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| 1 | Suppression or knockout of SaF/SaM overcomes the Sa-mediated hybrid male sterility in rice显示文摘Hybrids between the indica and japonica subspecies of rice(Oryza sativa) are usually sterile, which hinders utilization of heterosis in the inter-subspecific hybrid breeding. The complex locus Sa comprises two adjacently located genes, SaF and SaM, which interact to cause abortion of pollen grains carrying the japonica allele in japonica-indica hybrids. Here we showed that silencing of SaF or SaM by RNA interference restored male fertility in indica-japonica hybrids with heterozygous Sa. We further used clustered regularly interspaced short palindromic repeats(CRISPR)/Cas9-based genome editing to knockout the SaF and SaM alleles, respectively, of an indica rice line to create hybrid-compatible lines. The resultant artificial neutral alleles did not affect pollen viability and other agricultural traits, but did break down the reproductive barrier in the hybrids. We found that some rice lines have natural neutral allele Sa-n, which was compatible with the typical japonica or indica Sa alleles in hybrids. Our results demonstrate that SaF and SaM are required for hybrid male sterility, but are not essential for pollen development. This study provides effective approaches for the generation of hybrid-compatible lines by knocking out the Sa locus or using the natural Sa-n allele to overcome hybrid male sterility in rice breeding. | Yongyao Xie Baixiao Niu Yunming Long Gousi Li Jintao Tang Yaling Zhang Ding Ren Yao-Guang Liu Letian Chen | 2017 | Journal of Integrative Plant Biology2017，59，9： | 11 |
| 2 | Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China显示文摘 | Xu-Ying Luo Ying-Hong Hu Xiang-Yuan Cao Yan Kang Li-Ping Liu Shou-Hong Wang Rong-Guo Yu Xiang-You Yu Xia Zhang Bao-Shan Li Zeng-Xiang Ma Yi-Bing Weng Heng Zhang De-Chang Chen Wei Chen Wen-Jin Chen Xiu-Mei Chen Bin Du Mei-Li Duan Jin Hu Yun-Feng Hoang Gui-Jun Jia Li-Hong Li Yu-Min Liang Bing-Yu Qin Xian-Dong Wang Jian Xiong Li-Mei Yan Zheng-Ping Yang Chen-Ming Dong Dong-Xin Wang Qing-Yuan Zhan Shuang-Lin FU Lin Zhao Qi-Bing Huang Ying-Guang Xie Xiao-Bo Huang Guo-Bin Zhang Wang-Bin Xu Yuan Xu YaLing Liu He-Ling Zhao Rong-Qing Sun Ming Sun Qing-Hong Cheng Xin Qu Xiao-Feng Yang Ming Xu Zhong-Hua Shi Han Chen Xuan He Yan-Lin Yang Guang-Qiang Chen Xiu-Mei Sun Jian-Xin Zhou | 2016 | Chinese Medical Journal2016，，14： | 6 |
| 3 | PhieCBEs:Plant High-Efficiency Cytidine Base Editors with Expanded Target Range显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)-mediated genome editing can efficiently produce gene-knockout mutants.On the other hand,CRISPR/Cas-derived base editors offer the ability to induce precise nucleotide substitutions(Komor et al.,2016).Cytidine base editors(CBEs)consist of a cytidine deaminase fused with a Cas9-nickase variant(Cas9n,with a D10A substitu-tion)and can achieve site-specific C-to-T substitution.Similarly,adenine base editors use an adenine deaminase forA-to-G substi-tution.These systems have been used in various organisms(Mishra et al.,2019).However,the Cas9 complex requires target sites containing NGG protospacer adjacent motifs(PAMs),thus restricting selection of potential targets.A number of CBEs have been developed using Cas9 variants(mostly Cas9n),cytidine deaminases(such as rAPOBEC1 and PmCDA1),and uracil glycosylase inhibitor(UGI)domains.These CBEs of the first generation(BE1,rAPOBEC1-dCas9),second generation(BE2,rAPOBEC1-dCas9-UGI),and third generation(BE3,rAPOBEC1-Cas9n-UGI)have moderate editing efficiencies in mammalians(Komor etal.,2016). | Dongchang Zeng Taoli Liu Jiantao Tan Yaling Zhang Zhiye Zheng Bin Wang Degui Zhou Xianrong Xie Menghui Guo Yao-Guang Liu Qinlong Zhu | 2020 | Molecular Plant2020，13，12： | 5 |
| 4 | The Intronic cis Element SE1 Recruits trans-Acting Repressor Complexes to Repress the Expression of ELONGATED UPPERMOST INTERNODE1 in Rice显示文摘 | Yongyao Xie Yaling Zhang Jingluan Han Jikai Luo Gousi Li Jianle Huang Haibin WU Qingwei Tian Qinlong Zhu Yuanling Chen Yoji Kawano Yao-Guang Liu Letian Chen | 2018 | Molecular Plant2018，11，5： | 3 |
| 5 | Analysis of heat transfer and pressure drop for fin-and-tube heat exchangers with rectangular winglet-type vortex generators 显示文摘 | He Yaling Chu Pan Tao Wenquan Zhang Yuwen Xie Tao | 2013 | Applied Thermal Engineering2013，61，2： | 1 |
