis revealed that CmRAV1 contains an AP2 domain and a B3 domain,and subcellular localization assay revealed that CmRAV1 is localized in the nucleus.The transcript level of CmRAV1 was closely correlated with NaCl treatment,and the expression pattern of CmRAV1 differed between two cultivars(salt-tolerant and salt-sensitive cultivars)under NaCl treatment.In addition,yeasts transformed with CmRAV1 showed notably improved growth on medium containing 200 mM NaCl compared with wild-type ones.The overexpression of CmRAV1 in transgenic Arabidopsis thaliana resulted in enhanced salt tolerance at the seed germination and seedling growth stages.This study demonstrated that the expression of CmRAV1 was associated with saline stress and can potentially be utilized to improve plant salt tolerance. | Lina Zhao Furong Zhang Bin Liu Senlin Yang Xue Xiong Danial Hassani Yidong Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 1 |
| 10 | True-color real-time imaging and spectroscopy of carbon nanotubes on substrates using enhanced Rayleigh scattering显示文摘白光照亮的围单人赛的碳 nanotubes (SWCNT ) 应该由于散布的回声瑞利显得有颜色。然而,底层上的 SWCNT 的真彩成像没被报导,因为 SWCNT 和散布的强壮的底层的极其低的散布紧张。这里,我们证明散布的瑞利能被接口偶极子改进效果极大地提高。底层上的因而丰富多彩的 SWCNT 能被宽地 supercontinuum 激光照明直接在一台光显微镜下面想象,它便于单个 SWCNT 的高产量 chirality 赋值。这条途径,称为的瑞利成像显微镜学,没被限制为 SWCNT,但是对许多 nanomaterials 广泛地适用,它使丰富多彩的 nanoworld 能在光显微镜下面被探索。 | Wenyun Wu Jingying Yue Xiaoyang Lin Dongqi Li Fangqiang Zhu Xue Yin Jun Zhu Jiangtao Wang Jin Zhang Yuan Chen Xinhe Wang Tianyi Li Yujun He Xingcan Dai Peng Liu Yang wei Jiaping Wang Wei Zhang Yidong Huang Li Fan Lina Zhang Qunqing Li Shoushan Fan Kaili Jiang | 2015 | Nano Research2015，8，8： | 1 |
| 11 | Observation of antichiral edge states in a circuit lattice显示文摘We construct an electrical circuit to realize a modified Haldane lattice exhibiting the phenomenon of antichiral edge states. The circuit consists of a network of inductors and capacitors with interconnections reproducing the effects of a magnetic vector potential. The next nearest neighbor hoppings are configured differently from the standard Haldane model, and as predicted by earlier theoretical studies, this gives rise to antichiral edge states that propagate in the same direction on opposite edges and coexist with bulk states at the same frequency. Using pickup coils to measure voltage distributions in the circuit, we experimentally verify the key features of the antichiral edge states, including their group velocities and ability to propagate consistently in a M?bius strip configuration. | YuTing Yang DeJun Zhu ZhiHong Hang YiDong Chong | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，5： | 1 |
| 12 | Muta- ted cadherin alleles from a field population of Helicov- erpa armigera confer resistance to Bacillus thuring- iensis toxin CrylAc 显示文摘 | Yang Yihua Chen Haiyan Wu Yidong | 2007 | Appl Environ Microbiol2007，73，21： | 1 |
| 13 | Adaptive backstepping flight control with actuator saturation 显示文摘 | Su Bingwei Chen Xin Cao Yunfeng Yang Yidong | 2001 | Transactions of Nanjing University of Aeronautics & Astronautics (S1005-1120)2001，18，1： | 1 |
| 14 | Precise orbit determination of BeiDou constellation based on BETS and MGEX network显示文摘 | LOU Yidong LIU Yang SHI Chuang | 2014 | Scientific Reports2014，4，： | 1 |
| 15 | Flight control for helicopter显示文摘 | Yang Yidong | 2007 | Bei- jing : National Defense Industry Press2007，，： | 1 |
| 16 | Deep-learning based on-chip rapid spectral imaging with high spatial resolution显示文摘Spectral imaging extends the concept of traditional color cameras to capture images across multiple spectral channels and has broad ap-plication prospects.Conventional spectral cameras based on scanning methods suffer from the drawbacks of low acquisition speed and large volume.On-chip computational spectral imaging based on metasur-face filters provides a promising scheme for portable applications,but endures long computation time due to point-by-point iterative spec-tral reconstruction and mosaic effect in the reconstructed spectral im-ages.In this study,on-chip rapid spectral imaging was demonstrated,which eliminated the mosaic effect in the spectral image by deep-learning-based spectral data cube reconstruction.The experimental results show that 4 orders of magnitude faster than the iterative spec-tral reconstruction were achieved,and the fidelity of the spectral re-construction for the standard color plate was over 99%for a standard color board.In particular,video-rate spectral imaging was demon-strated for moving objects and outdoor driving scenes with good per-formance for recognizing metamerism,where the concolorous sky and white cars can be distinguished via their spectra,showing great po-tential for autonomous driving and other practical applications in the field of intelligent perception. | Jiawei Yang Kaiyu Cui Yidong Huang Wei Zhang Xue Feng Fang Liu | 2023 | Chip2023，2，2： | 1 |
