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| 1 | Predicting geological hazards during tunnel construction显示文摘The complicated geological conditions and geological hazards are challenging problems during tunnel construction,which will cause great losses of life and property.Therefore,reliable prediction of geological defective features,such as faults,karst caves and groundwater,has important practical significances and theoretical values.In this paper,we presented the criteria for detecting typical geological anomalies using the tunnel seismic prediction(TSP) method.The ground penetrating radar(GPR) signal response to water-bearing structures was used for theoretical derivations.And the 3D tomography of the transient electromagnetic method(TEM) was used to develop an equivalent conductance method.Based on the improvement of a single prediction technique,we developed a technical system for reliable prediction of geological defective features by analyzing the advantages and disadvantages of all prediction methods.The procedure of the application of this system was introduced in detail.For prediction,the selection of prediction methods is an important and challenging work.The analytic hierarchy process(AHP) was developed for prediction optimization.We applied the newly developed prediction system to several important projects in China,including Hurongxi highway,Jinping II hydropower station,and Kiaochow Bay subsea tunnel.The case studies show that the geological defective features can be successfully detected with good precision and efficiency,and the prediction system is proved to be an effective means to minimize the risks of geological hazards during tunnel construction. | Shucai Li Shuchen Li Qingsong Zhang Yiguo Xue Bin Liu Maoxin Su Zhechao Wang Shugang Wang | 2010 | Journal of Rock Mechanics and Geotechnical Engineering2010，2，3： | 25 |
| 2 | PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation显示文摘A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are unclear. Here we show that the M2 isoform of pyruvate kinase (PKM2), one of the rate-limiting enzymes in glycolysis, interacts with mitofusin 2 (MFN2), a key regulator of mitochondrial fusion, to promote mitochondrial fusion and OXPHOS, and attenuate glycolysis. mTOR increases the PKM2:MFN2 interaction by phosphorylating MFN2 and thereby modulates the effect of PKM2: MFN2 on glycolysis, mitochondrial fusion and OXPHOS. Thus, an mTOR-MFN2-PKM2 signaling axis couples glycolysis and OXPHOS to modulate cancer cell growth. | Tong Li Jinbo Han Liangjie Jia Xiao Hu Liqun Chen Yiguo Wang | 2019 | Protein & Cell2019，10，8： | 10 |
| 3 | Air-sea heat flux exchange over the South China Sea under different weather conditions before and after southwest monsoon onset in 2000显示文摘With the data observed from the Second SCS Air-Sea Flux Experiment on the Xisha air-sea flux research tower, the radiation budget, latent, sensible heat fluxes and net oceanic heat budgetswere caculated before and after summer monsoon onset. It is discovered that, after summer monsoononset, there are considerable changes in air-sea fluxes, especially in latent heat fluxes and net oceanicheat budget. Furthermre, the analyzed results of five synoptic stages are compared. And the character-istics of the flux transfer during different stages around onset of South China Sea monsoon are discussed.The flux change shows that there is an oceanic heat accumulating process during the pre-onset and thebreak period, as same as oceanic heat losing process during the onset period. Moreover, latent fluxes,the water vapor moving to the continent, even the rainfall appearance in Chinese Mainland also can beinfluenced by southwester. Comparing Xisha fluxes with those obtained from the Indian Ocean and thewestern Pacific Ocean, their differences may be obeerved. It is the reason why SSTs can keep stableover the South China Sea while they decrease quickly over the Arabian Sea and the Bay of Bengal aftermonsoon onset. | Junyue Yan, Huadong Yao, Jianglong Li, Zhiyi Tang, Guorong Jiang, Wenyu Sha, Xunqiang Li, Yiguo Xiao National Climate Center, Beijing 100081, China. E-mail: yanjy@cma.gov.cnPLA University of Science Technology, Nanjing 211101, China | 2003 | Acta Oceanologica Sinica2003，22，3： | 8 |
