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| 1 | An novel identification method of the environmental risk sources for surfacewater pollution accidents in chemical industrial parks显示文摘The chemical industry is a major source of various pollution accidents. Improving the management level of risk sources for pollution accidents has become an urgentdemand for most industrialized countries. In pollution accidents, the released chemicals harm the receptors to some extentdepending on their sensitivity or susceptibility. Therefore, identifying the potential risk sources from such a large number of chemical enterprises has become pressingly urgent. Based on the simulation of thewhole accident process, a novel and expandable identification method for risk sources causingwater pollution accidents is presented. The newlydeveloped approach, by analyzing and stimulating thewhole process of a pollution accident between sources and receptors, can be applied to identify risk sources, especially on the nationwide scale. Three major types of losses, such as social, economic and ecological losses,were normalized, analyzed and used for overall consequence modeling. A specific case study area, located in a chemical industry park (CIP) along the Yangtze River in Jiangsu Province, China,was selected to test the potential of the identification method. The results showed that therewere four risk sources for pollution accidents in this CIP. Aniline leakage in the HS Chemical Plantwould lead to the most serious impact on the surroundingwater environment. This potential accidentwould severelydamage the ecosystem up to3.8 kmdownstream of Yangtze River, and lead to pollution over adistance stretching to 73.7 kmdownstream. The proposed method is easily extended to the nationwide identification of potential risk sources. | Jianfeng Peng Yonghui Song Peng Yuan Shuhu Xiao Lu Han | 2013 | Journal of Environmental Sciences2013，25，7： | 9 |
| 2 | Recent advances in integrated optical directed logic operations for high performance optical computing: a review显示文摘Optical directed logic(DL)is a novel logic operation scheme that employs electrical signals as operands to control the working states of optical switches to perform the logic functions.This review first provides an overview of the concept and working principle of DL.The developing trends of DL computing are then discussed in detail,including the fundamental optical DL gates,combinational optical DL operations,reconfigurable logic computing,low power optical logic computing,and programmable photonic network.The concluding remarks provide an outlook on the DL future development and its impacts in optical computing. | Ciyuan Qiu Huifu Xiao Liheng Wang Yonghui Tian | 2022 | Frontiers of Optoelectronics2022，15，1： | 2 |
| 3 | Effects of catechins on litter size,reproductive performance and antioxidative status in gestating sows显示文摘This study was conducted to investigate the effects of catechins on reproductive performance, antioxidative capacity and immune function of gestating sows. A total of 60 cross-bred(Landrace × Large White) multiparious sows were blocked by body weight, parity and backfact and randomly allocated to 1 of 5 treatments: 0.100,200,300, or 400 mg/kg catechins. Dietary treatments were imposed from mating to d 40 of gestation of sows. At farrowing, litter total born, born alive, dead, and normal-(healthy piglets,>0.85 kg) and low-birth weight piglets(<0.85 kg) were recorded. Within 3.00 ± 0.50 days after farrowing litter size was standardized to 8,00 ± 1.50 piglets within treatment. The piglets were weighed at birth(d 1) and weaning(d 28). Sows serum samples were obtained from blood samples collected on d 40 of gestation for analyses of glutathione peroxidase(GSH-Px), superoxide dismutase(SOD), catalase(CAT),malondialdehyde(MDA), hydrogen peroxide(H2 O2), nitric oxide synthetase(NOS) and nitrogen monoxide(NO). Our results showed that supplementation of catechins at levels of 200 or 300 mg/kg led to improvements in litter born alive(P < 0.01) and piglet