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| 1 | Bisphenol A in combination with TNF-a selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity显示文摘Bisphenol A(BPA)is a monomer used in manufacturing a wide range of chemical products,including epoxy resins and polycarbonate.BPA,an important endocrine disrupting chemical that exerts estrogen-like activities,is detectable at nanomolar levels in human serum worldwide.The pregnancy associated doses of 17b-estradiol(E2)plus tumor-necrosis factor-a(TNF-a)induce distorted maturation of human dendritic cells(DCs)that result in an increased capacity to induce T helper(Th)2 responses.The current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs,thereby polarizing the subsequent Th response.In the presence of TNF-a,BPA treatment enhanced the expression of CC chemokine ligand 1(CCL1)in DCs.In addition,DCs exposed to BPA/TNF-a produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation,and preferentially induced Th2 deviation.BPA exerts the same effect with E2 at the same dose(0.01–0.1 mM)with regard to DC-mediated Th2 polarization.These findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions. | Hongchuan Guo Tianyi Liu Yasushi Uemura Shunchang Jiao Deqing Wang Zilin Lin Yayoi Narita Motoharu Suzuki Narumi Hirosawa Yasuko Ichihara Osamu Ishihara Hirosato Kikuchi Yasushi Sakamoto Satoru Senju Qiuhang Zhang Feng Ling | 2010 | Cellular & Molecular Immunology2010，7，3： | 6 |
| 2 | Spermatogenesis in aged rats after prenatal 3,3′,4,4′,5-pentachlorobiphenyl exposure显示文摘 | Shin Wakui Fumio Takagi Tomoko Muto Kiyofumi Yokoo Shyou Hirono Yasuko Kobayashi Kinji Shirota Fumiaki Akahori Yoshihiko Suzuki Hiroshi Hano Hitoshi Endou Yoshikatsu Kanai | 2007 | Toxicology2007，，2： | 3 |
| 3 | Inducing sleep by remote control facilitates memory consolidation in drosophila 显示文摘 | Jeffrey M Donlea Matthew S Thimgan Yasuko Suzuki | 2011 | Science2011，332，6037： | 1 |
| 4 | Mirror therapy activates outside of cerebellum and ipsilateral M1显示文摘 | Nobusada Shinoura Yuichi Suzuki Yasuko Watanabe Ryozi Yamada Yusuke Tabei Kuniaki Saito Kazuo Yagi | 2008 | Neurorehabilitation2008，，3： | 1 |
| 5 | Histopathological analyses of the antitumor activity of anti-glypican-3 antibody (GC33) in human liver cancer xenograft models: The essential role of macrophages显示文摘 | Hirotake Takai Atsuhiko Kato Yasuko Kinoshita Takahiro Ishiguro Yayoi Takai Yoshimi Ohtani Masamichi Sugimoto Masami Suzuki | 2009 | Cancer Biology & Therapy2009，，： | 1 |
| 6 | The perilipin homologue,lipid storage droplet 2,regulates sleep homeostasis and prevents learning impairments following sleep loss显示文摘 | Matthew S Thimgan Yasuko Suzuki Laurent Seugnet | | 0，，08： | 1 |
| 7 | Role of Nitric Oxide-cGMP Pathway in Adrenomedullin-Induced Vasodilation in the Rat显示文摘 | Hiroshi Hayakawa Yasunobu Hirata Masao Kakoki Yasuko Suzuki Hiroaki Nishimatsu Daisuke Nagata Etsu Suzuki Kazuya Kikuchi Tetsuo Nagano Kenji Kangawa Hisayuki Matsuo Tsuneaki Sugimoto Masao Omata | 1999 | Hypertension1999，，2： | 1 |
| 8 | Development of thin film thermocouple for measurement of instantaneous heat flux flowing into cast iron combustion chamber wall 显示文摘 | Masahiko Emi Yasuko Suzuki Yuichi Yamada | 2002 | Transaction of Society of Automotive Engineers of Japan2002，33，3： | 1 |
| 9 | Plasma adenosine levels and P-selectin expression on platelets in preeclampsia显示文摘 | Yoshio Yoneyama Shunji Suzuki Rintaro Sawa Yasuko Kiyokawa Gordon G Power Tsutomu Araki | 2001 | Obstetrics & Gynecology2001，，3： | 1 |
| 10 | Measuring Vehicle Speed at a License Plate Using a Pair of Line-scan Cameras 显示文摘 | Satoshi Sakuma Yasuko Takahashi Akira Suzuki | 2004 | Electronics and Communications in Japan Translated from Denshi doho Tsushin Gakkai Ronbunshi(S1942-9541)2004，7，6： | 1 |
| 11 | Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors显示文摘Background:Antiangiogenic tyrosine kinase inhibitors(TKIs)provide one of the few therapeutic options for effective treatment of hepatocellular carcinoma(HCC).However,patients with HCC often develop resistance toward antiangiogenic TKIs,and the underlying mechanisms are not understood.The aim of this study was to determine the mechanisms underlying antiangiogenic TKI resistance in HCC.Methods:We used an unbiased proteomic approach to define proteins that were responsible for the resistance to antiangiogenic TKIs in HCC patients.We evaluated the prognosis,therapeutic response,and serum insulin-like growth factor-binding protein-1(IGFBP-1)levels of 31 lenvatinib-treated HCC patients.Based on the array of results,a retrospective clinical study and preclinical experiments using mouse and human hepatoma cells were conducted.Additionally,in vivo genetic and pharmacological gain-and loss-of-function experiments were performed.Results:In the patient cohort,IGFBP-1 was identified as the signaling molecule with the highest expression that was inversely associated with overall survival.Mechanistically,antiangiogenic TKI treatment markedly elevated tumor IGFBP-1 levels via the hypoxia-hypoxia inducible factor signaling.IGFBP-1 stimulated angiogenesis through activation of the integrinα5β1-focal adhesion kinase pathway.Consequently,loss of IGFBP-1 and integrinα5β1 by genetic and pharmacological approaches re-sensitized HCC to lenvatinib treatment.Conclusions:Together,our data shed light onmechanisms underlying acquired resistance of HCC to antiangiogenic TKIs.Antiangiogenic TKIs induced an increase of tumor IGFBP-1,which promoted angiogenesis through activating the IGFBP-1-integrinα5β1 pathway.These data bolster the application of a new therapeutic concept by combining antiangiogenic TKIs with IGFBP-1 inhibitors. | Hiroyuki Suzuki Hideki Iwamoto Takahiro Seki Toru Nakamura Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Yasuko Imamura Takashi Niizeki Masahito Nakano Shigeo Shimose Tomotake Shirono Yu Noda Naoki Kamachi Miwa Sakai Kazutoyo Morita Masamichi Nakayama Tomoharu Yoshizumi Ryoko Kuromatsu Hirohisa Yano Yihai Cao Hironori Koga Takuji Torimura | 2023 | Cancer Communications2023，43，4： | 0 |
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