| 4 | Application of GA-SVM in classification of surrounding rock based on model reliability examination显示文摘In order to improve the discrimination precision of support vector machine(SVM) in classification of surrounding rock, a Genetic Algorithm(GA) was used to optimize SVM parameters in the solution space.The idea of examination of model reliability was introduced to check the reliability of the SVM parameters,obtained by genetic algorithms.In the process of model reliability,a trend examination method is presented,which checks the reliability of the model via the influence trend of impact factors on the object of evaluation and their evaluation level.Trend examination methods are universal,showing new ideas in model reliability examination and can be used in any problems of examination of reliability of models,based on previous experience.We established a GA-SVM based reliability model of a classification the surrounding rock and applied it to a practical engineering situation.The result shows that the improved SVM has a high capability for generalization and prediction accuracy in classification of surrounding rock. | QIU Daohong LI Shucai ZHANG Lewen XUE Yiguo | 2010 | Mining Science and Technology2010，20，3： | 6 |
| 5 | Tunable near-infrared plasmonic perfect absorber based on phase-change materials显示文摘A tunable plasmonic perfect absorber with a tuning range of 650 nm is realized by introducing a 20 nm thick phase-change material Ge2Sb2Te5 layer into the metal–dielectric–metal configuration.The absorption at the plasmonic resonance is kept above 0.96 across the whole tuning range.In this work we study this extraordinary optical response numerically and reveal the geometric conditions which support this phenomenon.This work shows a promising route to achieve tunable plasmonic devices for multi-band optical modulation,communication,and thermal imaging. | Yiguo Chen Xiong Li Xiangang Luo Stefan AMaier Minghui Hong | 2015 | Photonics Research2015，3，3： | 5 |
| 6 | Effect of electronic stimulation at Neiguan(PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia显示文摘OBJECTIVE:To investigate the effects of electronic stimulation at acupoints Neiguan(PC 6) and Lieque(LU 7) on the gene expression of the adenosine triphosphate(ATP)-Sensitive potassium channel(KATP:Kir6.1,Kir6.2,SUR2 A,and SUR2B) and protein kinases(PKA,PKG,and PKCβ2) in myocardial cells of rats with myocardial ischemia(Ml) induced by isoproterenol(ISO).METHODS:Rats were randomly divided into a control,model,Neiguan(PC 6),Lieque(LU 7),and non-acupoint groups.The Ml model was established by injecting rats with ISO.Electro-acupuncture treatment was given to the acupuncture groups,once a day for 7 days.Gene expression was analyzed with real-time PCR.RESULTS:The gene expression of KATP and protein kinases in the model group was higher than those in the control group(P < 0.05).After acupuncture treatment,the KATP and protein kinase expression levels were significantly lower in the Neiguan(PC 6)and Lieque(LU 7) groups compared with the model group[P < 0.05).The Neiguan(PC 6) group lowered these levels significantly more than that of the Lieque(LU 7) group(P < 0.05).No significant differences were observed between the model and non-acupoint groups(P > 0.05).CONCLUSION:Our findings suggest that electronic needling of Neiguan(PC 6) can both reduce the gene expression of KATP and protein kinases in rats with ISO-induced Ml. | Wang Wei Li Jiquan Meng Xiangyu Chen Yiguo | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 4 |
| 7 | An Optimal Control Strategy for Multi-UAVs Target Tracking and Cooperative Competition显示文摘An optimal control strategy of winner-take-all(WTA)model is proposed for target tracking and cooperative competition of multi-UAVs(unmanned aerial vehicles).In this model,firstly,based on the artificial potential field method,the artificial potential field function is improved and the fuzzy control decision is designed to realize the trajectory tracking of dynamic targets.Secondly,according to the finite-time convergence high-order differentiator,a double closed-loop UAV speed tracking the controller is designed to realize the speed control and tracking of the target tracking trajectory.Numerical simulation results show that the designed speed tracking controller has the advantages of fast tracking,high precision,strong stability and avoiding chattering.Finally,a cooperative competition scheme of multiple UAVs based on WTA is designed to find the minimum control energy from multiple UAVs and realize the optimal control strategy.Theoretical analysis and numerical simulation results show that the model has the fast convergence,high control accuracy,strong stability and good robustness. | Yiguo Yang Liefa Liao Hong Yang Shuai Li | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，12： | 4 |
| 8 | Fasting-induced hormonal regulation of lysosomal function显示文摘 | Chen, Liqun Wang, Ke Long, Aijun Jia, Liangjie Zhang, Yuanyuan Deng, Haiteng Li, Yu Han, Jinbo Wang, Yiguo | 2017 | Cell Research2017，27，6： | 3 |
