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| 1 | miR-145 improves metabolic inflammatory disease through multiple pathways显示文摘Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control.miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics.LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels.Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.Conversely,lentivirus-mediated miR-145 overexpression inhibited macrophage infiltration,reduced body weight,and improved glucose metabolism in db/db mice.And miR-145 overexpression markedly reduced plaque size in the aorta in ApoE−/−mice.Both OPG and KLF5 were targets of miR-145.miR-145 repressed cell proliferation and induced apoptosis partially by targeting OPG and KLF5.miR-145 also suppressed NF-κB activation by targeting OPG and KLF5.Our findings provide an association of the environment with the progress of metabolic disorders.Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. | Min He Nan Wu Man Cheong Leong Weiwei Zhang Zi Ye Rumei Li Jinyang Huang Zhaoyun Zhang Lianxi Li Xiao Yao Wenbai Zhou Naijia Liu Zhihong Yang Xuehong Dong Yintao Li Lili Chen Qin Li Xuanchun Wang Jie Wen Xiaolong Zhao Bin Lu Yehong Yang Qinghua Wang Renming Hu | 2020 | Journal of Molecular Cell Biology2020，12，2： | 7 |
| 2 | The essential oil components of Cinnamomum cassia: an analysis under different thinning models of plantation Pinus massoniana显示文摘Thinning is an important activity employed in forest management. To date, studies have mainly focused on the effects of thinning on the growth of trees during the same thinning period. In this study, plantation Pinus massoniana Lamb. near maturity were thinned at varying intensities and an economically important species, Cinnamomum cassia Presl., was planted beneath the thinned canopy. The aim of the study was to explore the effects of the extent of thinning on the essential oil content and its components of C. cassia in different parts of the plant, as well as the economic feasibility of the P. massoniana–C.cassia management model. Thinning significantly reduced the oil yield in the bark and branches of C. cassia, but hardly impacted the oil yield from C. cassia leaves compared with pure C. cassia forest(CK). Among the different thinning treatments, both light(T.4) and extensive(T.1)thinning reduced the oil yield of C. cassia bark and new branches. The concentrations of the main aldehydes differed in different parts of the plant and were affected by the extent of thinning. The influence on cinnamaldehyde in the bark was minor, but was much greater in the branches and leaves. Both the oil yield and content of cinnamaldehyde showed that moderate(T.3) thinning was more favorable than other thinning models. These results not only provide a potentially promising model for the transformation of low–yield artificial pure forests of P. massoniana in the future, but also offer a reference for the management of artificial mixed stands. | Dayan Tao Yuanfa Li Daodiao Lu Yehong Luo Sufang Yu Shaoming Ye | 2016 | Journal of Forestry Research2016，27，3： | 5 |
| 3 | Single Atom Alloy Preparation and Applications in Heterogeneous Catalysis显示文摘There have been remarkable progresses in manipulating heterogeneous catalysts' nanostructures in the past decade.The concept of single atom alloy (SAA) was firstly proposed in 2012 when researchers successfully stabilized single Pd atoms on the Cu(111) surface.However,earlier work in 2009,which focused on replacing one Au atom with a Pd atom in thiolate protected Au25 nanoclusters,could also be considered as the pioneer work of single atom alloy.Both kinds of single atom alloys exhibited the potential of maximum utilization of scarce elements and attractive catalytic performances.The well-defined structures of SAA catalysts make accurate modeling possible,which further realizes the rational design of single atom alloy catalysts.In this review,we summarize the research trajectory of single atom alloys as well as recent achievements in this field.We also Introduce several commonly adopted characterization methods for SAA catalysts such as scanning tunneling microscopy (STM),temperature programmed reaction (TPR),extended X-ray absorption fine structure (EXAFS) spectra,matrix assisted laser desorption/ionization mass spectrum (MALDI-MS) and differential pulse voltammetry (DPV).Through discussing recent progresses in SAA catalysts,we propose that future researches in this filed should be focused on exploring new kinds of metal nanocrystals and controlling the nanostructure of SAA even more precisely. | Jianyu Han jjanmin Lu Min Wang Yehong Wang Feng Wang | 2019 | Chinese Journal of Chemistry2019，37，9： | 4 |
