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| 1 | PhaseⅡstudy of induction chemotherapy followed by concurrent chemoradiotherapy with raltitrexed and cisplatin in locally advanced nasopharyngeal carcinoma显示文摘Objective:For locally advanced nasopharyngeal carcinoma(LA-NPC)patients,high incidences of distant metastases and severe treatment related toxicities are the main obstacles needed to be overcome.Raltitrexed,a specific thymidylate synthase inhibitor with a convenient administration schedule,has an acceptable and manageable toxicity,and possesses radio-sensitizing properties.To investigate the efficacy and safety of raltitrexed and cisplatin induction chemotherapy and concurrent chemoradiotherapy(IC+CCRT)in patients with LA-NPC,a phaseⅡclinical study was conducted.Methods:Sixty eligible patients with LA-NPC were enrolled into this study.A raltitrexed-cisplatin combination was used as part of an IC+CCRT regimen.Raltitrexed-cisplatin IC was given once every 3 weeks(q3 w)for two cycles,followed by raltitrexed-cisplatin based CCRT q3 w for two cycles.Intensity-modulated radiotherapy(IMRT)was given for all enrolled patients.Results:All patients were included in survival analysis according to the intent-to-treat principle.The objective response rate(ORR)3 months after treatment was 98%.The 2-year overall survival(OS)rate was 92%.The median relapse-free survival(RFS)time was 30.5[95%confidence interval(95%CI),28.4-32.3]months.The 2-year RFS rate was 85%.The 2-year local failure-free survival(LFFS)rate was 97%and the 2-year distant metastasis-free survival(DMFS)rate was 88%.Acute toxicities were mostly grade 2 and 3 reactions in bone marrow suppression,gastrointestinal side effect and oropharyngeal mucositis.Only two patients occurred grade 4 acute toxicities,one was bone marrow suppression and the other was dermatitis radiation.Conclusions:The combination of raltitrexed and cisplatin has a comparable efficacy to those in standard firstline therapy. | Yuan Wu Xueyan Wei Zilong Yuan Hongbin Xu Yanping Li Ying Li Liu Hu Guang Han Yu Qian Desheng Hu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 4 |
| 2 | Can nanoparticles and nano-protein interactions bring a bright future for insulin delivery?显示文摘Insulin therapy plays an essential role in the treatment of diabetes mellitus.However,frequent injections required to effectively control the glycemic levels lead to substantial inconvenience and low patient compliance.In order to improve insulin delivery,many efforts have been made,such as developing the nanoparticles (NPs)-based release systems and oral insulin.Although some improvements have been achieved,the ultimate results are still unsatisfying and none of insulin-loaded NPs systems have been approved for clinical use so far.Recently,nano?protein interactions and protein corona formation have drawn much attention due to their negative influence on the in vivo fate of NPs systems.As the other side of a coin,such interactions can also be used for constructing advanced drug delivery systems.Herein,we aim to provide an insight into the advance and flaws of various NPs-based insulin delivery systems.Particularly,an interesting discussion on nano?protein interactions and its potentials for developing novel insulin delivery systems is initiated. | Ting Zhang James Zhenggui Tang Xiaofan Fei Yanping Li Yi Song Zhiyong Qian Qiang Peng | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 3 |
| 3 | Community-Based User Domain Model Collaborative Recommendation Algorithm显示文摘Collaborative Filtering (CF) is a commonly used technique in recommendation systems. It can promote items of interest to a target user from a large selection of available items. It is divided into two broad classes: memory-based algorithms and model-based algorithms. The latter requires some time to build a model but recommends online items quickly, while the former is time-consuming but does not require pre-building time. Considering the shortcomings of the two types of algorithms, we propose a novel Community-based User domain Collaborative Recommendation Algorithm (CUCRA). The idea comes from the fact that recommendations