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| 1 | Distribution characteristics of magnetic susceptibility of the surface sediments in the southern Yellow Sea显示文摘The characteristic distributions of magnetic susceptibility (MS) are analyzed on the basis of susceptibility of 172 surface sediment samples in the southern Yellow Sea (SYS). The preliminary results are as follows: first, the distributions clearly correspond to different modern sediment assemblages in the continental sea, which indicates different sediment origins. With the 30 μCGS isoline being taken as demarcation line, the study area can then be divided into section H (high MS value area) and section L (low MS value area). Section H is mainly adjacent to land with two main sources of the Changjiang River and the Huanghe River.Section L is mainly an eddy sediment area, where Yellow Sea Cold Water is entrenched all the year round. The distribution pattern of MS could tell apart strong or weak hydrodynamic conditions and has a close relation to the circulation system in this area. At the areas of the SYS Circumfluent and northern East China Sea (NECS) Circumfluent (weak hydrodynamic), the MS has low values, while in the areas of Coastal Current (strong hydrodynamic), the values are high.At the same time, the oxidizing areas tend to take on higher MS, while the reducing areas have lower one. It seems safe to say that the MS in the continental sea reflects more of the sediment origin and sedimentary environment, which is different from that of loess, lake and surface soil as a climate proxy. | GE Shulan~(1,2,3), SHI Xuefa~1 & HAN Yibing~1 1. Key Laboratory of Marine Sedimentology and Environmental Geology, First Institute of Oceanography, State Oceanic Administration. Qingdao 266061. China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029. China 3. Graduate School. Chinese Academy of Sciences, Beijing 100039. China | 2003 | Chinese Science Bulletin2003，48，B06： | 8 |
| 2 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 3 | Organic carbon and nitrogen isotopes in surface sediments from the western Arctic Ocean and their implications for sedimentary environments显示文摘 | CHEN Zhihua SHI Xuefa CAI Deling HAN Yibing YANG Zuosheng | 2006 | Acta Oceanologica Sinica2006，25，5： | 4 |
| 4 | Identification of key genes affecting porcine fat deposition based on coexpression network analysis of weighted genes显示文摘Background:Fat deposition is an important economic consideration in pig production.The amount of fat deposition in pigs seriously affects production efficiency,quality,and reproductive performance,while also affecting consumers’choice of pork.Weighted gene co-expression network analysis(WGCNA)is effective in pig genetic studies.Therefore,this study aimed to identify modules that co-express genes associated with fat deposition in pigs(Songliao black and Landrace breeds)with extreme levels of backfat(high and low)and to identify the core genes in each of these modules.Results:We used RNA sequences generated in different pig tissues to construct a gene expression matrix consisting of 12,862 genes from 36 samples.Eleven co-expression modules were identified using WGCNA and the number of genes in these modules ranged from 39 to 3,363.Four co-expression modules were significantly correlated with backfat thickness.A total of 16 genes(RAD9A,IGF2R,SCAP,TCAP,SMYD1,PFKM,DGAT1,GPS2,IGF1,MAPK8,FABP,FABP5,LEPR,UCP3,APOF,and FASN)were associated with fat deposition.Conclusions:RAD9A,TCAP,SMYD1,PFKM,GPS2,and APOF were the key genes in the four modules based on the degree of gene connectivity.Combining these results with those from differential gene analysis,SMYD1 and PFKM were proposed as strong candidate genes for body size traits.This study explored the key genes that regulate porcine fat deposition and lays the foundation for further research into the molecular regulatory mechanisms underlying porcine fat deposition. | Kai Xing Huatao Liu Fengxia Zhang Yibing Liu Yong Shi Xiangdong Ding Chuduan Wang | 2022 | Journal of Animal Science and Biotechnology2022，13，1： | 3 |