| 4 | Human umbilical cord mesenchymal stem cells for psoriasis:a phase 1/2a,single-arm study显示文摘Psoriasis is a common,chronic immune-mediated systemic disease that had no effective and durable treatment.Mesenchymal stem cells(MSCs)have immunomodulatory properties.Therefore,we performed a phase 1/2a,single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs(UMSCs)in the treatment of psoriasis and to preliminarily explore the possible mechanisms.Seventeen patients with psoriasis were enrolled and received UMsC infusions.Adverse events,laboratory parameters,PASl,and PGA were analyzed.We did not observe obvious side effects during the treatment and 6-month follow-up.A total of 47.1%(8/17)of the psoriasis patients had at least 40%improvement in the PASl score,and 17.6%(3/17)had no sign of disease or minimal disease based on the PGA score.And the efficiency was 25%(2/8)for males and 66.7%(6/9)for females.After UMSC transplantation(UMSCT),the frequencies of Tregs and CD4^(+)memory T cells were significantly increased,and the frequencies of T helper(Th)17 and CD4^(+)naive T cells were significantly decreased in peripheral blood(PB)of psoriasis patients.And all responders showed significant increases in Tregs and CD4^(+)memory T cells,and significant decreases in Th17 cells and serum IL-17 level after UMsCT.And baseline level of Tregs in responders were significantly lower than those in nonresponders.In conclusion,allogeneic UMSCT is safe and partially effective in psoriasis patients,and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT.Trial registration Clinical Trials NCT03765957. | Lamei Cheng Siqi Wang Cong Peng Xiao Zou Chao Yang Hua Mei Chuang Li Xian Su Na Xiao Qi Ouyang Mi Zhang Qiaolin Wang Yan Luo Minxue Shen Qun Qin Honglin Wang Wu Zhu Guangxiu Lu Ge Lin Yehong Kuang Xiang Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 5 | High prevalence of diabetic neuropathy in population-based patients diagnosed with type 2 diabetes in the Shanghai downtown显示文摘 | Bin Lu Zhihong Yang Mei Wang Zhen Yang Wei Gong Yehong Yang Jie Wen Zhaoyun Zhang Naiqing Zhao Xixing Zhu Renming Hu | 2010 | Diabetes Research and Clinical Practice2010，，3： | 1 |
| 6 | PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis显示文摘Glaucoma is the leading cause of irreversible blindness worldwide.In the pathogen-esis of glaucoma,activated microglia can lead to retinal ganglion cells(RGCs)apoptosis and death,however,the molecular mechanisms remain largely unknown.We demonstrate that phospholipid scramblase 1(PLSCR1)is a key regulator promoting RGCs apoptosis and their clearance by microglia.As evidenced in retinal progenitor cells and RGCs of the acute ocular hypertension(AOH)mouse model,overexpressed PLSCR1 induced its translocation from the nucleus to the cytoplasm and cytomembrane,as well as elevated phosphatidylserine exposure and reactive oxygen species generation with subsequent RGCs apoptosis and death.These damages were effectively attenuated by PLSCR1 inhibition.In the AOH model,PLSCR1 led to an increase in M1 type microglia activation and retinal neuroinflammation.Upregulation of PLSCR1 resulted in strongly elevated phagocytosis of apoptotic RGCs by activated microglia.Taken together,our study provides important insights linking activated microglia to RGCs death in the glaucoma pathogenesis and other RGC-related neurodegenerative diseases. | Jingyi Luo Qing Lian Deliang Zhu Minglei Zhao Tingfang Mei Bizhi Shang Zeqiu Yang Chujun Liu Wenchang Xu Lan Zhou Keling Wu Xinqi Liu Yuhua Lai Fuxiang Mao Weihua Li Chengguo Zuo Kang Zhang Mingkai Lin Yehong Zhuo Yizhi Liu Lin Lu Ling Zhao | 2023 | Genes & Diseases2023，10，4： | 0 |
| 7 | Energy Spectra of Ions Sputtered from Surface by 200 keV Ar2+显示文摘 | Ruan Fangfang Wu Yehong Du Fan Yu Deyang Chen Jing Wang Wei Zhang Mingwu Shao Caojie Lu Rongchun Cai Xiaohong | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 8 | Angular Distribution of Lyman-1 Transition Following Nonradiative Electron Capture into Xe^53+Ions显示文摘Radiative electron capture(REC)and nonradiative capture(NRC)are two competing mechanisms in relativistic collisions of highly charged ions with atoms[1].REC means electron transfer from target to projectile with the emission of one photon for satisfying energy and momentum conservation laws. | Yang Bian Yu Deyang Cai Xiaohong Shao Caojie Xue Yingli Wang Wei Zhang Mingwu Liu Junliang Song Zhangyong Wu Yehong Lu Rongchun Ruan Fangfang | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 9 | Sanitary and Phytosanitary Measures in China:Efficiency and Challenge:A Case Study of Swine Industry显示文摘The Sanitary and Phytosanitary( SPS) measures are technical regulations,standards,and