are usually made by users with similar preferences. The first step is to build a user-user social network based on users' preference data. The second step is to find communities with similar user preferences using a community detective algorithm. Finally, items are recommended to users by applying collaborative filtering on communities. Because we recommend items to users in communities instead of to an entire social network, the method has perfect online performance. Applying this method to a collaborative tagging system, experimental results show that the recommendation accuracy of CUCRA is relatively good, and the online time-complexity reduces to O.n/. | Fulan Qian Yanping Zhang Yuan Zhang Zhen Duan | 2013 | Tsinghua Science and Technology2013，18，4： | 3 |
| 4 | Effect of current emission abatement strategies on air quality improvement in China:A case study of Baotou,a typical industrial city in Inner Mongolia显示文摘The national Air Pollution Prevention and Control Action Plan required significant decreases in PM_(2.5) levels over China.To explore more effective emission abatement strategies in industrial cities,a case study was conducted in Baotou to evaluate the current national control measures.The total emissions of SO_2,NO_X,PM_(2.5) and NMVOC(non-methane volatile organic compounds) in Baotou were 211.2 Gg,156.1 Gg,28.8 Gg,and 48.5 Gg,respectively in 2013,and they would experience a reduction of 30.4%,26.6%,15.1%,and 8.7%,respectively in 2017 and 39.0%,32.0%,24.4%,and 12.9%,respectively in2020.The SO_2,NO_Xand PM_(2.5) emissions from the industrial sector would experience a greater decrease,with reductions of 37%,32.7 and 24.3%,respectively.From 2013 to 2020,the concentrations of SO_2,NO_2,and PM_(2.5) are expected to decline by approximately 30%,10% and 14.5%,respectively.The reduction rate of SNA(sulfate,nitrate and ammonium)concentrations was significantly higher than that of PM_(2.5) in 2017,implying that the current key strategy toward controlling air pollutants from the industrial sector is more powerful for SNA.Although air pollution control measures implemented in the industrial sector could greatly reduce total emissions,constraining the emissions from lower sources such as residential coal combustion would be more effective in decreasing the concentration of PM_(2.5) from 2017 to 2020.These results suggest that even for a typical industrial city,the reduction of PM_(2.5) concentrations not only requires decreases in emissions from the industrial sector,but also from the low emission sources.The seasonal variation in sulfate concentration also showed that emission from coal-burning is the key factor to control during the heating season. | Xionghui Qiu Lei Duan Siyi Cai Qian Yu Shuxiao Wang Fahe Chai Jian Gao Yanping Li Zhaoming Xu | 2017 | Journal of Environmental Sciences2017，29，7： | 2 |
| 5 | Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma显示文摘 | Jin Cheng Ling Tian Jingjing Ma Yanping Gong Zhengxiang Zhang Zhiwei Chen Bing Xu Hui Xiong Chuanyuan Li Qian Huang | 2014 | Molecular Oncology2014，，： | 1 |
| 6 | Spherical indentation into elastoplastic materials:indentation-response based definitions of the representative strain显示文摘 | Cao Yanping Qian Xiuqing Huber N | 2007 | Materials Science and Engineering A2007，45，： | 1 |
| 7 | DOWNWARD LOOKING SPARSE LINEAR ARRAY 3D SAR IMAGING ALGORITHM BASED ON BACK-PROJECTION AND CONVEX OPTIMIZATION显示文摘Downward Looking Sparse Linear Array Three Dimensional SAR(DLSLA 3D SAR) is an important form of 3D SAR imaging, which has a widespread application field. Since its practical equivalent phase centers are usually distributed sparsely and nonuniformly, traditional 3D SAR algorithms suffer from low resolution and high sidelobes in cross-track dimension. To deal with this problem, this paper introduces a method based on back-projection and convex optimization to achieve 3D high accuracy imaging reconstruction. Compared with traditional SAR algorithms, the proposed method sufficiently utilizes the sparsity of the 3D SAR imaging scene and can achieve lower sidelobes and higher resolution in cross-track dimension. In the simulated experiments, the reconstructed results of both simple and complex imaging scene verify that the proposed method outperforms 3D back-projection algorithm and shows satisfying cross-track dimensional resolution and good robustness to noise. | Bao Qian Peng Xueming Wang Yanping Tan Weixian Hong Wen | 2014 | Journal of Electronics(China)2014，31，4： | 1 |
