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| 1 | Dysfunction of PLA2G6 and CYP2C44-associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma显示文摘很少长期的发炎怎么贡献 hepatocellular 癌(HCC ) 的前进被知道,特别癌症的开始。揭开从长期的发炎的批评转变到在网络水平的 HCC 和分子的机制,我们用我们的动态网络 biomarker (DNB ) 分析了土拨鼠肝炎 virus/c-myc 鼠标和匹配年龄的 wt-C57BL/6 鼠标的时间系列 proteomic 数据模型。DNB 分析显示在转基因的老鼠的出生以后的第 5 月是癌症开始的批评时期,就在批评转变前,它与临床的症状一致。同时,联系 DNB 的网络在批评转变前后显示出蛋白质表示和 coexpression 层次的激烈的倒置。DNB, PLA2G6 和 CYP2C44 的二个成员,与他们的联系差别一起表示了蛋白质,被发现导致 arachidonic 酸新陈代谢的机能障碍,进一步通过短暂受体潜力隧道的煽动性的调停人规定激活煽动性的回答,并且最后导致肝 detoxification 和恶意的转变的缺陷到癌症。作为一个 c-Myc 目标, PLA2G6 断然在表示与 c-Myc 相关,显示出从减少到在 carcinogenesis 期间增加的一个趋势,与在批评转变的最小的点或付小费给的点。相应 PLA2G6 和 c-Myc 的如此的趋势也在人的 hepatocarcinogenesis 期间被观察,与在高级 dysplastic 小瘤(就在 carcinogenesis 前的一个阶段) 的最小的点。我们的学习暗示 PLA2G6 可能在 hepatocarcinogenesis 期间作为象著名 c-Myc 一样的 oncogene 工作,当 PLA2G6 和 c-Myc 的 downregulation 能是显示逼近的 carcinogenesis 的一个警告信号时。 | Meiyi Li Chen Li Wei-Xin Liu Conghui Liu Jingru Cui Qingrun Li Hong Ni Yingcheng Yang Chaochao Wu Chunlei Chen Xing Zhen Tao Zeng Mujun zhao Lei Chen Jiarui Wu Rong Zeng Luonan Chen | 2017 | Journal of Molecular Cell Biology2017，9，6： | 12 |
| 2 | Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population显示文摘Serotonin plays an important role in mood regulation, but the involvement of serotonin pathway genes in the development of bipolar I disorder (BP-I), a mood disorder, is not clear. We selected 21 singlenucleotide polymorphisms (SNPs) within the HTR2A gene, 8 within the SLC6A4 gene and 23 within the TPH2 gene for genotyping using the GoldenGate genotyping assay. A total of 375 patients with BP-I and 475 normal controls were recruited. Two out of 21 SNPs (rs1475196 and rs9567747) in the HTR2A gene and 1/23 SNPs (rs17110566) in the TPH2 gene were significantly associated with BP-I, both genotype-wise and allele-wise. Furthermore, a specific haplotype in the HTR2A gene showed a significant association with BP-I. Our results indicate that the HTR2A and TPH2 genes in the serotonin pathway play important roles in susceptibility to BP-I. | Bo Xiang Zhenxing Yang Yin Lin Lijie Guan Xuan Li Wei Deng Zeyu Jiang Guohui Lao Qiang Wang Xiaoyu Hao Xiang Liu Yingcheng Wang Liansheng Zhao Xiaohong Ma Tao Li Liping Cao Xun Hu | 2014 | Neuroscience Bulletin2014，30，1： | 2 |
| 3 | AGRICULTURAL GREEN DEVELOPMENT TO ACHIEVE FOOD SECURITY AND CARBON REDUCTION IN THE CONTEXT OF CHINA'S DUAL CARBON GOALS显示文摘The agricultural sector,a major source of greenhouse gas emissions,and emissions from agriculture must be reduced substantially to achieve carbon(C)neutrality.Based on a literature analysis and other research results,this study investigated the effects and prospects of C reduction in agricultural systems under different scenarios(i.e.,methods and approaches)in the context of China's dual C goals,as those working in the agricultural sector have yet to reach a consensus on how to move forward.Different views,standards,and countermeasures were analyzed to provide a reference for agricultural action supporting China's C neutrality goal. | Yulong YIN Kai HE Zhong CHEN Yangyang LI Fengling REN Zihan WANG Yingcheng WANG Haiqing GONG Qichao ZHU Jianbo SHEN Xuejun LIU Zhenling CUI | 2023 | Frontiers of Agricultural Science and Engineering2023，10，2： | 2 |
| 4 | Lnc-RP5 Regulates the mi R-129-5p/Notch1/PFV Internal Promoter Axis to Promote the Expression of the Prototype Foamy Virus Transactivator Tas显示文摘Prototype foamy virus(PFV)is a unique retrovirus that infects animals and humans and does not cause clinical symptoms.Long noncoding RNAs(lncRNAs)are believed to exert multiple regulatory functions during viral infections.Previously,we utilized RNA sequencing(RNA-seq)to characterize and identify the lncRNA lnc-RP5-1086 D14.3.1-1:1(lnc-RP5),which is markedly decreased in PFV-infected cells.However,little is known about the function of lnc-RP5 during PFV infection.In this study,we identified lnc-RP5 as a regulator of the PFV transcriptional transactivator(Tas).Lnc-RP5 enhanced the activity of the PFV internal promoter(IP).The expression of PFV Tas was found to be promoted by lnc-RP5.Moreover,mi R-129-5 p was found to be involved in the lnc-RP5-mediated promotion of PFV IP activity,while the Notch1 protein suppressed the activity of PFV IP and the expression of Tas.Our results demonstrate that lnc-RP5 promotes the expression of PFV Tas through the miR-129-5 p/Notch1/PFV IP axis.This work provides evidence that host lnc RNAs can manipulate PFV replication by employing mi RNAs and proteins during an early viral infection. | Shanshan Xu Liujun Chen Yinglian Tang Peipei Yuan Jun Yan Yingcheng Zheng Li Huang Zhi Li Yan Sun Song Han Jun Yin Qin Pan Biwen Peng Xiaohua He Wanhong Liu | 2020 | Virologica Sinica2020，35，1： | 1 |
