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| 1 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 2 | Shading during the grain filling period increases 2-acetyl-1-pyrroline content in fragrant rice显示文摘 | Zhaowen Mo Wu Li Shenggang Pan Timothy L Fitzgerald Feng Xiao Yongjian Tang Yilei Wang Meiyang Duan Hua Tian Xiangru Tang | 2015 | Rice2015，，1： | 1 |
| 3 | Impact of typhoon Lekima(2019)on material transport in Laizhou Bay using Lagrangian coherent structures显示文摘Typhoon has an impact on an estuary and coastal environment.However,the present research lacks the detailed description of material transport processes during typhoon passage,such as the transport channels and barriers in the course of material transport and material accumulation area,etc.Therefore,Lagrangian coherent structures(a method developed for describing the transport structure of fluids in recent years)was introduced to investigate and predict the floating material and debris transport process in the Laizhou Bay,Bohai Sea,during typhoon Lekima in 2019.Results show that the Lagrangian coherent structure could well explain the complex flow phenomena in the bay.During the typhoon,the general direction of floating material transport in the Laizhou Bay was anticlockwise.There was a channel for material transport in the northwest and south of the bay,and there are transportation obstacles in the northeast-southwest direction in the middle of the bay.Therefore,the typhoon might worsen the water quality.These results provide references for precise countermeasures to control the formulation of pollution in the Laizhou Bay. | Qi LOU Zhengyan LI Yanwei ZHANG Yilei FENG Xueqing ZHANG | 2022 | Journal of Oceanology and Limnology2022，40，3： | 1 |
| 4 | Optimization of Chinese solar greenhouse building parameters based on CFD simulation and entropy weight method显示文摘The building parameters of Chinese solar greenhouse(CSG)directly affect the front roof lighting and indoor thermal environment.In order to obtain the optimal parameter combination,a building parameter optimization method based on computational fluid dynamics(CFD)simulation and entropy weight method was proposed.Firstly,a three-dimensional thermal and humidity environment model of CSG was constructed considering the coupling effect of soil,crop,and back wall based on CFD.The reliability of the model was validated through experiments in a CSG of Yongqing County,Hebei Province of China.Then,the indoor air temperature rise rate,air temperature and humidity uneven coefficient,and average air temperature and humidity were selected as the evaluation indicators of CSG thermal and humidity environment.The ridge height,back wall height and the horizontal projection of back roof of CSG were selected as the three factors of the orthogonal test plan,and a three-factor and four-level plan was designed,resulting in 16 different parameter combinations.By use of CFD simulation,the thermal and humidity environment evaluation indicators under different parameter combinations were calculated.The entropy weight method was used to assign weights to the evaluation indicators,and the comprehensive evaluation indicators of CSG thermal and humidity environment were obtained based on the linear weighting principle.By comparing comprehensive evaluation indicators,the optimal combination of building parameters was obtained with a ridge height of 5.72 m,a back wall height of 3.2 m,and a horizontal projection of 2.1 m on the back roof.The research results can provide a practical and feasible method for optimizing the building parameters of CSG,and provided theoretical guidance for the structural design and optimization of CSG. | Fen He Changqing Si Xiaoming Ding Zhenjun Gao Binbin Gong Fei Qi Yilei Yin Qian Feng | 2023 | International Journal of Agricultural and Biological Engineering2023，16，6： | 0 |
| 5 | Molecular characterization,expression patterns,and subcellular localization of a classical and a novel nonclassical MHC class Iαmolecules from Japanese eel Anguilla japonica显示文摘Major histocompatibility complex(MHC)molecules play a critical role in the immune response of vertebrate animals by presenting foreign antigens to T lymphocytes.In this study,we first cloned and identified a classical and a novel nonclassical MHC Iαmolecules from Japanese eel(Anguilla japonica),named as AjMHC I-UBA and AjMHC I-L,respectively.The full-length cDNA of AjMHC I-UBA contains an open reading frame(ORF)of 1047 bp encoding a predicted protein of 348 amino acids,while AjMHC I-L 1089 bp encodes 362 amino acids.The multiple alignment of the amino acid sequence showed that AjMHC I-UBA and AjMHC I-L consist of an N-terminal MHC I superfamily domain withinα1 andα2 helices,an IgC-MHC Iα3 domain,and a transmembrane region close to the C-terminal,which are similar to other fish and mammal species.Molecular polymorphism analysis showed that eight different major alleles of AjMHC I-UBA,named as AjMHC I-UBA*0101~1001,were identified from six Japanese eel individuals.Furthermore,a distinguishing signature of the nonclassical L-lineage genes specific motif“HINMTL”,including an N-glycosylation site(NXS/T),was present in theα3 domain of AjMHC I-L sequences.Although the predicted three-dimensional structures of AjMHC I-UBA and AjMHC I-L are similar to that of human MHC Iα,phylogenetic analysis showed that these two protein molecules belong to classical MHC I UBA gene of U-lineage and nonclassical MHC I gene of