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| 1 | Integrating a weighted-average method into the random walk framework to generate individual friend recommendations显示文摘Friend recommendation is a fundamental service in both social networks and practical applications,and is influenced by user behaviors such as interactions, interests, and activities. In this study, we first conduct in-depth investigations on factors that affect recommendation results. Next, we design Friend++, a hybrid multi-individual recommendation model that integrates a weighted average method(WAM) into the random walk(RW) framework by seamlessly employing social ties, behavior context, and personal information. In Friend++, the first plus signifies recommending a new friend through network features, while the second plus stands for using node features. To verify our method, we conduct experiments on three social datasets crawled from the Sina microblog system(Weibo). Experimental results show that the proposed method significantly outperforms six baseline methods in terms of recall, precision, F1-measure, and MAP. As a final step, we describe a case study that demonstrates the scalability and universality of our method. Through discussion, we reach a meaningful conclusion: although common interests are more important than user activities in making recommendations, user interactions may be the most important factor in finding the most appropriate potential friends. | Jibing GONG Xiaoxia GAO Hong CHENG Jihui LIU Yanqing SONG Mantang ZHANG Yi ZHAO | 2017 | Science China(Information Sciences)2017，60，11： | 7 |
| 2 | Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells显示文摘Porphyromonas gingivalis(P.gingivalis),a key pathogen in periodontitis,has been shown to accelerate the progression of atherosclerosis(AS).However,the definite mechanisms remain elusive.Emerging evidence supports an association between mitochondrial dysfunction and AS.In our study,the impact of P.gingivalis on mitochondrial dysfunction and the potential mechanism were investigated.The mitochondrial morphology of EA.hy926 cells infected with P.gingivalis was assessed by transmission electron microscopy,mitochondrial staining,and quantitative analysis of the mitochondrial network.Fluorescence staining and flow cytometry analysis were performed to determine mitochondrial reactive oxygen species(mtROS)and mitochondrial membrane potential(MMP)levels.Cellular ATP production was examined by a luminescence assay kit.The expression of key fusion and fission proteins was evaluated by western blot and immunofluorescence.Mdivi-1,a specific Drp1 inhibitor,was used to elucidate the role of Drp1 in mitochondrial dysfunction.Our findings showed that P.gingivalis infection induced mitochondrial fragmentation,increased the mtROS levels,and decreased the MMP and ATP concentration in vascular endothelial cells.We observed upregulation of Drp1(Ser616)phosphorylation and translocation of Drp1 to mitochondria.Mdivi-1 blocked the mitochondrial fragmentation and dysfunction induced by P.gingivalis.Collectively,these results revealed that P.gingivalis infection promoted mitochondrial fragmentation and dysfunction,which was dependent on Drp1.Mitochondrial dysfunction may represent the mechanism by which P.gingivalis exacerbates atherosclerotic lesions. | Tong Xu Qin Dong Yuxiao Luo Yanqing Liu Liang Gao Yaping Pan Dongmei Zhang | 2021 | International Journal of Oral Science2021，13，3： | 7 |
| 3 | On Frequency Sensitivity and Mode Orthogonality of Flexible Robotic Manipulators显示文摘This paper presents sensitivity analysis of vibration frequencies of flexible manipulators with respect to variations of systems parameters such as rotational inertia of hub,and mass,moment,and side of tip load.Both Euler-Bernoulli and Timoshenko dynamical models of flexible manipulators are discussed.By using variational method,sensitivity indices are obtained with explicit expressions for measuring the sensitivity of frequencies.Based on variational formulations,a novel method for deriving the orthogonal relations among vibration modal shape functions of flexible manipulators is introduced.With this method,the orthogonal relations can be derived easily without invoking the tedious process of differentiation and integration by part,as commonly used in their derivation. | Fei-Yue Wang Yanqing Gao | 2016 | IEEE/CAA Journal of Automatica Sinica2016，3，4： | 5 |