| 5 | Transcriptome sequencing analysis for the identification of stable lncRNAs associated with bovine Staphylococcus aureus mastitis显示文摘Background:Staphylococcus aureus(S.aureus)mastitis is one of the most difficult diseases to treat in lactating dairy cows worldwide.S.aureus with different lineages leads to different host immune responses.Long non-coding RNAs(lncRNAs)are reported to be widely involved in the progress of inflammation.However,no research has identified stable lncRNAs among different S.aureus strain infections.In addition,folic acid(FA)can effectively reduce inflammation,and whether the inflammatory response caused by S.aureus can be reduced by FA remains to be explored.Methods:lncRNA transcripts were identified from Holstein mammary gland tissues infected with different concentrations of S.aureus(in vivo)and mammary alveolar cells(Mac-T cells,in vitro)challenged with different S.aureus strains.Differentially expressed(DE)lncRNAs were evaluated,and stable DE lncRNAs were identified in vivo and in vitro.On the basis of the gene sequence conservation and function conservation across species,key lncRNAs with the function of potentially immune regulation were retained for further analysis.The function of FA on inflammation induced by S.aureus challenge was also investigated.Then,the association analysis between these keys lncRNA transcripts and hematological parameters(HPs)was carried out.Lastly,the knockdown and overexpression of the important lncRNA were performed to validate the gene function on the regulation of cell immune response.Results:Linear regression analysis showed a significant correlation between the expression levels of lncRNA shared by mammary tissue and Mac-T cells(P<0.001,R^(2)=0.3517).lncRNAs PRANCR and TNK2-AS1 could be regarded as stable markers associated with bovine S.aureus mastitis.Several HPs could be influenced by SNPs around lncRNAs PRANCR and TNK2-AS1.The results of gene function validation showed PRANCR regulates the mRNA expression of SELPLG and ITGB2 within the S.aureus infection pathway and the Mac-T cells apoptosis.In addition,FA regulated the expression change of DE lncRNA involved in toxin metabolism and inflammation to fight against S.aureus infection.Conclusions:The remarkable association between SNPs around these two lncRNAs and partial HP indicates the potentially important role of PRANCR and TNK2-AS1 in immune regulation.Stable DE lncRNAs PRANCR and TNK2-AS1 can be regarded as potential targets for the prevention of bovine S.aureus mastitis.FA supplementation can reduce the negative effect of S.aureus challenge by regulating the expression of lncRNAs. | Siyuan Mi Yongjie Tang Gerile Dari Yuanjun Shi Jinning Zhang Hailiang Zhang Xueqin Liu Yibing Liu Usman Tahir Ying Yu | 2022 | Journal of Animal Science and Biotechnology2022，13，2： | 2 |
| 6 | Soft-Fauh Diagnosis of Analog Circuit with Tolerance Using FNLP显示文摘 | Zhang Wei Shi Yibing Zhou Longfu | 2010 | Poland:Metrology and Measurement Systems2010，17，5： | 1 |
| 7 | Analog Circuit Fault Diagnosis Using AdaBoost and SVM 显示文摘 | Jingyuan Tang Yibing Shi Longfu Zhou | 2008 | International Conference on Communications Circuits and Systems Fujian China2008，2008，： | 1 |
| 8 | Parameter Selection, Analysis and Evaluation of an Improved Particle Swarm Optimizer with Lead- ership显示文摘 | Longfu Zhou Yibing Shi Yanjun Li | 2010 | Artificial Intelligence Review2010，34，4： | 1 |