born healthy(P < 0.01) and a decrease in stillborn(P < 0.05) at farrowing when compared with the control. In comparison with the control, catechins at any supplemental levels all enhanced the serum SOD(P < 0.05) and CAT(P < 0.01) activities of sows at farrowing but no obvious differences in the serum GSH-Px and NOS activities were observed in this trial(P > 0.05). Sows received 200 mg catechin per kg diets showed a reduction(P < 0.05) of the serum MDA level at farrowing compared with all other treatments. Sows received all the levels of catechin showed a reduction(P < 0.05) of serum H2 O2 level compared with sows received the control diet on both d 40 of gestation and farrowing. Our results demonstrated that the catechins may be a potential antioxidant to increase the reproductive performance and antioxidative capacity of sows when it was added into diets during the early gestation. | Zhiyong Fan Yong Xiao Yonghui Chen Xin Wu Guanglei Zhang Qinhua Wang Chunyan Xie | 2015 | Animal Nutrition2015，，4： | 2 |
| 4 | Genetic architecture of maize yield traits dissected by QTL mapping and GWAS in maize显示文摘The study of yield traits can reveal the genetic architecture of grain yield for improving maize production.In this study, an association panel comprising 362 inbred lines and a recombinant inbred line population derived from X178 × 9782 were used to identify candidate genes for nine yield traits. High-priority overlap(HPO) genes, which are genes prioritized in a genome-wide association study(GWAS), were investigated using coexpression networks. The GWAS identified 51 environmentally stable SNPs in two environments and 36 pleiotropic SNPs, including three SNPs with both attributes. Seven hotspots containing 41 trait-associated SNPs were identified on six chromosomes by permutation. Pyramiding of superior alleles showed a highly positive effect on all traits, and the phenotypic values of ear diameter and ear weight consistently corresponded with the number of superior alleles in tropical and temperate germplasm. A total of 61 HPO genes were detected after trait-associated SNPs were combined with the coexpression networks. Linkage mapping identified 16 environmentally stable and 16 pleiotropic QTL.Seven SNPs that were located in QTL intervals were assigned as consensus SNPs for the yield traits.Among the candidate genes predicted by our study, some genes were confirmed to function in seed development. The gene Zm00001 d016656 encoding a serine/threonine protein kinase was associated with five different traits across multiple environments. Some genes were uniquely expressed in specific tissues and at certain stages of seed development. These findings will provide genetic information and resources for molecular breeding of maize grain yield. | Xiao Zhang Zhiyong Ren Bowen Luo Haixu Zhong Peng Ma Hongkai Zhang Hongmei Hu Yikai Wang Haiying Zhang Dan Liu Ling Wu Zhi Nie Yonghui Zhu Wenzhu He Suzhi Zhang Shunzong Su Yaou Shen Shibin Gao | 2022 | The Crop Journal2022，10，2： | 2 |
| 5 | Effect of pyrocarbon content on thermal and frictional properties in C/C preforms of C/C-SiC composites显示文摘 | Zhang Yonghui Xiao Zhichao Wang Jiping | 2010 | Wear2010，269，12： | 1 |
| 6 | Degradation of biologically treated landfill leachate by using electrochemical process combined with UV irradiation显示文摘 | Shuhu Xiao Jianfeng Peng Yonghui Song Dongsheng Zhang Ruixia Liu Ping Zeng | 2013 | Separation and Purification Technology2013，，： | 1 |
| 7 | Treatment of berberine hydrochloride wastewater by using pulse electro-coagulation process with Fe electrode显示文摘 | Meijie Ren Yonghui Song Shuhu Xiao Ping Zeng Jianfeng Peng | 2011 | Chemical Engineering Journal2011，，1： | 1 |
| 8 | Effect of pyrocarbon content in C/C preforms on microstructure and mechanical properties of the C/C–SiC composites显示文摘 | Yonghui Zhang Zhichao Xiao Jiping Wang Jianfeng Yang Zhihao Jin | 2008 | Materials Science & Engineering A2008，，1： | 1 |
