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| 1 | Hypoxia-mimicking 3D bioglass-nanoclay scaffolds promote endogenous bone regeneration显示文摘Large bone defect repair requires biomaterials that promote angiogenesis and osteogenesis.In present work,a nanoclay(Laponite,XLS)-functionalized 3D bioglass(BG)scaffold with hypoxia mimicking property was prepared by foam replication coupled with UV photopolymerization methods.Our data revealed that the incorporation of XLS can significantly promote the mechanical property of the scaffold and the osteogenic differentiation of human adipose mesenchymal stem cells(ADSCs)compared to the properties of the neat BG scaffold.Desferoxamine,a hypoxia mimicking agent,encourages bone regeneration via activating hypoxia-inducible factor-1 alpha(HIF-1α)-mediated angiogenesis.GelMA-DFO immobilization onto BG-XLS scaffold achieved sustained DFO release and inhibited DFO degradation.Furthermore,in vitro data demonstrated increased HIF-1αand vascular endothelial growth factor(VEGF)expressions on human adipose mesenchymal stem cells(ADSCs).Moreover,BG-XLS/GelMA-DFO scaffolds also significantly promoted the osteogenic differentiation of ADSCs.Most importantly,our in vivo data indicated BG-XLS/GelMA-DFO scaffolds strongly increased bone healing in a critical-sized mouse cranial bone defect model.Therefore,we developed a novel BG-XLS/GelMA-DFO scaffold which can not only induce the expression of VEGF,but also promote osteogenic differentiation of ADSCs to promote endogenous bone regeneration. | Xiao Zheng Xiaorong Zhang Yingting Wang Yangxi Liu Yining Pan Yijia Li Man Ji Xueqin Zhao Shengbin Huang Qingqing Yao | 2021 | Bioactive Materials2021，6，10： | 4 |
| 2 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 3 | Effects of Early Intensive Blood Pressure-Lowering Treatment on the Growth of Hematoma and Perihematomal Edema in Acute Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT)显示文摘 | Craig S. Anderson Yining Huang Hisatomi Arima Emma Heeley Christian Skulina Mark W. Parsons Bin Peng Qiang Li Steve Su Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Lewis B. Morgenstern John Chalmers Ji Guang Wang | 2010 | Stroke2010，，2： | 3 |
| 4 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial 显示文摘 | Craig SA Yining H Ji GW | 2008 | The Lancet Neurology2008，7，5： | 1 |
| 5 | Intensive blood pressurereduction in acute cerebral haemorrhage trial(INTERACT);a randomised pilot trial显示文摘 | Craig S A Yining H Ji G W | 2008 | The Lancet Neurology2008，7，5： | 1 |
| 6 | Intensive blood pressure reduction in acute cerebral haemorrhage trial ( INTERACT ) ; a randomised polot trial显示文摘 | Craig SA Yining H Ji GW | 2008 | The Lancet Neurology2008，7，5： | 1 |
| 7 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 1 |
| 8 | Earlier Blood Pressure-Lowering and Greater Attenuation of Hematoma Growth in Acute Intracerebral Hemorrhage: INTERACT Pilot Phase显示文摘 | Hisatomi Arima Yining Huang Ji Guang Wang Emma Heeley Candice Delcourt Mark Parsons Qiang Li Bruce Neal John Chalmers Craig Anderson | 2012 | Stroke2012，，8： | 1 |
| 9 | A two-dimensional double layer-averaged model of hyperconcentrated turbidity currents with non-Newtonian rheology显示文摘Hyperconcentrated turbidity currents typically display non-Newtonian characteristics that influence sediment transport and morphological evolution in alluvial rivers.However,hydro-sedimentmorphological processes involving hyperconcentrated turbidity currents are poorly understood,with little known about the effect of the non-Newtonian rheology.The current paper extends a recent twodimensional double layer-averaged model to incorporate non-Newtonian constitutive relations.The extended model is benchmarked against experimental and numerical data for cases including subaerial mud flow,subaqueous debris flow,and reservoir turbidity currents.The computational results agree well with observations for the subaerial mud flow and independent numerical simulations of subaqueous debris flow.Differences between the non-Newtonian and Newtonian model results become more pronounced in terms of propagation distance and sediment transport rate as sediment concentration increases.The model is then applied to turbidity currents in the Guxian Reservoir planned for middle Yellow River,China,which connects to a tributary featuring hyperconcentrated sediment-laden flow.The non-Newtonian model predicts slower propagation of turbidity currents and more significant bed aggradation at the confluence between the tributary Wuding River and the Yellow River in the reservoir than its Newtonian counterpart.This difference in model performance could be of considerable importance when optimizing reservoir operation schemes. | Yining Sun Ji Li Zhixian Cao Alistair George Liam Borthwick | 2023 | International Journal of Sediment Research2023，38，6： | 0 |
