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| 1 | Identification and analysis of type II TGF-β receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells显示文摘我们的以前的研究表明了那根骨头形态基因的蛋白质(BMP-9 ) 9 是最有效的 BMP 之一导致间充质的干细胞(MSC ) 的造骨细胞区别。然而,位于 MSC 的 BMP-9-induced osteogenic 区别下面的分子的机制尚待充分被阐明。在这研究,主导否定(DN ) 类型 II TGF- 受体被构造并且介绍干细胞进 C3H10T1/2,然后,在 vitro 并且在 vivo,试金被执行分析并且识别为 BMP-9-induced 要求的类型 II TGF- 受体成骨。我们发现那三 DN 类型 II TGF-受体, DN-BMPRII , DN-ActRII ,和 DN-ActRIIB ,减少的 BMP-9-induced 碱的磷酸酶(高山)活动,在有约束力的元素( SBE )控制了的 BMP-9-induced Smad 导致了减少记者活动, Smad6 和 Smad7 的减少的 BMP-9-induced 表达式,并且减少在在 vivo 的 vitro 和宫外的骨头形成的 BMP-9-induced 矿化作用,最后导致了减少的骨头群众和不成熟的成骨。这些调查结果强烈建议了那三野类型的 II TGF- 受体, BMPRII, ActRII 和 ActRIIB,可以在 C3H10T1/2 房间的 BMP-9-induced osteogenic 区别起一个功能的作用。然而, C3H10T1/2 干细胞能表示 BMPRII 和 ActRII,然而并非 ActRIIB。用 RNA 干扰(RNAi ) ,我们发现那项酶记者活动和高山活动被 BMP-9 导致了因此被禁止与一起 BMPRII 和 ActRII 击倒。一起拿,我们的结果证明 BMPRII 和 ActRII 是在 C3H10T1/2 房间的 BMP-9-induced osteogenic 区别的功能的类型 II TGF- 受体。 | Ningning Wu Yingze Zhao Yibing Yin Yan Zhang Jinyong Luo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，10： | 20 |
| 2 | Spatial patterns of ephemeral plants in Gurbantünggüt Desert显示文摘In the present research,the authors measured parameters of richness,cover and importance value of ephemeral and ephemeroid plants on south-north and east-west transects in the Gurbantünggüt Desert in early spring,and investigated and analyzed the microhabitats,such as terrain,geomorphology,soil physical-chemical properties and crusts. By comparison,the regional differences in the ephemeral distribution in the desert were revealed. The species of ephemeral plants in the south and center are the richest and those in the west are the poorest in the desert. The cover of ephemeral plants in the mid-south is higher than that in the north,and that in the mid-east is higher than that in the west. The response of ephemeral plants to the spatial variation of the desert habitat forms the population-habitat gradient of ephemeral plants. The characteristics are:(1) In the habitat with higher terrain,coarser textured soil with poorer sorting and correspondingly higher organic matter and lower alkali-saline contents,Carex physoides and Eremopyrum orientale are the dominant ephemeral plants;(2) In the dry habitat with lower terrain,looser textured soil,some organic matter,alkali-saline soil,and developed crust,the ephemeral plants Alyssum linifolium and Erodium oxyrrhynchum are of characteristic of drought and alkali-saline tolerance;(3) In the habitat with lower terrain,some water and more alkali-saline soil,the ephemeral plants Neotorularia torulosa and Hypecoum parviflorum being of alkali-saline tolerance are mainly developed. However,most ephemerals are distributed in a habitat order of higher terrain,some organic,and less alkali-saline soil on the above-mentioned ephemeral population-habitat gradient. The spatial gradient of variation in desert microhabitats is small,and as a whole,the physio-logical character of mesophytism is represented by the desert ephemerals. | QIAN YiBing WU ZhaoNing ZHANG LiYun ZHAO RuiFeng WANG XiaoYan LI YouMin | 2007 | Chinese Science Bulletin2007，52，22： | 16 |
| 3 | Vegetation patterns and species-environment relationships in the Gurbantunggut Desert of China显示文摘Gurbantunggut 沙漠在中国是最大的马厩和半马厩沙沙漠,还很少数据为这些多样的荒芜的风景在植被模式和种类环境关系上存在。调查区域的沙沙丘主要具有 | QIAN Yibing WU Zhaoning ZHAO Ruifeng ZHANG Liyun | 2008 | Journal of Geographical Sciences2008，18，4： | 10 |
| 4 | Spatial heterogeneity for grain size distribution of eolian sand soil on longitudinal dunes in the southern Gurbantunggut Desert显示文摘The grain size composition, distribution characteristics and spatial variation of eolian sand soil on distinct positions across two longitudinal dunes and interdune areas were studied by means of conventional grain size analysis and geostatistical methods. In the study, 184 samples of eolian sand soil from the 0-30cm layer were systemically collected and measured from two longitudinal dunes and interdunes in the southern Gurbantunggut Desert. The results show that the dominant grain sizes are fine and very fine sands, and the differences of grain size compositions between the distinct geomorphologic positions are significant. The contents of clay and silt are highest on the interdune areas and lowest on the crests, and higher on the leeward slopes than on the windward slopes. The contents of very fine and fine sands are highest on