| 6 | Safety and Effectiveness of SA58 Nasal Spray Against COVID-19 Infection in Medical Personnel:An Open-Label,Blank-Controlled Study—Hohhot City,Inner Mongolia Autonomous Region,China,2022显示文摘Summary What is already known about this topic?The active ingredient of the SA58 Nasal Spray is a broad-spectrum neutralizing antibody with a high neutralizing capacity against different Omicron subvariants in vitro studies.What is added by this report?This study demonstrated the safety and effectiveness of SA58 Nasal Spray against coronavirus disease 2019(COVID-19)infection in medical personnel for the first time.What are the implications for public health practice?This study provides an effective approach for the public to reduce their risk of COVID-19 infection.The findings of this research have the potential to significantly reduce the risk of infection and limit human-to-human transmission in the event of a COVID-19 outbreak. | Shujie Si Canrui Jin Jianping Li Yunlong Cao Biao Kan Feng Xue Xiaoliang Sunney Xie Liang Fang Gang Zeng Shuo Zhang Yaling Hu Xiaoping Dong | 2023 | China CDC weekly2023，5，10： | 1 |
| 7 | Theoretical study on thermal conductivities of silica aerogel composite insula- ting material 显示文摘 | Xie Tao He Yaling Hu Zijun | 2013 | International Journal of Heat and Mass Transfer2013，58，12： | 1 |
| 8 | Relationship between peritumoral lymphatic microvessel density and the clinical and pathological characteristics of invasive breast cancer显示文摘Objective The aim of the study was to determine the morphological characteristics of lymphatic microvessels and the relationship between lymphatic microvessel density(LMVD) and clinical and pathological characteristics of invasive breast cancer.Methods Tissue specimens and clinical pathological data of 51 cases of female breast cancer were collected in the General Hospital of Shenyang Military Region(Shenyang, China) from January 2007 to October 2011. Another 20 breast fibroadenoma tissue samples were used as controls. All specimens were cut into 4-μm slices, and immunohistochemically stained using streptomycin-resistant avidin peroxidase antibody D2-40. SPSS 17.0 for Windows was used to perform all analyses.Results A total of 38 breast cancer tissue specimens showed varied staining with monoclonal antibody D2-40. The rate of positive staining was in these tissues was 74.5%(38/51), which is significantly higher than that observed in breast fibroadenoma tissues(chi-square = 35.197, P = 0.000). The average LMVD in 38 cases of breast cancer was(26.46 ± 10.06) microvessels/100× magnification field, which was higher than that in the control group(t = 10.74, P = 0.000). Microvessels in peritumoral tissues were abundant, with an average LMVD of(38.42 ± 11.38) microvessels/100× magnification field. Based on layered analysis, the expression level of peritumoral LMVD was correlated with metastasis of lymph nodes, tumor size, and the expression of C-erb B-2(P < 0.05); however, there was no correlation with age or expression of estrogen receptors or progesterone receptors(P > 0.05).Conclusion Lymphatic microvessels detected using D2-40 antibody are mainly present in the peritumoral region of breast cancer tissues, and LMVD showed a correlation with lymph node metastasis and the expression of C-erb B-2. Positive lymphatic vessels, especially in the peritumoral region, may provide a path for lymphatic metastasis in breast cancer. Peritumoral LMVD may be used to estimate the prognosis of patients with breast cancer and may aid in research on treatment methods. | Shuxian Qu Yongming Liu Zhaozhe Liu Liang Liu Yaling Han Xiaodong Xie Zhendong Zheng | 2016 | Oncology and Translational Medicine2016，2，6： | 1 |
| 9 | Experimental and numerical analysis of the hydraulic and thermal performances of the gradually-varied porous volumetric solar receiver显示文摘A gradually-varied porous structure is designed to increase the thermal performance of the porous volumetric solar receiver.Based on the replica method and multilayer recoating technique, the silicon carbide porous ceramic with linear-changed geometrical parameters is fabricated. The performances of the uniform and gradually-varied porous volumetric solar receivers are studied by both experiment and numerical simulation. An optimization method combining genetic algorithm and computational fluid dynamics analysis is applied to determine the optimum porosity distribution. The results present that porous volumetric solar receiver with linear-changed geometrical parameters exhibits better thermal performance than the uniform porous volumetric solar receivers, especially when the thickness of the receiver is small. Larger porosity in the front is beneficial for increasing the solar radiation penetration depth, which limits the reflectance and thermal radiative losses. Smaller porosity in the rear traps more solar radiation and increases the convective heat transfer. When the receiver’s thickness is larger, the performance of the gradually-varied volumetric solar receiver is nearly identical to that of the uniform receiver with largest porosity. The double-layer configuration is found to be the optimized structure of the gradually-varied porous volumetric solar receiver. The thermal efficiency could be further improved using genetic algorithm with an 11 K increase of the outlet temperature. | DU Shen LI ZengYao HE YaLing LI Dong XIE XiangQian GAO Yang | 2020 | Science China(Technological Sciences)2020，63，7： | 1 |