| 9 | Comparative WGBS identifies genes that influence non-ripe phenotype in tomato epimutant Colourless non-ripening显示文摘Whole-genome bisulfite sequencing(WGBS)allows single-base resolution and genome-wide profiling of DNA methylation in plants and animals.This technology provides a powerful tool to identify genes that are potentially controlled by dynamic changes of DNA methylation and demethylation.However,naturally occurring epimutants are rare and genes under epigenetic regulation as well as their biological relevances are often difficult to define.In tomato,fruit development and ripening are a complex process that involves epigenetic control.We have taken the advantage of the tomato epimutant Colourless non-ripening(Cnr)and performed comparative mining of the WGBS datasets for the Cnr and Sl CMT3-silenced Cnr fruits.We compared DNA methylation profiles for the promoter sequences of approximately 5,000 bp immediately upstream of the coding region of a list of20 genes.Differentially methylated regions were found for some of these genes.Virus-induced gene silencing(VIGS)of differentially methylated gene Sl DET1 or Sl PDS resulted in unusual brown pigmentation in Cnr fruits.These results suggest that comparative WGBS coupled with VIGS can be used to identify genes that may contribute to the colourless unripe phenotype of fruit in the Cnr epimutant. | Weiwei Chen Zhiming Yu Junhua Kong Hui Wang Yichen Li Mei Zhao Xiaohong Wang Qianqian Zheng Nongnong Shi Pengcheng Zhang Silin Zhong Paul Hunter Mahmut Tor Yiguo Hong | 2018 | Science China(Life Sciences)2018，61，2： | 3 |
| 10 | A new evaluation method for site selection of large underground water-sealed petroleum storage depots显示文摘Scientific site selection is the first step in constructing underground water-sealed petroleum storage depots, but no uniform standard and code for such activity has been established. Therefore, the main objective of this study is to propose an evaluation method for the site selection of an underground water-sealed petroleum storage depot. The first large underground water-sealed petroleum storage depot being built in China served as the background of this study. The following 12 indexes were used as evaluation factors based on comprehensive evaluation criteria and specifications for key project site selection: geographic structure development feature, topographic feature, lithostratic formation feature, crustal stress, strength of rock mass, joint development feature, hydrogeological conditions, long-term water sealing conditions, environmental/ecological vulnerability, regional stability, technical and economic conditions, and meteorological and hydrological conditions. The weight back analysis and power coefficient methods were also used to evaluate the site selected for the first underground water-sealed petroleum storage depot project. Petroleum site classification models based on the two aforementioned methods were established and used to verify the feasibility of the evaluation criteria and methods, and the evaluation results show the grade of the site selected for the underground water-sealed petroleum storage depot in Huangdao, China is good. The study results may be used as a reference for the site selection of future underground water-sealed petroleum storage depots. | XUE YiGuo LI ShuCai QIU DaoHong WANG ZheChao LI ZhiQiang TIAN Hao SU MaoXin YANG Wei Min LIN ChunJin ZHU JianYe | 2015 | Science China(Technological Sciences)2015，58，6： | 2 |
| 11 | Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating C-X-C motif chemokine receptor 4显示文摘Background:We previously found that overexpression of the gene known as amplified in breast cancer 1(AIB1)was associated with lymph node metastasis and poor prognosis in patients with lung adenocarcinoma.However,the role of AIB1 in that malignancy remains unknown.The present study aimed to investigate the function of AIB1 in the process of lung adenocarcinoma cell metastasis.Methods:A series of in vivo and in vitro assays were performed to elucidate the function of AIB1,while real-time PCR and Western blotting were utilized to identify the potential downstream targets of AIB1 in the process of lung adenocarcinoma metastasis.Rescue experiments and in vitro assays were performed to investigate whether the invasive-ness of AIB1-induced lung adenocarcinoma was mediated by C-X-C motif chemokine receptor 4(CXCR4).Results:The ectopic overexpression of AIB1 in lung adenocarcinoma cells substantially enhanced cell migration and invasive abilities in vitro and tumor metastasis in vivo,whereas the depletion of AIB1 expression substantially inhibited lung adenocarcinoma cell migration and invasion.CXCR4 was identified