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| 1 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 2 | Global Dynamic Molecular Profiling of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing显示文摘The regulation of stomatal lineage cell development has been extensively investigated.However,a comprehensive characterization of this biological process based on single-cell transcriptome analysis has not yet been reported.In this study,we performed RNA sequencing on 12844 individual cells from the cotyledons of 5-day-old Arabidopsis seedlings.We identified 11 cell clusters corresponding mostly to cells at specific stomatal developmental stages using a series of marker genes.Comparative analysis of genes with the highest variable expression among these cell clusters revealed transcriptional networks that regulate development from meristemoid mother cells to guard mother cells.Examination of the developmental dynamics of marker genes via pseudo-time analysis revealed potential interactions between these genes.Collectively,our study opens the door for understanding how the identified novel marker genes participate in the regulation of stomatal lineage cell development. | Zhixin Liu Yaping Zhou Jinggong Guo Jiaoai Li Zixia Tian Zhinan Zhu Jiajing Wang Rui Wu Bo Zhang Yongjian Hu Yijing Sun Yan Shangguan Weiqiang Li Tao Li Yunhe Hu Chenxi Guo Jean-David Rochaix Yuchen Miao Xuwu Sun | 2020 | Molecular Plant2020，13，8： | 11 |
| 3 | Effects of redox-active interlayer anions on the oxygen evolution reactivity of NiFe-layered double hydroxide nanosheets显示文摘镍铁分层的双氢氧化物(NiFe-LDH ) nanosheets 显示出最佳的氧进化反应(OER ) 性能;然而,在 OER 活动的设置的离子的角色仍然保持不清楚。在这个工作,我们证明 NiFe-LDHs 的活动能被设置的阴离子与不同氧化还原作用潜力定制。而 NiFe-LDHs 与高氧化还原作用潜力(低减少能力)的阴离子设置了,有低氧化还原作用潜力(高减少能力)的阴离子的置闰例如次磷酸盐,与 240 mV 的低 OER 过电位和 36.9 mV/dec 的一个小 Tafel 斜坡导致 NiFe-LDHs ,例如 fluorion ,显示出 370 mV 的高过电位和 80.8 mV/dec 的一个 Tafel 斜坡。OER 活动与标准氧化还原作用潜力显示出令人吃惊的线性关联。密度功能的理论计算和 X 光检查光电子光谱学分析显示设置的阴离子改变在表面暴露了的金属原子的电子结构。有低标准氧化还原作用潜力和强壮的减少能力的阴离子把更多的电子转移到氢氧化物层。这增加表面金属地点的电子密度并且稳定他们的高原子价的状态,其形成在 OER 过程以前作为关键步被知道。 | Daojin Zhou Zhao Cai Yongmin Bi Weiliang Tian Ma Luo Qian Zhang Qixian Xie Jindi Wang Yaping Li Yun Kuang Xue Duan Michal Bajdich Samira Siahrostami Xiaoming Sun | 2018 | Nano Research2018，11，3： | 6 |
| 4 | ATF4 is directly recruited by TLR4 signaling and positively regulates TLR4-trigged cytokine production in human monocytes显示文摘像使用费的受体(TLR ) 是主人防卫系统的哨兵,它认出很多微生物引起的病原体。主机防卫系统可能是低效的或如果由 TLR 和随后的被触发 TLR 的 cytokine 生产的微生物引起的识别是 deregulated,煽动性的疾病可以发展。激活抄写因素 4 (ATF4 ) , ATF/CREB 抄写因素家庭的一个成员,是参予几个 pathophysiological 过程的一个重要因素。在这份报告,我们发现 ATF4 也涉及调停 TLR 的天生的有免疫力的反应,它参予 TLR4 信号 transduction 并且调停许多 cytokines 的分泌物。我们观察到 ATF4 被激活并且 translocates 到经由 TLR4-MyD88-dependent 小径跟随 lipopolysaccharide (LPS ) 刺激的原子核。另外, cytokine 数组试金证明某关键煽动性的 cytokines 例如 IL-6, IL-8 和 RANTES,被 ATF4 断然调整。我们也证明 c6 月直接绑在 ATF4,从而支持煽动性的 cytokines 的分泌物。一起拿,这些结果显示 ATF4 在被触发 TLR4 的 cytokine 充当一个积极管理者生产。 | Chunyan Zhang Nan Bai Antao Chang Zhuhong Zhang Jing Yin Wenzhi Shen Yaping Tian RongXiang Chenghu Liu | 2013 | Cellular & Molecular Immunology2013，10，1： | 5 |
| 5 | Neural Stem Cells Transfected with Leukemia Inhibitory Factor Promote Neuroprotection in a Rat Model of Cerebral Ischemia显示文摘Leukemia inhibitory factor(LIF) contributes to the neuroprotection by neural stem cells(NSCs) after ischemic stroke. Our aim was to explore whether LIFtransfected NSCs(LIF-NSCs) can ameliorate brain injury and promote neuroprotection in a rat model of cerebral ischemia. To accomplish this goal, we transfected NSCs with a lentivirus carrying the LIF gene to stably overexpress LIF. The LIF-NSCs reduced caspase 3 activation under conditions of oxygen-glucose deprivation in vitro.Transient cerebral ischemia was induced in rats by 2 h of middle cerebral artery occlusion(MCAo), and LIF-NSCs were intravenously injected at 6 h post-ischemia. LIF-NSC treatment reduced the infarction volume and improved neurological recovery. Moreover, LIF-NSCs improved glial cell regeneration and ameliorated white matter injuryin the MCAo rats. The NSCs acted as carriers and increased the expression of LIF in the lesions to protect against cerebral infarction, suggesting that LIF-NSCs could be a potential treatment for cerebral infarction. | Lili Tian Wenli Zhu Yuanchu Liu Ye Gong Aowei Lv Zhen Wang Xiaoli Ding Shaowu Li Ying Fu Yi Lin Yaping Yan | 2019 | Neuroscience Bulletin2019，35，5： | 5 |
