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| 1 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 2 | Optimization of cold-sprayed AA2024/Al_2O_3 metal matrix composites via friction stir processing: Effect of rotation speeds显示文摘In this study, friction stir processing(FSP) was employed to modify cold-sprayed(CSed) AA2024/Al_2 O_3 metal matrix composites(MMCs). Three different rotation speeds with a constant traverse speed were used for FSP. Microstructural analysis of the FSPed specimens reveals significant Al_2 O_3 particle refinement and improved particle distribution over the as-sprayed deposits. After FSP, a microstructural and mechanical gradient MMC through the thickness direction was obtained. Therefore, a hybrid technique combining these two solid-state processes, i.e. CS and FSP, was proposed to produce functionally gradient deposits. The Guinier-Preston-Bagaryatskii zone was dissolved during FSP, while the amounts at different rotation speeds were approximately the same, which is possibly due to the excellent thermal conductivity of the used Cu substrate. Mechanical property tests confirm that FSP can effectively improve the tensile performance and Vickers hardness of CSed AA2024/Al_2 O_3 MMCs. The properties can be further enhanced with a larger rotation speed with a maximum increase of 25.9% in ultimate tensile strength and27.4% in elongation at 1500 rpm. Friction tests show that FSP decreases the wear resistance of CSed MMCs deposits due to the breakup of Al_2 O_3 particles. The average values and fluctuations of friction coefficients at different rotation speeds vary significantly. | Kang Yang Wenya Li Chunjie Huang Xiawei Yang Yaxin Xu | 2018 | Journal of Materials Science & Technology2018，34，11： | 3 |
| 3 | Graphene Oxide Assemblies for Sustainable Clean-Water Harvesting and Green-Electricity Generation显示文摘CONSPECTUS:The urgent problems of water scarcity and the energy crisis have given rise to the development of a range of sustainable technologies with the great advancement of nanotechnologies and advent of attractive nanomaterials.Graphene oxides(GO),a derivative of graphene with an atom-thin thickness and abundant oxygen-containing functional groups(such as−OH,−COOH),are water-soluble and can be assembled into a variety of structures(such as fiber,membrane,and foam)with great potential in environmental and energy-related fields.As a typical precursor of graphene,GO can be easily reduced to graphene by chemical or thermal treatments to demonstrate excellent photothermal properties as well as tunable thermal conduction,which is highly desirable for efficient solar-driven water evaporation.The intrinsic large specific area of GO nanosheets can provide enough sites for ions adsorption and its porous assemblies facilitate the transport of water.In addition,the abundant functional groups allow the spontaneous adsorption of water molecules from the ambient environment and give birth to movable ions(usually protons)under the solvation effect.Once a chemical gradient is formed on the component,a remarkable electricity is generated from the directional transport of protons.Thanks to the excellent chemical properties of GO nanosheets,a wide range of assemblies with 1D aligned fibers,2D layered membranes and 3D porous foam can be easily fabricated by wet-spinning,solution-filtration,and freezingdrying methods.The various GO assemblies are able to exhibit abundant functions with remarkable weaving capability for GO fibers,superior flexibility for GO membranes,and exceptional adsorption capacity for GO foams.In light of all the advantages,GO and its assemblies are remarkably promising in the fields of sustainable development to meet the pressing challenges of water and energy crisis.In this Account,we will discuss the progress of clean-water production and green-electricity generation technologies based on GO assemblies.The fundamental working mechanism,optimization strategies,and promising applications are explored with an emphasis on the materials development.We also discuss the functions of GO assemblies in the water and electricity generation process and present their limitations and possible solutions.Current challenges and promising directions for the development of clean-water production and green-electricity generation are also demonstrated for their realistic implementations.We anticipate that this Account would promote more efforts toward fundamental research on graphene functionalization and encourage a broad exploration on the application of graphene assemblies in clean-water production and electric power generation systems. | Yaxin Huang Chengzhi Wang Changxiang Shao Boyu Wang Nan Chen Haibo Jin Huhu Cheng Liangti Qu | 2021 | Accounts of Materials Research2021，2，2： | 2 |