L-lineage,respectively.Quantitative real-time polymerase chain reaction(qRT-PCR)analysis revealed that the highest expression of AjMHC I-UBA and AjMHC I-L was found in the intestine and the expression level of AjMHC I-UBA in all of the examined tissues was significantly higher than that of AjMHC I-L.The expressions of AjMHC I-UBA and AjMHC I-L in liver,kidney and spleen were significantly induced following injection with the viral mimic poly I:C,LPS,and Aeromonas hydrophila infection.In vitro,the AjMHC I-UBA and AjMHC I-L transcripts of Japanese eel liver cells were significantly enhanced by the treatment of poly I:C or the stimulation of the high concentration of A.hydrophila.Subcellular localization showed that under natural conditions,AjMHC I-UBA and AjMHC I-L were uniformly distributed in the cytoplasm,and aggregated into spots or flakes in the cytoplasm after the stimulation of poly I:C or LPS.These results collectively suggested that AjMHC I-UBA and AjMHC I-L are important components possibly involved in Japanese eel defense against viral and bacterial infection.Taken together,these findings provide valuable insight into the immune function of MHC class I in the immune system of teleost. | Jianjun Feng Xinwei Peng Peng Lin Yilei Wang Ziping Zhang Yuankai Xu Pengyun Chen Jingying Wu | 2023 | Aquaculture and Fisheries2023，8，2： | 0 |
| 6 | Erratum to:Impact of typhoon Lekima(2019)on material transport in Laizhou Bay using Lagrangian coherent structures显示文摘Erratum to:http://gffzzd3cc09b8251d45dfsn5f5u5vub9bv60kf.ffgz.tsg.suse.edu.cn/10.1007/s00343-021-0384-7 The authors’affiliations of this article contain a few mistakes.The correct ones are given below:1 College of Environmental Science and Engineering,Ocean University of China,Qingdao 266100,China 2 Key Laboratory of Marine Environment and Ecology,Ministry of Education of China,Ocean University of China,Qingdao 266100,China The online version of the original articles can be found at:http://gffzzd3cc09b8251d45dfsn5f5u5vub9bv60kf.ffgz.tsg.suse.edu.cn/10.1007/s00343-021-0384-7. | Qi LOU Zhengyan LI Yanwei ZHANG Yilei FENG Xueqing ZHANG | 2022 | Journal of Oceanology and Limnology2022，40，3： | 0 |
| 7 | Visual acuity is correlated with ischemia and neurodegeneration in patients with early stages of diabetic retinopathy显示文摘Purpose:We investigated the effects of retinal ischemia,neurodegeneration,and subclinical edema on best-corrected visual acuity(BCVA)in the early stages of diabetic retinopathy(DR).Methods:Ischemia was evaluated by the microvascular parameters measured by optical coherence tomography angiography.Neurodegeneration and subclinical edema were identified by the intraretinal layer thickness obtained by optical coherence tomography.Eyes with nonproliferative diabetic retinopathy(n=132)from 89 patients were analyzed.Eyes were classified as having normal BCVA(n=88[66.7%],Snellen equivalent≥20/20)or decreased BCVA(n=44[33.3%],Snellen equivalent<20/20).The prevalence of ischemia,neurodegeneration,and subclinical edema was explored in patients with and without decreased BCVA,and correlations between BCVA and these pathological pathways were determined.Results:Vessel density in the deep retinal capillary plexus(DRCP)and thickness of ganglion cell layer plus inner plexiform layer(GCL-IPL)were significantly lower in eyes with decreased BCVA compared with eyes with normal BCVA(both P<0.05).In the final multiple regression predictive model,age,DRCP vessel density,and GCL-IPL thickness(all P≤0.044)were predictors of BCVA.DRCP vessel density and GCL-IPL thickness have an interactive effect on visual acuity.The proportions of ischemia and neurodegeneration were significantly higher in eyes with decreased BCVA than in eyes with normal BCVA(P=0.001 and P=0.004,respectively).Conclusion:During the natural course of the early stages of DR,ischemia and neurodegeneration were the main disease pathways associated with visual acuity,and the mechanisms varied among patients. | Jin Li Yue Zhou Feng Chen Yingzi Li Rong Zhou Chaoming Wu Huankai Yu Zhiyang Lin Ce Shi Gu Zheng Yilei Shao Qi Chen Fan Lu Meixiao Shen | 2021 | Eye and Vision2021，8，1： | 0 |
| 8 | Vibration-based bearing fault diagnosis of high-speed trains:A literature review显示文摘Due to the advantages of comfort and safety,high-speed trains are gradually becoming the mainstream public transport in China.Since the operating speed and mileage of high-speed trains have achieved rapid growth,it is more and more urgent to ensure their reliability and safety.As an important component in the bogies of highspeed trains,the health state of the bearing directly affects the operational safety of the trains.It is therefore necessary to diagnoze the faults of bearings in the bogies of high-speed trains as early as possible.In this paper,the bearing fault diagnostic methods for high-speed trains have been systematically summarized with their challenges and perspectives.First,it briefly introduces the structure of bearings in the bogies as well as the fault characteristic frequencies.Then,a brief review of the research on vibration-based signal processing methods and machine learning methods has been provided.Finally,the challenges and future developments of vibrationbased bearing fault diagnostic methods for high-speed trains have been analyzed. | Wanchun Hu Ge Xin Jiayi Wu Guoping An Yilei Li Ke Feng Jerome Antoni | 2023 | High-Speed Railway2023，1，4： | 0 |
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