| 6 | Breast cancer-specific serum peptide profiles显示文摘Early detection of breast cancer is paramount to successful clinical therapy. Yet, early-stage breast cancer lacks specific symptoms or biomarkers. With the emerging of the mass spectrometric (MS) -based signatures as biomarkers, we investigated breast cancer-related serum profile pattern through class prediction and independent validation, and used Fourier transfer MS to identify breast cancer signature. We now show a distinctive serum peptide pattern that discriminates breast cancer from healthy controls with 93.2% sensitivity and 95.4% specificity. m/z 5901.70 and 4465.74 of ion fragment of FPA and alpha1-antichymotrypsin are found in the signatures that predominantly discriminate breast cancer from healthy individuals. These novel findings identify an MS-based serum peptide pattern of breast cancer that may have direct clinical utility in future. | WANG Na WEN XinYu WANG Jie LI AiLing LI WeiHua LI Tao Li Yan ZHANG XueMin WANG HongXia YANG SongCheng ZHOU Tao GONG WeiLi TIAN YaPing HE Kun | 2009 | Chinese Science Bulletin2009，54，3： | 4 |
| 7 | Essential sequence of the N-terminal cytoplasmic localization-related domain of huntingtin and its effect on huntingtin aggregates显示文摘Huntington's disease(HD) is caused by abnormal CAG repeat expansion in the 5′-end of the Huntingtin(HTT) gene.In addition to the canonical C-terminal full-length huntingtin(htt) nuclear export signal,a cytoplasmic localization-related domain(CLRD) in the N-terminus of htt has recently been reported.Here,we analyzed this domain by introducing deletion and substitution mutations in a truncated N-terminal htt protein and subsequently monitored htt expression,aggregation and subcellular localization by immunocytochemistry and Western blot analysis.We demonstrated that Htt4-17 was the essential sequence for htt cytoplasmic localization.We also found that the subcellular distribution of htt was altered when Htt1-17 was mutated to contain amino acids of different charges,suggesting a structural requirement of Htt1-17 for the cytoplasmic localization of htt. Deletion of the first three amino acids did not affect its association with mitochondria.We observed that defective cytoplasmic localization resulted in a reduction of total htt aggregates and increased nuclear aggregates,indicating that the subcellular distribution of the protein might influence the aggregation process.These studies provide new insight into the molecular mechanism of htt aggregation in HD. | YAN YaPing PENG DanTao TIAN Jun CHI JingWei TAN JieQiong YIN XinZhen PU JiaLi XIA Kun ZHANG BaoRong | 2011 | Science China(Life Sciences)2011，54，4： | 4 |
| 8 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 9 | Scale invariant features extraction for stereo vision显示文摘Stable local feature detection is a fundamental component of many stereo vision problems such as 3-D reconstruction, object localization, and object tracking. A robust method for extracting scale-invariant feature points is presented. First, the Harris corners in three-level pyramid are extracted. Then, the points detected at the highest level of the pyramid are correctly propagated to the lower level by pyramid based scale invariant (PBSI) method. The corners detected repeatedly in different levels are chosen as ffnal feature points. Finally, the characteristic scale is obtained based on maximum entropy method. The experimental results show that the algorithm has low computation cost, strong antinoise capability, and excellent performance in the presence of significant scale changes. | Liu Li Peng Fuyuan Tian Yani Wan Yaping | 2009 | Journal of Systems Engineering and Electronics2009，20，1： | 4 |