| 4 | Five Independent Cases of Human Infection with Avian Influenza H5N6—Sichuan Province,China,2021显示文摘Summary What is known about this topic?The emerging H5Ny lineages of the avian influenza virus(AIV)with genomic reassortments have posed a continuous threat to animals and human beings.Since the first case of avian influenza A(H5N6)virus infection in 2014,the World Health Organization has reported a total of 38 cases by August 6,2021. | Chongkun Xiao Jianan Xu Yu Lan Zhongping Huang Lijun Zhou Yaxin Guo Xiyan Li Lei Yang George F.Gao Dayan Wang William J.Liu Xingyu Zhou Huiping Yang | 2021 | China CDC weekly2021，3，36： | 2 |
| 5 | Stimuli-responsive photofunctional materials for green and security printing显示文摘Information recording on paper has always been the most important approach to keep records of human activity and to spread civilization.With the progress of science and technology,paper with different functions should be exploited to conform to the increasing demands in various scenarios.In one aspect,traditional paper can only be used once,and using large amounts of paper causes deforestation,additional solid waste treatment,environmental pollution,and high energy consumption.Consequently,the development of rewritable paper that is environment-friendly,low cost,and can save resources is significant for green printing.In the other aspect,information leakage brings security issues,which may lead to severe consequences,such as war outbreak,economic loss,social problems,and so on.Therefore,the development of security printing has also attracted wide interests.Stimuli-responsive photofunctional materials that have reversible variations in absorption or emission in response to changes in the external environmental have a great potential for the achievement of green and security printing.To date,much progress has been made in these research areas.This paper lists different smart materials that respond to various external stimuli,such as light,water,pH,heat,and metal ions,and summarizes the recent advances towards green and security printing.Also,we discuss the current challenges and future directions in this rapidly growing research field.It is expected that this review article will stimulate and guide future studies for the advanced green and security printing. | Yun Ma Yaxin Yu Jiangang Li Shujuan Liu Wei Huang Qiang Zhao | 2021 | InfoMat2021，3，1： | 2 |
| 6 | Post-mortem tissue proteomics reveals the pathogenesis of multi-organ injuries of COVID-19显示文摘Multi-organ injuries are a major complication of severe Coronavirus Disease 2019(COVID-19).However,its pathogenesis is barely understood.Herein;we profile host responses to fatal SARS-CoV-2 infection by performing quantitative proteomics of 19 post-mortem samples of 8 different organs or tissues,including lungs,liver,intestine,kidney;spleen,brain,heart and muscle,from 3 deceased COVID-19 victims during the first wave of the pandemic(Supplementary Fig.S1A and B,Tables SI-S3). | Yang Qiu Di Wu Wanshan Ning Jiqian Xu Ting Shu Muhan Huang Rong Chen Jiancheng Zhang Yang Han Qingyu Yang Ruiting Li Xiaobo Yang Yaxin Wang Xiaojing Zou Shangwen Pan Chaolin Huang Yu Xue You Shang Xi Zhou | 2021 | National Science Review2021，8，11： | 1 |
| 7 | Atomistic modeling of the interaction between matrix dislocation and interfacial misfit dislocation networks in Ni-based single crystal superalloy显示文摘 | Yaxin Zhu Zhenhuan Li Minsheng Huang | 2013 | Computational Materials Science2013，，： | 1 |
| 8 | Human mobility data in the COVID-19 pandemic:characteristics,applications,and challenges显示文摘The COVID-19 pandemic poses unprecedented challenges around the world.Many studies have applied mobility data to explore spatiotemporal trends over time,investigate associations with other variables,and predict or simulate the spread of COVID-19.Our objective was to provide a comprehensive overview of human mobility open data to guide researchers and policymakers in conducting data-driven evaluations and decision-making for the COVID-19 pandemic and other infectious disease outbreaks.We summarized the mobility data usage in COVID-19 studies by reviewing recent publications on COVID-19 and human mobility from a data-oriented perspective.We identified three major sources of mobility data:public transit systems,mobile operators,and mobile phone applications.Four approaches have been commonly used to estimate human mobility:public transit-based flow,social activity patterns,index-based mobility data,and social media-derived mobility data.We compared mobility datasets’characteristics by assessing data privacy,quality,space–time coverage,high-performance data storage and processing,and accessibility.We also present challenges and future directions of using mobility data.This review makes a pivotal contribution to understanding the use of and access to human mobility data in the COVID-19 pandemic and future disease outbreaks. | Tao Hu Siqin Wang Bing She Mengxi Zhang Xiao Huang Yunhe Cui Jacob Khuri Yaxin Hu Xiaokang Fu Xiaoyue Wang Peixiao Wang Xinyan Zhu Shuming Bao Wendy Guan Zhenlong Li | 2021 | International Journal of Digital Earth2021，14，9： | 1 |