| 9 | Impact of hepatitis B vaccination among children in Guangdong Province, China显示文摘 | Jianpeng Xiao Jikai Zhang Chenggang Wu Xiaoping Shao Guowen Peng Zhiqiang Peng Wenjun Ma Yonghui Zhang Huizhen Zheng | 2012 | International Journal of Infectious Diseases2012，，9： | 1 |
| 10 | A prospective study of the incidence and correlate factors of post-stroke depres- sion in China显示文摘 | Zhang Weina Pan Yonghui Yu Xiao | 2013 | PLOS ONE2013，8，11： | 1 |
| 11 | Application of the quantitative oil monitoring to analysing the operating condition of marine machinery显示文摘Based on the data of Fourier transform infra-red (FTIR) spectroscopy, spectrometric oilanalysis (SOA) and other routine methods, the experiment of oil monitoring for steering propellersis discussed. The experiment demonstrates the FTIR spectroscopy can rapidly and easily obtainthe results in laboratory analysis, and combine with spectrometer oil analysis, complementary in-formation is most effective to condition monitoring of marine machinery. | YIN Yonghui GAO Hongliang YAN Xinping XIAO Hanliang Reliability Engineering Institute, Wuhan University of Technology Yu Jia Tou Campus, Wuhan 430063, China | 2001 | Science China Mathematics2001，44，S1： | 1 |
| 12 | Eupalinolide B inhibits hepatic carcinoma by inducing ferroptosis and ROS-ER-JNK pathway显示文摘Primary hepatic carcinoma is a common malignant tumor.The classic molecular targeted drug sorafenib is costly and is only effective for some patients.Therefore,it is of great clinical significance to search for new molecular targeted drugs.Eupalinolide B(EB)from Eupatorium lindleyanum DC.is used to treat chronic tracheitis in clinical practice.However,the role of EB in hepatic carcinoma is unknown.In this study,we first measure the effect of EB on tumor growth in a xenograft model and PDX model.The cell proliferation and migration are also detected in human hepatocarcinoma cell lines(SMMC-7721 and HCCLM3).Then,we investigate cell cycle,cell apoptosis,cell necrosis,cell autophagy,and ferroptosis by flow cytometry,western blot analysis and electron microscopy.The results demonstrate that EB exerts anti-proliferative activity in hepatic carcinoma by blocking cell cycle arrest at S phase and inducing ferroptosis mediated by endoplasmic reticulum(ER)stress,as well as HO-1 activation.When HO-1 is inhibited,EB-induced cell death and ER protein expression are rescued.The migration-related mechanism consists of activation of the ROS-ER-JNK signaling pathway and is not connected to ferroptosis.In summary,we first discover that EB inhibits cell proliferation and migration in hepatic carcinoma,and thus EB is a promising anti-tumor compound that can be used for hepatic carcinoma. | Yonghui Zhang Haoyang Zhang Jinage Mu Meiyue Han Zhihao Cao Feng Dong Tingting Wang Lian Pan Wujing Luo Jiaxin Li Huan Liu Lishan Jin Wenxuan Ding Yong Wei Xuesong Deng Dan Liu Xiuzhen He Yi Pang Xiao Mu Zhongjun Wu Dilong Chen | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 1 |
| 13 | Effect of pyrocarbon content in C/C preforms on microstructure and mechanical properties of the C/C-SiC composites显示文摘 | Zhang Yonghui Xiao Zhichao Wang Jiping | 2009 | Mater Sci Eng A2009，502，： | 1 |
| 14 | Ambient Temperature and Years of Life Lost:A National Study in China显示文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics. | Tao Liu Chunliang Zhou Haoming Zhang Biao Huang Yanjun Xu Lifeng Lin Lijun Wang Ruying Hu Zhulin Hou Yize Xiao Junhua Li Xiaojun Xu Donghui Jin Mingfang Qin Qinglong Zhao Weiwei Gong Peng Yin Yiqing Xu Jianxiong Hu Jianpeng Xiao Weilin Zeng Xing Li Siqi Chen Lingchuan Guo Zuhua Rong Yonghui Zhang Cunrui Huang Yaodong Du Yuming Guo Shannon Rutherford Min Yu Maigeng Zhou Wenjun Ma | 2021 | The Innovation2021，2，1： | 1 |