requirements closely related to food safety,plant and animal health,and environmental safety,aiming to prevent disease,pests,pathogens and other alien risk from entering China.Pork is favorite meat for Chinese consumers; its safety directly concerns the safety of whole food supply chain with rapid increasing of pork import. This paper analyzed SPS management system of swine and pork import,and evaluated SPS efficiency of swine industry in China from SPS notification number,swine health situation,and pork import standard. The study found that as for SPS notification number and chemical residue control standard,China's SPS protection level is relatively high,while the control level of swine diseases is still low. In China,SPS management system has the problem of involving multiple authorities and poor coordination among them,leading to some standards lacking scientific basis and low enforcement. | Yinguo DONG Yehong LU | 2015 | Asian Agricultural Research2015，7，11： | 0 |
| 10 | 50-200 MeV/u全裸氙离子与氪、氙气体靶碰撞的电子俘获及辐射退激发显示文摘In collisions between energetic highly charged ions and atoms,the ions could remove the electrons of the target atoms,or be excited into high-level states.In the first case,the target electrons not only be captured into ground and excited states of the projectile ions,but also be ionized to free.Non-radiative capture(NRC)and radiative electron capture(REC)are two competing mechanisms in fast collisions[1].NRC means electron transfer from a bound state of the target to a bound states of the projectile without the emission of radiation;REC is produced with simultaneous the emission of photon for satisfying energy and momentum conservation laws.The physical essence is the competition between the“electron-nucleus”interaction and the“electron-vacuum”interaction.NRC is dominant in collisions of high-Z ions with heavy target atoms at moderate energies.REC entirely determine the electron capture channel for high collision velocities and light targets[1].Measuring the relative strength of the projectile x-ray emission associated with electron capture could determine state-selective population,angular distribution of single capture Ly 1 or double capture Kα1 and Kα2,would provide new detailed information on the dynamics of ion-atom collisions and atomic structure studies[1]. | Yang Bian Yu Deyang Cai Xiaohong Xue Yingli Shao Caojie Wang Wei Liu Junliang Zhang Mingwu Song Zhangyong Wu Yehong Lu Rongchun Ruan Fangfang | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 11 | Glutamate and GABAA receptor crosstalk mediates homeostatic regulation of neuronal excitation in the mammalian brain显示文摘Maintaining a proper balance between the glutamate receptor-mediated neuronal excitation and the A type of GABA receptor(GABAAR)mediated inhibition is essential for brain functioning;and its imbalance contributes to the pathogenesis of many brain disorders including neurodegenerative diseases and mental illnesses.Here we identify a novel glutamate-GABAAR interaction mediated by a direct glutamate binding of the GABAAR.In HEK293 cells overexpressing recombinant GABAARs,glutamate and its analog ligands,while producing no current on their own,potentiate GABA-evoked currents.This potentiation is mediated by a direct binding at a novel glutamate binding pocket located at theα+/β−subunit interface of the GABAAR.Moreover,the potentiation does not require the presence of aγsubunit,and in fact,the presence ofγsubunit significantly reduces the potency of the glutamate potentiation.In addition,the glutamate-mediated allosteric potentiation occurs on native GABAARs in rat neurons maintained in culture,as evidenced by the potentiation of GABAAR-mediated inhibitory postsynaptic currents and tonic currents.Most importantly,we found that genetic impairment of this glutamate potentiation in knock-in mice resulted in phenotypes of increased neuronal excitability,including decreased thresholds to noxious stimuli and increased seizure susceptibility.These results demonstrate a novel cross-talk between excitatory transmitter glutamate and inhibitory GABAAR.Such a rapid and short feedback loop between the two principal excitatory and inhibitory neurotransmission systems may play a critical homeostatic role in fine-tuning the excitation-inhibition balance(E/I balance),thereby maintaining neuronal excitability in the mammalian brain under both physiological and pathological conditions. | Ya Wen Zhifang Dong Jun Liu Peter Axerio-Cilies Yehong Du Junjie Li Long Chen Lu Zhang Lidong Liu Jie Lu Ning Zhou Dong Chuan Wu Yu Tian Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 0 |
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