| 9 | Quantitative study on interactions between interfacial misfit dislocation networks and matrix dislocations in Ni-based single crystal superalloys显示文摘The interactions between the moving dislocation within matrix channel and the interfacial misfit dislocation networks on the two-phase interfaces in Ni-based single crystal superalloys are studied carefully via atomic modeling, with special focus on the factors influencing the critical bowing stress of moving dislocations in the matrix channel. The results show that the moving matrix dislocation type and its position with respect to the interfacial misfit dislocation segments have considerable influences on the interactions. If the moving matrix dislocation is pure screw, it reacts with the interfacial misfit dislocation segments toward dislocation linear energy reduction, which decreases the critical bowing stress of screw dislocation due to dislocation linear energy release during the dislocation reactions. If the moving matrix dislocation is of 60°-mixed type, it is obstructed by the interaction between the mixed matrix dislocations and the misfit interfacial dislocation segments. As a result, the critical bowing stress increases significantly because extra interactive energy needs to be overcome. These two different effects on the critical bowing stress become increasingly significant when the moving matrix dislocation is very close to the interfacial misfit dislocation segments. In addition, the matrix channel width also has a significant influence on the critical bowing stress, i.e. the narrower the matrix channel is, the higher the critical bowing stress is. The classical Orowan formula is modified to predict these effects on the critical bowing stress of moving matrix dislocation, which is in good agreement with the computational results. | Jun Xiong Yaxin Zhu Zhenhuan Li Minsheng Huang | 2017 | Acta Mechanica Solida Sinica2017，30，4： | 1 |
| 10 | Design of clamping-pot-type planetary gear train transplanting mechanism for rice wide-narrow-row planting显示文摘To design a clamping-pot-type wide-narrow-row pot seedling transplanting(WPST)mechanism with desired spatial beak-shaped trajectory and working posture,a new design method of planetary gear train transplanting mechanism(PGTM)with non-circular gears based on several key spatial poses(position and posture)was proposed.The PGTM was simplified to a spatial open-loop chain with two-revolute(2R)joints.The geometric constraint equations containing only the structural parameters of the chain were then established on the basis of the three key spatial poses,and the homotopy algorithm was used to obtain all the required parameters of the mechanism.In accordance with the parameters obtained,the relative angular displacement relation between the planet carrier and the transplanting arm was optimized,the trajectory of the mechanism was replayed,and the total transmission ratio was determined.The degree of freedom of the spatial 2R mechanism was reduced by attaching to the unequal gear pair,and the transmission ratio was distributed in accordance with the gear type to realize the design of a non-circular gear pitch curve.Lastly,a clamping-pot-type PGTM for rice WPST driven by the combination of planar non-circular and non-conical gears was designed,and virtual simulation and prototype test were conducted.Results showed that the simulation and prototype test trajectories were consistent with the desired trajectory.Under the operating speeds of 50 r/min and 90 r/min,the success rates of seedling picking were 95.32%and 90.15%,respectively,which verified the feasibility of the theoretical method.This method could provide a reference for the design of a spatial PGTM with nonuniform transmission. | Lei Wang Liang Sun Hengmin Huang Yaxin Yu Gaohong Yu | 2021 | International Journal of Agricultural and Biological Engineering2021，14，2： | 1 |
| 11 | Giant Phase Transition Properties at Terahertz Range in VO2 films Deposited by Sol-Gel Method显示文摘 | Qiwu Shi Wanxia Huang Yaxin Zhang | | 0，，： | 1 |