the windward slopes and lowest on the crests. The contents of medium, coarse and very coarse sands are lowest on the interdune lands, and highest on the crests, and are identical on the two slopes. The coarser sizes (φ1) and mean sizes (Mz) for eolian sand soil all have a varying tendency from fine to coarse sizes with interdune area → leeward slope → windward slope → crest, and the sorting (σ) are poorly to well sorted. The results of geostatistical analysis reveal that φ1, Mz and σ values are moderately to strongly spatially autocorrelated. The values of the spatially correlated ranges are φ1<σ | Qian, YiBing Wu, ZhaoNing Yang, HaiFeng Jiang, Chao | 2009 | Journal of Arid Land2009，1，1： | 9 |
| 5 | Vegetation-environment Relationships Between Northern Slope of Karlik Mountain and Naomaohu Basin,East Tianshan Mountains显示文摘Based on data from 22 sample plots and applying the Canonical Correspondence Analysis (CCA),this paper discusses the vegetation-environment relationships between the northern slope of Karlik Mountain and Naomaohu Basin,which is situated in the easternmost end of the Tianshan Mountains,Xinjiang Uygur Autonomous Region,China.For the zonal vegetation,community diversity of mountain vegetation is higher than that of the desert vegetation due to environmental factors.The CCA ordination diagram revealed that the composition and distribution of vegetation types are mainly determined by altitude,soil pH and soil salt content.With increasing elevation,the soil pH and total salt content decrease but the contents of soil organic matter,soil water,total nitrogen and total phosphorus increase gradually.In the CCA ordination diagrams,the sample plots and main species can be divided into five types according to their adaptations to the environmental factors.Type I is composed of desert vegetation distributed on the low mountains,hills,plains and deserts below an elevation of 1900 m;type II is distributed in the mountain and desert ecotone with an elevation of 1900-2300 m,and includes steppe desert,desert steppe and wetland meadow;type III is very simply composed of only salinized meadow;type IV is distributed above an elevation of 2300 m,containing mountain steppe,meadow steppe,subalpine meadow and alpine meadow;type V only contains salinized meadow.The results show that with increasing elevation,species combination changes from the xerophytic shrubs,semi-shrubs and herbs distributed in the low altitude zone with arid climate to the cold-tolerant perennial herbs growing in the high altitudinal zone with cold climate. | ZHANG Haiyan QIAN Yibing WU Zhaoning WANG Zhongchen | 2012 | Chinese Geographical Science2012，22，3： | 9 |
| 6 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 7 | China CDC in Action-Hypertension Prevention and Control显示文摘Summary Hypertension contributes to a quarter of all-cause mortality in China.The Chinese government has put forward aims to control and prevent hypertension,and China CDC and other professional public health institutions have carried out a series of related efforts including the promotion of related policies and legislation,the improvement of modifiable risk factors of hypertension in the population,and promoting the National Primary Public Health Services to discover and manage patients with hypertension.China CDC has conducted multiple hypertension-related campaigns such as advocating for salt reduction,weight loss,and increased physical activity.Additionally,on behalf of the Chinese government,China CDC has organized and carried out the construction of national demonstration areas for the comprehensive prevention and control of chronic diseases. | Lei Hou Bo Chen Yibing Ji Baohua Wang Jing Wu | 2020 | China CDC weekly2020，2，40： | 5 |
| 8 | A facile and general approach for the synthesis of fluorescent silica nanoparticles doped with inert dyes显示文摘A general and facile approach was developed for the synthesis of almost monodisperse fluorescent silica nanoparticles (NPs) doped with inert dyes, which are organic fluorophores that are strongly fluorescent but are hydrophobic or lack a covalent binding group. The prepared NPs were mesoporous and the dye molecules were encapsulated in the pores via hydrophobic interaction with the CTAB template. The NPs were stable and highly fluorescent in aqueous solution, and have potential applications in bioanalysis and fluorescence encoding. | MU Xue WU ChuanLiu LAI JinPing CHEN JianBin ZHENG JinSheng LI Chong ZHAO YiBing | 2011 | Chinese Science Bulletin2011，56，31： | 5 |