| 10 | Telmisartan prevents high-fat diet-induced hypertension and decreases perirenal fat in rats显示文摘We sought to investigate the effects of telmisartan on high-fat diet-induced hypertension and to explore the possible underlying mechanisms.Rats receiving high-fat diet were randomly divided into two groups,the telmisartan group(n = 9) and the high-fat diet group(n = 10).The control group consisted of age-matched rats on a regular diet(n = 10).At the end of the treatment,the body weight,blood pressure,insulin sensitivity and serum adiponectin levels of all rats were examined,and their visceral fat was extracted and weighed.Our results showed that telmisartan improved insulin resistance and dyslipidemia and increased serum adiponectin levels.Telmisartan also lowered both systolic blood pressure and diastolic blood pressure,and decreased the accumulation of perirenal fat associated with high-fat diet.Furthermore,telmisartan increased adiponectin mRNA expression in the perirenal fat.Correlation analysis showed that both systolic blood pressure and diastolic blood pressure were positively correlated with perirenal fat.These effects of telmisartan may be mediated through decreases in perirenal fat and contributed to the improvement of perirenal fat function.Our findings suggested a strong link between perirenal fat and high-fat diet-induced hypertension,and identified telmisartan as a potential drug for the treatment of obesity-related hypertension. | Yaping Wang Yan Song Meng Suo Xin Jin Gang Tian | 2012 | The Journal of Biomedical Research2012，26，3： | 3 |
| 11 | A computational coding model for saliency detection in primary visual cortex显示文摘This study researches the coding model adaptive for information processing of the bottom-up attention mechanism.We constructed a coding model satisfying the neurobiological constraints of the primary visual cortex.By quantitatively changing the coding constraints,we carried out experiments on images used in cognitive psychology and natural image sets to compare the effects on the saliency detection performance.The experimental results statistically demonstrated that the encoding of invariant features and representation of overcomplete bases is advantageous to the bottom-up attention mechanism. | ZOU Qi WANG Zhe LUO SiWei HUANG YaPing TIAN Mei | 2012 | Chinese Science Bulletin2012，57，30： | 2 |
| 12 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 13 | Effect of amlodipine combined with telmisartan or compound amiloride on plasma ET-1 concentration and left ventricular diastolic function of essential hypertension patients with left ventricular hypertrophy显示文摘Objective: To observe the effect of different combination antihypertensive therapies on plasma endothelin-1(ET-1) concentration and left ventricular diastolic function of essential hypertension patients with left ventricular hypertrophy(LVH). Methods: A total of 111 patients with essential hypertension were selected, including 60 cases(34 males, 26 females) aged(60.7±5.6) years with simple hypertension, and 51 cases(28 males, 23 females) aged(61.8±7.0) years with essential hypertension complicated with LVH. Essential hypertension patients with LVH were randomly divided into the group of amlodipine(2.5 mg/d) combined with telmisartan(40 mg/d, n=26) and the group of amlodipine(2.5 mg/d) combined with amiloride(half tablet/d, n=25),and the treatment lasted for 1 year. Echocardiography was performed before and after the treatment. Left ventricular mass index(LVMI), left ventricular isovolumic relaxation time(IVRT) and other indicators were detected, and plasma ET-1 concentrations were measured for comparative analysis. And 56 patients(31 males, 25 females) aged(59.3±6.7) years with normal blood pressure in the same period in our hospital were selected as the normal control group. Results: The general clinical characteristics were similar between hypertensive LVH group, simple hypertensive group and normal healthy control group. Plasma ET-1 concentrations, LVMI and IVRT of hypertensive LVH group were significantly higher than those of normal control group and simple hypertension group, and the difference was statistically significant. The patients' baseline blood pressure, ET-1, LVMI, interventricular septal thickness(IVST), left ventricular posterior wall thickness(LVPWT), left ventricular end-diastolic diameter(LVEDd) and other clinical parameters showed no significant difference(P>0.05) between the group of amlodipine