| 12 | Dingxin recipe alleviates atherosclerosis injury in Apo E-knockout mice via downregulation of visfatin expression and inhibition of the visfatin-induced inflammatory response显示文摘OBJECTIVE:To further elucidate the mechanism underlying the anti-atherosclerotic effect of Dingxin recipe(DXR).METHODS:Fifty 6-week-old male Apo E^-/-mice were randomly divided into the following groups:model,simvastatin(5 mg·kg^-1·d^-1),DXR low-dose(9.30 g·kg^-1·d^-1),DXR middle-dose(18.59 g·kg^-1·d^-1)and DXR high-dose(37.18 g·kg^-1·d^-1)(n=10).Ten male C57BL/6J mice were used as the control group.All Apo E^-/-mice were fed a high-fat diet(HFD)and the control mice received a common diet.After HFD for 12 weeks,the mice were treated with DXR or simvastatin for another 12 weeks.The expression of inflammatory cytokines and visfatin was determined in serum and atherosclerotic lesions by enzyme-linked immunosorbent assay.Visfatin expression was also assessed in aortic atherosclerotic plaques.Cultured vessel endothelial cells(VECs)were pretreated with DXR sera prior to visfatin.The effects of DXR were analyzed to elucidate its protective mechanism against visfatin-induced inflammation in VECs.RESULTS:DXR regulated blood lipids and reduced tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),intercellular adhesion molecules-1(ICAM-1),vascular cell adhesion molecule-1(VCAM-1)and visfatin expression in Apo E^-/-mice,particularly at the higher doses.The areas of atherosclerotic lesions in the DXR groups were significantly smaller than those in the model group.DXR alleviated visfatin-induced VEC injury via downregulation of TNF-α,IL-6,ICAM-1 and VCAM-1 through mitogen-activated protein kinase pathways.CONCLUSION:DXR alleviated atherosclerosis injury via downregulation of visfatin expression and inhibition of the visfatin-induced inflammatory response in VECs. | Cui Xiaobing Huang Zhiyong Lou Linjie Cheng Saibo Zhang Yu Zhang Yaxin Jia Yuhua Zhou Fenghua | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 1 |
| 13 | The development of the alt electric propulsion warship by the United States Navy 显示文摘 | CHEN Yaxin | 2002 | Marine Electric & Electronic Technology2002，22，3： | 1 |
| 14 | Lipidomic analyses reveal enhanced lipolysis in planthoppers feeding on resistant host plants显示文摘The brown planthopper(BPH)(Nilaparvata lugens St?l)is a highly destructive pest that seriously damages rice(Oryza sativa L.)and causes severe yield losses.To better understand the physiological and metabolic mechanisms through which BPHs respond to resistant rice,we combined mass-spectrometry-based lipidomics with transcriptomic analysis and gene knockdown techniques to compare the lipidomes of BPHs feeding on either of the two resistant(NIL-Bph6 and NIL-Bph9)plants or a wild-type,BPH susceptible(9311)plant.Insects that were fed on resistant rice transformed triglyceride(TG)to phosphatidylcholine(PC)and digalactosyldiacylglycerol(DGDG),with these lipid classes showing significant alterations in fatty acid composition.Moreover,the insects that were fed on resistant rice were characterized by prominent expression changes in genes involved in lipid metabolism processes.Knockdown of the NlBmm gene,which encodes a lipase that regulates the mobilization of lipid reserves,significantly increased TG content and feeding performance of BPHs on resistant plants relative to dsGFP-injected BPHs.Our study provides the first detailed description of lipid changes in BPHs fed on resistant and susceptible rice genotypes.Results from BPHs fed on resistant rice plants reveal that these insects can accelerate TG mobilization to provide energy for cell proliferation,body maintenance,growth and oviposition. | Xiaohong Zheng Yeyun Xin Yaxin Peng Junhan Shan Ning Zhang Di Wu Jianping Guo Jin Huang Wei Guan Shaojie Shi Cong Zhou Rongzhi Chen Bo Du Lili Zhu Fang Yang Xiqin Fu Longping Yuan Guangcun He | 2021 | Science China(Life Sciences)2021，64，9： | 1 |
| 15 | Combined Electrohydrodynamic(EHD) and Vacuum Freeze Drying of Sea Cucumber显示文摘 | Bai Yaxiang Yang Yaxin Huang Qiang | 2012 | Drying Technology2012，30，10： | 1 |
| 16 | Automatic Anomaly Detection for Swarm Observations显示文摘The Swarm satellite mission was launched on 22 November 2013,it is the first European Space Agency’s constellation of three satellites,dedicated to monitoring geomagnetic field changes.The measurements delivered by the three satellites are very valuable for a range of applications,including the earthquake prediction study.However,for more than 5 years,relatively little advancement has been achieved in establishing a systematic approach for detecting anomalies from the satellite measurements for predicting earthquakes.This paper presents the challenges of developing a pragmatic framework for automatic anomaly detection and highlights innovative features of functional components developed.Through a case study we demonstrate a functionality pipeline of the system in detecting anomalies,and present our solutions to coping with data sparsity and parameter tuning as well as insights into the differences between discovering seismic anomalies from periodic and non-periodic data observed by the Swarm satellites. | Yaxin BI Vyron CHRISTODOULOU George WILKIE Guoze ZHAO Peter NICHOLL Mingjun HUANG Bin HAN Ji TANG | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 1 |