| 9 | Parameter selection,analysis and evaluation of an improved particle swarm optimizer with leadership显示文摘 | Longfu Zhou Yibing Shi Yanjun Li | 2010 | Artificial Intelligence Review2010，34，： | 1 |
| 10 | Soft-fault diagnosis of analog circuit with tolerance using FNLP显示文摘 | Wei Zhang Longfu Zhou Yibing Shi | 2010 | Metrology and Measurement Systems2010，，： | 1 |
| 11 | Diafnosis of soft faults in alog integrated circuits based on fractional correlation 显示文摘 | Deng Yong Shi Yibing Zhang Wei | 2012 | Journal of S- Semiconductors2012，33，8： | 1 |
| 12 | The roles of Eu 2+ and Dy 3+ in the blue long-lasting phosphor Sr 2 MgSi 2 O 7 : Eu 2+ , Dy 3+显示文摘 | Chaoshu Shi Yibing Fu Bo Liu Guobin Zhang Yonghu Chen Zeming Qi Xixian Luo | 2006 | Journal of Luminescence2006，，： | 1 |
| 13 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 14 | Soft-Fault Diagnosis of Analog Circuit with Tolerance Using FNLP显示文摘 | Wei Zhang Yibing Shi Longfu Zhou | 2010 | Metrology and Measurement Systems2010，17，3： | 1 |
| 15 | Parameter selection, analysis and evaluation of an improved particle swarm poptimizer with leadershi显示文摘 | Longfu Zhou Yibing Shi Yanjun Li | 2010 | Artificial Intelligence Review2010，34，4： | 1 |
| 16 | The roles of Eu2+ and Dy3+ in the blue long-lasting phosphor Sr2MgSi2O7: Eu2+, Dya+ 显示文摘 | Shi Chaoshu Fu Yibing Liu Bo | 2007 | Limin2007，12，： | 1 |
| 17 | A Selection Strategy of Test Node in Analogy Circuit with Sensitivity显示文摘 | Longfu Zhou Yonghe Hu Ming Zhao Yibing Shi Yi Sun Hong Tang Shuo Li | 2011 | 通讯和计算机(中英文版)2011，8，10： | 1 |
| 18 | CXCL12–CXCR4 contributes to the implication of bone marrow in cancer metastasis显示文摘 | Jingsheng Shi Yibing Wei Jun Xia Siqun Wang Jianguo Wu Feiyan Chen Gangyong Huang Jie Chen | 2014 | Future Oncol2014，，5： | 1 |
| 19 | Time-resolved fluoroimmunoassay for ractopamine in swine tissue显示文摘 | Jianzhong Shen Zhen Zhang Yan Yao Weimin Shi Yibing Liu Suxia Zhang | 2007 | Analytical and Bioanalytical Chemistry2007，，4： | 1 |
| 20 | Combination of Click Chemistry and Enzymatic Ligation for Stable and Efficient Protein Immobilization for Single-Molecule Force Spectroscopy显示文摘Protein immobilization is an essential method for both basic and applied research for protein,and covalent,site-specific attachment is the most desirable strategy.Classic methods typically rely on a heterobifunctional cross-linker,such as N-hydroxysuccinimide(NHS)-linker-maleimide,or a similar two-step process.It utilizes the amino-reactive NHS and the thiolreactive maleimide to conjugate protein to the solid support.However,NHS as a chemical is susceptible to hydrolysis during storage and handling,and maleimide reacts nonspecifically with all cysteines available in the protein,leading to an inconsistent result.To solve these problems,we have developed a method by combining a strain-promoted azide–alkyne cycloaddition(SPAAC)click reaction and an OaAEP1(C247A)-based enzymatic ligation.The method was demonstrated by the successful immobilization of enhanced green fluorescent protein(eGFP),which was visualized by fluorescent imaging.Moreover,the correct folding and stability of the immobilized protein were verified by atomic force microscopy-based single-molecule force spectroscopy(AFM-SMFS)measurement with a high success rate(89%).Finally,the strength of the 1,2,3-triazole linkage from the azide-dibenzocyclooctyne(DBCO)-based SPAAC reaction was quantified with an ultrahigh rupture force>1.7 nN.Thus,this stable,efficient,and site-specific immobilization method can be used for many challenging systems,especially SMFS studies. | Shengchao Shi Ziyi Wang Yibing Deng Fang Tian Qingsong Wu Peng Zheng | 2022 | CCS Chemistry2022，4，2： | 0 |
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