| 10 | Evolution of drug regulations and regulatory innovation for anticancer drugs in China显示文摘Over the past two decades,China has introduced significant changes to drug regulations through regulatory innovations to accelerate drug review and approvals,keeping in line with the rapidly growing scientific innovation in drug research and development(R&D).In this study,we outlined the revolution of drug regulation in China since the establishment of the State Drug Administration in 1998.More particularly,we performed a comprehensive analysis of newly approved anticancer drugs in China from the year 2005 to May 2021,as a powerful illustration of how the revolution has changed the drug R&D landscape.Innovative drug development in China has boomed,benefiting in particular from pro-innovation policies as well as expedited program designations by the authority.We found a significant increase in the number of both imported and domestic new anticancer drugs from 2005 to 2021,with the emergence of drugs with novel mechanisms of action,including immune checkpoint inhibitors and cell therapy products.Drug lag has also been dramatically shortened by more than 70%for imported drugs in years 2016-2020 compared to years 2006-2010.Furthermore,we provide an insight into the potential approaches to further optimize the science-based and clinical value-based regulatory and R&D drug ecosystem in China.This review provides evidence of significant impacts of regulations and policies on drug R&D and suggests that the constantly adapting regulatory ecosystem will speed up drug development in China and worldwide. | Yang Liu Ning Zhang Cuicui Xie Yale Jiang Yunhe Qin Liyun Zhou Yi Fan Lianjie Ren Chen Yin Huan Yang Wei Xie Qing Zhai Guanqiao Li Hongzhuan Chen Xiaoyuan Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 1 |
| 11 | Theoretical Study on Ther- mal Conductivities of Silica Aerogel Composite Insulat- ing Material 显示文摘 | Xie Tao He Yaling Hu Zijun | 2013 | International Journal of Heat and Mass Transfer2013，58，12： | 1 |
| 12 | Clinical observation of capecitabine monotherapy in elderly patients with advanced breast cancer显示文摘Objective The aim of the study was to evaluate the safety and efficacy of capecitabine mono-chemotherapy in elderly patients with advanced breast cancer. Methods The data from 36 cases of capecitabine monotherapy in elderly patients with advanced breast cancer were retrospectively analyzed. Oral administration of capecitabine 2000 mg/m2 twice daily(D1–14) for 21 days constituted a cycle. The effect of the disease and main adverse reactions were evaluated every 2 cycles. Results The data from 36 elderly patients were studied. The median number of chemotherapy cycles was 4. The total effective rate was 30.6%(11/36) and the disease control rate was 72.2%(26/36). The number of patients with clinical complete remission was 2, clinical partial response was 9, stable disease was 15, and progressive disease was 10. Where treatment was effective, the median time to progression was 6 months and the median overall survival was 9.5 months. The main adverse events were gastrointestinal reactions, bone marrow suppression, and oral mucositis; most of the reactions were grade 1 to 2. Grade 3 to 4 adverse reactions included granulocytopenia in 2 patients(12.5%) and hand-foot syndrome in 1 patient(6.7%).Conclusion Capecitabine monotherapy was effective in controlling disease progression, and adverse reactions were tolerated by elderly patients with advanced breast cancer. | Miao Zhang Zhaozhe Liu Zhendong Zheng Tao Han Yaling Han Min Song Xiaodong Xie | 2015 | The Chinese-German Journal of Clinical Oncology2015，14，2： | 1 |
| 13 | Advances of Thermal Conductiv- ity Models of Nanoscale Silica Aerogel Insulation Material 显示文摘 | HE Yaling TAO Xie | 2015 | Applied Thermal Engineering2015，81，1： | 1 |
| 14 | Theoretical Study oil Thermal Conductivities of Silica Aerogel Composite In- sulating Material 显示文摘 | XIE Tao HE Yaling HU Zijun | 2013 | Internal Journal of Heat and Mass Transfer2013，58，12： | 1 |