| 10 | Molecular Detection of FGFR2 Rearrangements in Resected Intrahepatic Cholangiocarcinomas:FISH Could Be An Ideal Method in Patients with Histological Small Duct Subtype显示文摘Background and Aims:Intrahepatic cholangiocarcinoma(ICC)is a subtype of primary liver cancer for which effective therapeutic agents are lacking.Fibroblast growth factor receptor 2(FGFR2)has become a promising therapeutic target in ICC;however,its incidence and optimum testing method have not been fully assessed.This study investigated the rearrangement of FGFR2 in intrahepatic cholangiocarcinoma using multiple molecular detection methods.Methods:The samples and clinical data of 167 patients who underwent surgical resection of intrahepatic cholangiocarcinoma in Zhongshan hospital,Fudan university were collected.The presence of FGFR2 gene rearrangement was confirmed using fluorescence in situ hybridization(FISH)and targeted next-generation sequencing(NGS).FGFR2 protein expression was determined using immunohistochemistry(IHC).The concordance between the methods was statistically compared.PD-L1 expression was also assessed in this cohort.The clinicopathological characteristics and genomic profile related to FGFR2 rearrangements were also analyzed to assist candidatescreening for targeted therapies.Results:FGFR2 rearrangement was detected in 21 of the 167 ICC cases(12.5%)using FISH.NGS analysis revealed that FGFR2 rearrangement was present in 16 of the 20 FISH-positive cases,which was consistent with the FISH results(kappa value=0.696,p<0.01).IHC showed that 80 of the 167 cases(48%)were positive for FGFR2 expression,which was discordant with both FISH and NGS results.By comparison,FGFR2-positivity tended to correlate with unique clinicopathological subgroups,featuring early clinical stage,histologically small duct subtype,and reduced mucus production(P<0.05),with improved overall survival(p<0.05).FGFR2-positivity was not associated with PD-L1 expression in ICCs.In genome research,we identified eight partner genes fused with FGFR2,among which FGFR2-BICC1 was the most common fusion type.BAP1,CDKN2A,and CDKN2B were the most common concomitant genetic alterations of FGFR2,whereas KRAS and IDH1 mutations were mutually exclusive to FGFR2 rearrangements.Conclusions:FISH achieved satisfactory concordance with NGS,has potential value for FGFR2 screening for targeted therapies.FGFR2 detection should be prioritized for unique clinical subgroups in ICC,which features a histological small duct subtype,early clinical stage,and reduced mucus production. | Yining Zou Kun Zhu Yanrui Pang Jing Han Xin Zhang Zhengzeng Jiang Yufeng Huang Wenyi Gu Yuan Ji | 2023 | Journal of Clinical and Translational Hepatology2023，11，6： | 0 |
| 11 | Characteristics and health risks of population exposure to phthalates via the use of face towels显示文摘The production of face towels is growing at an annual rate of about 4%in China,reaching 1.13 million tons by 2021.Phthalates(PAEs)are widely used in textiles,and face towels,as an important household textile,may expose people to PAEs via the skin,further leading to health risks.We collected new face towels and analyzed the distribution characterization of PAEs in them.The changes of PAEs were explored in a face towel use experiment and a simulated laundry experiment.Based on the use of face towels by 24 volunteers,we calculated the estimated daily intake(EDI)and comprehensively assessed the hazard quotient(HQ),hazard index(HI),and dermal cancer risk(DCR)of PAEs exposure in the population.PAEs were present in new face towels at total concentrations of | Wenhui Zhang Na Zheng Sujing Wang Siyu Sun Qirui An Xiaoqian Li Zimeng Li Yining Ji Yunyang Li Jiamin Pan | 2023 | Journal of Environmental Sciences2023，，8： | 0 |