| 8 | Research of vowel mapping theory for speaker identification of Chinese mandarin 显示文摘 | LI Yanping TANG Zhenmin QIAN Bo | 2008 | International Journal of Computer Processing of Oriental Languages2008，21，3： | 1 |
| 9 | Simultaneous analysis of 11 main active components in C irsium setosum based on HPLC ‐ ESI ‐ MS / MS and combined with statistical methods显示文摘 | Qian Sun Lu Chang Yanping Ren Liang Cao Yingguang Sun Yingfeng Du Xiaowei Shi Qiao Wang Lantong Zhang | 2012 | J. Sep. Science2012，，21： | 1 |
| 10 | Robust nonlinear controller design of wind turbine with doubly fed induction generator by using Hamiltonian energy approach显示文摘Based on Hamiltonian energy theory, this paper proposes a robust nonlinear controller for the wind turbine with doubly fed induction generator (DFIG), such that the closed-loop system can achieve its stability. Furthermore, in the presence of disturbances, the closed-loop system is finite-gain L 2 stable by the Hamiltonian controller. The Hamiltonian energy approach provides us a physical insight and gives a new way to the controller design. The simulation results illustrate that the proposed method is effective and has its advantage. | Bing WANG Yanping QIAN Yiming ZHANG | 2013 | 控制理论与应用(英文版)2013，11，2： | 1 |
| 11 | Jumonji domain-containing 6 (JMJD6) identified as a potential therapeutic target in ovarian cancer显示文摘Jumonji domain-containing 6(JMJD6)is a candidate gene associated with tumorigenesis,and JMJD6 overexpression predicts poor differentiation and unfavorable survival in some cancers.However,there are no studies reporting the expression of JMJD6 in ovarian cancer,and no JMJD6 inhibitors have been developed and applied to targeted cancer therapy research.In the present study,we found that the high expression of JMJD6 in ovarian cancer was correlated with poor prognosis in ovarian cancer.A potential inhibitor(SKLB325)was designed based on the crystal structure of the jmjC domain of JMJD6.This molecule significantly suppressed proliferation and induced apoptosis in a dose-dependent manner in SKOV3 cell lines as detected by CCK-8 cell proliferation assays and flow cytometry.A Matrigel endothelial tube formation assay showed that SKLB325 inhibited capillary tube organization and migration in HUVECs in vitro.We also observed that JMJD6 colocalized with p53 protein in the nucleus,with mRNA and protein expression of p53 as well as its downstream effectors significantly increasing both in vitro and in intraperitoneal tumor tissues treated with SKLB325.In addition,SKLB325 significantly reduced the intraperitoneal tumor weight and markedly prolonged the survival of tumor-bearing mice.Taken together,our findings suggest that JMJD6 may be a marker of poor prognosis in ovarian cancer and that SKLB325 may be a potential candidate drug for the treatment of ovarian cancer. | Heng Zheng Yan Tie Zhen Fang Xiaoai Wu Tao Yi Shuang Huang Xiao Liang Yanping Qian Xi Wang Ruyu Pi Siyuan Chen Yong Peng Shengyong Yang Xia Zhao Xiawei Wei | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 1 |
| 12 | Spherical indenta- tion into elastoplastic materials: Indentation- response based definitions of the representative strain 显示文摘 | Cao Yanping Qian Xiuqing Huber Norbert | 2007 | Materials Science and Engineering A2007，45，： | 1 |