| 5 | An alternative approach to determine critical angle of contrast reversal and surface roughness of oil slicks under sunglint显示文摘The critical angle is the angle at which the contrast of oil slicks reverse their contrasts against the surrounding oil-free seawater under sunglint.Accurate determination of the critical angle can help estimate surface roughness and refractive index of the oil slicks.Although it’s difficult to determine a certain critical angle,the potential critical angle range help to improve the estimation accuracy.In this study,the angle between the viewing direction and the direction of mirror reflection is used as an indicator for quantifying the critical angle and could be calculated from the solar/viewing geometry from observations of the Moderate Resolution Imaging Spectroradiometer(MODIS).The natural seep oil slicks in the Gulf of Mexico were first delineated using a customized segmentation approach to remove noise and apply a morphological filter.On the basis of the histograms of the brightness values of the delineated oil slicks,the potential range of the critical angle was determined,and then an optimal critical angle between oil slicks and seawater was then determined from statistical and regression analyses in this range.This critical angle corresponds to the best fitting between the modeled and observed surface roughness of seep oil slicks and seawater. | Yansha Wen Mengqiu Wang Yingcheng Lu Shaojie Sunc Minwei Zhang Zhihua Mao Jing Shi Yongxue Liu | 2018 | International Journal of Digital Earth2018，11，9： | 1 |
| 6 | Connectivity distribution and attack tolerance of general networks with both preferential and random attachments显示文摘 | LIU Zonghua LAI Yingcheng YE Nong | 2002 | Physics Letters A2002，303，56： | 1 |
| 7 | Connectivity distribution and attack tolerance of general networks with both preferential and random attachments 显示文摘 | Liu Zonghua Lai Yingcheng Ye Nong | 2002 | Phys Lett A2002，303，： | 1 |
| 8 | Automotive hydraulic deceleration (braking)显示文摘 | Yingcheng Liu Wanzheng Shao | 2005 | MC Modem cmnponents2005，，23： | 1 |
| 9 | Optical Remote Sensing of Oil Spills in the Ocean: What Is Really Possible?显示文摘Optical remote sensing(ORS)of reflected sun light has been used to assess oil spills in the ocean for several decades.While most applications are toward simple presence/absence detections based on the spatial contrast between oiled water and oil-free water,recent advances indicate the possibility of classifying oil types and quantifying oil volumes based on their spectral contrasts with oil-free water.However,a review of the current literature suggests that there is still confusion on whether this is possible and,if so,how.Here,based on the recent findings from numerical models,laboratory measurements,and applications to satellite or airborne imagery,we attempt to clarify this situation by summarizing(1)the optics behind oil spill remote sensing,and in turn,(2)how to interpret optical remote sensing imagery based on optical principles.In the end,we discuss the existing limitations and challenges as well as pathways forward to advance ORS of oil spills. | Chuanmin Hu Yingcheng Lu Shaojie Sun Yongxue Liu | 2021 | Journal of Remote Sensing2021，，1： | 1 |
| 10 | Progress in Marine Oil Spill Optical Remote Sensing: Detected Targets, Spectral Response Characteristics, and Theories显示文摘 | Yingcheng Lu Xiang Li Qingjiu Tian Guang Zheng Shaojie Sun Yongxue Liu Qiang Yang | 2013 | Marine Geodesy2013，，3： | 1 |
| 11 | Propagation and immunization of infection on general networks with both homogeneous and heterogeneous components显示文摘 | Liu Zonghua Lai Yingcheng Ye Nong | 2003 | Phys Rev E2003，67，03： | 1 |
| 12 | A Bifunctional Brønsted Acidic Deep Eutectic Solvent to Dissolve and Catalyze the Depolymerization of Alkali Lignin显示文摘Lignin is an abundant renewable macromolecular material in nature,and degradation of lignin to improve its hydroxyl content is the key to its efficient use.Alkali lignin(AL)was treated with Brønsted acidic deep eutectic solvent(DES)based on choline chloride and p-toluenesulfonic acid at mild reaction temperature,the structure of the lignin before and after degradation,as well as the composition of small molecules of lignin were analyzed in order to investigate the chemical structure changes of lignin with DES treatment,and the degradation mechanism of lignin in this acidic DES was elucidated in this work.FTIR and NMR analyses demonstrated the selective cleavage of the lignin ether linkages in the degradation process,which was in line with the increased content of phenolic hydroxyl