| 4 | A systematical study on the electrodeposition process of metallic lithium显示文摘In this study,commercial copper(Cu)foil and Cu foam are used as the working electrodes to systematically investigate the electrochemical deposition and dissolution processes of metallic lithium(Li)on these electrodes;Li metal deposited on the Cu foil electrode is porous and loose.The surface solid electrolyte interface(SEI)film after dissolution from Li dendrites maintains a dendritic porous structure,resulting in a large volume effect of the electrode during the cycle.The Cu foam electrode provides preferential nucleation and deposition sites near the side surface of the separator;the difference in Li affinity results in a heterogeneous deposition and dendrite growth of metallic Li. | Hailin Fan Chunhui Gao Huai Jiang Qingyuan Dong Bo Hong Yanqing Lai | 2020 | Journal of Energy Chemistry2020，29，10： | 4 |
| 5 | The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention显示文摘Mechanical stimulation plays an important role in bone remodeling. Exercise-induced mechanical loading enhances bone strength,whereas mechanical unloading leads to bone loss. Increasing evidence has demonstrated that long noncoding RNAs(lnc RNAs) play key roles in diverse biological, physiological and pathological contexts. However, the roles of lnc RNAs in mechanotransduction and their relationships with bone formation remain unknown. In this study, we screened mechanosensing lnc RNAs in osteoblasts and identified Neat1, the most clearly decreased lnc RNA under simulated microgravity. Of note, not only Neat1 expression but also the specific paraspeckle structure formed by Neat1 was sensitive to different mechanical stimulations, which were closely associated with osteoblast function. Paraspeckles exhibited small punctate aggregates under simulated microgravity and elongated prolate or larger irregular structures under mechanical loading. Neat1 knockout mice displayed disrupted bone formation, impaired bone structure and strength, and reduced bone mass. Neat1 deficiency in osteoblasts reduced the response of osteoblasts to mechanical stimulation. In vivo, Neat1 knockout in mice weakened the bone phenotypes in response to mechanical loading and hindlimb unloading stimulation. Mechanistically, paraspeckles promoted nuclear retention of E3 ubiquitin ligase Smurf1 m RNA and downregulation of their translation, thus inhibiting ubiquitination-mediated degradation of the osteoblast master transcription factor Runx2, a Smurf1 target. Our study revealed that Neat1 plays an essential role in osteoblast function under mechanical stimulation, which provides a paradigm for the function of the lnc RNA-assembled structure in response to mechanical stimulation and offers a therapeutic strategy for long-term spaceflight-or bedrest-induced bone loss and age-related osteoporosis. | Caizhi Liu Xingcheng Gao Yuheng Li Weijia Sun Youjia Xu Yingjun Tan Ruikai Du Guohui Zhong Dingsheng Zhao Zizhong Liu Xiaoyan Jin Yinlong Zhao Yinbo Wang Xinxin Yuan Junjie Pan Guodong Yuan Youyou Li Wenjuan Xing Guanghan Kan Yanqing Wang Qi Li Xuan Han Jianwei Li Shukuan Ling Yingxian Li | 2022 | Bone Research2022，10，2： | 3 |
| 6 | Effects of Yishendaluo decoction on blood-brain barrier integrity in mice with experimental autoimmune encephalomyelitis显示文摘This study investigated the effects of Yishendaluo decoction on the loss of blood-brain barrier integrity in mice exhibiting experimental autoimmune encephalomyelitis.To this end,we used real-time fluorescent quantitative PCR to measure the levels of mRNAs specific to the T cell markers CD4 and CD8,and the monocyte marker CD11b.In addition,we used Evans blue dye extravasation in the spinal cord and brain tissues to assess blood-brain barrier permeability.The results indicated that an increase in blood-brain barrier permeability was associated with an increase in CD4,CD8 and CD11b mRNA expression in experimental autoimmune encephalomyelitis mice.Yishendaluo decoction administration significantly reversed inflammatory cell accumulation in cerebral tissues of experimental autoimmune encephalomyelitis mice. | Yanqing Wu Ying Gao Lingqun Zhu Yonghong Gao Dongmei Zhang Lixia Lou Yanfang Yan | 2011 | Neural Regeneration Research2011，6，15： | 2 |
| 7 | miR-24-3p promotes colon cancer progression by targeting ING1显示文摘Dear Editor,Activation or upregulation of oncogenes and/or loss of function or downregulation of tumour suppressors are central to the processes involved in the transformation from normal colonic mucosa to malignant tumours.Inhibitor of growth 1(ING1)has been functionally linked to cell cycle arrest,apoptosis and chromatin remodelling. | Zhiying Gao Likun Zhou Shiyu Hua Huan Wu Laizhi Luo Libo Li Shuping Wang Yanqing Liu Zhen Zhou Xi Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 8 | Experimental study of the mass transfer behavior of carbon dioxide absorption into ternary phase change solution in a packed tower显示文摘Phase change absorbents for CO_(2)are of great interest because they are expected to greatly reduce the heat energy consumption during the regeneration process.Compared with other phase change absorbents,monoethanolamine(MEA)-sulfolane-water is inexpensive