combined with telmisartan and the group of amlodipine combined with amiloride. It was found that compared with that before treatment, blood pressure could be effectively controlled(P<0.05), and LVMI, IVST, LVPWT and IVRT(P<0.05) were all lowered, and ET-1(P<0.01) was significantly reduced after 1 year of antihypertensive therapy in both the group of amlodipine combined with telmisartan and the group of amlodipine combined with amiloride. The group of amlodipine combined with telmisartan was better in lowering blood pressure and reducing LVMI, IVST, LVPWT, IVRT and ET-1 than the group of amlodipine combined with amiloride(P<0.05). Conclusion: Amlodipine-based combination antihypertensive therapy could reverse LVH and improve left ventricular diastolic function partly by lowering blood pressure and ET-1, and the effect of amlodipine combined with telmisartan was superior to that of amlodipine combined with amiloride. | YIN Yanrong WANG Xin WANG Yaping ZHANG Yong TIAN Gang | 2013 | Journal of Medical Colleges of PLA(China)2013，28，6： | 2 |
| 14 | All in one theranostic nanoplatform enables efficient anti-tumor peptide I delivery for triple-modal imaging guided cancer therapy显示文摘Developing a reliable system to efficiently and safely deliver peptide drugs into tumor tissues still remains a great challenge since the instability of peptide drugs and low ability to traverse the cell membrane. Herein, we constructed a multifunctional nanoplatform based on porous europium/gadolinium (Eu/Gd)-doped NaLa(MoO4)2 nanoparticles (NLM NPs) to deliver antitumor peptide of B-cell lymphoma/leukemia-2-like protein 11 (BIM) for cancer therapy. The porous NLM NPs exhibited inherent photoluminescent, magnetic and X-ray absorbable properties, which enable them for triple-modal bioimaging, including fluorescence, magnetic resonance imaging (MRI) and computed tomography (CT). This triple-modal bioimaging can contribute to monitoring NLM NPs biodistribution and guiding therapy in vitro and in vivo. Furthermore, the NLM NPs showed negligible cytotoxicity in vitro and tissue toxicity in vivo. Importantly, NLM NPs could load the antitumor peptide of BIM and efficiently improve the resistance of peptide drugs to proteolysis. The BIM peptide was efficiently delivered into the tumor cells by NLM NPs, which can inhibit the growth and promote the apoptosis of cancer cells in vitro, significantly inhibit the tumor growth in vivo. Notably, NLM-BIM theranostic nanoplatform exhibits low systemic toxicity and fewer side effects in vivo. The NLM NPs can serve as a promising multifunctional peptide delivery nanoplatform for multi-modal bioimaging and cancer therapy. | Xiaoyan Qu Zhengqing Liu Bohan Ma Na Li Hongyang Zhao Tian Yang Yumeng Xue Xiaozhi Zhang Yongping Shao Ying Chang Jun Xu Bo Lei Yaping Du | 2019 | Nano Research2019，12，3： | 2 |
| 15 | Impact of Lithium-Ion Coordination on Lithium Electrodeposition显示文摘The lithium dendrite and parasitic reactions are two major challenges for lithium(Li)metal anode—the most promising anode materials for high-energy-density batteries.In this work,both the dendrite and parasitic reactions that occurred between the liquid electrolyte and Li-metal anode could be largely inhibited by regulating the Li+-solvation structure.The saturated Li+-solvation species exist in commonly used LiPF 6 liquid electrolyte that needs extra energy to desolvation during Li-electrodeposition.Partial solvation induced high-energy state Li-ions would be more energy favorable during the electron-reduction process,dominating the competition with solvent reduction reactions.The Li-symmetric cells that are cycling at higher temperatures show better performance;the cycled lithium metal anode with metallic lustre and the dendrite-free surface is observed.Theoretical calculation and experimental measurements reveal the existence of high-energy state Li+-solvates species,and their concentration increases with temperature.This study provides insight into the Li+-solvation structure and its electrodeposition characteristics. | Li Sheng Yanzhou Wu Jiekang Tian Li Wang Jianlong Wang Yaping Tang Hong Xu Xiangming He | 2023 | Energy & Environmental Materials2023，6，1： | 2 |