| 9 | Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer显示文摘Colorectal cancer is one of the leading causes of cancer death worldwide.According to global genomic status,colorectal cancer can be classified into two main types:microsatellite-stable and microsatellite-instable tumors.Moreover,the two subtypes also exhibit different responses to chemotherapeutic agents through distinctive molecular mechanisms.Recently,mitochondrial DNA depletion has been shown to induce apoptotic resistance in microsatellite-instable colorectal cancer.However,the effects of altered mitochondrial DNA copy number on the progression of microsatellite-stable colorectal cancer,which accounts for the majority of colorectal cancer,remain unclear.In this study,we systematically investigated the functional role of altered mitochondrial DNA copy number in the survival and metastasis of microsatellite-stable colorectal cancer cells.Moreover,the underlying molecular mechanisms were also explored.Our results demonstrated that increased mitochondrial DNA copy number by forced mitochondrial transcription factor A expression significantly facilitated cell proliferation and inhibited apoptosis of microsatellitestable colorectal cancer cells both in vitro and in vivo.Moreover,we demonstrated that increased mitochondrial DNA copy number enhanced the metastasis of microsatellite-stable colorectal cancer cells.Mechanistically,the survival advantage conferred by increased mitochondrial DNA copy number was caused in large part by elevated mitochondrial oxidative phosphorylation.Furthermore,treatment with oligomycin significantly suppressed the survival and metastasis of microsatellite-stable colorectal cancer cells with increased mitochondrial DNA copy number.Our study provides evidence supporting a possible tumor-promoting role for mitochondrial DNA and uncovers the underlying mechanism,which suggests a potential novel therapeutic target for microsatellite-stable colorectal cancer. | Xiacheng Sun Lei Zhan Yibing Chen Gang Wang Linjie He Qian Wang Feng Zhou Fang Yang Jin Wu Yousheng Wu Jinliang Xing Xianli He Qichao Huang | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 3 |
| 10 | Vegetation composition and distribution on the northern slope of Karlik Mountain to Naomaohu basin,East Tianshan Mountains显示文摘This paper reports the characteristics of plant flora in the region of the northern slope of Karlik Mountain to Naomaohu basin,based on field investigation of the vegetation and referring to relevant literature. The results show that the flora of the study area mainly consists of communities of single species or a limited number of species,genera and families. The flora composition is marked by the phenomenon of dominant families and genera;the temperate element occupies a dominant position,while in terms of the genera the Tethys element is an important component. Areal-types of the species are dominated by the floral element of Asian Central-part with xerophytic characteristic,and the life-forms of plants are mainly perennial and herbaceous. These characteristics reflect that the compositions of the species in this region possess both ancient and young elements. Analysis of the relationship between the species composition,plant community diversity and altitude gradient,we found that the structure of the vegetation has an obvious vertical distribution. The lower and higher altitude areas,where the climate conditions are relative inclement,are mainly occupied by the plant communities with simple structure and single dominant population,while the species richness in the mid-altitude area increases with favorable temperature and precipitation. Consequently,the species diversity and evenness indices show single-peak distribution with increasing elevation(about < 2500 m) ,while the dominance indices decrease in elevation from 500 m to 2500 m and increase in elevation of > 2500m. | YiBing QIAN HaiYan ZHANG ZhaoNing WU ZhongChen WANG | 2011 | Journal of Arid Land2011，3，1： | 3 |