| 15 | Effect of dendritic cell/cytokine-induced killer cell immunobiological cancer therapy combined with adjuvant chemotherapy in patients with triple-negative breast cancer显示文摘Objective The aim of the present study was to investigate the effect of dendritic cell(DC)/cytokine-induced killer cell(CIK) immunobiological cancer therapy in patients with triple-negative breast cancer(TNBC) who underwent adjuvant chemotherapy. Methods From January 2010 to October 2013, 120 patients with postoperative TNBC were recruited and included in the study. Patients were enrolled in one of two groups according to whether they accepted DC/CIK immunobiological cancer therapy during adjuvant chemotherapy; the patients in the DC/CIK group underwent adjuvant chemotherapy combined with DC/CIK immunobiological cancer therapy, and the control group underwent adjuvant chemotherapy alone. When six cycles of adjuvant chemotherapy and six cycles of DC/CIK immunobiological cancer therapy had been completed, differences between the two groups with regard to quality of life(Qo L), immunological indicators(CD3, CD4, CD8, and NK cell levels), disease-free survival(DFS), and side effects of chemotherapy and DC/CIK treatment were evaluated.Results In the DC/CIK group, the proportion of NK cells and CD3+ and CD4+ T-cell subgroups significantly increased, and the proportion of CD8+ cells decreased when they were compared before and after DC/CIK therapy(P < 0.05). However, there were no significant changes in the control group. By the final follow-up, DFS of the treatment group and the control group was 38.4 and 34.2 months, respectively. The Qo L improved in the patients treated with chemotherapy plus DC/CIK therapy compared with the patients treated with chemotherapy alone, and the difference between groups was significant(P < 0.05). The side effects of two groups were tolerable and not significantly different between the two groups.Conclusion The DC/CIK treatment had potential benefits for patients with TNBC compared with the control group, and was not associated with any obvious side effects. Therefore, DC/CIK therapy is a safe and effective method for the treatment of TNBC. | Ranran Zhang Wanqing Xie Tao Han Yongye Liu Zhaozhe Liu Fang Guo Yaling Han Zhenyu Ding Yinghui Sun Dongchu Ma Xiaodong Xie | 2015 | The Chinese-German Journal of Clinical Oncology2015，14，1： | 1 |
| 16 | 多西他赛联合卡培他滨新辅助化疗方案治疗局部晚期乳腺癌的临床观察(英文)显示文摘Objective: The recent clinical curative effect and adverse events of docetaxel and capecitabine(DX) of neoadjuvant chemotherapy in patients with locally advanced breast cancer was discussed. Methods: The data of 72 cases of neoadjuvant chemotherapy(DX) in locally advanced breast cancer after 4 cycles were retrospectively analyzed. Docetaxel 75 mg/m2 by infusion 1 h on d1, capecitabine 2000 mg/m2 by oral for twice daily on d1–14, 21 days was a cycle. Results: All 72 patients were assessed for efficacy and adverse events. The total effective rate was 80.5%(58/72), including pathological complete response(p CR) was 7(9.7%), clinical complete remission(c CR) was 15(20.8%), clinical partial response(PR) was 43(59.7%), stable disease(SD) was 8(11.1%) and progressive disease(PD) was 6(8.3%). The main adverse events were gastrointestinal reactions and bone marrow suppression. The 3 to 4 degrees of adverse reactions including granulocytopenia in 7 patients(20.6%), hand-foot syndrome in 6 patients(15.2%). Conclusion: The DX regimen provide a favorable efficacy and safety profile in patients with locally advanced breast cancer for neoadjuvant chemotherapy. | Miao Zhang Jianing Qiu Shuxian Qu Yaling Han Zhaozhe Liu Xiaodong Xie | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，11： | 0 |
| 17 | 依托泊苷胶囊联合顺铂或卡铂治疗老年小细胞肺癌的临床观察(英文)显示文摘Objective: We aimed to explore the efficacy and safety of etoposide capsule combined with cisplatin or carboplatin in the treatment of elderly patients with small cell lung cancer(SCLC). Methods: From October 2011 to November 2013, 32 elderly patients(71–79 years old) with histopathologically confirmed SCLC in General Hospital of Shenyang Military Region(China) were enrolled in the research. The patients were administrated with lastet capsule 150–175 mg, d1–5, combined with cisplatin 20 mg/m2 d1–3 or carboplatin AUC = 5, applied over 2 days. Twenty-one days were 1 treatment cycle. Results: After treatments, 2 cases acquired complete response(CR), 19 cases acquired partial response(PR), 8 cases acquired stable disease(SD), and 3 cases had progression of disease(PD). The objective response rate was 65.6%(21/32), disease control rate was 90.6%(29/32). The median time of progression-free survival(PFS) was 6.9 months, the median survival time was 14.0 months, and 1 year survival rate was 62.4%. The main adverse reactions of I/II leukopenia and gastrointestinal reaction were observed. Conclusion: Etoposide capsule combined with cisplatin or carboplatin therapy have curative effect and good tolerance in elderly patients with SCLC. | Guanzhong Zhang Zhaozhe Liu Tao Han Fang Guo Qingqing Sun Yanan Ge Yaling Han Xiaodong Xie | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，11： | 0 |