species.XPS revealed that the O/C atomic ratio of the regenerated lignin was lower than that of the AL sample,revealing that the lignin underwent decarbonylation during the DES treatment.Regenerated lignin with low molecular weight and narrow polydispersity index was obtained,and the average molecular weight(Mw)decreased from 17680 g/mol to 2792 g/mol(130°C,3 h)according to GPC analysis.The lignin-degraded products were mainly G-type phenolics and ketones,and small number of aldehydes were also generated,the possible degradation pathway of lignin in this acidic DES was proposed. | Lifen Li Zhigang Wu Xuedong Xi Baoyu Liu Yan Cao Hailong Xu Yingcheng Hu | 2021 | Journal of Renewable Materials2021，9，2： | 1 |
| 13 | Effects of the adaptations to climate changes on the income of herdsmen in Qinghai Province显示文摘This study aims to implement the empirical analysis of the effects of the adaptive measures on the income of herdsmen in the context of the climate change with the positive mathematical programming(PMP)model.The survey was first implemented in three counties in the Three Headwaters Region.Finally the measures and recommendations suitable for the economic development in the ecologically fragile areas were proposed.The main conclusions are as follows:priority can be given to the measures to prevent the damage from rats and the engineering measures for pasture maintenance in Zeku County,where the geological conditions and grass quality are inferior,while the fiscal subsidy can be prioritized in Tongde County where the grassland area is relatively less.These recommendations can not only provide good reference for the protection of grassland resources,but they also lay a foundation for the implementation of more suitable measures to help the herdsmen in the ecologically fragile areas to adapt to the climate change. | Yingcheng Liu Zhaohua Li Feng Wu Fang Yin | 2013 | Chinese Journal of Population,Resources and Environment2013，11，3： | 0 |
| 14 | Sequential Growth of Cs_(3)Bi_(2)I_(9)/BiVO_(4)Direct Z-Scheme Heterojunction for Visible-Light-Driven Photocatalytic CO_(2)Reduction显示文摘The high exciton binding energy and lack of a positive oxidation band potential restrict the photocatalytic CO_(2)reduction efficiency of lead-free Bi-based halide perovskites Cs_(3)Bi_(2)X_(9)(X=Br,I).In this study,a sequential growth method is presented to prepare a visible-light-driven(λ>420 nm)Z-scheme heterojunction photocatalyst composed of BiVO_(4)nanocrystals decorated on a Cs_(3)Bi_(2)I_(9)nanosheet for photocatalytic CO_(2)reduction coupled with water oxidation.The Cs_(3)Bi_(2)I_(9)/BiVO_(4)Z-scheme heterojunction photocatalyst is stable in the gas-solid photocatalytic CO_(2)reduction system,demonstrating a high visible-light-driven photocatalytic CO_(2)-to-CO production rate of 17.5μmol/(g·h),which is approximately three times that of pristine Cs_(3)Bi_(2)I_(9).The high efficiency of the Cs_(3)Bi_(2)I_(9)/BiVO_(4)heterojunction was attributed to the improved charge separation in Cs_(3)Bi_(2)I_(9).Moreover,the Z-scheme charge-transfer pathway preserves the negative reduction potential of Cs_(3)Bi_(2)I_(9)and the positive oxidation potential of BiVO_()4.This study off ers solid evidence of constructing Z-scheme heterojunctions to improve the photocatalytic performance of lead-free halide perovskites and would inspire more ideas for developing leadfree halide perovskite photocatalysts. | Long Jiang Hanrui Du Le Li Xiangjiu Guan Yihao Zhang Liwei Li Xiaoxu Liu Lei Li Yingcheng Tian Li Zhang Shuai Wang Jie Chen Shaohua Shen | 2023 | Transactions of Tianjin University2023，29，6： | 0 |
| 15 | Dynamical-invariant-based holonomic quantum gates:Theory and experiment显示文摘Among existing approaches to holonomic quantum computing,the adiabatic holonomic quantum gates(HQGs)suffer errors due to decoherence,while the non-adiabatic HQGs either require additional Hilbert spaces or are difficult to scale.Here,we report a systematic,scalable approach based on dynamical invariants to realize HQGs without using additional Hilbert spaces.While presenting the theoretical framework of our approach,we design and experimentally evaluate single-qubit and two-qubits HQGs for the nuclear magnetic resonance system.The single-qubit gates acquire average fidelity 0.9972 by randomized benchmarking,and the controlled-NOT gate acquires fidelity 0.9782 by quantum process tomography.Our approach is also platform-independent,and thus may open a way to large-scale holonomic quantum computation. | Yingcheng Li Tao Xin Chudan Qiu Keren Li Gangqin Liu Jun Li Yidun Wan Dawei Lu | 2023 | Fundamental Research2023，3，2： | 0 |
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