| 15 | A fast on-demand preparation of injectable self-healing nanocomposite hydrogels for efficient osteoinduction显示文摘Injectable hydrogels have been considered as promising materials for bone regeneration,but their osteoinduction and mechanical performance are yet to be improved.In this study,a novel biocompatible injectable and self-healing nano hybrid hydrogel was on-demand prepared via a fast(within 30 s)and easy gelation approach by reversible Schiff base formed between-CH=O of oxidized sodium alginate(OSA)and-NH2 of glycol chitosan(GCS)mixed with calcium phosphate nanoparticles(CaP NPs).Its raw materials can be ready in large quantities by a simple synthesis process.The mechanical strength,degradation and swelling behavior of the hydrogel can be readily controlled by simply controlling the molar ratio of-CH=O and-NH2.This hydrogel exhibits pH responsiveness,good degradability and biocompatibility.The hydrogel used as the matrix for mesenchymal stem cells can significantly induce the proliferation,differentiation and osteoinduction in vitro.These results showed this novel hydrogel is an ideal candidate for applications in bone tissue regeneration and drug delivery. | Panpan Pan Xiao Chen Huaran Xing Yonghui Deng Jingdi Chen Fahad AAlharthi Abdulaziz AAlghamdi Jiacan Su | 2021 | Chinese Chemical Letters2021，32，7： | 0 |
| 16 | Coalbursts in China: Theory, practice and management显示文摘Coalburst is one of the most serious disasters that threaten the safe production of coal mines, and this disaster is particularly serious in China. This paper presents an overview of coalbursts in China since 1980s. From the 'stress and energy' and 'regional and local' perspectives, the achievements in the theory, practice and management of coalbursts in China are systematically summarized. A theoretical system of coalbursts has been formed to reveal the deformational behavior of coalbursts and explain the mechanism of coalbursts. The occurrence conditions of coalbursts are put forward and the critical stress is obtained. The stress index method for risk evaluation of coalbursts before mining is proposed, and the deformation localization prediction method of coalbursts is put forward. The relationship between energy release and absorption in the process of coalbursts is found, and the prevention and control methods of coalbursts, including the regional method, the local method and support, are presented. The safety evaluation index of coalburst prevention and control is put forward. The integrated prevention and control method for coal and gas outbursts is proposed. The prevention and control technology and equipment of coalbursts have also been developed. Amongst them, the distribution law of the critical stress in China coalburst mines is discovered. The technology and equipment for monitoring, prevention and control of coalbursts, as well as for integrated prevention and control of combined coalbursts and other disasters, have been developed. The energy-absorbing and coalburst-preventing support technology for roadways is invented, and key engineering parameters of coalburst prevention and control are pointed out. In China, coalburst prevention and control laws and standards have been developed. Technical standards for coalbursts are formulated, statute and regulations for coal mines are established, and regulatory documents are promoted. | Yishan Pan Yimin Song Hao Luo Yonghui Xiao | 2024 | Journal of Rock Mechanics and Geotechnical Engineering2024，16，1： | 0 |
| 17 | 2D/2D atomic double-layer WS_(2)/Nb_(2)O_(5)shell/core nanosheets with ultrafast interfacial charge transfer for boosting photocatalytic H_(2)evolution显示文摘Low-efficiency charge transfer is a critical factor to limit the photocatalytic H_(2)evolution activity of semiconductor photocatalysts.The interface design is a promising approach to achieve high chargetransfer efficiency for photocatalysts.Herein,a new 2 D/2 D atomic double-layer WS_(2)/Nb_(2)O_(5)shell/core photocatalyst(DLWS/Nb_(2)O_(5))is designed.The atom-resolved HAADF-STEM results unravel the presence of an unusual 2 D/2 D shell/core interface in DLWS/Nb_(2)O_(5).Taking advantage of the advanced femtosecond-resolved ultrafast TAS spectra,the average lifetime of charge carriers for DLWS/Nb_(2)O_(5)(180.97 ps)is considerably shortened as compared to that of Nb_(2)O_(5)(230.50 ps),strongly indicating that the 2 D/2 D shell/core interface enables DLWS/Nb_(2)O_(5)to achieve ultrafast charge transfer from Nb_(2)O_(5)to atomic double-layer WS_(2),thus yielding a high photocatalytic H_(2)evolution rate of 237.6 mmol/h,up to10.8 times higher than that of pure Nb_(2)O_(5)nanosheet.This study will open a new window for the development of high-efficient photocatalytic systems through the interface design. | Bo Lin Hao Chen Yao Zhou Xiao Luo Dan Tian Xiaoqing Yan Ruihuan Duan Jun Di Lixing Kang Aimin Zhou Guidong Yang Yonghui Li Jiadong Zhou Zheng Liu Fucai Liu | 2021 | Chinese Chemical Letters2021，32，10： | 0 |