| 18 | Effect of pore size and porosity distribution on radiation absorption and thermal performance of porous solar energy absorber显示文摘In this paper, experimental and numerical study were both conducted to investigate the effect of pore size and porosity distribution on radiation absorption and thermal performance of porous solar energy absorber. Ultraviolet-visible-near infrared(UV-Vis-NIR) spectrophotometer was used to measure the transmittance of porous media to reflect its radiation absorption capabilities. Numerical model was established based on the assumption of thermal nonequilibrium condition as well as using P1 model to consider the radiation heat transfer. The UV-Vis-NIR spectrophotometer measurement showed that:(1) With smaller pore size, the spectral transmittance of the porous media would be lower and the solar radiation absorption would be better;(2)Among the materials with different pore size distributions, pore-size-decreased combo and pore-size-increased combo have almost equal absorption coefficient which are higher than that of uniform structure. Numerical simulation demonstrated that:(3)For materials with different pore size distributions, pore-size-decreased structure has the best radiation absorption due to its ability of maximizing the volumetric absorption effect, which is agreed with the UV-Vis-NIR spectrophotometer experimental results;(4) For materials with different porosity distributions, porosity-gradually-increased structure has the highest mean fluid/solid temperatures because it can utilize the enhanced convective/conductive heat transfer to improve the overall thermal performance of porous receiver;(5) Porous structure with pore-size-decreased distribution and porosity-gradually-increased distribution has the best thermal performance of which the mean temperatures of fluid/solid phases are the highest among all the studied cases. | XIE Tao XU KaiDi YANG BoLun HE YaLing | 2019 | Science China(Technological Sciences)2019，62，12： | 0 |
| 19 | Analysis on Similarity Characteristics of 4 Heavy Rainstorms of Regional Station near FAST显示文摘Based on routine data of MICAPS system and data of regional automatic station,characteristics of similar environmental field for 4 heavy rainstorms of regional station in Luodian County near FAST in summer were analyzed.It was found that 4 heavy rainstorms of regional station had internal similarity:it maintained high-altitude situation of'high in west and low in east'from Lake Baikal to North China;the Western Pacific subtropical high was zonal;ridge line of subtropical high was near 15°N;θse at 850 hPa reached certain index value,showing that air mass had extremely strong warm and humid characteristics.Under common influence of high-altitude trough,low-value system at low layer and weak cold air,heavy rainstorm occurred. | Qixue PAN Yaling XIE Yidong MO Yang CHEN | 2021 | Meteorological and Environmental Research2021，12，1： | 0 |
| 20 | 血管内皮生长因子C与人类表皮生长因子-2在人类乳腺癌中表达的相关性研究(英文)显示文摘Objective: We aimed to study the transcription level of VEGF-C in human breast cancer tissue, and explore the correlations with the expression of C-erbB-2. Methods: The expression of VEGF-C mRNA in 51 cases of human breast cancer was assessed by hybridization in situ. The expressions of C-erbB-2 was assessed by immunohistochemistry. Results: The positive rate of VEGF-C mRNA was 54.9% in 51 cases of breast cancer. The transcription level had correlation with tumor size and status of lymph nodes(P < 0.05). The expression of VEGF-C mRNA had a positive correlation with the expression of C-erbB-2(P < 0.05). Conclusion: The up-expression of VEGF-C has a significant correlation with the malignancy level and clinical stage of breast cancer. The combined detection of VEGF-C, C-erbB-2 may help to estimate the prognosis of patients with breast cancer and study on thetherapeutic implications. | Shuxian Qu Zhendong Zheng Zhaozhe Liu Liang Liu Miao Zhang Yaling Han Xiaodong Xie | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，10： | 0 |
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