as a potential downstream target of AIB1 in lung adenocarcinoma.The knockdown of AIB1 greatly reduced CXCR4 gene expression at both the transcription and protein levels,whereas the knockdown of CXCR4 in cells with AIB1 ectopic overexpression diminished AIB1-induced migration and invasion in vitro and tumor metastasis in vivo.Furthermore,we found a significant positive association between the expression of AIB1 and CXCR4 in lung adenocarcinoma patients(183 cases),and the co-overexpression of AIB1 and CXCR4 predicted the poorest prognosis.Conclusions:These findings suggest that AIB1 promotes the aggressiveness of lung adenocarcinoma in vitro and in vivo by upregulating CXCR4 and that it might be usable as a novel prognostic marker and/or therapeutic target for this disease. | Liru He Haixia Deng Shiliang Liu Jiewei Chen Binkui Li Chenyuan Wang Xin Wang Yiguo Jiang Ningfang Ma Mengzhong Liu Dan Xie | 2018 | Cancer Communications2018，38，1： | 2 |
| 12 | Phylogenetic Diversity and Ecological Pattern of Ammonia-oxidizing Archaea in the Surface Sediments of the Western Pacific显示文摘 | CAO HUILUO HONG YIGUO LI MENG GU JIDONG | 2011 | Micrnbial Ecology2011，62，： | 1 |
| 13 | Offset-free fuzzy model predictive control of a boiler-turbine system based on genetic algorithm显示文摘 | LI Yiguo SHEN Jiong Lee K Y | 2012 | Simulation Modelling Practice and Theory2012，26，1： | 1 |
| 14 | A comparison of primer sets for detecting 16S rRNA and hydrazine oxidoreductase genes of anaerobic ammonium-oxidizing bacteria in marine sediments显示文摘 | Meng Li Yiguo Hong Martin Gunter Klotz Ji-Dong Gu | 2010 | Applied Microbiology and Biotechnology2010，，2： | 1 |
| 15 | Spatial distribution and abundances of ammonia-oxidizing archaea(AOA) and ammonia- oxidizing bacteria (AOB) in mangrove sediments 显示文摘 | Li Meng Cao Huiluo Hong Yiguo | 2011 | Applied Mi- crobiology and Bioteehnology2011，89，4： | 1 |
| 16 | GA-based nonlinear predictive switching control for a boiler-turbine system显示文摘In this paper, the problem of designing a controller for a highly coupled constrained nonlinear boilerturbine system is addressed with a predictive controller. First, a nonlinear predictive control is implemented by genetic algorithm. Second, to guarantee fast output stabilization, an H-infinity fuzzy state-feedback tracking control is applied with a designed switching principle. The success of such a control structure is based on taking advantage of the optimal input sequence derived from the nonlinear predictive control based on artificial intelligent while ensuring a fast decay of the steady state error. Simulation results of the proposed design are given to illustrate its effectiveness and compared to other control schemes. | Jie WU Jiong SHEN Mattias KRUG Sing Kiong NGUANG Yiguo LI | 2012 | 控制理论与应用(英文版)2012，10，1： | 1 |
| 17 | China starts the world’s hardest “Sky-High Road” project: Challenges and countermeasures for Sichuan-Tibet railway显示文摘InChina,a new“epic project”named theSichuan-Tibet railway linkingChengdu and Lhasa is in the construction phase.This 1,592-km-long railway passes through the western Sichuan basin,subsequently climbing 5,000 m and running across the“roof of the world”Tibet plateau,which is dubbed the“Sky-High Road”(Figure 1). | Yiguo Xue Fanmeng Kong Shucai Li Qingsong Zhang Daohong Qiu Maoxin Su Zhiqiang Li | 2021 | The Innovation2021，2，2： | 1 |
| 18 | 显示文摘 | Su Yiguo Li Liping Li Guangshe | 2008 | Chem Mater2008，20，19： | 1 |
| 19 | Diversity and abundance of ammonia-oxidizing archaea and bacteria in polluted mangrove sediment显示文摘 | Huiluo Cao Meng Li Yiguo Hong Ji-Dong Gu | 2011 | Systematic and Applied Microbiology2011，，7： | 1 |
| 20 | Depletion ofPHF14, a novel histone-binding protein gene, causes neonatal lethality in mice due to respiratory failure显示文摘植物 homeodomain (哲学博士) 手指在许多染色质绑定蛋白质被识别,并且作为 recognizesspecific epigenetic 在 histone 尾巴上标记的一个阅读器工作,衔接到染色质的抄写因素和他们的联系建筑群, andregulating 基因表示。哲学博士包含手指的蛋白质执行许多生物功能并且包括癌症涉及许多 humandiseases。PHF14 用多重哲学博士手指为蛋白质被预言到代码。然而,它的功能是未辩别出的。这 studyis 到的目的描绘 PHF14 并且由包括老鼠 gene-targetingknockout,并且分子的克隆和描述采用多重途径调查它的生物意义。在人的房间行的 PHF14 的三个抄本被反向的 transcriptase 聚合酶链反应识别。PHF14 (PHF14 和 PHF14 ) 的二 isoforms 在这研究被克隆。PHF14 无所不在地在老鼠纸巾和人的房间行被表示,这被发现。PHF14, PHF14 的主要 isoform,在原子核是局部性的并且也在房间分割期间跳了到染色质。有趣地, co-immunoprecipitation 结果建议 PHF14 经由它的哲学博士手指跳了到 histones。惊人地,在老鼠的 PHF14 的指向基因的大美人由于呼吸失败导致了新生的致命性。病理学的分析在多重机关揭示了 tissueand 房间结构的严重混乱,特别地在肺。这些结果显示 PHF14 可能是 epigeneticregulator 并且在鼠标在多重机关的开发起一个重要作用。 | Qin Huang Lin Zhang Yiguo Wang Chenyi Zhang Shuhua Zhou Guang Yang Zhongqiang Li Xiang Gao Zhengjun Chen Zhe Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 1 |
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