| 11 | Weighted Sparse Image Classification Based on Low Rank Representation显示文摘The conventional sparse representation-based image classification usually codes the samples independently,which will ignore the correlation information existed in the data.Hence,if we can explore the correlation information hidden in the data,the classification result will be improved significantly.To this end,in this paper,a novel weighted supervised spare coding method is proposed to address the image classification problem.The proposed method firstly explores the structural information sufficiently hidden in the data based on the low rank representation.And then,it introduced the extracted structural information to a novel weighted sparse representation model to code the samples in a supervised way.Experimental results show that the proposed method is superiority to many conventional image classification methods. | Qidi Wu Yibing Li Yun Lin Ruolin Zhou | 2018 | Computers, Materials & Continua2018，，7： | 2 |
| 12 | Combination therapy of thiamine,vitamin C and hydrocortisone in treating patients with sepsis and septic shock:a meta-analysis and trial sequential analysis显示文摘Background:The objective of this study was to evaluate the clinical efficacy of thiamine and vitamin C with or without hydrocortisone coadministration on the treatment of sepsis and septic shock.Methods:MEDLINE,EMBASE and CENTRAL databases were searched for randomized controlled trials(RCTs)that made a comparative study between the combination therapy of vitamin C and thiamine with or without hydrocortisone and the administration of placebo in patients with sepsis or septic shock.Two reviewers independently performed study selection,data extraction and quality assessment.Both short-term mortality and change in the sequential organ failure assessment(SOFA)score from baseline(delta SOFA)were set as the primary outcomes.Secondary endpoints included intensive care unit(ICU)mortality,new onset of acute kidney injury,total adverse events,ICU and hospital length of stay,duration of vasopressor usage and ventilator-free days.Meanwhile,trial sequential analysis was conducted for primary outcomes.Results:Eight RCTs with 1428 patients were included in the current study.The results showed no significant reduction of short-term mortality in sepsis and septic shock patients who received combination therapy of vitamin C and thiamine with or without hydrocortisone compared to those with placebo{risk ratio(RR),1.02[95%confidence interval(CI),0.87 to 1.20],p=0.81,I2=0%;risk difference(RD),0[95%CI,−0.04 to 0.05]}.Nevertheless,the combination therapy was associated with significant reduction in SOFA score[mean difference(MD),−0.63,(95%CI,−0.96 to−0.29,p<0.001,I^(2)=0%]and vasopressors duration(MD,−22.11[95%CI,−30.46 to−13.77],p<0.001,I2=6%).Additionally,there were no statistical differences in the pooled estimate for other outcomes.Conclusions:In the current meta-analysis,the combination therapy of vitamin C and thiamine,with or without hydrocortisone had no impact on short-term mortality when compared with placebo,but was associated with significant reduction in SOFA score among patients with sepsis and septic shock. | Renqi Yao Yibing Zhu Yue Yu Zhixuan Li Lixue Wang Liyu Zheng Jingyan Li Huibin Huang Guosheng Wu Feng Zhu Zhaofan Xia Chao Ren Yongming Yao | 2021 | Burns & Trauma2021，9，1： | 2 |
| 13 | Phosphorus Efficacy in Four Chinese Long-Term Experiments with Different Soil Properties and Climate Characteristics显示文摘 | Linping Zhao Yibing Ma Guoqing Liang Shutian Li Lishu Wu | 2009 | Communications in Soil Science and Plant Analysis . 2009 (19-2)2009，，19： | 1 |
| 14 | Genomic amplification of the human telomerase RNA gene for differential diagnosis of cervical disorders显示文摘 | Zheng Tu Aipeng Zhang Ruifang Wu Jing Jiang Yali Li Na Wulan Jingran Li Yongmei Zhang Yibing Li Zhong Chen Lihui Wei | 2009 | Cancer Genetics and Cytogenetics2009，，1： | 1 |
| 15 | Responses of ground-dwelling spiders to four hedgerow species on sloped agricultural fields in Southwest China显示文摘Spiders are important predators in agroecosystems and contribute to the control of agricultural pest populations. Habitat manage- ment such as the creation of new semi-natural habitats around or within fields enhances spider abundance and species diversity. Using pitfall traps, we investigated the effects of four hedgerow plant species, which serve as undisturbed and permanent semi-natural habitats, on ground-dwelling spider activity density (a parameter of population density and relative activity) and species richness. Samples were collected over two winter wheat and two summer maize growing seasons during 2005-2007 in trial field 1 (slope gradient of 20%) and field 2 (slope gradient of 12%) at the Ziyang Experimental Site in Sichuan Province, China. The