| 12 | LncRNA ZFAS1 regulates cardiomyocyte differentiation of human embryonic stem cells显示文摘Background:Cardiomyocytes derived from human embryonic stem cells(hESCs)are regulated by complex and stringent gene networks during differentiation.Long non-coding RNAs(lncRNAs)exert critical epigenetic regulatory functions in multiple differentiation processes.However,the involvement of lncRNAs in the differentiation of hESCs into cardiomyocytes has not yet been fully elucidated.Here,we identified the key roles of ZFAS1(lncRNA zinc finger antisense 1)in the differentiation of cardiomyocytes from hESCs.Methods:A model of cardiomyocyte differentiation from stem cells was established using the monolayer differentiation method,and the number of beating hESCs-derived cardiomyocytes was calculated.Gene expression was analyzed by quantitative real-time PCR(qRTPCR).Immunofluorescence assays were performed to assess the expression of cardiac troponin T(cTnT)andα-actinin protein in cardiomyocytes.Results:qRT-PCR showed that ZFAS1 expression in the mesoderm was significantly higher than that in embryonic stem cells,cardiac progenitor cells,and cardiomyocytes.Knockdown of ZFAS1 inhibited cardiomyocyte differentiation from hESCs,which was characterized by reduced expression of the cardiac-specific markers cTnT,α-actinin,myosin heavy chain 6(MYH6),and myosin heavy chain 7(MYH7).In contrast,ZFAS1 overexpression remarkably increased the percentage of spontaneously beating cardiomyocytes.In terms of the mechanism,we found that ZFAS1 is an antisense lncRNA at the 5′end of the protein-coding gene ZNFX1.Knockdown of ZFAS1 could increase the mRNA expression level of ZNFX1.Furthermore,qRT-PCR demonstrated that the silencing of ZNFX1 led to an increase in cardiac-specific markers that predicted the promotion of cardiomyocyte differentiation.Conclusion:Altogether,these data suggest that lncRNA-ZFAS1 is required for cardiac differentiation by functionally inhibiting the expression of ZNFX1,which may provide a reference for the treatment of heart disease to a certain extent. | YANG CAO YINING LIU YANG YU XIAOFEI GUO XIUXIU WANG WENYA MA HANJING LI ZHONGYU REN XINLU GAO SIJIA LI HAOYU JI HONGYANG CHEN HONG YAN YANAN TIAN XIN WANG BENZHI CAI | 2023 | BIOCELL2023，47，6： | 0 |
| 13 | Association between exposure to particulate matter during pregnancy and birthweight:a systematic review and a metaanalysis of birth cohort studies显示文摘Studies of the associations between maternal exposure to particulate matter(PM) and risk of adverse effects on fetal growth are inconsistent and inconclusive. This question can be well answered by carefully designed birth cohort studies; however, so far the evidence from such studies has not come to the same conclusion. We sought to evaluate the association between maternal exposures to PM and low birthweight(LBW) enrolling 14 studies from 11 centers,and to explore the influence of trimester and exposure assessment methods on between-center heterogeneity in this association. Data were derived from PubMed, Embase, Google Scholar, CNKI, and WanFang database, references from relevant articles, and results from published studies until March 2017. Using a random-effects meta-analysis, we combined the coefficient and odds ratios(OR) of individual studies conducted among 14 birth cohort studies.Random-effect meta-analysis results suggested that a 17% and 6% increase in risk of LBW was relevant to a 10 μg/m^3 rise in PM_(2.5) and PM_(10) exposure concentrations at the 3 rd trimester(pooled odds ratios(OR), 1.17 and 1.06; 95%confidence interval(CI), 0.94-1.46 and 0.97-1.15, respectively), but the null value was included in our 95% CI. Our results showed that exposure to PM_(2.5) and PM_(10) during pregnancy has a positive relevance to LBW based on birth cohort studies. However, neither reached formal statistical significance. Negative impacts on outcomes of birth is implied by maternal exposure to PM. Further mechanistic researches are needed to explain the connection between PM pollution and LBW. | Yinwen Ji Fei Song Bo Xu Yining Zhu Chuncheng Lu Yankai Xia | 2019 | The Journal of Biomedical Research2019，33，1： | 0 |
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