| 18 | A human antibody potently neutralizes RSV by targeting the conserved hydrophobic region of prefusion F显示文摘Respiratory syncytial virus(RSV) continues to pose serious threats to pediatric populations due to the lack of a vaccine and effective antiviral drugs. RSV fusion(F) glycoprotein mediates viral-host membrane fusion and is a key target for neutralizing antibodies. We generated 23 full-human monoclonal antibodies(hm Abs) against prefusion F protein(pre-F) from a healthy adult with natural RSV infection by single B cell cloning technique. A highly potent RSV-neutralizing hm Ab, named as 25-20, is selected, which targets a new site Φ-specific epitope. Site-directed mutagenesis and structural modelling analysis demonstrated that 25-20 mainly targets a highly conserved hydrophobic region located at the a4 helix and a1 helix of pre-F, indicating a site of vulnerability for drug and vaccine design. It is worth noting that 25-20 uses an unreported inferred germline(i GL) that binds very poorly to pre-F, thus high levels of somatic mutations are needed to gain high binding affinity with pre-F. Our observation helps to understand the evolution of RSV antibody during natural infection. Furthermore, by in silico prediction and experimental verification, we optimized 25-20 with KD values as low as picomolar range. Therefore, the optimized 25-20 represents an excellent candidate for passive protection against RSV infection. | Chunyan Yi Caixia Su Xiaoyu Sun Xiao Lu Chuanya Si Caixuan Liu Zhuo Yang Hong Yuan Yuying Huang Jing Wen Yonghui He Yaguang Zhang Liyan Ma Yao Cong Gan Zhao Zhiyang Ling Bin Wang Bing Sun | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 19 | Advances in Plant Resistance to Viral Diseases Induced by Exogenous Double-stranded RNA显示文摘Application of exogenous double-stranded RNA( dsRNA) for virus resistance in plants represents a very attractive alternative to virus resistant transgenic crops or pesticides targeting virus vectors.However,the instability of dsRNA is a major challenge as spraying naked dsRNA onto plants provides protection against homologous viruses for only five days.Innovative approaches,such as the use of nanoparticles as carriers of dsRNA for improved stability and sustained release,are emerging as key disruptive technologies.Knowledge about the mechanism of entry,transport and processing of exogenously applied dsRNA in plants is still limited.In addition,cost of dsRNA and regulatory framework are still key influencers towards practical adoption of this technology. | Qiang XIE Junfeng XIN Longfei YU Xiao LEI Yonghui ZHANG | 2018 | Agricultural Biotechnology2018，7，6： | 0 |
| 20 | Laser Study on Q-switch of Cr4+:YAG Self-saturated Crystals显示文摘In recent years,with the rapid development of computer technology applications,computer simulation experiments have been widely used in various fields of science and application,plays an important and indispensable role.Similarly,computer simulation experiments in laser research are also important;it can be a limited amount of time in a large number of repeated experiments,resulting in the characteristics of the laser curve to study.If the same actual experiment,the time required is very long,the investment of funds is huge.So through the computer simulation experiment to guide the actual experiment,can study the smooth progress.It is the guarantee of actual experiment. | Yonghui Lin Xiao Wang Xiaodong Zhao | 2018 | Insight-Physics2018，1，1： | 0 |
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