hedgerow species evaluated were Amorpha fruticosa (field 1), Vetiveria zizanioides (field 1), Eulaliopsis binata (field 2), and Medicago sativa (field 2). Compared to control plots, hedgerow plots had significantly higher activity density and species richness of ground-dwelling spiders within strips in both fields 1 and 2 during the wheat growing season. The presence of hedgerow strips did not augment the activity density and species richness of ground-dwelling spiders within the crop fields during the wheat or maize growing seasons. The ground-dwelling spider activity density within hedgerow strips was significantly higher in the Vetiveria than in the Amorpha plots and in the Medicago than in the Eulaliopsis plots, and the species richness was significantly higher in the Vetiveria than in the Amorpha plots during the wheat season. Our results suggest that hedgerows may serve as important overwintering sites for ground-dwelling spiders during the wheat growing season. In addition, the diversification of agroecosystems by using hedgerow strips may be a viable strategy for maintaining ground-dwelling spider populations in agricultural areas. However, ground-dwelling spiders did not move into adjacent crop fields; therefore, future work should address the mechanisms of attracting spiders into crop fields, thereby contributing to the bio-control of pests. | Yuhong Wu Qingnian Cai Chaowen Lin Yibing Chen Yuying Li Xu Cheng | 2009 | Progress in Natural Science:Materials International2009，19，3： | 1 |
| 16 | Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis显示文摘 | Yibing Yao Yu Fan Jun Wu Haisu Wan Jing Wang Stephen Lam Wan L. Lam Luc Girard Adi F. Gazdar Zhihao Wu Qinghua Zhou | 2012 | Biochemical and Biophysical Research Communications2012，，3： | 1 |
| 17 | 显示文摘 | Wu Long Chen hualing Xu Yibing | 2005 | Mechanical Science and Technology2005，24，6： | 1 |
| 18 | Recognition and processing of cisplatin- and oxaliplatin-DNA adducts显示文摘 | Stephen G. Chaney Sharon L. Campbell Ekaterina Bassett Yibing Wu | 2004 | Critical Reviews in Oncology and Hematology2004，，1： | 1 |
| 19 | Damage and recovery of the Gurbantunggut Desert vegetation following engineering activities显示文摘 | Yibing Qian Liyun Zhang Zhaoning Wu | 2002 | Science in China Series D: Earth Sciences2002，，1： | 1 |
| 20 | Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome显示文摘Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation.In an effort to unravel the basic principle underlying genome folding,here we focus on the genome itself and report a fundamental role for L1(LINE1 or LINE-1)and B1/Alu retrotransposons,the most abundant subclasses of repetitive sequences,in chromatin compartmentalization.We find that homotypic clustering of L1 and B1/Alu demarcates the genome into grossly exclusive domains,and characterizes and predicts Hi-C compartments.Spatial segregation of L1-rich sequences in the nuclear and nucleolar peripheries and B1/Alu-rich sequences in the nuclear interior is conserved in mouse and human cells and occurs dynamically during the cell cycle.In addition,de novo establishment of L1 and B1 nuclear segregation is coincident with the formation of higher-order chromatin structures during early embryogenesis and appears to be critically regulated by L1 and B1 transcripts.Importantly,depletion of L1 transcripts in embryonic stem cells drastically weakens homotypic repeat contacts and compartmental strength,and disrupts the nuclear segregation of L1-or B1-rich chromosomal sequences at genome-wide and individual sites.Mechanistically,nuclear co-localization and liquid droplet formation of L1 repeat DNA and RNA with heterochromatin protein HP1αsuggest a phase-separation mechanism by which L1 promotes heterochromatin compartmentalization.Taken together,we propose a genetically encoded model in which L1 and B1/Alu repeats blueprint chromatin macrostructure.Our model explains the robustness of genome folding into a common conserved core,on which dynamic gene regulation is overlaid across cells. | J.Yuyang Lu Lei Chang Tong Li Ting Wang Yafei Yin Ge Zhan Xue Han Ke Zhang Yibing Tao Michelle Percharde Liang Wang Qi Peng Pixi Yan Hui Zhang Xianju Bi Wen Shao Yantao Hong Zhongyang Wu Runze Ma Peizhe Wang Wenzhi Li Jing Zhang Zai Chang Yingping Hou Bing Zhu Miguel Ramalho-Santos Pilong Li Wei Xie Jie Na Yujie Sun Xiaohua Shen | 2021 | Cell Research2021，31，6： | 1 |
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