| 17 | Adaptive Control for High-order Nonlinear Feedforward Systems With Input and State Delays显示文摘 | Yaxin Huang Xinghui Zhang Mengmeng Jiang | 2017 | 自动化学报2017，43，7： | 1 |
| 18 | A Longitudinal Cohort Study Using a Modified Child-Pugh Score to Escalate Respiratory Support in COVID-19 Patients—Hubei Province,China,2020显示文摘Background:We explored a phenotype of liver dysfunction based on modified Child-Pugh(MCP)with coronavirus disease 2019(COVID-19)and evaluated its relationship with escalation of respiratory support and survival.Methods:This was a retrospective cohort study involving COVID-19 in-patients at the Wuhan Jinyintan Hospital.This study was performed between January 24,2020 and March 31,2020.Escalation of respiratory support and survival were evaluated.Furthermore,the trajectory of liver function was delineated considering the risk of escalation of respiratory support and survival using multilevel logistic regression.Results:A total of 298 patients were enrolled in this study.A higher proportion of patients with MCPB on admission exhibited an escalated respiratory support(26 of 55;47.3%)when compared to patients with MCP-A(9 of 62;14.5%),indicating that MCP-B was strongly associated with escalation of respiratory support[adjusted hazard ratio(HR):4.530;95%confidence interval(CI):2.060–9.970;P<0.001].Among the patients on escalated respiratory support,5(55.6%of 9)patients with MCP-A died compared to 10(38.5%of 26)of the patients with MCP-B.Patients with a history of liver disease had a higher mortality risk(adjusted HR:7.830;95%CI:1.260-48.420).Conclusion:MCP is efficient at stratifying liver dysfunction levels in COVID-19 patients and is strongly associated with escalation of respiratory support. | Yibai Xiong Yan Ma Yaxin Tian Chi Zhang Wei Yang Bin Liu Lianguo Ruan Cheng Lu Luqi Huang | 2021 | China CDC weekly2021，3，20： | 1 |
| 19 | Robotic in situ bioprinting for cartilage tissue engineering显示文摘Articular cartilage damage caused by trauma or degenerative pathologies such as osteoarthritis can result in significant pain,mobility issues,and disability.Current surgical treatments have a limited capacity for efficacious cartilage repair,and long-term patient outcomes are not satisfying.Three-dimensional bioprinting has been used to fabricate biochemical and biophysical environments that aim to recapitulate the native microenvironment and promote tissue regeneration.However,conventional in vitro bioprinting has limitations due to the challenges associated with the fabrication and implantation of bioprinted constructs and their integration with the native cartilage tissue.In situ bioprinting is a novel strategy to directly deliver bioinks to the desired anatomical site and has the potential to overcome major shortcomings associated with conventional bioprinting.In this review,we focus on the new frontier of robotic-assisted in situ bioprinting surgical systems for cartilage regeneration.We outline existing clinical approaches and the utilization of robotic-assisted surgical systems.Handheld and robotic-assisted in situ bioprinting techniques including minimally invasive and non-invasive approaches are defined and presented.Finally,we discuss the challenges and potential future perspectives of in situ bioprinting for cartilage applications. | Yaxin Wang Rúben F Pereira Chris Peach Boyang Huang Cian Vyas Paulo Bartolo | 2023 | International Journal of Extreme Manufacturing2023，5，3： | 0 |
| 20 | Effect of Hydrogen on Dislocation Nucleation and Motion:Nanoindentation Experiment and Discrete Dislocation Dynamics Simulation显示文摘The hydrogen effect on the nucleation and motion of dislocations in single-crystal bcc Fe with(110)surface was investigated by both nanoindentation experiments and discrete dislocation dynamics(DDD)simulation.The results of nanoindentation experiments showed that the pop-in load decreased evidently for the electrochemical hydrogen charging specimen,indicating that the dislocation nucleation strength might be reduced by hydrogen.In addition,the decrease of hardness due to hydrogen charging was also captured,implying that the dislocation motion might be promoted by hydrogen.By incorporating the effect of hydrogen on dislocation core energy,a DDD model was specifically proposed to investigate the influence of hydrogen on dislocation nucleation and motion.The results of DDD simulation revealed that under the effect of hydrogen,the dislocation nucleation strength is decreased and the motion of dislocation is promoted. | Jian Wang Lv Zhao Minsheng Huang Yaxin Zhu Zhenhuan Li | 2022 | Acta Mechanica Solida Sinica2022，35，1： | 0 |
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