| 16 | Dehydrated layered double hydroxides: Alcohothermal synthesis and oxygen evolution activity显示文摘分层的双氢氧化物(LDH ) 是一个班二维(2D ) 有在水的媒介的广泛的应用程序和开发得好的综合方法的分层的材料。在这个工作,我们为与使脱水的画廊制作 NiFe-LDHs 介绍一个 alcohothermal 合成方法。建议过程为金属离子的同时的降水包含脲的不完全的水解作用,与结果导致使脱水的结构的形成的水缺乏的乙醇环境。使画廊脱水的层结构的形成被 X 光检查衍射(XRD ) ,以及由一个随后的水和过程证实。这里介绍的方法论为制作基于 Fe 的 LDH (NiFe-LDH 和 NiCoFe-LDH ) 也是适用的 nanoarrays,它因为包含的不同降水过程,不能在水的媒介在一样的条件下面被生产。LDH nanoarrays 展览在氧进化反应的优秀 electrocatalytic 性能,由于他们的高内在的活动和唯一的结构的特征。在摘要,这研究不仅为综合介绍一个新方法 LDH 材料,而且为 electrocatalysis 向高度活跃、柔韧的电极提供一条新线路。 | Zhiyi Lu Li Qian Wenwen Xu Yang Tian Ming Jiang Yaping Li Xiaoming Sun Xue Duan | 2016 | Nano Research2016，9，10： | 2 |
| 17 | Amorphization activated FeB_(2) porous nanosheets enable efficient electrocatalytic N_(2) fixation显示文摘Designing active,robust and cost-effective catalysts for the nitrogen reduction reaction(NRR) is of paramount significance for sustainable electrochemical NH3 synthesis.Transition-metal diborides(TMB_2)have been recently theoretically predicted to be a new class of potential NRR catalysts,but direct experimental evidence is still lacking.Herein,we present the first experimental demonstration that amorphous FeB_2 porous nanosheets(a-FeB_2 PNSs) could be a highly efficient NRR catalyst,which exhibited an NH3 yield of 39.8 μg h^(-1) mg^(-1)(-0.3 V) and a Faradaic efficiency of 16.7%(-0.2 V),significantly outperforming their crystalline counterpart and most of existing NRR catalysts.First-principle calculations unveiled that the amorphization could induce the upraised d-band center of a-FeB_2 to boost d-2π~* coupling between the active Fe site and ~*N_2 H intermediate,resulting in enhanced ~*N_2 H stabilization and reduced reaction barrier.Out study may facilitate the development and understanding of earth-abundant TMB_2-based catalysts for electrocatalytic N_2 fixation. | Ke Chu Weicong Gu Qingqing Li Yaping Liu Ye Tian Wuming Liu | 2021 | Journal of Energy Chemistry2021，30，2： | 2 |
| 18 | Multiplexed cytokine profiling of serum for detection of colorectal cancer显示文摘 | Zhang Pengjun Wen Xinyu Gu Feng Deng Xinxin Liu Yulan Li Juan Jia Xingwang Dong Zhennan Tian Yaping | 2013 | Future Oncol2013，，7： | 2 |
| 19 | Ribonuclease H-like gene SMALL GRAIN2 regulates grain size in rice through brassinosteroid signaling pathway显示文摘Grain size is a key agronomic trait that determines the yield in plants.Regulation of grain size by brassinosteroids(BRs)in rice has been widely reported.However,the relationship between the BR signaling pathway and grain size still requires further study.Here,we isolated a rice mutant,named small grain2(sg2),which displayed smaller grain and a semi-dwarf phenotype.The decreased grain size was caused by repressed cell expansion in spikelet hulls of the sg2 mutant.Using map-based cloning combined with a Mut Map approach,we cloned SG2,which encodes a plant-specific protein with a ribonuclease H-like domain.SG2 is a positive regulator downstream of GLYCOGEN SYNTHASE KINASE2(GSK2)in response to BR signaling,and its mutation causes insensitivity to exogenous BR treatment.Genetical and biochemical analysis showed that GSK2 interacts with and phosphorylates SG2.We further found that BRs enhance the accumulation of SG2 in the nucleus,and subcellular distribution of SG2 is regulated by GSK2 kinase activity.In addition,Oryza sativa OVATE family protein 19(OsOFP19),a negative regulator of grain shape,interacts with SG2 and plays an antagonistic role with SG2 in controlling gene expression and grain size.Our results indicated that SG2 is a new component of GSK2-related BR signaling response and regulates grain size by interacting with Os OFP19. | Yunshuai Huang Hui Dong Changling Mou Ping Wang Qixian Hao Min Zhang Hongmin Wu Fulin Zhang Tengfei Ma Rong Miao Kai Fu Yaping Chen Ziyan Zhu Cheng Chen Qikai Tong Zhuoran Wang Shirong Zhou Xi Liu Shijia Liu Yunlu Tian Ling Jiang Jianmin Wan | 2022 | Journal of Integrative Plant Biology2022，64，10： | 1 |
| 20 | Clinical value of serum tumor markers CA199, CA125 and CA72 -4 in the diagnosis of pancreatic carci- noma显示文摘 | Zi Wang Yaping Tian | 2014 | Mol Clin 0ncol2014，2，： | 1 |
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