| 13 | Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons显示文摘The expression of linear DNA sequence is precisely regulated by the three-dimensional(3D)architecture of chromatin.Morphine-induced aberrant gene networks of neurons have been extensively investigated;however,how morphine impacts the 3D genomic architecture of neurons is still unknown.Here,we applied digestion-ligation-only high-throughput chromosome conformation capture(DLO Hi-C)technology to investigate the effects of morphine on the 3D chromatin architecture of primate cortical neurons.After receiving continuous morphine administration for 90 days on rhesus monkeys,we discovered that morphine re-arranged chromosome territories,with a total of 391 segmented compartments being switched.Morphine altered over half of the detected topologically associated domains(TADs),most of which exhibited a variety of shifts,followed by separating and fusing types.Analysis of the looping events at kilobase-scale resolution revealed that morphine increased not only the number but also the length of differential loops.Moreover,all identified differentially expressed genes from the RNA sequencing data were mapped to the specific TAD boundaries or differential loops,and were further validated for changed expression.Collectively,an altered 3D genomic architecture of cortical neurons may regulate the gene networks associated with morphine effects.Our finding provides critical hubs connecting chromosome spatial organization and gene networks associated with the morphine effects in humans. | Liang Wang Xiaojie Wang Chunqi Liu Wei Xu Weihong Kuang Qian Bu Hongchun Li Ying Zhao Linhong Jiang Yaxing Chen Feng Qin Shu Li Qinfan Wei Xiaocong Liu Bin Liu Yuanyuan Chen Yanping Dai Hongbo Wang Jingwei Tian Gang Cao Yinglan Zhao Xiaobo Cen | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 14 | Comparison of the Contributions of Hop Pellets,Supercritical Fluid Hop Extracts,and Extracted Hop Material to the Hop Aroma and Terpenoid Content of Kettle-Hopped Lager Beers显示文摘Brewers who create hop-forward styles such as American-style India Pale Ales typically add hops toward the end of or after wort boiling to avoid aroma volatilization and thereby impart strong hopderived aromas.However,previous studies have demonstrated that despite the volatilization effects of boiling wort,hops that are added early in the kettle boil can contribute to hop aroma.Nonvolatile hopderived precursors,specifically glycosides,may survive the boiling process and become hydrolyzed to release volatile aglycones capable of contributing to aroma.To investigate the contribution of these different hop fractions to the aroma of kettle-hopped beers,12 single-hopped pilot-scale(3 hL)beers were brewed using pellet,supercritical CO2 extract,and spent hop fractions of Citra,Simcoe,Centennial,or Cascade cultivars.Pellet,extract,and spent additions consisted of a single hop add让ion 5 min into a 60 min boil.Volatile analysis of beers was perfonned using stir-bar sorptive extraction and quantified using gas chromatographymass spectrometry.Beers were analyzed for the common terpenoid compoundsα-pinene,β-pinene,3-myrcene,limonene,linalool,E,β-caryophyllene,α-humulene,andα-terpineol.In addition,beers were evaluated using descriptive sensory analysis.The descriptive sensory data identified significant differences among the cultivar and hop product treatments.The spent hop treatments produced beers that had a noticeable hop aroma,which suggests that the water-soluble components left behind in the spent hops may contribute to hop aroma in beer.The intensity and nature of the hop aroma in the spent treatments were hop variety specific.However,the contributions of water-soluble components found in spent hops to increased aroma intensity in beer were small,especially compared with the pellet and extract treatments. | Daniel C.Sharp YanPing Qian Jeff Clawson Thomas H.Shellhammer | 2020 | 中外酒业2020，0，5： | 0 |
| 15 | Combining Topological Properties and Strong Ties for Link Prediction显示文摘Link prediction is an important task that estimates the probability of there being a link between two disconnected nodes. The similarity-based algorithm is a very popular method that employs the node similarities to find links. Most of these types of algorithms focus only on the contribution of common neighborhoods between two nodes. In sociological theory relationships within three degrees are the strong ties that can trigger social behaviors.Thus, strong ties can provide more connection opportunities for unconnected nodes in the networks. As critical topological properties in networks, nodes degrees and node clustering coefficients