| 17 | Genetic diversity of sea buckthorn (Hippophae rhamnoides) populations in northeastern and northwestern China as revealed by ISSR markers显示文摘 | Chunjie Tian Yidong Lei Suhua Shi Peng Nan Jiakuan Chen Yang Zhong | 2004 | New Forests2004，，3： | 1 |
| 18 | Experimental Investigation on Flow Pattern and Bubble Behavior during Subcooled Flow Boiling of R1233zd(E)in Parallel Channels显示文摘In this study,the flow pattern and bubble behavior of R1233zd(E)during subcooled flow boiling in parallel channels are experimentally investigated with visualization and thermal measurement.The test section is composed of 21 rectangular mini channels with the hydraulic diameter of 1.5 mm and the length of 140 mm.Bubbly flow,slug flow,churn flow and wavy-annular flow occur in sequence with the increase of vapor quality,while transient flow pattern transition process involving multiple flow patterns are also captured.The distribution of flow pattern is non-synchronized and axial-asymmetric,with earlier flow pattern transitions observed in peripheral channels away from the center axis.The initial nucleate site in each channel also show a random and axial-asymmetric distribution,while faster bubble growth can be noted in some channel under the comprehensive effects of liquid evaporation and bubble coalescence.The variation of heat transfer coefficient is correspondence to the flow pattern transition,showing different trends along the flow direction.The increase of mass flux can lead to delayed flow pattern transition and variation of heat transfer coefficient.In addition,higher heat transfer coefficient can be noted in channels away from the center axis. | FANG Yidong ZHANG Zhao XU Dan WANG Yuchen YANG Huinan HUANG Yuqi | 2023 | Journal of Thermal Science2023，32，6： | 0 |
| 19 | Effects of SARS-CoV-2 infection on human reproduction显示文摘The worldwide infection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)impacts human health and life on multiple levels.People infected with SARS-CoV-2 suffer from physical disorders and psychological distress.At present,no direct evidence indicates that SARS-CoV-2 negatively influences human reproduction,and the possibility that gametes and embryos are affected requires further investigation.To evaluate the potential effects of SARS-CoV-2 infection on human reproduction and fetal health,this review summarizes the basic and clinical research of SARS-CoV-2 on reproduction up to date,hoping to offer guidance and advice to people at reproductive age and provide dues for the prevention and treatment of associated diseases. | Ming Yang Jing Wang Yidong Chen Siming Kong Jie Qiao | 2021 | Journal of Molecular Cell Biology2021，13，10： | 0 |
| 20 | Analysis on Similarity Characteristics of 4 Heavy Rainstorms of Regional Station near FAST显示文摘Based on routine data of MICAPS system and data of regional automatic station,characteristics of similar environmental field for 4 heavy rainstorms of regional station in Luodian County near FAST in summer were analyzed.It was found that 4 heavy rainstorms of regional station had internal similarity:it maintained high-altitude situation of'high in west and low in east'from Lake Baikal to North China;the Western Pacific subtropical high was zonal;ridge line of subtropical high was near 15°N;θse at 850 hPa reached certain index value,showing that air mass had extremely strong warm and humid characteristics.Under common influence of high-altitude trough,low-value system at low layer and weak cold air,heavy rainstorm occurred. | Qixue PAN Yaling XIE Yidong MO Yang CHEN | 2021 | Meteorological and Environmental Research2021，12，1： | 0 |
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