and has a fast absorption rate.It is one of the most promising solvents for large-scale industrial applications.Therefore,this study investigates the mass transfer performance of this phase change system in the process of CO_(2)absorption in a packed tower.By comparing the phase change absorbent and the ordinary absorbent,it is concluded that the use of MEA/sulfolane phase change absorbent has significantly improved mass transfer efficiency compared to a single MEA absorbent at the same concentration.In the 4 mol·L^(-1)MEA/5 mol·L^(-1)sulfolane system,the CO_(2)loading of the upper liquid phase after phase separation is almost zero,while the volume of the lower liquid phase sent to the desorption operation is about half of the total volume of the absorbent,which greatly reduces the energy consumption.This study also investigates the influence of operating parameters such as lean CO_(2)loading,gas and liquid flow rates,CO_(2)partial pressure,and temperature on the volumetric mass transfer coefficient(K_(G)α_(V)).The research shows that K_(G)α_(V) increases with increasing liquid flow rate and decreases with the increase of lean CO_(2)loading and CO_(2)partial pressure,while the inert gas flow rate and temperature have little effect on K_(G)α_(V).In addition,based on the principle of phase change absorption,a predictive equation for the K_(G)α_(V) of MEA-sulfolane in the packed tower was established.The K_(G)α_(V) obtained from the experiment is consistent with the model prediction,and the absolute average deviation(AAD)is 7.8%. | Yihan Yin Aoqian Qiu Hongxia Gao Yanqing Na Zhiwu Liang | 2022 | Chinese Journal of Chemical Engineering2022，35，3： | 2 |
| 9 | Molecular characteristics of segment B of seven very virulent infectious bursal disease viruses isolated in china显示文摘 | Fei Yu Xiaole Qi Yanqing Yuwen Yongqiang Wang Honglei Gao Yulong Gao Litin Qin Xiaomei Wang | 2010 | Virus Genes2010，，2： | 1 |
| 10 | Optimal design of grounding system considering the influence of seasonal frozen soil layer显示文摘 | He Jinliang Gao Yanqing Zeng Rong | 2005 | IEEE Trans on Power Delivery2005，20，1： | 1 |
| 11 | Seasonal influences on safety of substation grounding system显示文摘 | He Jinliang Zeng Rong Gao Yanqing | 2003 | IEEE Trans on Power Delivery2003，18，3： | 1 |
| 12 | Effective Length of Counterpoise Wire Under Lightning Current,IEEK Trans on power delivery显示文摘 | Jinliang He Yanqing Gao Rong Zeng | 2005 | 20(2) :1585 - 15912005，20，2： | 1 |
| 13 | Preparation and Characterization of Ag_2S/PMMA Nanocomposites by Microemulsion显示文摘Ag_2S nanoparticles in polymethyl methacrylate(PMMA) are prepared in n-heptane/sodium bis(2-ethylhexyl)sulfosuccinate/water microemulsions.The Ag_2S nanoparticles dispersed in the polymer are characterized by FT-IR spectrum,UV-Vis absorption spectroscopy,transmission electron microscopy(TEM),and X-ray powder diffraction(XRD).The FT-IR spectrum shows that the composite has the characteristic bands of nano-Ag_2S and pure PMMA.The TEM photograph of the sample shows that the Ag_2S nanoparticles are elliptical.The phase structure of the composite is characterized by XRD,which reveals that Ag_2S particles are formed.The UV-Vis absorption recorded at various times indicates an initial rapid formation of the nanoparticles and the quantum confinement effect of Ag_2S nanoparticles. | Yuzhen Li Lizhen Gao Wenjun Chen Weike Zhang Lili Gao Yanqing Yang Likun Shang Meilu Wang | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，1： | 1 |
| 14 | Effective length of counterpoise wire under lightning current 显示文摘 | He Jinliang Gao Yanqing Zeng Rong | 2005 | IEEE Transactions on Power Delivery2005，20，2： | 1 |
| 15 | Effective length of counterpoise wire under lightning current 显示文摘 | He Jinliang Gao Yanqing Zeng Rong | 2005 | IEEE Transac tions on Power Delivery2005，20，2： | 1 |
| 16 | Effective length of counterpoise wire under lightning current显示文摘 | Jinliang He Yanqing Gao Rong Zeng | 2005 | Power Delivery IEEE Transactions on2005，20，2： | 1 |
| 17 | Low-temperature growth and optical properties of Ce-doped ZnO nanorods显示文摘 | Jinghai Yang Ming Gao Yongjun Zhang Lili Yang Jihui Lang Dandan Wang Huilian Liu Yanqing Liu Yaxin Wang Hougang Fan | 2008 | Applied Surface Science2008，255，： | 1 |
| 18 | Seasonal Influences on Safety of Substation Grounding System显示文摘 | He Jinliang Zeng Rong Gao Yanqing | 2003 | PowerDelivery IEEE Transactions on2003，18，3： | 1 |
| 19 | Seasonal influences on safety of substation grounding system显示文摘 | He Jinliang Zeng Rong Gao Yanqing | 2003 | IEEE Trans on Power Delivery2003，18，3： | 1 |
| 20 | Optimal design of grounding system considering the influence of seasonal frozen soil layer显示文摘 | He Jinliang Gao Yanqing Zeng Rong | 2005 | IEEE Trans on Power Delivery2005，20，1： | 1 |
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