are well-suited for describing the tightness of connections between nodes. In this paper, we characterize node similarity by utilizing the strong ties of the ego network(i.e., paths within three degrees) and its close connections(node degrees and node clustering coefficients). We propose a link prediction algorithm that combines topological properties with strong ties, which we called the TPSR algorithm. This algorithm includes TPSR2, TPSR3, and the TPSR4 indices. We evaluate the performance of the proposed algorithm using the metrics of precision and the Area Under the Curve(AUC). Our experimental results show the TPSR algorithm to perform remarkably better than others. | Fulan Qian Yang Gao Shu Zhao Jie Tang Yanping Zhang | 2017 | Tsinghua Science and Technology2017，22，6： | 0 |
| 16 | COVID-19 mortality in ICUs associated with critical care staffing显示文摘To the Editor Coronavirus disease 2019(COVID-19)has been around for over a year since December 2019,and the global outlook is not optimistic.Because of its high transmissibility and high mortality,management of the COVID-19 pandemic has become a major challenge for health systems globally,especially for critical care. | Jingjing Xi Lin Zeng Shusheng Li Yuhang Ai Xiandi He Yan Kang Yimin Li Yanping Mo Yue Peng Kejian Qian Bingyu Qin Chunting Wang Jing Yan Fachun Zhou Hua Zhang Penglin Ma | 2021 | Burns & Trauma2021，9，1： | 0 |
| 17 | Edge localized modes suppression via edge E × B velocity shear induced by RF sheath of ion cyclotron resonance heating in EAST显示文摘The control of large edge localized modes(ELMs) is a critical issue for the successful operation of future burning plasma devices,such as the international thermonuclear experimental reactor(ITER) and China fusion engineering test reactor(CFETR). In this paper, we present a new active and effective means of ELM suppression using ion cyclotron resonant heating(ICRH) on the experimental advanced superconducting tokamak(EAST). We obtained the key role of the external E × B velocity shear near the pedestal top and the scrape-off-layer(SOL) induced by the RF sheath potential of ICRH in ELM suppression. The experimental results showed a positive correlation between the RF sheath and the E × B shear rate in SOL. BOUT++ simulations indicate that increased E × B velocity shear rates in the pedestal and SOL regions promote ELM suppression;thereby, supporting the experimental observations on EAST. These findings suggest a new simple approach to access the ELM suppressed regimes in plasma with low torque input as ITER baseline discharges. | XinJun Zhang Chu Zhou XiaoLan Zou TianYang Xia YanLong Li ChengMing Qin XianZu Gong Qing Zang MingHui Li Tao Zhang ShouXin Wang HaiQing Liu Guillaume Urbanczyk Adi Liu YanMing Duan YanPing Zhao JinPing Qian Robert Isaac Pinsker MinYou Ye BaoNian Wan | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，3： | 0 |
| 18 | Copper-catalyzed C(sp)-H aryl amination enables modular synthesis of quinolines and 2-quinolinones显示文摘Herein,we disclose a novel copper-catalyzed C(sp)-H aryl amination of terminal alkynes with anthranils,enabling the rapid generation of highly reactive secondary N-aryl ynamines for the modular synthesis of structurally diverse C2-substituted quinolines and 2-quinolinones.The in-situ formed carbonyl-ynamines are prone to tautomerize to carbonyl-ketenimines,which can efficiently react with a series of nucleophiles,including amines,alcohols,phenols,thiols,thiophenols,active-methylene compounds,and even water to produce various quinoline derivatives with the generation of H_(2)O as a sole and green byproduct.This method also unlocks a practical route to create various quinoline-fused heterocycles and can be successfully applied to the late-stage modification of complex molecules and the concise synthesis of bioactive targets.Mechanistic studies reveal a coppercatalyzed inner-sphere nitrene transfer process by using anthranils as novel aryl nitrene precursors. | Yang Gao Haixia Li Simin Yang Yanping Huo Qian Chen Xianwei Li Zhe Wang Xiao-Qiang Hu | 2024 | Science China Chemistry2024，67，2： | 0 |
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